TNFRSF1A Protein

TNFRSF1A

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TNFRSF1A

Official Full Name tumor necrosis factor receptor superfamily, member 1A
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq, Jul 2008]
Synonyms TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; MS5; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; TNFR1-d2; tumor necrosis factor receptor superfamily member 1A; TNF-R1; TNF-RI; TNFR-I; tumor necrosis factor-alpha receptor; tumor necrosis factor receptor type 1; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1A isoform beta;
    • Species :
    • Bos taurus (Bovine)
    • Chicken
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Rat
    • Rattus norvegicus (Rat)
    • Sus scrofa (Pig)
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • Human
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Yeast
    • Tag :
    • Fc
    • His
    • Fc-His(C-ter)
    • GST
    • hFc
    • Avi
    • HIgG
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF1A-152H Active Recombinant Human TNFRSF1A, Fc Chimera HEK293 Fc Inquiry
    Human TNFRSF1A-1690H Active Recombinant Human TNFRSF1A, Fc&His-tagged Mammalian cells Fc/His Inquiry
    Human TNFRSF1A-3190H Active Recombinant Human TNFRSF1A Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Inquiry
    Human TNFRSF1A-65H Active Recombinant Human TNF-R1, Fc-tagged HEK293 Fc Inquiry
    Human TNFRSF1A-707H Active Recombinant Human TNFRSF1A, Fc-tagged, Biotinylated Human Cell Fc Inquiry
    Human TNFRSF1A-66H Active Recombinant Human TNFRSF1A protein (Met1-Thr211), hFc-tagged HEK293 hFc Inquiry
    Human TNFRSF1A-1577H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A Sf9 Insect Cell N/A Inquiry
    Human TNFRSF1A-1908H Recombinant Human TNFRSF1A, Fc-His Mammalian cells Fc Inquiry
    Human TNFRSF1A-248H Recombinant Human TNFRSF1A protein E.coli N/A Inquiry
    Human TNFRSF1A-30481TH Recombinant Human TNFRSF1A, Fc-tagged HEK293 Fc Inquiry
    Human TNFRSF1A-31571TH Recombinant Human TNFRSF1A, His-tagged E.coli His Inquiry
    Human TNFRSF1A-3189H Recombinant Human TNFRSF1A, His tagged Human Cell His Inquiry
    Human TNFRSF1A-3251H Recombinant Human TNFRSF1A, Fc-His tagged Human Cell Fc/His Inquiry
    Human TNFRSF1A-4172H Recombinant Human Tumor Necrosis Factor Receptor Type 1, His Tag Human His Inquiry
    Human TNFRSF1A-46H Recombinant Human TNFRSF1A protein, hIgG-His-tagged Insect Cell His/HIgG Inquiry
    Human TNFRSF1A-592H Recombinant Human TNFRSF1A E.coli N/A Inquiry
    Human TNFRSF1A-660H Recombinant Human tumor necrosis factor receptor superfamily, member 1A, His-tagged E.coli His Inquiry
    Human TNFRSF1A-7048H Recombinant Human TNFRSF1A protein, His & GST-tagged E.coli His/GST Inquiry
    Human TNFRSF1A-7162H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A, His-tagged E.coli His Inquiry
    Mouse Tnfrsf1a-1780M Recombinant Mouse Tnfrsf1a Mammalian cells N/A Inquiry
    Mouse Tnfrsf1a-3306M Recombinant Mouse Tnfrsf1a, His tagged Human Cell His Inquiry
    Mouse Tnfrsf1a-634M Recombinant Mouse Tnfrsf1a, Fc tagged Human Cell Fc Inquiry
    Mouse Tnfrsf1a-7049M Recombinant Mouse Tnfrsf1a protein, His-tagged E.coli His Inquiry
    Rat TNFRSF1A-413R Recombinant Rat Tnfrsf1a, His tagged Human Cell His Inquiry
    Rat TNFRSF1A-6197R Recombinant Rat TNFRSF1A Protein Mammalian Cell His Inquiry
    Rat Tnfrsf1a-7050R Recombinant Rat Tnfrsf1a protein, His-tagged E.coli His Inquiry
    Rat Tnfrsf1a-7051R Recombinant Rat Tnfrsf1a protein, His-tagged E.coli His Inquiry
    Rat Tnfrsf1a-7449R Recombinant Rat Tnfrsf1a, Fc tagged Human Cell Fc Inquiry
    Chicken TNFRSF1A-2478C Recombinant Chicken TNFRSF1A Mammalian Cell His Inquiry
    Zebrafish TNFRSF1A-12401Z Recombinant Zebrafish TNFRSF1A Mammalian Cell His Inquiry
    Human TNFRSF1A-2390HCL Recombinant Human TNFRSF1A cell lysate Human Cell N/A Inquiry
    Mouse TNFRSF1A-1693MCL Recombinant Mouse TNFRSF1A cell lysate Human Cell N/A Inquiry
    Rat TNFRSF1A-1084RCL Recombinant Rat TNFRSF1A cell lysate Human Cell N/A Inquiry
    Bos taurus (Bovine) RFL16330BF Recombinant Full Length Bovine Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Inquiry
    Homo sapiens (Human) RFL17232HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Inquiry
    Mus musculus (Mouse) RFL24306MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Inquiry
    Rattus norvegicus (Rat) RFL26145RF Recombinant Full Length Rat Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Inquiry
    Sus scrofa (Pig) RFL4762SF Recombinant Full Length Pig Tumor Necrosis Factor Receptor Superfamily Member 1A(Tnfrsf1A) Protein, His-Tagged E.coli expression system His Inquiry
    Human TNFRSF1A-141H Recombinant Human TNFRSF1A Protein, His-tagged Human Cells His Inquiry
    Human TNFRSF1A-203T Recombinant Human TNFRSF1A Protein CHO Inquiry
    Human TNFRSF1A-252H Recombinant Human TNFRSF1A Protein E.coli Inquiry
    Mouse Tnfrsf1a-314M Recombinant Mouse TNFRSF1A Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Inquiry
    Human TNFRSF1A-444H Recombinant Human TNFRSF1A Protein, His-tagged E.coli N-His Inquiry
    Human TNFRSF1A-445H Recombinant Human TNFRSF1A Protein, His-tagged E.coli N-His Inquiry
    Human TNFRSF1A-5235H Recombinant Human TNFRSF1A protein, GST-tagged E.coli GST Inquiry
    Human TNFRSF1A-5535H Recombinant Human TNFRSF1A protein, His-tagged Yeast His Inquiry
    Human TNFR-P002H Recombinant Human TNFRSF1A, Fc-tagged therapeutic protein CHO Fc Inquiry
    Human TNFRSF1A-P013H Recombinant Human TNFRSF1A, Fc-tagged therapeutic protein Fc Inquiry
    Human TNFRSF1A-P017H Recombinant Human TNFRSF1A therapeutic protein N/A Inquiry
    Human TNFRSF1A-P018H Recombinant Human TNFRSF1A therapeutic protein E.coli N/A Inquiry
    Mouse Tnfrsf1a-141M Recombinant Mouse Tnfrsf1a Protein E.coli Inquiry
    Mouse Tnfrsf1a-2029M Recombinant Mouse Tnfrsf1a protein E.coli N/A Inquiry

    TNFRSF1A involved in several pathways and played different roles in them. We selected most pathways TNFRSF1A participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway RASA1; FGF6; RAC1; FGFR2; FGF18A; ELK1; RPS6KA3B; RAP1AA; RAC1B; CACNA2D4
    Cytokine-cytokine receptor interaction IFNA10; Ccl21c; IFNA16; TNFRSF8; IL2RA; CCR9A; CXCR2; EDAR; KIT; CNTF
    NF-kappa B signaling pathway RELB; BCL2A1A; Ccl21a; BTK; TRADD; IRAK1; MAP3K14; BCL2L1; CXCL2; LAT
    Sphingolipid signaling pathway FCER1A; RAC3; DEGS2; PIK3CB; RAC1; DEGS1; MAP2K2; LASS2; FYN; RHOA
    Apoptosis GZME; BAX; NFKBIA; CASP2; BIRC7; FASLG; CSF2RB; PRKACAB; TRAF2; PPP3R2
    Osteoclast differentiation PLCG2; FCGR2A; FHL2; TGFB1; MAPK10; PPP3CC; LILRA2; FCGR2C; BTK; IL1B
    TNF signaling pathway CREB5; TNFAIP3; CXCL2; MAPK8; PIK3R3; TNF; MAP3K14; BIRC3; PIK3R2; TNFRSF1A
    Adipocytokine signaling pathway IRS4; RXRG; MAPK10; NFKBIB; ADIPOR1B; JAK2B; CAMKK2; MAPK8B; PRKAG1; ACSL3A
    Insulin resistance PIK3CG; G6PC2; RELA; INSRB; MAPK8B; PRKAB2; INSR; IKBKB; PTENA; OGT
    Non-alcoholic fatty liver disease (NAFLD) NDUFB1; NDUFA13; UQCR11; UQCRH; PRKAG1; NDUFC2; NDUFA10; Il6ra; IL6R; NDUFA2
    Alzheimers disease SNCA; COX6A2; COX7A2L; UQCRQ; ATP5A1; NDUFA11; CALM3; CALM4; PPP3R1; GNAQ
    Amyotrophic lateral sclerosis (ALS) TNF; ALS2; PPP3CC; NEFM; APAF1; CASP1; GRIA2; MAPK13; Casp3; CASP12
    Chagas disease (American trypanosomiasis) PLCB3; IL1B; GNA11; CXCL8; CCL3; FASLG; TGFBR1; MAPK13; TNFRSF1A; TRAF6
    Toxoplasmosis HSPA1B; GNAI3; TNF; TGFB2; BIRC3; LAMC2; IRAK4; SOCS1; NFKBIB; MAPK13
    Tuberculosis IFNA21; Ifna15; IFNA13; TLR1; ATP6AP1; MRC2; IRAK1; RAF1; CALML5; MAPK8
    Hepatitis C SOS1; OAS2; NRAS; NR1H3; CLDN23; PPP2CB; PPP2R1A; CLDN16; PPP2CA; IFIT1
    Influenza A TLR3; IFNGR1; HLA-DPB1; MAP2K6; LOC100033925; LOC100686744; HSPA1B; IFNA2; TNFRSF10D; IFNAR1
    HTLV-I infection TNF; POLE; FZD9; HLA-F; MAPK8; SMAD2; NFKBIA; STAT5A; KRAS; Pdgfa&Pdgfb
    Herpes simplex infection HLA-DRB1; ARNTL1B; CASP8; PER1B; C3A.3; Ifna15; IFNA3; MHC2DAB; HCFC1; TRAF1

    TNFRSF1A has several biochemical functions, for example, protein binding, tumor necrosis factor binding, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1A itself. We selected most functions TNFRSF1A had, and list some proteins which have the same functions with TNFRSF1A. You can find most of the proteins on our site.

    Function Related Protein
    protein binding RAB1B; TBX18; RAB26; P2RX7; PPP2CA; RSU1; ZNF593; GIPC2; DNM2; PARN
    tumor necrosis factor binding A2M; Tnfrsf26; TNFRSF1A
    tumor necrosis factor-activated receptor activity TNFRSF11A; TNFRSFA; HDR; TNFRSF9; TNFRSF14; TNFRSF1A; TNFRSF21; CD27; TNFRSF25; TNFRSF11B

    TNFRSF1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1A.

    TRADD; TNF

    Cantarini, L; Lopalco, G; et al. Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis. AUTOIMMUNITY REVIEWS 14:90-97(2015).
    Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).

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