The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members.
TRIM34; tripartite motif containing 34; RNF21, tripartite motif containing 34; tripartite motif-containing protein 34; IFP1; Interferon Responsive Finger Protein 1; Ring Finger Protein 21; Ring finger protein 21 interferon responsive; RNF21; TRIM 34; Tripartite motif containing protein 34; tripartite motif-containing 34; interferon-responsive finger protein 1; ring finger protein 21, interferon-responsive