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Official Full Name C12orf65 chromosome 12 open reading frame 65 [ Homo sapiens (human) ]
Background This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants.
Synonyms C12orf65; chromosome 12 open reading frame 65; CL065_HUMAN; COXPD7; mitochondrial; Probable peptide chain release factor C12orf65; probable peptide chain release factor C12orf65, mitochondrial; SPG55
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human C12orf65-6454H Recombinant Human C12orf65 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human C12orf65-10376H Recombinant Human C12orf65, GST-tagged E.coli GST
    Human C12orf65-4328H Recombinant Human C12orf65 Protein, GST-tagged Wheat Germ GST
    Human C12orf65-624H Recombinant Human C12orf65 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human C12orf65-8310HCL Recombinant Human C12orf65 293 Cell Lysate HEK293 N/A

    c12orf65 involved in several pathways and played different roles in them. We selected most pathways c12orf65 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with c12orf65 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    c12orf65 has several biochemical functions, for example, aminoacyl-tRNA hydrolase activity, ribosome binding, translation release factor activity, codon nonspecific. Some of the functions are cooperated with other proteins, some of the functions could acted by c12orf65 itself. We selected most functions c12orf65 had, and list some proteins which have the same functions with c12orf65. You can find most of the proteins on our site.

    Function Related Protein
    aminoacyl-tRNA hydrolase activity C12orf65; PTRH1; PTRHD1; ICT1; PTRH2
    ribosome binding ETF1; CPEB1A; ETF1B; EIF5A2; WIBG; CPEB1B; CPEB4; CPEB1; CPEB2; EIF2A
    translation release factor activity, codon nonspecific C12orf65; ICT1
    NOT translation release factor activity, codon specific ICT1; C12orf65

    c12orf65 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with c12orf65 here. Most of them are supplied by our site. Hope this information will be useful for your research of c12orf65.


    Akabane, S; Ueda, T; et al. Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria. PLOS GENETICS 10:-(2014).
    Spiegel, R; Mandel, H; et al. Delineation of C12orf65-related phenotypes: a genotype-phenotype relationship. EUROPEAN JOURNAL OF HUMAN GENETICS 22:-(2014).

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