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Official Full Name complement component 1, s subcomponent
Background This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Synonyms C1S; complement component 1, s subcomponent; complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s;
    • Species :
    • Chicken
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human C1S-10489H Recombinant Human C1S, GST-tagged E.coli GST
    Human C1S-120H Recombinant Human C1S, His-tagged NS0 His
    Human C1S-1788H Recombinant Human C1S protein, His & T7-tagged E.coli His/T7
    Human C1S-26615TH Recombinant Human C1S Wheat Germ N/A
    Human C1S-5501H Recombinant Human C1S Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human C1S-550H Native Human C1S Enzyme N/A
    Human C1S-597H Recombinant Human C1S, His tagged Human Cell His
    Human C1S-8131HCL Recombinant Human C1S 293 Cell Lysate HEK293 N/A
    Rat C1S-1049R Recombinant Rat C1S Protein Mammalian Cell His
    Chicken C1S-2476C Recombinant Chicken C1S Mammalian Cell His

    c1s involved in several pathways and played different roles in them. We selected most pathways c1s participated on our site, such as Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with c1s were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades C6; F9; PLAT; SERPINE1; F13A1; KLKB1; TFPI; CFH; SERPING1; F7
    Pertussis C1QA; C3; CASP7; LY96; GNAI2; C1S; CALM3; C4BPB; RHOA; ITGA5
    Staphylococcus aureus infection ITGB2L; C1RA; HLA-DMA; FCGR4; FCGR2A; cgr2b; HLA-DRB4; MBL2; ITGAL; MBL1
    Systemic lupus erythematosus HIST1H2AJ; HIST1H4E; HIST1H2BH; HIST1H4H; C1QA; HIST1H4N; FCGR1A; HLA-DRA; HIST1H2AM; HIST1H4I

    c1s has several biochemical functions, for example, calcium ion binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by c1s itself. We selected most functions c1s had, and list some proteins which have the same functions with c1s. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CDHR1A; EYS; PCDHGA8; PCDHB5; CBLC; SCUBE2; JAG1; PCDH2AB7; PCDHGB4; CALUA
    identical protein binding KCTD17; TRIM55; SMAD3; IGF2R; TYROBP; CCDC91; GAPDH; GBP5; VPS41; CNTN2
    protein binding TDO2; NUP85; ASAP1; IER3; NELL1; PHAX; ETV1; SIAH2; FAM206A; CDT1
    serine-type endopeptidase activity KLK1B26; TMPRSS15; HTRA1A; CTRB1; PRSS40; PRSS50; MST1; MASP1; PCSK5; PCSK2

    c1s has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with c1s here. Most of them are supplied by our site. Hope this information will be useful for your research of c1s.

    C1R; calcium(2+); Dlg4; q7ckm5_yerpe; eutG; yrbF; q81um1_bacan; q81ux8_bacan; emrR; d-mannose

    Keizer, MP; Pouw, RB; et al. TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. EUROPEAN JOURNAL OF IMMUNOLOGY 45:544-550(2015).
    Muia, J; Zhu, J; et al. Allosteric activation of ADAMTS13 by von Willebrand factor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:18584-18589(2014).

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