C1s
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Official Full Name
complement component 1, s subcomponent
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Overview
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009] -
Synonyms
C1S; complement component 1, s subcomponent; complement C1s subcomponent; C1 esterase; basic proline-rich peptide IB-1; complement component 1 subcomponent s;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- C1s Related Articles
C1s involved in several pathways and played different roles in them. We selected most pathways C1s participated on our site, such as Complement and coagulation cascades, Pertussis, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1s were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | PLAT;THBD;SERPIND1;FGG;CR1;C4BPB;MBL1;CFI;C1QB |
Pertussis | CALM3;CALM4;CXCL5;SERPING1;MAPK13;C1S;C1R;ITGB2L;IRAK4 |
Staphylococcus aureus infection | HLA-DQA1;HLA-DPA1;H2-AB1;C1QC;CFH;DSG1C;HLA-DRB5;SELPLG;C5 |
Systemic lupus erythematosus | HIST1H3E;HIST1H4F;H2AFY2;HLA-DRA;HIST2H3C1;C9;SNRPD1;GRIN2B;HLA-DRB5 |
C1s has several biochemical functions, for example, calcium ion binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1s itself. We selected most functions C1s had, and list some proteins which have the same functions with C1s. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | EHD1A;CANX;DST;KCNIP1;PRSS2;PCDHB7;SLC25A25A;ANXA13L;CDHR1 |
identical protein binding | LYZ;EIF2AK3;LTBR;KCNJ2;MAP3K13;BNIP3;RUNX1T1;CLDN14;GLUD1 |
protein binding | SFTPC;FGFRL1A;ZRANB1;SPTSSB;PHYHD1;BAG2;NAP1L2;REXO1L1;ENSA |
serine-type endopeptidase activity | KLK1B8;PCSK9;KLK1B1;TMPRSS11E;HABP2;PCSK6;KLK1B16;GZME;CELA2B |
C1s has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1s here. Most of them are supplied by our site. Hope this information will be useful for your research of C1s.
C1R; calcium(2+); Dlg4; q7ckm5_yerpe; eutG; yrbF; q81um1_bacan; q81ux8_bacan; emrR; d-mannose
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, C1S protein deficiency is rare, but it is more common in patients with a family history of HAE.
Side effects can include infusion site reactions or hypersensitivity reactions, so treatment is typically administered under medical supervision.
C1S protein replacement therapy is usually given intravenously, and the frequency of administration may vary depending on the patient's needs.
C1S replacement therapy is primarily used for HAE, but researchers are investigating its potential use in other complement-related disorders.
Yes, ongoing research aims to better understand the role of C1S in HAE and explore new treatment options, such as gene therapy.
Customer Reviews (3)
Write a reviewThis level of sensitivity and specificity has streamlined my research and allowed for precise protein characterization.
The protein bands detected were exceptionally distinct, enabling easy interpretation and accurate analysis of protein expression patterns.
To summarize, the C1S protein is a highly recommended asset for various research endeavors, including ELISA, protein electron microscopy structure analysis, and Western blotting.
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