tnfrsf11b
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  • Official Full Name
  • tumor necrosis factor receptor superfamily, member 11b
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG; TR1; OCIF; tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor;
Cat.#:TNFRSF11B-365HTag:HIgG1 Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TNFRSF11B Protein (Met1-Leu401), HIgG1 Fc-tagged
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Cat.#:TNFRSF11B-5526HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b
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Cat.#:TNFRSF11B-142HTag:Fc
Source (Host):YeastSpecies:Human
Product nameRecombinant Human tumor necrosis factor receptor superfamily, member 11b, Fc-tagged
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Cat.#:TNFRSF11B-143HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF11B,His-tagged
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Cat.#:TNFRSF11B-152HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human tumor necrosis factor receptor superfamily, member 11b, HIgG1 Fc-tagged
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Cat.#:TNFRSF11B-169HTag:His
Source (Host):High-5 insect cellsSpecies:Human
Product nameRecombinant Human TNFRSF11B,His-tagged
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Cat.#:TNFRSF11B-187HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF11B
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Cat.#:TNFRSF11B-191HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF11B
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Cat.#:TNFRSF11B-19HTag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TNFRSF11B, Fc Chimera
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Cat.#:TNFRSF11B-210HTag:
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human TNFRSF11B
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Cat.#:TNFRSF11B-211HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human TNFRSF11B, Fc Chimera
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Cat.#:TNFRSF11B-212HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TNFRSF11B
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Cat.#:TNFRSF11B-28920THTag:His
Source (Host):Species:Human
Product nameRecombinant Human TNFRSF11B, His-tagged
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Cat.#:TNFRSF11B-4141HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b
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Cat.#:TNFRSF11B-456HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human TNFRSF11B protein, His-tagged
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Cat.#:TNFRSF11B-487HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11B, His tagged
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Cat.#:TNFRSF11B-5142HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b, His-tagged
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Cat.#:TNFRSF11B-654HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human TNFRSF11B, Fc-tagged, Biotinylated
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Cat.#:TNFRSF11B-655HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11B Protein, Fc-tagged
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Cat.#:Tnfrsf11b-1018MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Tnfrsf11b Protein, Fc-tagged
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Cat.#:TNFRSF11B-17153MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TNFRSF11B Protein
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Cat.#:Tnfrsf11b-189MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Tnfrsf11b, Fc-His
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Cat.#:Tnfrsf11b-70MTag:His
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Tnfrsf11b Protein, His-tagged
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Cat.#:TNFRSF11B-6196RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNFRSF11B Protein
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Cat.#:TNFRSF11B-8841CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF11B, Fc tagged
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Cat.#:TNFRSF11B-3262CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFRSF11B
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Cat.#:TNFRSF11B-54HTag:
Source (Host):Species:Human
Product nameNative Human Osteoprotegerin
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Cat.#:TNFRSF11B-2176HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF11B cell lysate
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Cat.#:TNFRSF11B-1183CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus TNFRSF11B cell lysate
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Cat.#:TNFRSF11B-20HTag:Fc
Source (Host):Mammalian CellsSpecies:Human
Product nameHuman Osteoprotegrin Reference Standard
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Involved Pathway

TNFRSF11B involved in several pathways and played different roles in them. We selected most pathways TNFRSF11B participated on our site, such as Cytokine-cytokine receptor interaction, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PDGFAA; IRX1; CCL17; FLT1; TNFRSF1A; CCR5; CCL21; KDRL; ACVR1; Ifna15
Osteoclast differentiation
CSF1; STAT1; FCGR3B; FCGR3; TGFB2; TNFSF11; FOSL1; TYK2; IFNG; NCF2

Protein Function

TNFRSF11B has several biochemical functions, for example, cytokine activity, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11B itself. We selected most functions TNFRSF11B had, and list some proteins which have the same functions with TNFRSF11B. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein Cxcl15; IL17C; Kitl; IFNPHI4; IFNB; CXCL9; SECTM1; IFNB1; IL31; INHBAA
Function receptor activity
Related Protein TNPO3; NLGN4B; KLRK1; CD46; P2RY11; VMN1R52; XPR1; CD86; EXTL3; NLGN2A
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF11A; TNFRSF10B; Tnfrsf26; TNFRSF18; CD40; LTBR; TNFRSF8; TNFRSF11B; TNFRSF1B; TNFRSF21

TNFRSF11B Related Articles

Polyzos, SA; Singhellakis, PN; et al. Denosumab Treatment for Juvenile Paget's Disease: Results From Two Adult Patients With Osteoprotegerin Deficiency ("Balkan" Mutation in the TNFRSF11B Gene). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:703-707(2014).
Chen, XJ; Lu, J; et al. Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells. TUMOR BIOLOGY 35:791-798(2014).

TNFRSF11B Related Gene Family

TNF