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TNFRSF11A

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 11a

  • Overview

    Murine sRANK-Ligand or Soluble Receptor Activator of NF-κB Ligand, also known as Tumor Necrosis Factor Ligand Superfamily Member 11, is a 316 amino acid cytokine protein expressed from the Tnfsf11 gene located on chromosome 14. The peptide chain that exists from residue 1-36 is the membrane form of the RANK-Ligand while the chain that exists from residue 139-178 is the soluble form of the RANK-Ligand. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. The sRANK-Ligand is the cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK and acts as an osteoclast differentiation and activation factor. Moreover, the sRANK-Ligand homotrimer augments the ability of dendritic cells to stimulate naive T- cell proliferation, and thus may be an important regulator of interactions between T-cells and dendritic cells as well as T- cell-dependent immune responses. It is highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells; a high level expression is also seen in the trabecular bone and lung. Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
  • Synonyms

    Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK; osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of NF-kappaB; tumor necrosis factor receptor superfamily member 11A;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • Fc|His
  • GST
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|HIgG
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF11A-400H Active Recombinant Human TNFRSF11A protein, hFc-tagged HEK293 hFc Met1-Pro212
Human TNFRSF11A-663H Active Recombinant Human TNFRSF11A, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF11A-591H Recombinant Human TNFRSF11A protein E.coli N/A 174
Human TNFRSF11A-30901TH Recombinant Human TNFRSF11A, Fc-tagged HEK293 Fc 285 amino acids
Human TNFRSF11A-1678H Recombinant Human TNFRSF11A, Fc-His Mammalian cells Fc/His
Human TNFRSF11A-401H Recombinant Human TNFRSF11A, His-tagged Human Cell His Met1-Pro212
Human TNFRSF11A-40H Recombinant Human TNFRSF11A Protein, hIgG-His-tagged Insect Cell His/HIgG
Human TNFRSF11A-392H Active Recombinant Human TNFRSF11A protein, mFc-tagged HEK293 mFc Ile 30 - Pro 212
Human TNFRSF11A-155H Recombinant Human TNFRSF11A Protein, His-tagged E.coli His
Human TNFRSF11A-1997H Recombinant Human TNFRSF11A Protein E.coli N/A
Human TNFRSF11A-184H Recombinant Human TNFRSF11A Protein, His-tagged E.coli His Val330~Lys615
Human TNFRSF11A-151H Recombinant Human TNFRSF11A Protein, His-tagged Human Cells His
Human TNFRSF11A-1333H Recombinant Human TNFRSF11A Protein (Tyr76-Pro317), N-His tagged E.coli N-His Tyr76-Pro317
Human TNFRSF11A-301530H Recombinant Human TNFRSF11A protein, GST-tagged E.coli GST Pro33-Asn205
Human TNFRSF11A-235H Recombinant Human TNFRSF11A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF11A-235H-B Recombinant Human TNFRSF11A Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF11A-5243H Recombinant Human TNFRSF11A Protein (Met1-Pro212), C-His tagged Mammalian cells C-His Met1-Pro212
Mouse Tnfrsf11a-955M Active Recombinant Mouse Tnfrsf11a Protein, Fc Chimera Mammalian cells Fc
Mouse TNFRSF11A-17152M Recombinant Mouse TNFRSF11A Protein Mammalian Cell His
Mouse Tnfrsf11a-1775M Recombinant Mouse Tnfrsf11a Mammalian cells N/A
Mouse Tnfrsf11a-472M Active Recombinant Mouse Tnfrsf11a, Fc-tagged HEK293 Fc
Mouse Tnfrsf11a-10622M Recombinant Mouse Tnfrsf11a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfrsf11a-112M-B Recombinant Mouse Tnfrsf11a Protein Pre-coupled Magnetic Beads HEK293
Mouse TNFRSF11A-9475M-B Recombinant Mouse TNFRSF11A Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfrsf11a-10622M-B Recombinant Mouse Tnfrsf11a Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfrsf11a-112M Recombinant Mouse Tnfrsf11a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfrsf11a-6785M Recombinant Mouse Tnfrsf11a Protein (Val31-Ser214), C-His tagged Mammalian cells C-His Val31-Ser214
Mouse TNFRSF11A-9475M Recombinant Mouse TNFRSF11A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfrsf11a-185M Recombinant Mouse Tnfrsf11a Protein, His-tagged E.coli His Leu359~Thr542
Rat TNFRSF11A-1084R Recombinant Rat TNFRSF11A Protein, Fc-tagged HEK293 Fc
Rat TNFRSF11A-1085R Recombinant Rat TNFRSF11A Protein, His-tagged HEK293 His
Rat TNFRSF11A-1413RCL Recombinant Rat TNFRSF11A cell lysate Human Cell N/A
Rat Tnfrsf11a-186R Recombinant Rat Tnfrsf11a Protein, His-tagged E.coli His Val31~Ser214
Rhesus monkey TNFRSF11A-1642R Recombinant Rhesus Monkey TNFRSF11A Protein HEK293 N/A
Rhesus monkey TNFRSF11A-1643R Recombinant Rhesus Monkey TNFRSF11A Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TNFRSF11A-1644R Recombinant Rhesus Monkey TNFRSF11A Protein, hIgG4-tagged HEK293 hIgG4
Mus musculus (Mouse) RFL2528MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 11A(Tnfrsf11A) Protein, His-Tagged E.coli expression system His Full Length (31-625)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF11A Related Signal Pathway

TNFRSF11A involved in several pathways and played different roles in them. We selected most pathways TNFRSF11A participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL17RA;IL20RA;CXCL9;Ifnlr1;NGFRB;THPO;CXCL8;CCL26;TNFRSF10D
NF-kappa B signaling pathwayLY96;TRAF3;RELA;TNF;IL-8;BIRC2;LTB;TNFSF11;Bcl2a1b
Osteoclast differentiationIFNGR1;PIK3R1;cgr2b;MAPK1;PPP3R1;PPP3CC;NFATC1;PIK3CB;LILRB1
Prolactin signaling pathwayNRAS;SOCS2;CSH;MAPK10;SLC2A2;KRAS;PIK3CA;MAPK8;CCND1
Rheumatoid arthritisATP6V1E1;HLA-DMB;ATP6V0B;Il23a; Il12b;IL-8;TGFB2;ATP6V1A;ATP6V1C1;ATP6V1C2

TNFRSF11A has several biochemical functions, for example, cytokine binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11A itself. We selected most functions TNFRSF11A had, and list some proteins which have the same functions with TNFRSF11A. You can find most of the proteins on our site.

Function Related Protein
cytokine bindingCSF1RA;IL31RA;GBP1;LIFR;CSF1R;IL17F;TNFRSF11A;CRLF1;KITB
metal ion bindingZNF292A;PHLPP2;ZFP354C;ZDHHC3B;ZFP106;DNAJA3;JADE3;ZFP259;FAM96A
protein bindingNSMCE4A;PTH2R;WIF1;PRRC1;BAG1;PDZD11;MAPK13;AIG1;RINT1
receptor activityERBB3B;NLGN3B;RRBP1B;CMKLR1;LRP1;GRIN1B;CD226;OR3A2;GUCY1B3
transmembrane signaling receptor activityNRXN3;OR4C12;GHRHR2;CLEC1B;KLRC2;ADCYAP1R1A;CD27;TNFRSF10C;IL4R.1
tumor necrosis factor-activated receptor activityTNFRSF14;TNFRSF21;NGFRB;TNFRSF11B;TNFRSF10C;TNFRSF8;TNFRSF6B;TNFRSF19;NGFR

TNFRSF11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF11A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF11A.

TMPRSS15; TRAF5; TRAF2; TRAF6

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