|Official Full Name||chib|
|Background||Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.|
|Synonyms||C; chib; C22orf2, chromosome 22 open reading frame 2 , PGEA1, PKD2 interactor, golgi and endoplasmic reticulum associated 1; protein chibby homolog 1; Cby; Chibby; PIGEA 14; PIGEA14; C22orf2; Cytosolic leucine rich protein; HRIHFB2025; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; Protein Chibby; OTTHUMP00000198875; OTTHUMP00000198876; OTTHUMP00000198878; ARPP-binding protein; coiled-coil protein PIGEA-14; cytosolic leucine-rich protein; PKD2 interactor, golgi and end; arb1; PGEA1; PIGEA-14; HS508I15A|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
c involved in several pathways and played different roles in them. We selected most pathways c participated on our site, such as Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Deactivation of the beta-catenin transactivating complex||CTBP1; BCL9L; TLE3B; SOX9B; C; SRY; SOX6; TLE1; PYGO1; TLE2|
|Signal Transduction||ARHGAP28; GPR18; IQGAP3; NEDD8L; EVL; GPR31; PNOC; CRABP2; CALML4; CCDC88C|
|Signaling by Wnt||SOX6; SOX4B; WNT8-2; DACT1; KLHL12; HECW1; BCL9; CSNK1G2; C; SOX9A|
|TCF dependent signaling in response to WNT||RSPO3; RBBP5; BCL9L; HECW1; SOX9A; LGR4; SRY; TNKS; SOX4A; RSPO1|
c has several biochemical functions, for example, beta-catenin binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by c itself. We selected most functions c had, and list some proteins which have the same functions with c. You can find most of the proteins on our site.
|beta-catenin binding||CHD8; RORA; PTBP3; PTPRU; PTPRJ; CDH5; Ar; SOX9; CDH1; CDH2|
|identical protein binding||NOXO1; KCNJ10; CAV1; DNM1; CRYAB; GRB7; BIRC5; KCNRG; SHANK3; SLK|
c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with c here. Most of them are supplied by our site. Hope this information will be useful for your research of c.