TNFRSF1A

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 1A

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
  • Synonyms

    TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • Zebrafish
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Yeast
  • C
  • hFc
  • His
  • Fc
  • Fc|His
  • His(C
  • ter)
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|GST
  • His|HIgG
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF1A-65H Active Recombinant Human TNFRSF1A protein, Fc-tagged HEK293 Fc Ile 22 - Thr 211
Human TNFRSF1A-152H Active Recombinant Human TNFRSF1A, Fc Chimera HEK293 Fc
Human TNFRSF1A-1690H Active Recombinant Human TNFRSF1A, Fc&His-tagged Mammalian cells Fc/His
Human TNFRSF1A-707H Active Recombinant Human TNFRSF1A, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF1A-3189H Active Recombinant Human TNFRSF1A protein, His-tagged HEK293 His Met1-Thr211
Human TNFRSF1A-3190H Active Recombinant Human TNFRSF1A Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Ile 22 - Thr 211
Human TNFRSF1A-66H Active Recombinant Human TNFRSF1A protein (Met1-Thr211), hFc-tagged HEK293 hFc
Human TNFRSF1A-592H Recombinant Human TNFRSF1A E.coli N/A
Human TNFRSF1A-248H Recombinant Human TNFRSF1A protein E.coli N/A 190
Human TNFRSF1A-46H Recombinant Human TNFRSF1A protein, hIgG-His-tagged Insect Cell His/HIgG
Human TNFRSF1A-7162H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A, His-tagged E.coli His 41-201aa
Human TNFRSF1A-4172H Recombinant Human Tumor Necrosis Factor Receptor Type 1, His Tag Human His
Human TNFRSF1A-31571TH Recombinant Human TNFRSF1A, His-tagged E.coli His
Human TNFRSF1A-1577H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A Sf9 Insect Cell N/A
Human TNFRSF1A-7048H Recombinant Human TNFRSF1A protein, His & GST-tagged E.coli His/GST Thr60~Tyr236 (Accession # P19438)
Human TNFRSF1A-660H Recombinant Human tumor necrosis factor receptor superfamily, member 1A, His-tagged E.coli His
Human TNFRSF1A-1908H Recombinant Human TNFRSF1A, Fc-His Mammalian cells Fc
Human TNFRSF1A-3251H Recombinant Human TNFRSF1A, Fc-His tagged Human Cell Fc/His
Human TNFRSF1A-30481TH Recombinant Human TNFRSF1A, Fc-tagged HEK293 Fc 190 amino acids
Human TNFRSF1A-2390HCL Recombinant Human TNFRSF1A cell lysate Human Cell N/A
Human TNFR-P002H Recombinant Human TNFRSF1A, Fc-tagged therapeutic protein CHO Fc 467 Aa
Human TNFRSF1A-P018H Recombinant Human TNFRSF1A therapeutic protein E.coli N/A
Human TNFRSF1A-P013H Recombinant Human TNFRSF1A, Fc-tagged therapeutic protein Fc
Human TNFRSF1A-456H Recombinant Human TNFRSF1A Protein, His-tagged HEK293 His 455
Human TNFRSF1A-5235H Recombinant Human TNFRSF1A protein, GST-tagged E.coli GST 31-210aa
Human TNFRSF1A-444H Recombinant Human TNFRSF1A Protein, His-tagged E.coli N-His Cys248-Met428
Human TNFRSF1A-141H Recombinant Human TNFRSF1A Protein, His-tagged Human Cells His
Human TNFRSF1A-1481H Recombinant Human TNFRSF1A Protein (Met1-Thr211), C-His tagged Mammalian cells C-His Met1-Thr211
Human TNFRSF1A-5535H Recombinant Human TNFRSF1A protein, His-tagged Yeast His 22-211aa
Human TNFRSF1A-445H Recombinant Human TNFRSF1A Protein, His-tagged E.coli N-His Leu30-Thr211
Human TNFRSF1A-237H Recombinant Human TNFRSF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF1A-P017H Recombinant Human TNFRSF1A therapeutic protein N/A
Human TNFRSF1A-149H Recombinant Human TNFRSF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF1A-252H Active Recombinant Human TNFRSF1A Protein E.coli
Human TNFRSF1A-457H Recombinant Human TNFRSF1A Protein, Fc-tagged HEK293 Fc 455
Human TNFRSF1A-203T Active Recombinant Human TNFRSF1A Protein CHO
Human TNFRSF1A-149H-B Recombinant Human TNFRSF1A Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF1A-237H-B Recombinant Human TNFRSF1A Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF1A-1484H Recombinant Human TNFRSF1A Protein (Arg235-Arg455), N-His tagged E.coli N-His Arg235-Arg455
Mouse Tnfrsf1a-634M Active Recombinant Mouse Tnfrsf1a protein, hFc-tagged HEK293 hFc Met1-Ala212
Mouse Tnfrsf1a-7049M Recombinant Mouse Tnfrsf1a protein, His-tagged E.coli His Arg239~Cys433
Mouse Tnfrsf1a-1780M Recombinant Mouse Tnfrsf1a Mammalian cells N/A
Mouse Tnfrsf1a-3306M Recombinant Mouse Tnfrsf1a protein(Met1-Ala212), His-tagged HEK293 C-His Met1-Ala212
Mouse TNFRSF1A-1693MCL Recombinant Mouse TNFRSF1A cell lysate Human Cell N/A
Mouse Tnfrsf1a-6827M Recombinant Mouse Tnfrsf1a Protein (Ile22-Ala212) E.coli Tag Free Ile22-Ala212
Mouse Tnfrsf1a-10624M-B Recombinant Mouse Tnfrsf1a Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfrsf1a-10624M Recombinant Mouse Tnfrsf1a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfrsf1a-314M Recombinant Mouse TNFRSF1A Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Met1-Ala212
Mouse Tnfrsf1a-2029M Recombinant Mouse Tnfrsf1a protein E.coli N/A 191
Mouse Tnfrsf1a-141M Recombinant Mouse Tnfrsf1a Protein E.coli
Rat Tnfrsf1a-7449R Active Recombinant Rat Tnfrsf1a protein(Met1-Ala211), hFc-tagged HEK293 C-hFc Met1-Ala211
Rat TNFRSF1A-413R Recombinant Rat Tnfrsf1a, His tagged Human Cell His
Rat Tnfrsf1a-7051R Recombinant Rat Tnfrsf1a protein, His-tagged E.coli His Val257~His458 (Accession # P22934)
Rat Tnfrsf1a-7050R Recombinant Rat Tnfrsf1a protein, His-tagged E.coli His Leu43~Leu194 (Accession # P22934)
Rat TNFRSF1A-6197R Recombinant Rat TNFRSF1A Protein Mammalian Cell His
Rat TNFRSF1A-1084RCL Recombinant Rat TNFRSF1A cell lysate Human Cell N/A
Rat TNFRSF1A-5854R Recombinant Rat TNFRSF1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TNFRSF1A-5854R-B Recombinant Rat TNFRSF1A Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL16330BF Recombinant Full Length Bovine Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-471)
Homo sapiens (Human) RFL17232HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-455)
Mus musculus (Mouse) RFL24306MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (30-454)
Rattus norvegicus (Rat) RFL26145RF Recombinant Full Length Rat Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-461)
Sus scrofa (Pig) RFL4762SF Recombinant Full Length Pig Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-461)
Zebrafish TNFRSF1A-12401Z Recombinant Zebrafish TNFRSF1A Mammalian Cell His
Chicken TNFRSF1A-2478C Recombinant Chicken TNFRSF1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF1A Related Signal Pathway

TNFRSF1A involved in several pathways and played different roles in them. We selected most pathways TNFRSF1A participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPP3CA;MAP2K6;CDC25B;TNF;MAP2K4B;DUSP8A;TGFBR1A;MINK1;FASLG
Cytokine-cytokine receptor interactionCCL6;MET;CXCL3;IL28A;Cxcl15;CCL11;IL2RG;CXCR4;IL6
NF-kappa B signaling pathwayRELA;CCL21;Bcl2a1b;IL1R1;CXCL2;Ccl21c;PLAU;RIPK1;MAP3K14
Sphingolipid signaling pathwayPIK3R5;LASS2;GNAI3;LASS5;BAX;SGPP1;PDPK1;FYN;MAPK8
ApoptosisPLECA;RELA;SATB1;BCAP31;PIK3R5;ENDOG;CAPN2A;HRK;MYC
Osteoclast differentiationSPI1;TNFSF11;LILRA4;MAPK9;TEC;IFNAR1;FCGR2B;RELB;RELA
TNF signaling pathwayTNFRSF1B;PTGS2;PIK3R5;TRAF5;BCL3;MAPK12;BAG4;MAP2K1;FAS
Adipocytokine signaling pathwayRXRG;CHUK;PRKAA1;JAK2B;CPT1C;ADIPOQB;TNFRSF1B;G6PCA.2;G6PC
Insulin resistanceACACB;G6PCA.1;PRKAG3B;SLC27A2;NFKBIAA;PCK2;CREB3L2;PTPN11A;PDPK1B
Non-alcoholic fatty liver disease (NAFLD)SDHC;COX6A2;PIK3CG;MAPK9;ATF4;GSK3A;BID;BAX;ERN1
Alzheimers diseaseCASP9;BACE1;NDUFA5;FAS;ITPR3;PLCB4;NDUFA13;PPP3CB;PPP3CA
Amyotrophic lateral sclerosis (ALS)SLC1A2;BAX;PPP3R1;BID;RAC1;GRIN1;MAPK13;DAXX;PPP3CC
Chagas disease (American trypanosomiasis)PLCB2;NOS2;PPP2R2D;NFKB1;PIK3CA;FOS;GNA14;C1QB;CXCL8
ToxoplasmosisMAP2K6;H2-AB1;CYCS;ITGA6;AKT2;BIRC7;PIK3CD;PPIF;HSPA1B
TuberculosisIL12A;CD209A;HLA-DRB4;CLEC4E;IL18;RFXAP;HLA-DRB1;PMAP-36;C3
Hepatitis CPDPK1;IFNA14;IFNA21;CLDN14;IFN-a;TRADD;LDLR;NFKB1;PPP2CA
Influenza AIFNA8;TBK1;ACTG1;EIF2AK1;IFNA21;IRAK4;DNAJC3;PABPN1;MAPK10
HTLV-I infectionHLA-G;PIK3R2;TERT;GM-CSF;CRTC1;WNT8A;EGR1;TGFBR2;CRTC2
Herpes simplex infectionOAS2;JAK2A;CUL1B;OAS1B;TLR3;HLA-DQA1;C5;PPP1CBL;TAF3

TNFRSF1A has several biochemical functions, for example, protein binding, tumor necrosis factor binding, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1A itself. We selected most functions TNFRSF1A had, and list some proteins which have the same functions with TNFRSF1A. You can find most of the proteins on our site.

Function Related Protein
protein bindingEIF2S1;RAB35;FAM49B;NAGK;ZMYND10;SERPINE1;UBA2;COMMD6;CCNB2
tumor necrosis factor bindingTnfrsf26;A2M;TNFRSF1A
tumor necrosis factor-activated receptor activityLTBR;TNFRSF25;EDA2R;TNFRSF1A;TNFRSFA;TNFRSF18;NRADD;TNFRSF11B;CD40

TNFRSF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1A.

TRADD; TNF

Gene Family

TNF Cytokines

Research Area

Related articles

Cantarini, L; Lopalco, G; et al. Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis. AUTOIMMUNITY REVIEWS 14:90-97(2015).
Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).
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