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Official Full Name tumor necrosis factor receptor superfamily, member 9
Background Human 4-1BB Ligand Receptor, also known as the Tumor Necrosis Factor Receptor Superfamily Member 9, is a 255 amino acid cytokine protein implicated in T-cell activation pathways. After initial synthesis of the peptide, the cytokine is proteolytically cleaved by proteases, thus separating the 23 residue signal sequence from the actual mature 232 residue 4-1BB Receptor sequence. The protein is expressed from the TNFRSF9 gene located at locus 1p36 on chromosome 1. The 4-1BB receptor or TNFRSF9 inherently has high affinity binding for the 4-1BB ligand such that upon binding, the receptor contributes to clonal expansion, survival and development of T-cells. It can also induce proliferation in peripheral monocytes, enhance T-cell apoptosis induced by TCR/CD3 triggered activation and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins such as TRAF1, TRAF2 and TRAF 3 have been shown to bind to this receptor and transducer the signals leading to activation of NF-κB.
Synonyms TNFRSF9; 4-1BB; CD137; CDw137; ILA; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; tumor necrosis factor receptor superfamily member 9
    • Species :
    • Canine
    • Cynomolgus/Rhesus macaque
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Tag :
    • Avi
    • Fc
    • DDK
    • His
    • Fc Chimera
    • hIgG1
    • hIgG4
    • HIgG
    • human
    • IgG1
    • Mouse
    • IgG2a
    • N/A
    • RlgG Fc
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF9-212H Recombinant Human TNFRSF9 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human TNFRSF9-098HG GMP Recombinant Human TNFRSF9 protein, His-tagged HEK293 His
    Human TNFRSF9-110H Recombinant Human TNFRSF9 E.coli N/A
    Human TNFRSF9-133H Recombinant Human TNFRSF9 Protein, His-tagged CHO His
    Human TNFRSF9-134H Recombinant Human TNFRSF9 Protein, Fc-tagged CHO Fc
    Human TNFRSF9-136H Recombinant Human TNFRSF9, HIgG1 Fc-tagged CHO Fc
    Human TNFRSF9-15862H Recombinant Human TNFRSF9, His-tagged E.coli His
    Human TNFRSF9-2162HCL Recombinant Human TNFRSF9 cell lysate Human Cell N/A
    Human TNFRSF9-232H Recombinant Human TNFRSF9 protein, Fc-tagged HEK293 Fc
    Human TNFRSF9-234H Recombinant Human TNFRSF9, MIgG2a Fc-tagged CHO Fc
    Human TNFRSF9-27833TH Recombinant Human TNFRSF9, Fc-tagged HEK293 Fc
    Human TNFRSF9-328H Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-Fc-tagged, Biotinylated HEK293 His/Fc
    Human TNFRSF9-329H Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-tagged, Biotinylated HEK293 His
    Human TNFRSF9-343H Recombinant Human TNFRSF9 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human TNFRSF9-344H Recombinant Human TNFRSF9 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human TNFRSF9-345H Recombinant Human TNFRSF9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNFRSF9-346H Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human TNFRSF9-39H Recombinant Human TNFRSF9 Protein, hIgG-His-tagged Insect Cell His/HIgG
    Human TNFRSF9-43H Recombinant Human TNFRSF9, Fc-tagged Human Cell Fc
    Human TNFRSF9-517H Recombinant Human TNFRSF9 protein E.coli N/A
    Human TNFRSF9-525H Recombinant Human TNFRSF9, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFRSF9-526H Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human TNFRSF9-550H Recombinant Human TNFRSF9, His tagged Human Cell His
    Human TNFRSF9-551H Recombinant Human TNFRSF9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNFRSF9-5598H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 9, His-tagged E.coli His
    Human TNFRSF9-576H Recombinant Human TNFRSF9 protein, His-tagged E.coli His
    Human TNFRSF9-581H Recombinant Human TNFRSF9, Fc-His tagged Human Cell Fc/His
    Human TNFRSF9-954H Recombinant Human TNFRSF9 Protein, DDK/His-tagged HEK293 DDK/His
    Mouse TNFRSF9-1792MCL Recombinant Mouse TNFRSF9 cell lysate Human Cell N/A
    Mouse TNFRSF9-347M Recombinant Mouse TNFRSF9 protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse TNFRSF9-348M Recombinant Mouse TNFRSF9 protein, His-tagged HEK293 His
    Mouse Tnfrsf9-635M Recombinant Mouse Tnfrsf9, Fc tagged Human Cell Fc
    Mouse Tnfrsf9-82M Recombinant Mouse Tnfrsf9 protein, His-tagged Insect Cell His
    Mouse TNFRSF9-844M Recombinant Mouse TNFRSF9 Protein (Met1-Leu211), RlgG Fc-tagged HEK293 RlgG Fc
    Rat Tnfrsf9-650R Recombinant Rat Tnfrsf9, Fc Chimera NS0 Fc Chimera
    Rhesus monkey TNFRSF9-1508R Recombinant Rhesus Monkey TNFRSF9 Protein HEK293 N/A
    Rhesus monkey TNFRSF9-1509R Recombinant Rhesus Monkey TNFRSF9 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey TNFRSF9-1510R Recombinant Rhesus Monkey TNFRSF9 Protein, hIgG4-tagged HEK293 hIgG4
    Rhesus Macaque TNFRSF9-4870R Recombinant Rhesus monkey TNFRSF9 Protein, His-tagged Mammalian Cell His
    Rhesus TNFRSF9-550R Recombinant Rhesus TNFRSF9 Protein, His-tagged HEK293 His
    Rhesus TNFRSF9-550RB Recombinant Rhesus TNFRSF9 protein, His-tagged, Biotinylated HEK293 His
    Rhesus TNFRSF9-551R Recombinant Rhesus TNFRSF9 Protein, Fc-tagged HEK293 Fc
    Canine TNFRSF9-1052C Recombinant Canine TNFRSF9 Protein, Fc-tagged HEK293 Fc
    Canine TNFRSF9-257C Recombinant Canine TNFRSF9, His tagged Human Cell Fc
    Canine TNFRSF9-928CCL Recombinant Canine TNFRSF9 cell lysate Human Cell N/A
    Rabbit TNFRSF9-3093R Recombinant Rabbit TNFRSF9 protein, His-tagged HEK293 His
    Cynomolgus/Rhesus macaque TNFRSF9-19C Recombinant Cynomolgus/Rhesus macaque TNFRSF9 protein, His-tagged HEK293 His

    tnfrsf9 involved in several pathways and played different roles in them. We selected most pathways tnfrsf9 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction VEGFC; BMPR1BA; IL2RGA; TNFRSF21; THPO; XCR1; Cxcl15; TNFSF11; CXCL1; Pdgfa&Pdgfb

    tnfrsf9 has several biochemical functions, for example, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf9 itself. We selected most functions tnfrsf9 had, and list some proteins which have the same functions with tnfrsf9. You can find most of the proteins on our site.

    Function Related Protein
    receptor activity TNFRSF10A; ANTXR2B; TLR6; THRAP3; SEC63; MED4; TREML2; PVRL1B; NLGN4B; NOTCH4
    tumor necrosis factor-activated receptor activity CD40; NRADD; RELT; TNFRSF25; TNFRSF1B; TNFRSF6B; TNFRSF19; TNFRSF9; TNFRSF18; TNFRSFA

    tnfrsf9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf9 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf9.

    Campana, D; Schwarz, H; et al. 4-1BB Chimeric Antigen Receptors. CANCER JOURNAL 20:134-140(2014).
    Song, C; Sadashivaiah, K; et al. Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy. ONCOIMMUNOLOGY 3:-(2014).

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