TRIM28

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TRIM28

Official Full Name tripartite motif containing 28
Background The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.
Synonyms TRIM28; tripartite motif containing 28; transcription intermediary factor 1-beta; KAP1; RNF96; TF1B; TIF1B; KAP-1; KRIP-1; TIF1-beta; RING finger protein 96; KRAB-associated protein 1; nuclear corepressor KAP-1; KRAB-interacting protein 1; E3 SUMO-protein
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Flag
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM28-053H Recombinant Human TRIM28 Mutant (K779R) Protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human TRIM28-1825HCL Recombinant Human TRIM28 cell lysate N/A
    Human TRIM28-225H Recombinant Human TRIM28 Protein, GST-tagged E.coli GST
    Human TRIM28-226H Recombinant Human TRIM28 Protein, His-tagged E.coli His
    Human TRIM28-2325H Recombinant Human TRIM28, His-tagged E.coli His
    Human TRIM28-2658H Recombinant Human TRIM28 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TRIM28-82H Recombinant Human TRIM28, His&FLAG-tagged E.coli His/Flag
    Mouse Trim28-1697M Recombinant Mouse Trim28 protein, His & T7-tagged E.coli His/T7
    Mouse Trim28-6649M Recombinant Mouse Trim28 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat TRIM28-6275R Recombinant Rat TRIM28 Protein Mammalian Cell His

    TRIM28 involved in several pathways and played different roles in them. We selected most pathways TRIM28 participated on our site, such as C-MYB transcription factor network, Corticotropin-releasing hormone, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor network MYOD1; ELANE; CEBPB; MYC; ADA; CDK6; CDKN1B; TOM1; PPID; CREBBP
    Corticotropin-releasing hormone CRHR2; TBX19; JUNB; TCF4; CYP11B1; TFAP2A; CYP21A2; CRH; CASP12; KRT1
    E2F transcription factor network UXT; SMARCA2; CDKN2C; HIC1; CEBPA; CES1; DHFR; PRMT5; TRIM28; CBX5
    Gene Expression ZNF286A; SEC61B; ZNF287; ZIM3; ZNF773; ZNF548; HNRNPL; RARAA; ZNF41; ZNF2
    Generic Transcription Pathway USP9; ZNF12; ZNF167; NR0B1; NR2F1A; ZNF473; MED25; ZNF180; ZNF200; NR6A1
    p53 pathway KAT8; TTC5; NEDD8; HUWE1; CSE1L; FBXO11; E4F1; SMYD2; CSNK1G3; RASSF1

    TRIM28 has several biochemical functions, for example, DNA binding, Krueppel-associated box domain binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM28 itself. We selected most functions TRIM28 had, and list some proteins which have the same functions with TRIM28. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding KCNIP3; HOXA5A; TERT; KIF22; H2AFJ; HOXB2A; ZNF571; NR4A2B; CREB3; CARF
    Krueppel-associated box domain binding TRIM28
    RNA polymerase II transcription coactivator activity POU3F1; MKL1; HYAL2; CITED1; NCOA1; SOX4; ANKRD1; MYOCD; PRRX1; SOX11
    chromo shadow domain binding CHAF1A; SP100; NIPBL; ATRX; LBR; TRIM28
    ligase activity UBE4B; ACSF2; CDC34B; PCXA; RTCB; UBE2L3A; RNF170; UBE2F; UBE2IA; HUWE1
    poly(A) RNA binding CDK5R2; MRPL11; NSUN5; RPP30; NTPCR; QK; DDX5; EZR; ELAVL2; ALDH18A1
    protein binding C14orf104; ELF2; ZNF263; G6PD; JAGN1; CCNA1; KIF20B; HSPE1; TMEM110; MRFAP1
    protein kinase activity RPS6KAL; SNRKB; MAP3K4; PTK2AA; ARAF; STK38A; RPS6KB1B; GSG2; EIF2AK2; DCKL1B
    contributes_to sequence-specific DNA binding HNRNPAB; EPAS1; HDAC4; FIGLA; PPARG; TCF3; NEUROD1; HIF1A; SMAD4; TRIM28
    transcription corepressor activity SKOR2; JAZF1; RBFOX2; PAWR; ATF3; HDAC7A; ZNF136; CTBP2; SFMBT1; HAND1
    contributes_to transcription factor activity, sequence-specific DNA binding NFE2L2A; TAF6; VDRA; RXRA; HNRNPAB; GATA4; SOX19A; VDRB; SMAD3; MAFGA
    ubiquitin protein ligase binding TMEM189; FBXW7; BCL10; VCP; UBE2O; FHIT; UCHL1; TOLLIP; RIPK1; CCT2
    ubiquitin-protein transferase activity UBE2G2; TRIM21; UBE2O; TOPORS; UBA7; RNF115; BARD1; FBXL14; TRAF2; ARIH2
    zinc ion binding ZRANB2; MUL1A; MMP23BB; TADA2A; RC3H1; TRIM12A; ENPEP; AKT1S1; POLR1A; ZRANB1

    TRIM28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM28 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM28.

    MAGEC2; CBX5

    Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
    Lee, M; Dworkin, AM; et al. Metastasis-Associated Protein Ribosomal RNA Processing 1 Homolog B (RRP1B) Modulates Metastasis through Regulation of Histone Methylation. MOLECULAR CANCER RESEARCH 12:1818-1828(2014).

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