TNFRSF11A

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TNFRSF11A

Official Full Name tumor necrosis factor receptor superfamily, member 11a
Background Murine sRANK-Ligand or Soluble Receptor Activator of NF-κB Ligand, also known as Tumor Necrosis Factor Ligand Superfamily Member 11, is a 316 amino acid cytokine protein expressed from the Tnfsf11 gene located on chromosome 14. The peptide chain that exists from residue 1-36 is the membrane form of the RANK-Ligand while the chain that exists from residue 139-178 is the soluble form of the RANK-Ligand. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. The sRANK-Ligand is the cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK and acts as an osteoclast differentiation and activation factor. Moreover, the sRANK-Ligand homotrimer augments the ability of dendritic cells to stimulate naive T- cell proliferation, and thus may be an important regulator of interactions between T-cells and dendritic cells as well as T- cell-dependent immune responses. It is highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells; a high level expression is also seen in the trabecular bone and lung. Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes.
Synonyms Ly109; ODFR; OFE; Rank; TRANCE-R; mRANK; osteoclast differentiation factor receptor; receptor activator of NF-KB; receptor activator of NF-kappaB; tumor necrosis factor receptor superfamily member 11A
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • His
    • GST
    • hIgG1
    • hIgG4
    • HIgG
    • Mouse
    • IgG2a
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF11A-151H Recombinant Human TNFRSF11A Protein, His-tagged Human Cells His
    Human TNFRSF11A-301530H Recombinant Human TNFRSF11A protein, GST-tagged E.coli GST
    Human TNFRSF11A-1678H Recombinant Human TNFRSF11A, Fc-His Mammalian cells Fc/His
    Human TNFRSF11A-184H Recombinant Human TNFRSF11A Protein, His-tagged E.coli His
    Human TNFRSF11A-1997H Recombinant Human TNFRSF11A Protein E.coli N/A
    Human TNFRSF11A-30901TH Recombinant Human TNFRSF11A, Fc-tagged HEK293 Fc
    Human TNFRSF11A-392H Recombinant Human TNFRSF11A protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human TNFRSF11A-400H Recombinant Human TNFRSF11A, Fc-tagged Human Cell Fc
    Human TNFRSF11A-401H Recombinant Human TNFRSF11A, His-tagged Human Cell His
    Human TNFRSF11A-40H Recombinant Human TNFRSF11A Protein, hIgG-His-tagged Insect Cell His/HIgG
    Human TNFRSF11A-591H Recombinant Human TNFRSF11A protein E.coli N/A
    Human TNFRSF11A-663H Recombinant Human TNFRSF11A, Fc-tagged, Biotinylated Human Cell Fc
    Mouse TNFRSF11A-17152M Recombinant Mouse TNFRSF11A Protein Mammalian Cell His
    Mouse Tnfrsf11a-1775M Recombinant Mouse Tnfrsf11a Mammalian cells N/A
    Mouse Tnfrsf11a-185M Recombinant Mouse Tnfrsf11a Protein, His-tagged E.coli His
    Mouse Tnfrsf11a-472M Recombinant Mouse Tnfrsf11a, Fc-tagged HEK293 Fc
    Mouse Tnfrsf11a-955M Recombinant Mouse Tnfrsf11a Protein, Fc Chimera Mammalian cells Fc
    Rat TNFRSF11A-1084R Recombinant Rat TNFRSF11A Protein, Fc-tagged HEK293 Fc
    Rat TNFRSF11A-1085R Recombinant Rat TNFRSF11A Protein, His-tagged HEK293 His
    Rat TNFRSF11A-1413RCL Recombinant Rat TNFRSF11A cell lysate Human Cell N/A
    Rat Tnfrsf11a-186R Recombinant Rat Tnfrsf11a Protein, His-tagged E.coli His
    Rhesus monkey TNFRSF11A-1642R Recombinant Rhesus Monkey TNFRSF11A Protein HEK293 N/A
    Rhesus monkey TNFRSF11A-1643R Recombinant Rhesus Monkey TNFRSF11A Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey TNFRSF11A-1644R Recombinant Rhesus Monkey TNFRSF11A Protein, hIgG4-tagged HEK293 hIgG4

    TNFRSF11A involved in several pathways and played different roles in them. We selected most pathways TNFRSF11A participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL3L3; TNFRSF6B; TNFRSF10C; IL23; IL10RB; IFNK; TNFSF11; TGFBR2; Il6ra; IL4R
    NF-kappa B signaling pathway IL-8; TNFRSF13C; CARD11; TRAF5; CCL21B; NFKBIA; TICAM2; RIPK1; MAP3K14; CD40
    Osteoclast differentiation TGFBR1; IL1B; GRB2; STAT2; PIK3CB; IFNGR2; ITGB3; NFATC1; PIK3R2; FCGR1
    Prolactin signaling pathway INS2; RAF1; MAPK10; AKT2; MAPK13; PIK3R5; SRC; HRAS; NEK3; ESR1
    Rheumatoid arthritis HLA-DMA; IL1B; ATP6V1C2; IL11; CD86; ATP6V1B2; IL-8; IL18; TNFSF13B; CD28

    TNFRSF11A has several biochemical functions, for example, cytokine binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11A itself. We selected most functions TNFRSF11A had, and list some proteins which have the same functions with TNFRSF11A. You can find most of the proteins on our site.

    Function Related Protein
    cytokine binding ELANE; CNTFR; CHRD; NOG; CD74; IL17F; NRP1; CSF1R; IFNGR1; PARK7
    metal ion binding ZNF726; SUCLA2; TIMM8A2; ZIC3; BA1; TATDN1; ASAP2B; NOS2A; MTMR3; SCRT2
    protein binding TAG-260; PRKAA2; GSN; LDLR; INPP5B; ZFAND6; RASL10B; ATP4B; NME2; PFDN5
    receptor activity ANTXR2A; ADCYAP1R1; ITGAX; NCR3; NLGN4X; RAMP1; NOTCH1B; PVRL1B; TNPO3; ANTXR2B
    transmembrane signaling receptor activity OR115-6; CLEC1B; EBP; TLR1; FZD3A; EGFR; TLR4; RYK; TLR10; SLAMF1
    tumor necrosis factor-activated receptor activity RELT; TNFRSF1A; TNFRSF14; CD40; TNFRSF10B; LTBR; TNFRSF21; TNFRSF18; TNFRSF10A; Tnfrsf26

    TNFRSF11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF11A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF11A.

    TMPRSS15; TRAF5; TRAF2; TRAF6

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