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TNFRSF11B

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 11b

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms

    TNFRSF11B; tumor necrosis factor receptor superfamily, member 11b; OPG; TR1; OCIF; tumor necrosis factor receptor superfamily member 11B; osteoprotegerin; osteoclastogenesis inhibitory factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Rhesus
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • Hi-5 Inscet Cell
  • Human
  • Human Cell
  • Human Embryo Kidney
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Yeast
  • C
  • His
  • Fc
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • hFc
  • HIgG1 Fc
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • N/A
  • N
  • GST
  • MBP
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF11B-654H Active Recombinant Human TNFRSF11B, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF11B-212H Active Recombinant Human TNFRSF11B Mammalian cells N/A
Human TNFRSF11B-210H Active Recombinant Human TNFRSF11B CHO N/A
Human TNFRSF11B-211H Active Recombinant Human TNFRSF11B, Fc Chimera Sf21 Insect Cell Fc Chimera
Human TNFRSF11B-4141H Active Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b Human N/A
Human TNFRSF11B-152H Active Recombinant Human tumor necrosis factor receptor superfamily, member 11b, HIgG1 Fc-tagged CHO Fc
Human TNFRSF11B-487H Active Recombinant Human TNFRSF11B protein, His-tagged HEK293 His Met1-Leu401
Human TNFRSF11B-187H Recombinant Human TNFRSF11B Mammalian cells N/A
Human TNFRSF11B-143H Recombinant Human TNFRSF11B,His-tagged E.coli His
Human TNFRSF11B-19H Recombinant Human TNFRSF11B, Fc Chimera Mammalian Cell Fc
Human TNFRSF11B-655H Recombinant Human TNFRSF11B protein, Fc-tagged HEK293 human/IgG1/Fc 380
Human TNFRSF11B-5526H Recombinant Human TNFRSF11B protein E.coli N/A 173
Human TNFRSF11B-191H Recombinant Human TNFRSF11B E.coli N/A
Human TNFRSF11B-28920TH Recombinant Human TNFRSF11B, His-tagged His
Human TNFRSF11B-456H Recombinant Human TNFRSF11B protein, His-tagged HEK293F His Tyr31~Leu401
Human TNFRSF11B-169H Recombinant Human TNFRSF11B,His-tagged Hi-5 Inscet Cell His
Human TNFRSF11B-142H Recombinant Human TNFRSF11B protein, Fc-tagged Yeast Fc 412
Human TNFRSF11B-5142H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b, His-tagged Human His
Human TNFRSF11B-2176HCL Recombinant Human TNFRSF11B cell lysate Human Cell N/A
Human TNFRSF11B-2454H Recombinant Human TNFRSF11B protein(91-160 aa), N-MBP & C-His-tagged E.coli N-MBP & C-His 91-160 aa
Human TNFRSF11B-365H Recombinant Human TNFRSF11B Protein (Met1-Leu401), HIgG1 Fc-tagged Insect Cell HIgG1 Fc Met1-Leu401
Human TNFRSF11B-2767H Recombinant Human TNFRSF11B Protein, His&GST-tagged E.coli N-His&GST Met1-Gly196
Human TNFRSF11B-2768H Recombinant Human TNFRSF11B Protein, His-tagged E.coli N-His Met1-Gly196
Human TNFRSF11B-54H Native Human Osteoprotegerin Human Embryo Kidney N/A
Human TNFRSF11B-829H Recombinant Human TNFRSF11B Protein HEK293 401
Human TNFRSF11B-20H Active Human Osteoprotegrin Reference Standard Mammalian Cell Fc
Human TNFRSF11B-311H Recombinant Human TNFRSF11B Protein, His-tagged(C-ter) HEK293 His(C-ter) Glu22-Leu401
Human TNFRSF11B-830H Recombinant Human TNFRSF11B Protein, Fc-tagged HEK293 Fc 401
Human TNFRSF11B-4496H Recombinant Human TNFRSF11B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF11B-2694H Active Recombinant Human TNFRSF11B protein, His-tagged HEK293 His Glu22-Leu401
Human TNFRSF11B-5882H Recombinant Human TNFRSF11B Protein (Glu22-Leu401), C-His tagged Mammalian cells C-His Glu22-Leu401
Human TNFRSF11B-4496H-B Recombinant Human TNFRSF11B Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF11B-2455H Recombinant Human TNFRSF11B protein(22-401 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 22-401 aa
Human TNFRSF11B-5883H Recombinant Human TNFRSF11B Protein (Thr76-Lys317), N-His tagged E.coli N-His Thr76-Lys317
Mouse TNFRSF11B-17153M Recombinant Mouse TNFRSF11B Protein Mammalian Cell His
Mouse Tnfrsf11b-189M Recombinant Mouse Tnfrsf11b, Fc-His Mammalian cells Fc
Mouse Tnfrsf11b-1018M Recombinant Mouse Tnfrsf11b Protein, Fc-tagged HEK293 Fc
Mouse Tnfrsf11b-70M Recombinant Mouse Tnfrsf11b Protein, His-tagged Insect Cell His
Mouse Tnfrsf11b-310M Recombinant Mouse TNFRSF11B Protein, Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Met1-Leu401
Mouse Tnfrsf11b-113M-B Recombinant Mouse Tnfrsf11b Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfrsf11b-7291M Recombinant Mouse Tnfrsf11b Protein, His-tagged His 22-401
Mouse Tnfrsf11b-113M Recombinant Mouse Tnfrsf11b Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfrsf11b-2137M Recombinant Mouse Tnfrsf11b Protein, His&GST-tagged E.coli N-His&GST Glu22-Val281
Rat TNFRSF11B-6196R Recombinant Rat TNFRSF11B Protein Mammalian Cell His
Rat TNFRSF11B-5853R Recombinant Rat TNFRSF11B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tnfrsf11b-1163R Recombinant Rat Tnfrsf11b Protein, His-tagged HEK293F N-His Glu22-Leu401
Rat TNFRSF11B-5853R-B Recombinant Rat TNFRSF11B Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TNFRSF11B-8841C Recombinant Cynomolgus TNFRSF11B, Fc tagged Human Cell Fc/His
Cynomolgus Monkey TNFRSF11B-1183CCL Recombinant Cynomolgus TNFRSF11B cell lysate Human Cell N/A
Rhesus TNFRSF11B-487R Recombinant Rhesus TNFRSF11B protein, hFc-tagged HEK293 hFc Met28-Leu428
Pig TNFRSF11B-1162P Recombinant Pig TNFRSF11B Protein, His-tagged E.coli N-His Thr1-Gln225
Chicken TNFRSF11B-3262C Recombinant Chicken TNFRSF11B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF11B Related Signal Pathway

TNFRSF11B involved in several pathways and played different roles in them. We selected most pathways TNFRSF11B participated on our site, such as Cytokine-cytokine receptor interaction, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionLIF;IL17RA;IL2RGA;IFNGR1;LIFRA;CCL25B;IL6R;IL4;LEPB
Osteoclast differentiationNFATC2;CYBB;MAPK8;IKBKG;NCF1;SPI1;NFKB2;CSF1R;FCGR1A

TNFRSF11B has several biochemical functions, for example, cytokine activity, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11B itself. We selected most functions TNFRSF11B had, and list some proteins which have the same functions with TNFRSF11B. You can find most of the proteins on our site.

Function Related Protein
cytokine activityBMP10;LEFTY2;IL3;EDN1;LTA;BMP8A;GREM1;ILTIFB;FAM3C
receptor activityCD1D;LYVE1;ANTXR2B;CADM1A;PAQR5;CD2;MED24;IGSF1;FKBP3
tumor necrosis factor-activated receptor activityTNFRSF10B;NGFRB;HDR;TNFRSF11A;TNFRSF18;TNFRSF19;CD40;TNFRSF1B;RELT

TNFRSF11B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF11B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF11B.

Gene Family

TNF

Research Area

Related articles

Polyzos, SA; Singhellakis, PN; et al. Denosumab Treatment for Juvenile Paget's Disease: Results From Two Adult Patients With Osteoprotegerin Deficiency ("Balkan" Mutation in the TNFRSF11B Gene). JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99:703-707(2014).
Chen, XJ; Lu, J; et al. Cytokines in osteoblast-conditioned medium promote the migration of breast cancer cells. TUMOR BIOLOGY 35:791-798(2014).
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