C1QB

  • Official Full Name

    complement component 1, q subcomponent, B chain
  • Overview

    This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in;order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus;erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six;C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The;A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of;human complement subcomponent C1q.
  • Synonyms

    C1QB;complement component 1, q subcomponent, B chain;complement component 1, q subcomponent, beta polypeptide;complement C1q subcomponent subunit B;Complement component 1 q subcomponent B chain;Complement component 1 q subcomponent beta polypeptide;Complement component C1q B chain;Complement subcomponent C1q chain B;OTTHUMP00000002940;OTTHUMP00000002941;complement component C1q, B chain

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Zebrafish
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Non
  • Avi
  • Fc
  • Flag
  • DDK
  • Myc
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
C1QB-596H Recombinant Human C1QB protein(Met1-Ala253), His-tagged Insect Cells Human His 1-253 a.a.
C1QB-1042R Recombinant Rat C1QB Protein Mammalian Cells Rat His
C1QB-2561M Recombinant Mouse C1QB Protein Mammalian Cells Mouse His
C1QB-926Z Recombinant Zebrafish C1QB Mammalian Cells Zebrafish His
C1QB-651HCL Recombinant Human C1QB cell lysate Insect Cells Human Non
C1QB-1132M Recombinant Mouse C1QB Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
C1QB-1132M-B Recombinant Mouse C1QB Protein Pre-coupled Magnetic Beads HEK293 Mouse
C1QB-2136HFL Recombinant Full Length Human C1QB Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
C1QB-464H Recombinant Human C1QB Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
C1QB-464H-B Recombinant Human C1QB Protein Pre-coupled Magnetic Beads HEK293 Human
C1QB-4752H Recombinant Human C1QB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
C1QB-598H Active Recombinant Human C1QB Protein, His-SUMO-tagged E.coli Human His&SUMO
C1QB-599H Recombinant human C1QB protein, His-tagged E.coli Human His 28-253 a.a.
C1QB-700R Recombinant Rat C1QB Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
C1QB-700R-B Recombinant Rat C1QB Protein Pre-coupled Magnetic Beads HEK293 Rat
C1qb-730M Recombinant Mouse C1qb Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    C1QB involved in several pathways and played different roles in them. We selected most pathways C1QB participated on our site, such as Complement and coagulation cascades,Prion diseases,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prion diseases ELK1,PRKACA,CCL5,C6,MAP2K1,C9,IL6,C5,C1QC,SOD1
    Complement and coagulation cascades F2,PROS1,CPB2,BDKRB2,FGA,SERPINA1,C3,C8G,A2M,Serpina1b
    Chagas disease (American trypanosomiasis) PLCB2,MAPK12,PIK3CD,FADD,CCL2,CCL3L1,MAPK10,CFLAR,PIK3CB,Il2
    Systemic lupus erythematosus H2-AB1,CD40,HIST1H2BI,FCGR4,HIST1H2BP,GRIN2B,HIST1H2BM,HIST1H3A,HLA-DQA2,Hc
    Staphylococcus aureus infection HLA-DQB1,C1RA,HLA-DPB1,HLA-DRB3,HLA-DRB5,C5,H2-AB1,HLA-DMA,CFI,SELPLG
    Pertussis RELA,Hc,ITGA5,IL1B,TICAM2,AMCF-II,NLRP3,CFL2,ITGAM,RHOA

    Protein Function

    C1QB has several biochemical functions, for example, protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QB itself. We selected most functions C1QB had, and list some proteins which have the same functions with C1QB. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ALKBH3,PPP3CC,ACAD9,RPS2,PHF10,STAT5B,MAGEA4,MAP4,CD84,OSTC
    protein homodimerization activity PEX11A,PDGFRA,SLC4A1,BOKA,STK25,PPP2R4,TENM1,ANO6,CECR1,CCDC88A

    Interacting Protein

    C1QB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QB here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QB.

    C1QA;RELA;q7chk1_yerpe;sbcD;treC;q81sh2_bacan;EDA2R

    Resources

    Unveiling the C1QB Protein: The Unsung Hero of Our Immune System

    Unveiling the C1QB Protein: The Unsung Hero of Our Immune System

    References

    • Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
    • Nagano, F; Kaneko, T; et al. Gram-positive bacteria as an antigen topically applied into gingival sulcus of immunized rat accelerates periodontal destruction. JOURNAL OF PERIODONTAL RESEARCH 48:420-427(2013).

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