C1QB
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Official Full Name
complement component 1, q subcomponent, B chain -
Overview
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in;order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus;erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six;C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The;A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of;human complement subcomponent C1q. -
Synonyms
C1QB;complement component 1, q subcomponent, B chain;complement component 1, q subcomponent, beta polypeptide;complement C1q subcomponent subunit B;Complement component 1 q subcomponent B chain;Complement component 1 q subcomponent beta polypeptide;Complement component C1q B chain;Complement subcomponent C1q chain B;OTTHUMP00000002940;OTTHUMP00000002941;complement component C1q, B chain
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Insect Cells
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
- SUMO
Involved Pathway
C1QB involved in several pathways and played different roles in them. We selected most pathways C1QB participated on our site, such as Complement and coagulation cascades,Prion diseases,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chagas disease (American trypanosomiasis) | C1QC,PIK3CA,TLR2,IL1B2,CASP8,MAPK8,PLCB3,GNAL,Fasl,CD247 |
| Pertussis | GNAI1,CASP1,IRF1,IL12B,CALM4,NOS2,RHOA,MAPK1,MAPK13,IL1B |
| Staphylococcus aureus infection | C1S,C1RA,HLA-DQA1,FCGR1A,C3,HLA-DMB,FPR3,HLA-DMA,DSG1,ITGAM |
| Prion diseases | SOD1,PRKACA,C6,BAX,MAP2K1,C5,PRKACB,HSPA5,C9,Hc |
| Complement and coagulation cascades | C7,CFI,CFH,C5AR1,F3,SERPINF2,Serpina1c,KLKB1,PLAT,C4BPA |
| Systemic lupus erythematosus | GM14482,HIST1H2BC,HIST1H2BK,HIST1H2BN,H2-AB1,HIST1H4N,H2BFWT,GM14479,HIST2H2AA2,HIST1H3E |
Protein Function
C1QB has several biochemical functions, for example, protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QB itself. We selected most functions C1QB had, and list some proteins which have the same functions with C1QB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | VIL1,ALS2,JAM3,SYT16,RENBP,CEBPB,FZD9,TBX18,TRPM8,IRF3 |
| protein binding | H2-KE2,NRADD,DLAT,POU3F2,H3F3A,IVL,ARMC2,RSPH3,TREML1,SPRED1 |
Interacting Protein
C1QB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QB here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QB.
C1QA;RELA;q7chk1_yerpe;sbcD;treC;q81sh2_bacan;EDA2R
Resources
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References
- Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
- Nagano, F; Kaneko, T; et al. Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction. JOURNAL OF PERIODONTAL RESEARCH 48:420-427(2013).
