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C1QA

  • Official Full Name

    complement component 1, q subcomponent, alpha polypeptide

  • Overview

    C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
  • Synonyms

    C1QA; complement component 1, q subcomponent, alpha polypeptide; C1q; AI255395; complement C1q subcomponent subunit A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • Human Serum
  • Insect Cell
  • Mammalian Cell
  • Yeast
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human C1QA-10475H Recombinant Human C1QA, GST-tagged E.coli GST 1-245a.a.
Human C1QA-925H Recombinant Human C1QA Protein, His-tagged E.coli His
Human C1QA-8143HCL Recombinant Human C1QA 293 Cell Lysate HEK293 N/A
Human C1QA-2203H Recombinant Human C1QA protein, His&Myc-tagged Insect Cell His&Myc 23-245aa
Human C1QA-26126TH Native Human C1QA Human Serum N/A
Human C1QA-2607H Recombinant Human C1QA protein, His&Myc-tagged E.coli His&Myc 23-245aa
Human C1QA-0112H Recombinant Human C1QA Protein (Ala28-Ala245), His-tagged E.coli His Ala28-Ala245
Human C1QA-2528H Recombinant Human C1QA protein(23-245 aa), C-His-tagged E. coli C-His 23-245 aa
Human C1QA-926H Recombinant human C1QA protein, His-tagged E.coli His
Human C1QA-2606H Recombinant Human C1QA protein, His-SUMO-tagged E.coli His-SUMO 23-245aa
Human C1QA-333H Recombinant Human C1QA Protein, His-tagged E.coli N-His Ala28-Ala245
Mouse C1qa-7932M Recombinant Mouse C1qa protein, His & T7-tagged E.coli His/T7 Glu23~Ala245 (Accession # P98086)
Mouse C1QA-2560M Recombinant Mouse C1QA Protein Mammalian Cell His
Mouse C1QA-1131M-B Recombinant Mouse C1QA Protein Pre-coupled Magnetic Beads HEK293
Mouse C1qa-2608M Recombinant Mouse C1qa protein, His-SUMO-tagged E.coli His-SUMO 23-245aa
Mouse C1QA-1131M Recombinant Mouse C1QA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse C1qa-2609M Recombinant Mouse C1qa protein, His-tagged E.coli His 23-245aa
Mouse C1QA-1345M Recombinant Mouse C1QA Protein (23-245 aa), His-tagged Yeast His 23-245 aa
Rat C1QA-1041R Recombinant Rat C1QA Protein Mammalian Cell His
Rat C1qa-7933R Recombinant Rat C1qa protein, His & T7-tagged E.coli His/T7 Glu23~Ala245 (Accession # P31720)
Rat C1QA-699R-B Recombinant Rat C1QA Protein Pre-coupled Magnetic Beads HEK293
Rat C1QA-699R Recombinant Rat C1QA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat C1qa-2610R Recombinant Rat C1qa protein, His-SUMO-tagged E.coli His-SUMO 23-245aa
Zebrafish C1QA-2722Z Recombinant Zebrafish C1QA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • C1QA Related Articles
  • C1QA Related Research Area

C1QA involved in several pathways and played different roles in them. We selected most pathways C1QA participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesGM5077;SERPINE1;C1S;BDKRB1;LOC100514666;C4A;MASP2;C5AR1;PROC
Prion diseasesC1QC;LAMC1;MAPK1;Hc;HSPA5;SOD1;C8B;PRKACG;C8A
PertussisMAPK8;RELA;IL12B;MAPK1;NOS2;C4BPB;ITGA5;CALM2;CASP7
Chagas disease (American trypanosomiasis)Fasl;ACE;IL10;MAP2K4;PIK3R1;TLR9;IFNGR2;IKBKB;CD247
Staphylococcus aureus infectionFCGR2A;SELP;FCAR;H2-AB1;FPR2;ITGAM;CFH;C1QA;HLA-DOB
Systemic lupus erythematosusHLA-DOB;C4A;FCGR3A;HIST1H2BF;HIST1H3G;HIST1H4G;GRIN2B;CD28;FCGR1A

C1QA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QA itself. We selected most functions C1QA had, and list some proteins which have the same functions with C1QA. You can find most of the proteins on our site.

Function Related Protein
protein bindingSTXBP3A;ZNF317;CEP63;WBP1;ATP6V0A1;CXorf48;TXNDC16;IFT20;DRD1

C1QA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QA here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QA.

C1QB; C1QC; LRP1; SGTA; PIAS2; PPP1CC; BAG6; PPP1CA; SLC25A47; GNPNAT1; HIPK3; q9k5j5_bacan; UBQLN2; UBQLN1; APOA1

Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
Trouw, LA; Daha, N; et al. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 173:76-83(2013).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What role does C1QA play in the clearance of apoptotic cells? 01/23/2022

It plays a role in recognizing and promoting the removal of apoptotic cells.

What therapeutic strategies are being explored involving C1QA modulation? 07/08/2021

Strategies are being explored to modulate C1QA activity in conditions like lupus and rheumatoid arthritis.

Are there known genetic mutations in C1QA associated with specific health conditions? 03/15/2021

Genetic deficiencies in C1QA are linked to increased susceptibility to infections and autoimmune conditions.

In which immune responses is C1QA critically involved? 03/01/2021

C1QA is involved in immune responses against pathogens and in the clearance of immune complexes.

How is C1QA implicated in autoimmune diseases? 06/27/2020

Dysregulation of C1QA can contribute to impaired clearance of immune complexes, leading to autoimmune diseases.

How does C1QA contribute to the activation of the complement system? 02/09/2020

It binds to antibodies or C-reactive protein on pathogen surfaces, activating C1r and C1s in the C1 complex.

What is the primary function of C1QA in the immune system? 08/27/2019

C1QA is a vital component of the C1 complex, initiating the classical complement pathway.

Customer Reviews (3)

Write a review
Reviews
01/23/2022

    Excellent quality, fast delivery.

    03/01/2021

      Reliable in experiments, quality.

      02/09/2020

        Product met all requirements.

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