c2

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c2

Official Full Name complement component 2
Background Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
Synonyms C2; complement component 2; CO2; ARMD14; complement C2; C3/C5 convertase; complement component C2;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II)
    • NS0
    • Tag :
    • Fc
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human C2-26739TH Recombinant Human C2 E.coli N/A
    Human C2-3068HCL Recombinant Human C2 cell lysate Human Cell N/A
    Human C2-598H Recombinant Human Complement Component 2, His-tagged HEK293 His
    Human C2-599H Recombinant Human Complement Component 2, Fc Chimera HEK293 Fc
    Human C2-6878H Recombinant Human C2, His tagged Human Cell His
    Human C2-7265H Recombinant Human C2, Fc tagged Human Cell Fc
    Human C2-7846H Recombinant Human C2 protein, His & T7-tagged E.coli His/T7
    Human C2-98H Native Human C2 Protein Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II) N/A
    Mouse C2-001MCL Recombinant Mouse C2 cell lysate Human Cell N/A
    Mouse C2-1012M Recombinant Mouse C2 Protein, His-tagged NS0 His
    Mouse C2-480M Recombinant Mouse C2, His-tagged Human Cell His
    Rat C2-7847R Recombinant Rat C2 protein, His & T7-tagged E.coli His/T7

    c2 involved in several pathways and played different roles in them. We selected most pathways c2 participated on our site, such as Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with c2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades Hc; SERPINA1A; FGB; C4BPA; C3; LOC100514666; PROS1; MASP2; F13B; SERPINA1
    Pertussis IL6; Il23a; CALML3; C1QB; C4A; RELA; FOS; MAPK11; CFL2; CASP7
    Staphylococcus aureus infection FCAR; H2-AA; FCGR3B; Hc; FPR1; C5AR1; FCGR3; FCGR1; FCGR2A; FCGR2B
    Systemic lupus erythematosus HIST1H2AP; HIST1H4G; FCGR1; C1S; HIST1H2AO; HIST1H2BQ; FCGR2A; HIST1H4L; HIST1H2AB; HIST1H2BL

    c2 has several biochemical functions, for example, metal ion binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by c2 itself. We selected most functions c2 had, and list some proteins which have the same functions with c2. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding RARGB; ATP1A3; MT1; ACVRL1; PPM1DB; CTDSP2; ZNF789; AGAP5; ZHX1; GNA14
    serine-type endopeptidase activity PRTN3; ELA2L; HP; MASP2; MCPT9; PLG; GM5077; TMPRSS13B; PRSS48; GZMC

    c2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with c2 here. Most of them are supplied by our site. Hope this information will be useful for your research of c2.

    q81l39_bacan

    Kahle, J; Orlowski, A; et al. Epitope mapping via selection of anti-FVIII antibody-specific phage-presented peptide ligands that mimic the antibody binding sites. THROMBOSIS AND HAEMOSTASIS 113:396-405(2015).
    Shetty, KA; Kosloski, MP; et al. Soy Phosphatidylinositol Containing Nanoparticle Prolongs Hemostatic Activity of B-Domain Deleted Factor VIII in Hemophilia A Mice. JOURNAL OF PHARMACEUTICAL SCIENCES 104:388-395(2015).

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