tnfrsf11b

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tnfrsf11b

Official Full Name tumor necrosis factor receptor superfamily, member 11b
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Synonyms TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG; TR1; OCIF; tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Hi-5 Inscet Cell
    • Human
    • Human Cell
    • Human Embryo Kidney
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf21 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • HIgG1 Fc
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF11B-142H Recombinant Human TNFRSF11B protein, Fc-tagged Yeast Fc
    Human TNFRSF11B-143H Recombinant Human TNFRSF11B,His-tagged E.coli His
    Human TNFRSF11B-152H Recombinant Human tumor necrosis factor receptor superfamily, member 11b, HIgG1 Fc-tagged CHO Fc
    Human TNFRSF11B-169H Recombinant Human TNFRSF11B,His-tagged Hi-5 Inscet Cell His
    Human TNFRSF11B-187H Recombinant Human TNFRSF11B NSO N/A
    Human TNFRSF11B-191H Recombinant Human TNFRSF11B E.coli N/A
    Human TNFRSF11B-19H Recombinant Human TNFRSF11B, Fc Chimera Mammalian Cell Fc
    Human TNFRSF11B-20H Human Osteoprotegrin Reference Standard Mammalian Cell Fc
    Human TNFRSF11B-210H Recombinant Human TNFRSF11B CHO N/A
    Human TNFRSF11B-211H Recombinant Human TNFRSF11B, Fc Chimera Sf21 Insect Cell Fc Chimera
    Human TNFRSF11B-212H Recombinant Human TNFRSF11B NS0 N/A
    Human TNFRSF11B-2176HCL Recombinant Human TNFRSF11B cell lysate Human Cell N/A
    Human TNFRSF11B-28920TH Recombinant Human TNFRSF11B, His-tagged His
    Human TNFRSF11B-365H Recombinant Human TNFRSF11B Protein (Met1-Leu401), HIgG1 Fc-tagged Insect Cell HIgG1 Fc
    Human TNFRSF11B-4141H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b Human N/A
    Human TNFRSF11B-456H Recombinant Human TNFRSF11B protein, His-tagged HEK293F His
    Human TNFRSF11B-487H Recombinant Human TNFRSF11B, His tagged Human Cell His
    Human TNFRSF11B-5142H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b, His-tagged Human His
    Human TNFRSF11B-54H Native Human Osteoprotegerin Human Embryo Kidney N/A
    Human TNFRSF11B-5526H Recombinant Human TNFRSF11B protein E.coli N/A
    Human TNFRSF11B-654H Recombinant Human TNFRSF11B, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFRSF11B-655H Recombinant Human TNFRSF11B protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse Tnfrsf11b-1018M Recombinant Mouse Tnfrsf11b Protein, Fc-tagged HEK293 Fc
    Mouse TNFRSF11B-17153M Recombinant Mouse TNFRSF11B Protein Mammalian Cell His
    Mouse Tnfrsf11b-189M Recombinant Mouse Tnfrsf11b, Fc-His NSO Fc
    Mouse Tnfrsf11b-70M Recombinant Mouse Tnfrsf11b Protein, His-tagged Insect Cell His
    Mouse Tnfrsf11b-7291M Recombinant Mouse Tnfrsf11b Protein, His-tagged His
    Rat TNFRSF11B-6196R Recombinant Rat TNFRSF11B Protein Mammalian Cell His
    Cynomolgus Monkey TNFRSF11B-1183CCL Recombinant Cynomolgus TNFRSF11B cell lysate Human Cell N/A
    Cynomolgus Monkey TNFRSF11B-8841C Recombinant Cynomolgus TNFRSF11B, Fc tagged Human Cell Fc/His
    Chicken TNFRSF11B-3262C Recombinant Chicken TNFRSF11B Mammalian Cell His

    tnfrsf11b involved in several pathways and played different roles in them. We selected most pathways tnfrsf11b participated on our site, such as Cytokine-cytokine receptor interaction, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf11b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CSF2; IL-15RA; CXCL2; IL10RB; IL4R; CCR1L1; CXCL12B; IFNPHI3; IFNAR2; TGFBR1B
    Osteoclast differentiation MAP3K14; NFKB1; IFNB1; PIK3R5; MAPK12; PLCG2; MAP2K1; FCGR3; MAPK11; TNFSF11

    tnfrsf11b has several biochemical functions, for example, cytokine activity, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf11b itself. We selected most functions tnfrsf11b had, and list some proteins which have the same functions with tnfrsf11b. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity SECTM1; TXLNA; Ifna11; IL4; IL13; FGF2; Il1f9; MIF; Ccl27a; CCL20A.3
    receptor activity CD33; VPREB1; CSF2RA; HTR3A; NOTCH1A; Siglece; V1RA8; VMN1R54; FKBP3; GRIN2A
    tumor necrosis factor-activated receptor activity TNFRSF11A; NGFR; LTBR; NRADD; TNFRSF10B; EDA2R; TNFRSF1B; TNFRSF21; TNFRSF6B; TNFRSF8

    tnfrsf11b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf11b here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf11b.

    Polyzos, SA; Singhellakis, PN; et al. Denosumab Treatment for Juvenile Paget's Disease: Results From Two Adult Patients With Osteoprotegerin Deficiency ("Balkan" Mutation in the TNFRSF11B Gene). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:703-707(2014).
    Chen, XJ; Lu, J; et al. Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells. TUMOR BIOLOGY 35:791-798(2014).

    TNF

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