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TNFRSF9

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 9

  • Overview

    Human 4-1BB Ligand Receptor, also known as the Tumor Necrosis Factor Receptor Superfamily Member 9, is a 255 amino acid cytokine protein implicated in T-cell activation pathways. After initial synthesis of the peptide, the cytokine is proteolytically cleaved by proteases, thus separating the 23 residue signal sequence from the actual mature 232 residue 4-1BB Receptor sequence. The protein is expressed from the TNFRSF9 gene located at locus 1p36 on chromosome 1. The 4-1BB receptor or TNFRSF9 inherently has high affinity binding for the 4-1BB ligand such that upon binding, the receptor contributes to clonal expansion, survival and development of T-cells. It can also induce proliferation in peripheral monocytes, enhance T-cell apoptosis induced by TCR/CD3 triggered activation and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins such as TRAF1, TRAF2 and TRAF 3 have been shown to bind to this receptor and transducer the signals leading to activation of NF-κB.
  • Synonyms

    TNFRSF9; 4-1BB; CD137; CDw137; ILA; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; tumor necrosis factor receptor superfamily member 9;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Chromatography Reagents
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Cynomolgus
  • Cynomolgus monkey
  • Cynomolgus/Rhesus
  • Cynomolgus/Rhesus macaque
  • Dog
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Avi|Fc
  • C
  • 6×His
  • hFc
  • His
  • DDK|His
  • DYKDDDDK
  • Fc
  • Fc Chimera
  • Fc|His
  • His(C
  • ter)
  • GST
  • Avi
  • hIgG1
  • hIgG4
  • His (Fc)
  • His|Avi
  • His|Fc
  • His|HIgG
  • human|IgG1|Fc
  • Mouse|IgG2a|Fc
  • N/A
  • N
  • RlgG Fc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF9-43H Active Recombinant Human TNFRSF9 protein(Met1-Gln186), hFc-tagged HEK293 C-hFc Met1-Gln186
Human TNFRSF9-526H Active Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc Leu 24 - Gln 186
Human TNFRSF9-551H Active Recombinant Human TNFRSF9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Leu 24 - Gln 186
Human TNFRSF9-234H Active Recombinant Human TNFRSF9, MIgG2a Fc-tagged CHO Fc
Human TNFRSF9-136H Active Recombinant Human TNFRSF9, HIgG1 Fc-tagged CHO Fc
Human TNFRSF9-133H Active Recombinant Human TNFRSF9 Protein, His-tagged HEK293 His Met 1-Gln 186
Human TNFRSF9-525H Active Recombinant Human TNFRSF9, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF9-134H Active Recombinant Human TNFRSF9 Protein, Fc-tagged CHO Fc
Human TNFRSF9-232H Active Recombinant Human TNFRSF9 protein, Fc-tagged HEK293 Fc
Human TNFRSF9-051H Active Recombinant Human TNFRSF9 protein, hFc&Avi-tagged, Biotinylated HEK293 hFc&Avi Met1-Gln186
Human TNFRSF9-954H Recombinant Human TNFRSF9 Protein, DDK/His-tagged HEK293 DDK/His
Human TNFRSF9-517H Recombinant Human TNFRSF9 protein E.coli N/A 166
Human TNFRSF9-581H Recombinant Human TNFRSF9, Fc-His tagged Human Cell Fc/His
Human TNFRSF9-110H Recombinant Human TNFRSF9 E.coli N/A
Human TNFRSF9-15862H Recombinant Human TNFRSF9, His-tagged E.coli His 18-186aa
Human TNFRSF9-550H Recombinant Human TNFRSF9, His tagged Human Cell His
Human TNFRSF9-27833TH Recombinant Human TNFRSF9, Fc-tagged HEK293 Fc 186 amino acids
Human TNFRSF9-5598H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 9, His-tagged E.coli His
Human TNFRSF9-39H Recombinant Human TNFRSF9 Protein, hIgG-His-tagged Insect Cell His/HIgG
Human TNFRSF9-576H Recombinant Human TNFRSF9 protein, His-tagged E.coli His Asn40~Glu153
Human TNFRSF9-2162HCL Recombinant Human TNFRSF9 cell lysate Human Cell N/A
Human TNFRSF9-345H Active Recombinant Human TNFRSF9 Protein, His & Avi-tagged, Biotinylated HEK293 His/Avi Leu 24 - Gln 186
Human TNFRSF9-301562H Recombinant Human TNFRSF9 protein, GST-tagged E.coli GST Leu16-Gln186
Human TNFRSF9-343H Recombinant Human TNFRSF9 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 163
Human TNFRSF9-346H Active Recombinant Human TNFRSF9 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc Leu 24 - Gln 186
Human TNFRSF9-581HAF488 Recombinant Human TNFRSF9 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 409
Human TNFRSF9-550HAF488 Recombinant Human TNFRSF9 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 174
Human TNFRSF9-344H Recombinant Human TNFRSF9 protein, Fc-tagged HEK293 human/IgG1/Fc 162
Human TNFRSF9-329H Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-tagged, Biotinylated HEK293 His Met1-Gln186
Human TNFRSF9-550HAF555 Recombinant Human TNFRSF9 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 174
Human TNFRSF9-1512H Recombinant Human TNFRSF9 Protein (Leu24-Gln186), N-His tagged E.coli N-His Leu24-Gln186
Human TNFRSF9-550HF Recombinant Human TNFRSF9 Protein, His-tagged, FITC conjugated HEK293 His 174
Human TNFRSF9-212H Recombinant Human TNFRSF9 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human TNFRSF9-328H Recombinant Human TNFRSF9 Protein (Met1-Gln186), His-Fc-tagged, Biotinylated HEK293 His/Fc Met1-Gln186
Human TNFRSF9-581HAF555 Recombinant Human TNFRSF9 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 409
Human TNFRSF9-315H Recombinant Human TNFRSF9 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Leu24-Gln186
Human TNFRSF9-550HAF647 Recombinant Human TNFRSF9 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 174
Human TNFRSF9-581HAF647 Recombinant Human TNFRSF9 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 409
Human TNFRSF9-580H Recombinant Human TNFRSF9 Protein HEK293 255
Human TNFRSF9-01H Active Recombinant Human TNFRSF9 Protein, His-Tagged NS0 His
Human TNFRSF9-0902H Recombinant Human TNFRSF9 Protein (Met1-Gln186), C-His tagged Mammalian cells C-His Met1-Gln186
Human TNFRSF9-581HF Recombinant Human TNFRSF9 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 409
Human TNFRSF9-518H Recombinant Human TNFRSF9 Protein (Leu24-Gln186), C-6×His-tagged HEK293 C-6×His Leu24-Gln186
Human TNFRSF9-1271H Active Recombinant Human TNFRSF9 protein, hFc&His-tagged HEK293 hFc&His Leu 24 - Gln 186
Human TNFRSF9-1108H Recombinant Human TNFRSF9 protein(Met1-Leu152), His-tagged HEK293 C-His Met1-Leu152
Human TNFRSF9-1022H Recombinant Human TNFRSF9 protein, His-tagged HEK293 His Leu 24 - Gln 186
Human TNFRSF9-0327H Recombinant Human TNFRSF9 Protein (Leu24-Gln186), C-His-tagged Mammalian cells C-His Leu24-Gln186
Human TNFRSF9-076H Recombinant Human TNFRSF9 Protein, C-His-tagged E.coli C-His
Human TNFRSF9-098HG Active GMP Recombinant Human TNFRSF9 protein HEK293 DNA sequence encoding Human 4-1BB(UniProtKB/Swiss-Prot: Q07011.1) was expressed with His tag at the C-terminal.
Human TNFRSF9-711H Active Recombinant Human TNFRSF9 Protein, His-tagged HEK293 His Glu19-Ser184
Human TNFRSF9-97M CD137 protein-coupled magnetic MicroBeads
Mouse Tnfrsf9-635M Recombinant Mouse Tnfrsf9 protein(Met1-Leu211), hFc-tagged HEK293 C-hFc Met1-Leu211
Mouse Tnfrsf9-82M Recombinant Mouse Tnfrsf9 protein, His-tagged Insect Cell His
Mouse TNFRSF9-1792MCL Recombinant Mouse TNFRSF9 cell lysate Human Cell N/A
Mouse TNFRSF9-0243M Active Recombinant Mouse TNFRSF9 protein, His-tagged HEK293 His Met1-Leu187
Mouse Tnfrsf9-635MAF488 Recombinant Mouse Tnfrsf9 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 429
Mouse TNFRSF9-347M Recombinant Mouse TNFRSF9 protein, Fc-tagged HEK293 human/IgG1/Fc 188
Mouse TNFRSF9-844M Recombinant Mouse TNFRSF9 Protein (Met1-Leu211), RlgG Fc-tagged HEK293 RlgG Fc Met1-Leu211
Mouse TNFRSF9-583M Recombinant Mouse TNFRSF9 Protein, Fc-tagged HEK293 Fc 211
Mouse Tnfrsf9-635MF Recombinant Mouse Tnfrsf9 Protein, Fc-tagged, FITC conjugated HEK293 Fc 429
Mouse TNFRSF9-582M Recombinant Mouse TNFRSF9 Protein HEK293 211
Mouse Tnfrsf9-453M Recombinant Mouse Tnfrsf9 Protein, His-tagged E.coli N-His Val24-Pro179
Mouse TNFRSF9-0291M Recombinant Mouse TNFRSF9 protein, His-tagged, Biotinylated HEK293 His Met1-Leu187
Mouse TNFRSF9-495M Recombinant Mouse TNFRSF9 Protein, His-Avi-tagged HEK293 His-Avi Val24-Ser183
Mouse Tnfrsf9-635MAF555 Recombinant Mouse Tnfrsf9 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 429
Mouse TNFRSF9-348M Recombinant Mouse TNFRSF9 protein, His-tagged HEK293 His 188
Mouse Tnfrsf9-635MAF647 Recombinant Mouse Tnfrsf9 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 429
Rat Tnfrsf9-650R Active Recombinant Rat Tnfrsf9, Fc Chimera Mammalian cells Fc Chimera
Rat Tnfrsf9-29R Recombinant Rat Tnfrsf9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TNFRSF9-1015R Recombinant Rat TNFRSF9 protein, His-tagged HEK293 His Thr 24 - Gln 187
Rat Tnfrsf9-29R-B Recombinant Rat Tnfrsf9 Protein Pre-coupled Magnetic Beads HEK293
Monkey TNFRSF9-551RAF488 Active Recombinant Monkey TNFRSF9 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Met1-Gln186, 401
Monkey TNFRSF9-550RF Active Recombinant Monkey TNFRSF9 Protein, His-tagged, FITC conjugated HEK293 His Met1-Gln186, 174
Monkey TNFRSF9-550RAF488 Active Recombinant Monkey TNFRSF9 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Met1-Gln186, 174
Monkey TNFRSF9-551RAF555 Active Recombinant Monkey TNFRSF9 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Met1-Gln186, 401
Monkey TNFRSF9-551RAF647 Active Recombinant Monkey TNFRSF9 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Met1-Gln186, 401
Monkey TNFRSF9-550RAF647 Active Recombinant Monkey TNFRSF9 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Met1-Gln186, 174
Monkey TNFRSF9-551RF Active Recombinant Monkey TNFRSF9 Protein, Fc-tagged, FITC conjugated HEK293 Fc Met1-Gln186, 401
Monkey TNFRSF9-550RAF555 Active Recombinant Monkey TNFRSF9 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Met1-Gln186, 174
Rhesus monkey TNFRSF9-1508R Recombinant Rhesus Monkey TNFRSF9 Protein HEK293 N/A
Rhesus monkey TNFRSF9-1509R Recombinant Rhesus Monkey TNFRSF9 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TNFRSF9-1510R Recombinant Rhesus Monkey TNFRSF9 Protein, hIgG4-tagged HEK293 hIgG4
Rabbit TNFRSF9-3093R Recombinant Rabbit TNFRSF9 protein, His-tagged HEK293 His Val29-Ile191
Dog TNFRSF9-1052CAF488 Recombinant Canine TNFRSF9 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 403
Dog TNFRSF9-1052CAF555 Recombinant Canine TNFRSF9 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 403
Dog TNFRSF9-257CAF488 Recombinant Canine TNFRSF9 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 173
Dog TNFRSF9-257CAF555 Recombinant Canine TNFRSF9 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 173
Dog TNFRSF9-1052CAF647 Recombinant Canine TNFRSF9 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 403
Dog TNFRSF9-257CAF647 Recombinant Canine TNFRSF9 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 173
Dog TNFRSF9-1052CF Recombinant Canine TNFRSF9 Protein, Fc-tagged, FITC conjugated HEK293 Fc 403
Dog TNFRSF9-257CF Recombinant Canine TNFRSF9 Protein, His-tagged, FITC conjugated HEK293 His 173
Canine TNFRSF9-257C Active Recombinant Canine TNFRSF9 protein, His-tagged HEK293 His Met1-Ser185
Canine TNFRSF9-1052C Recombinant Canine TNFRSF9 protein(Met1-Ser185), hFc-tagged HEK293 C-hFc Met1-Ser185
Canine TNFRSF9-928CCL Recombinant Canine TNFRSF9 cell lysate Human Cell N/A
Cynomolgus TNFRSF9-191C Active Recombinant Cynomolgus TNFRSF9 protein, hFc-tagged HEK293 hFc Met1-Gln186
Cynomolgus TNFRSF9-1025C Recombinant Cynomolgus TNFRSF9 protein, His-tagged HEK293 His Leu 24 - Gln 186
Cynomolgus monkey TNFRSF9-579C Recombinant Cynomolgus monkey TNFRSF9 Protein HEK293 254
Cynomolgus/Rhesus TNFRSF9-1233C Acitve Recombinant Cynomolgus/Rhesus TNFRSF9 protein(Met1-Gln186), His-tagged HEK293 C-His Met1-Gln186
Cynomolgus/Rhesus macaque TNFRSF9-19C Recombinant Cynomolgus/Rhesus macaque TNFRSF9 protein, His-tagged HEK293 His 163
Mus musculus (Mouse) RFL2231MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 9(Tnfrsf9) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-256)
Rhesus TNFRSF9-550R Active Recombinant Rhesus TNFRSF9 Protein, His-tagged HEK293 His Met1-Gln186
Rhesus TNFRSF9-551R Active Recombinant Rhesus TNFRSF9 Protein, Fc-tagged HEK293 Fc Met1-Gln186
Rhesus TNFRSF9-550RB Recombinant Rhesus TNFRSF9 protein, His-tagged, Biotinylated HEK293 His Met1-Gln186
Rhesus Macaque TNFRSF9-4870R Recombinant Rhesus monkey TNFRSF9 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFRSF9-4684R Recombinant Rhesus Macaque TNFRSF9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TNFRSF9-4684R-B Recombinant Rhesus Macaque TNFRSF9 Protein Pre-coupled Magnetic Beads HEK293
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF9 Related Signal Pathway

What is TNFRSF9 protein?

TNFRSF9 (TNF receptor superfamily member 9) gene is a protein coding gene which situated on the short arm of chromosome 1 at locus 1p36. Human 4-1BB Ligand Receptor, also known as the Tumor Necrosis Factor Receptor Superfamily Member 9, is a 255 amino acid cytokine protein implicated in T-cell activation pathways. After initial synthesis of the peptide, the cytokine is proteolytically cleaved by proteases, thus separating the 23 residue signal sequence from the actual mature 232 residue 4-1BB Receptor sequence. The TNFRSF9 protein is consisted of 255 amino acids and its molecular mass is approximately 27.9 kDa.

What is the function of TNFRSF9 protein?

The 4-1BB receptor or TNFRSF9 inherently has high affinity binding for the 4-1BB ligand such that upon binding, the receptor contributes to clonal expansion, survival and development of T-cells. It can also induce proliferation in peripheral monocytes, enhance T-cell apoptosis induced by TCR/CD3 triggered activation and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins such as TRAF1, TRAF2 and TRAF 3 have been shown to bind to this receptor and transducer the signals leading to activation of NF-κB.

TNFRSF9 Related Signaling Pathway

TNFRSF9 (also known as CD137 or 4-1BB) protein is a receptor protein on the cell membrane, mainly through the binding of its ligand CD137L to activate downstream signaling pathways, involved in a variety of immune responses and cell-mediated immune regulation processes. Signaling pathways involved in TNFRSF9 protein mainly include: NF-κB signaling pathway: Activation of TNFRSF9 protein can trigger activation of the NF-κB signaling pathway, leading to a series of NF-κB-mediated inflammatory responses and cell proliferation processes in the cell.

PI3K/AKT signaling pathway: TNFRSF9 protein can also activate the PI3K/AKT signaling pathway to promote cell survival, proliferation and metabolism.

MAPK/ERK signaling pathway: Activation of TNFRSF9 protein can also activate the MAPK/ERK signaling pathway, affecting cell proliferation and survival.

TNFRSF9-9.jpg

Fig1. CD137 ligand signaling pathways in man and mouse. (Zhe Shao, 2011)

TNFRSF9 Related Diseases

TNFRSF9 plays an important role in immune system function. Therefore, diseases related to CD137 protein mainly include: immune diseases such as rheumatoid arthritis, systemic lupus erythematosus and so on. The CD137 protein plays a role in regulating the function of T and NK cells and is therefore relevant for tumor immunotherapy. CD137 signaling pathway is involved in regulating the body's immune response to infection and is associated with viral and bacterial infections. It is also associated with a number of other diseases, such as multiple sclerosis, inflammatory bowel disease, etc. These diseases are usually caused by an abnormal response of the immune system.

Bioapplications of TNFRSF9

TNFRSF9 protein has a wide range of applications in immunotherapy, cancer therapy and the treatment of autoimmune diseases. Several drug and immune cell engineering techniques have been used for cancer treatment research and development using TNFRSF9 proteins.

Case study 1: Kang Yi Lee, 2021

Rhabdomyosarcoma (RMS) is a heterogeneous soft tissue neoplasm most frequently found in children and adolescents. As the prognosis for recurrent and metastatic RMS remains poor, immunotherapies are hoped to improve quality of life and survival. But it was puzzling to find expression of CD137 on an RMS tissue microarray by multiplex staining. Functional in vitro experiments demonstrate that CD137 on RMS cells is being transferred to adjacent antigen-presenting cells by trogocytosis, where it downregulates CD137 ligand, and thereby reduces T cell costimulation which results in reduced killing of RMS cells. The transfer of CD137 and the subsequent downregulation of CD137 ligand is a physiological negative feedback mechanism that is likely usurped by RMS, and may facilitate its escape from immune surveillance. This study implicates ectopic CD137 expression as a pathogenesis mechanism in RMS, and it demonstrates that CD137 may be a novel target for immunotherapy of RMS.

TNFRSF9-3.jpg

Fig1. Rd18, Rh41, Rd and JR1 cells were cultured with 75 ng/ml of TNF for 24 h. CD137 expression was measured by flow cytometry.

TNFRSF9-4.jpg
Fig2. Anti-CD137 CAR-KHYG-1 cells specifically kill CD137-expressing RMS cells. Percentages of RMS cell TNF level. Top row: Rd18 cells, bottom row: Rh41 cells.

Case study 2: Benjamin I Philipson, 2020

Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4-1BB-costimulated CAR (BBζ) T cells exhibit longer persistence after adoptive transfer than do CD28-costimulated CAR (28ζ) T cells. 4-1BB signaling improves T cell persistence even in the context of 28ζ CAR activation, which indicates distinct prosurvival signals mediated by the 4-1BB cytoplasmic domain. To specifically study signal transduction by CARs, we developed a cell-free, ligand-based activation and ex vivo culture system for CD19-specific CAR T cells.

This study showed that only BBζ CARs activated noncanonical nuclear factor κB (ncNF-κB) signaling in T cells basally and that the anti-CD19 BBζ CAR further enhanced ncNF-κB signaling after ligand engagement. Although the findings do not exclude the importance of other signaling differences between BBζ and 28ζ CARs, they demonstrate the necessary and nonredundant role of ncNF-κB signaling in promoting the survival of BBζ CAR T cells.

TNFRSF9-5.jpg

Fig3. Representative ex vivo expansion of the indicated CAR T cells stimulated by irradiated Nalm6 target cells at the indicated times at a T cell to target cell ratio of 2:1.

TNFRSF9-6.jpg
Fig4. Representative Western blotting analysis of the cytoplasmic and nuclear fractions from anti-CD19 BBζ CAR T cells before and at the indicated times after the addition of target beads.
TNFRSF9-7.jpg

Fig1. Schematic model depicting the likely molecular mechanisms by which K-Ras regulates CD137 gene transcription. (Christophe Glorieux, 2019)

TNFRSF9-8.jpg

Fig2. Signal transduction of CD137 in T cells. Ligation of the trimerized receptor promotes recruitment of tumor necrosis factor receptor associated factors (TRAFs). (Leif Å Söderström, 2018)

TNFRSF9 involved in several pathways and played different roles in them. We selected most pathways TNFRSF9 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCTF1;TNFRSF10A;TNFRSF25;IL18R1;Cxcl15;BMPR1AA;RELT;IL17RB;CCR6

TNFRSF9 has several biochemical functions, for example, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF9 itself. We selected most functions TNFRSF9 had, and list some proteins which have the same functions with TNFRSF9. You can find most of the proteins on our site.

Function Related Protein
receptor activityITGB8;ICAM1;CD4;AGER;VMN1R50;NLGN4Y;CADM1;GFRA2A;NOTCH1
tumor necrosis factor-activated receptor activityTNFRSF11A;TNFRSF8;RELT;TNFRSF10B;TNFRSF4;TNFRSF19;CD40;EDA2R;NGFRB

TNFRSF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF9.

Research Area

Related articles

Campana, D; Schwarz, H; et al. 4-1BB Chimeric Antigen Receptors. CANCER JOURNAL 20:134-140(2014).
Song, C; Sadashivaiah, K; et al. Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy. ONCOIMMUNOLOGY 3:-(2014).
  • Q&As
  • Reviews

Q&As (6)

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What diseases are associated with abnormal expression levels of TNFRSF9? 12/10/2022

Studies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.

What is the association of TNFRSF9 with other cytokines? 10/27/2022

It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.

What are the main functions of TNFRSF9 in the human body? 07/11/2022

TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.

Are there potential therapeutic applications for TNFRSF9 inhibitors or activators? 08/21/2021

Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.

How does TNFRSF9 bind to its ligands? 06/08/2021

The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.

How is TNFRSF9 related to immuno-oncology? 05/27/2020

TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.

Customer Reviews (3)

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Reviews
03/11/2022

    Good heat resistance, long time treatment at high temperature, still has activity.

    10/11/2021

      The results obtained by SDS-PAGE or Western blot analysis were good.

      07/30/2021

        The purity is good, and the experimental results obtained are accurate.

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