c3
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  • Official Full Name
  • complement component 3
  • Background
  • C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
  • Synonyms
  • complement C3; Acylation Stimulating Protein Cleavage Product; ASP; C3 and PZP like alpha 2 macroglobulin domain containing protein 1; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3; CO3_HUMAN; Complement C3 precursor; Complement C3c alpha'' chain fragment 2; Complement Component 3; Complement factor 3; CPAMD 1; CPAMD1
Cat.#:C3-1149HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C3 Protein, His-tagged
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Cat.#:C3-1841HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human C3 Protein, MYC/DDK-tagged
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Cat.#:C3-4324RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit C3 Protein
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Cat.#:C3-4325STag:
Source (Host):YeastSpecies:Swine
Product nameRecombinant Swine C3 Protein
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Cat.#:C3-10522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C3, His-tagged
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Cat.#:C3-558HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C3 Protein, His/GST-tagged
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Cat.#:C3-603HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C3
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Cat.#:C3-7631HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C3 protein, His-tagged
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Cat.#:C3-7842HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human C3 protein, His-tagged
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Cat.#:C3-559MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse C3 Protein, His/GST-tagged
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Cat.#:C3-7632MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse C3 protein, His-tagged
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Cat.#:C3-7843MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse C3 protein, His-tagged
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Cat.#:C3-1050RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat C3 Protein
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Cat.#:C3-561RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat C3 Protein, His/GST-tagged
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Cat.#:C3-7845RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat C3 protein, His-tagged
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Cat.#:C3-6956CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken C3
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Cat.#:C3-560PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig C3 Protein, His/GST-tagged
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Cat.#:C3-7844PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig C3 protein, His & T7-tagged
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Cat.#:C3-194HTag:
Source (Host):Species:Human
Product nameNative Human Complement C3c
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Cat.#:C3-365HTag:
Source (Host):Human serumSpecies:Human
Product nameNative Human C3 Protein
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Cat.#:C3-8092HTag:N/A
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Plasma COMPLEMENT C (C3)
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Cat.#:C3-8391HTag:
Source (Host):PlasmaSpecies:Human
Product nameNative Human C3
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Cat.#:C3-001CTag:
Source (Host):C. botulinumSpecies:C. botulinum
Product nameNative C. botulinum C3 Enzyme
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Cat.#:C3-147CTag:
Source (Host):Clostridium botulinum D bacteriophageSpecies:Clostridium botulinum D bacteriophage
Product nameNative Botulinum C3 Enzyme
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Cat.#:C3-7HTag:
Source (Host):Species:Human
Product nameHuman C3 Reference Standard
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Cat.#:C3-33MTag:N/A
Source (Host):Species:Mouse
Product nameMouse C3 Reference Standard
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Cat.#:C3-73RTag:N/A
Source (Host):Species:Rat
Product nameRat C3 Reference Standard
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Involved Pathway

C3 involved in several pathways and played different roles in them. We selected most pathways C3 participated on our site, such as Phagosome, Complement and coagulation cascades, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
STX12; NOX1; ITGAV; ATP6V1F; TFRC; C1RA; MPO; THBS4B; SEC22BB; CLEC4M
Complement and coagulation cascades
SERPIND1; C5; GM5077; F13B; C1QC; F7; SERPINA1D; SERPINA5; C6; SERPING1
Pertussis
GNAI2; MAPK11; ITGB2; C1RA; MAPK3; C1R; C4BP; PYCARD; C4A; LY96
Legionellosis
TNF; HSPA2; RAB1; CYCS; IL18; ITGB2; NAIP1; IL6; RAB1A; CLK1
Leishmaniasis
IL12A; STAT1; MAP3K7; NFKBIA; NCF1; MAPK3; FCGR3A; ITGB1; NCF2; CYBA
Chagas disease (American trypanosomiasis)
MAPK12; CD3G; TLR4; C1QB; GNAI2; RELA; TNF; TLR6; MAPK1; FOS
Staphylococcus aureus infection
H2-AA; MBL1; C3AR1; HLA-DMB; PTAFR; C5; FCGR2C; FPR1; HLA-DRA; HLA-DRB4
Tuberculosis
Pla2r1; IFNA7; IFNA17; CD209A; RFX5; TRADD; HLA-DRB4; FCGR3B; CD14; FCGR1A
Herpes simplex infection
EIF2AK2; SP100; CDC34A; TRAF2; IFN-a; Ifna15; TRAF6; HLA-B; IFNA12; HLA-DMA
Viral carcinogenesis
CDC20; HIST1H4F; GTF2H2; STAT5B; TRAF5; HLA-G; HIST1H2BJ; PRKACB; TRAF3; HIST1H2BG
Systemic lupus erythematosus
H2BFWT; HIST1H2AN; HIST1H4L; C2; HIST1H2BH; HIST1H3D; H2AFJ; SNRPD3; H2AFB1; CD86

Protein Function

C3 has several biochemical functions, for example, C5L2 anaphylatoxin chemotactic receptor binding, cofactor binding, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C3 itself. We selected most functions C3 had, and list some proteins which have the same functions with C3. You can find most of the proteins on our site.
Function
Related Protein
Function C5L2 anaphylatoxin chemotactic receptor binding
Related Protein C3
Function cofactor binding
Related Protein HIF1AN; DDO; TKT; ACLY; HACL1; TYMS; C3; UROS; ASNS; ACLYA
Function endopeptidase inhibitor activity
Related Protein PZP; MUG2; C3; C3A.2; Serpina1c; A2ML; SERPINF2; C5; C3P1; PROS1
Function lipid binding
Related Protein PLEKHA2; APOA1A; FABP11B; LPAR4; COQ9; SNX27; LTC4S; APOC2; ACOT11B; FABP7
Function protein binding
Related Protein SLC41A3; MPDZ; RPSA; PEPD; BMP2; ARNTL2; MED22; IRF1; HSP90AA1.1; CHMP1B
Function receptor binding
Related Protein HIST2H3C2; CADM2A; ANKRD13C; POMC; FLT3LG; WNT7A; FRK; GIPC1; HTT; CALCA

Interacting Protein

C3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C3 here. Most of them are supplied by our site. Hope this information will be useful for your research of C3.
VSIG4; VSIG4; CD46; d3jib2_staau; IGM; VHL; ASF1B; TGM2; q99ib8-pro_0000045598; q99ib8-pro_0000045601; d-mannose; crlkekhc; IGHM

C3 Related Articles

Ohta, T; Urayama, K; et al. Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. PEDIATRIC NEPHROLOGY 30:603-608(2015).
Yue, PJ; He, L; et al. Long-term toxicity study of rAd5-hTERTC27 in SD rats and Cynomolgus monkeys by intravenous injection. REGULATORY TOXICOLOGY AND PHARMACOLOGY 71:285-294(2015).