| Cat. No.: | TNFRSF17-2604H |
| Product Overview: | Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 17 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 5.3 kDa. The TNFRSF17 is purified by standard chromatographic techniques. |
| Description: | TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. |
| Source: | E.Coli. |
| Purity: | Greater than 98% as determined by SDS-PAGE. |
| Sequence: | AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA. |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | 1mg of TNFRSF17 Human contains 20mM PBS, pH-7.4, and 130mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized TNFRSF17 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
| Storage: | Lyophilized TNFRSF17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TNFRSF17 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze/thaw cycles. |
| Gene Name: | TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ] |
| Synonyms: | TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B-cell maturation protein |
| Gene ID: | 608 |
| mRNA Refseq: | NM_001192 |
| Protein Refseq: | NP_001183 |
| MIM: | 109545 |
| UniProt ID: | Q02223 |
| Chromosome Location: | 16p13.1 |
| Pathway: | Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production |
| Function: | protein binding; receptor activity; tumor necrosis factor receptor activity |
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