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Recombinant Rat C5 Protein, His/GST-tagged

Cat.No. : C5-564R
Product Overview : Recombinant Rat C5(Asp1~Arg77) fused with His/GST tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
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Description : C5 played an important role in many functions.
Source : E. coli
Species : Rat
Tag : His/GST
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 41.0kDa
Identity : Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Protein length : Asp1~Arg77
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : C5 complement component 5 [ Rattus norvegicus ]
Official Symbol : C5
Synonyms : C5; complement component 5; Hc; C5a;
Gene ID : 25397

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can C5 inhibition be a potential therapy for neuroinflammatory conditions such as multiple sclerosis? 01/10/2023

Yes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.

How is the C5 protein targeted in therapeutic interventions, and what are the available modalities? 08/25/2022

C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.

How is the C5 protein involved in the pathogenesis of diseases like PNH? 02/21/2019

In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.

How does C5 inhibition impact the risk of infections in patients undergoing treatment? 11/16/2016

C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.

What role does C5 play in the progression of inflammatory diseases like rheumatoid arthritis? 09/01/2016

In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.

Customer Reviews (3)

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Reviews
09/29/2019

    Whether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

    10/23/2018

      Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

      11/20/2016

        Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

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