|Official Full Name||chromosome 16 open reading frame 57|
|Background||This gene encodes a protein with several conserved domains, however, its exact function is not known. Mutations in this gene are associated with poikiloderma with neutropenia (PN), which shows phenotypic overlap with Rothmund-Thomson syndrome (RTS) caused by mutations in the RECQL4 gene. It is believed that this gene product interacts with RECQL4 protein via SMAD4 proteins, explaining the partial clinical overlap between PN and RTS. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.|
|Synonyms||C16ORF57; chromosome 16 open reading frame 57; UPF0406 protein C16orf57; FLJ13154; HVSL motif containing 1; HVSL1; poikiloderma with neutropenia; PN|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
c16orf57 involved in several pathways and played different roles in them. We selected most pathways c16orf57 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with c16orf57 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
c16orf57 has several biochemical functions, for example, 3-5-exoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by c16orf57 itself. We selected most functions c16orf57 had, and list some proteins which have the same functions with c16orf57. You can find most of the proteins on our site.
|3-5-exoribonuclease activity||CNOT8; ISG20; PAN2; DIS3; PNPT1; EXOSC7; DIS3L; EXOSC3; SMFN; EXOSC2|
c16orf57 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with c16orf57 here. Most of them are supplied by our site. Hope this information will be useful for your research of c16orf57.