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C6

Official Full Name

complement component 6
Overview

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Synonyms

C6; complement component 6; complement component C6;

Type

Recombinant Proteins
Cell & Tissue Lysates
Native Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
Human Cell
Human Plasma
In Vitro Cell Free System
Mammalian Cell
Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	C6-10553H	Recombinant Human C6, GST-tagged	E.coli	GST	586-934a.a.	$319 / 25ug
Human	C6-8191H	Recombinant Human C6 protein, His & T7-tagged	E.coli	His/T7	Gln682~Ala934 (Accession # P13671)	Inquiry
Human	C6-1055H	Recombinant Human C6 protein, His-tagged	HEK293	His	Met1-Ala934	Inquiry
Human	C6-10552H	Recombinant Human C6 protein, His/T7-tagged	E.coli	His/T7	Gln682~Ala934	$298 / 10ug
Human	C6-0098H	Recombinant Human C6 Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	C6-1647HCL	Recombinant Human C6 cell lysate	Human Cell	N/A		Inquiry
Human	C6-2678HF	Recombinant Full Length Human C6 Protein, GST-tagged	In Vitro Cell Free System	GST	934 amino acids	Inquiry
Human	C6-101H	Native Human C6 Protein	Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)	N/A		Inquiry
Human	C6-55H	Native Human Complement C6	Human Plasma	N/A		Inquiry
Human	C6-0619H	Recombinant Human C6 Protein (Gln682-Ala934), N-His-tagged	E.coli	N-His	Gln682-Ala934	Inquiry
Rat	C6-1054R	Recombinant Rat C6 Protein	Mammalian Cell	His		Inquiry
Rat	C6-712R	Recombinant Rat C6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	C6-712R-B	Recombinant Rat C6 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	C6-10910Z	Recombinant Zebrafish C6	Mammalian Cell	His		Inquiry
Chicken	C6-3905C	Recombinant Chicken C6	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
C6 Related Articles
C6 Related Research Area

C6 involved in several pathways and played different roles in them. We selected most pathways C6 participated on our site, such as Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with C6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Complement and coagulation cascades	C6;F8;C1R;CFH;C8G;MASP2;FGA;CR1;F10
Prion diseases	C1QC;IL1A;LOC100033925;MAPK1;PRKACG;MAPK3;FYN;LAMC1;C8G
Systemic lupus erythematosus	HIST3H3;HIST2H3C1;HIST2H2AA4;H2AFY;GM14482;CD86;H2AFB2;H2AFB1;HIST2H4A

C6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C6 itself. We selected most functions C6 had, and list some proteins which have the same functions with C6. You can find most of the proteins on our site.

Function	Related Protein
protein binding	TLE2;KDM1A;CCDC41;SCNN1B;COL1A1;DDX20;PRL2C2;CRYBA1;TDRKH

C6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C6 here. Most of them are supplied by our site. Hope this information will be useful for your research of C6.

ABL1; FYN; NCK1; GRB2; SART3; d-mannose

Prantner, AM; Turini, M; et al. Anti-Mesothelin Nanobodies for Both Conventional and Nanoparticle-Based Biomedical Applications. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11:1201-1212(2015).

Tiezzi, F; Parker-Gaddis, KL; et al. A Genome-Wide Association Study for Clinical Mastitis in First Parity US Holstein Cows Using Single-Step Approach and Genomic Matrix Re-Weighting Procedure. PLOS ONE 10:-(2015).

Membrane Attack Complex (MAC)