TNFRSF13B
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Official Full Name
tumor necrosis factor receptor superfamily, member 13B -
Overview
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. -
Synonyms
TNFRSF13B;tumor necrosis factor receptor superfamily, member 13B;CVID;TACI;CD267;FLJ39942;MGC39952;MGC133214;TNFRSF14B;Tumor necrosis factor receptor superfamily member 13B;Transmembrane activator and CAML interactor;OTTHUMP00000065442;CD267 antigen;tumor necrosis factor receptor 13B
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Cynomolgus
- Mouse
- E.coli
- HEK293
- Human Cells
- Mammalian Cells
- GST
- His
- Avi
- Fc
- Non
- hIgG4
- Flag
Involved Pathway
TNFRSF13B involved in several pathways and played different roles in them. We selected most pathways TNFRSF13B participated on our site, such as Cytokine-cytokine receptor interaction,Intestinal i,ne network for IgA production, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF13B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | KIT,CXCR4B,CCL25B,IFNG1-2,BMPR2A,ACVR1,IFNE,HGF,NGFRB,CCL15 |
| Intestinal i | CXCL12,HLA-DQA2,CD40,IL4,ITGB7,HLA-DRB3,HLA-DMA,CCL25,HLA-DOB,CCL27B |
| nodeficiency | ORAI1,AIRE,RFXANK, Cd79b,RFXAP,IGLL1,CD79A,CD3E,TAP1,PTPRC |
| ne network for IgA production | CXCL12,HLA-DPA1,IL15RA,MAP3K14,IL4,CD40LG,CD28,CXCR4A,HLA-DRA,HLA-DQA2 |
| Primary i | RFXANK,IKBKG,CD3D,UNG,CD79A,RAG2,RFXAP,TAP2,CD19, Cd79b |
Protein Function
TNFRSF13B has several biochemical functions, for example, protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF13B itself. We selected most functions TNFRSF13B had, and list some proteins which have the same functions with TNFRSF13B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | GFRA1A,RTN4R,CMKLR1,ITGB1A,MED4,GFRA2A,GFRA4A,GUCY1B3,CHRM3,CD46 |
| protein binding | FFAR2,AGBL4,TFAM,NUBP1,EXOC1,UBASH3B,PPIA,GSTM4,NRIP3,CCT2 |
Interacting Protein
TNFRSF13B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF13B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF13B.
TNFSF13B;MYD88;SGTA
TNFRSF13B Related Signal Pathway
Resources
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References
- Chew, G; Gatenby, P; et al. TNFRSF13B VARIANTS IN SYSTEMIC LUPUS ERYTHEMATOSUS AND PRIMARY ANTIBODY DEFICIENCY. INTERNAL MEDICINE JOURNAL 44:6-7(2014).
- Martinez-Gallo, M; Radigan, L; et al. TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 131:468-476(2013).
