tumor necrosis factor receptor superfamily, member 9
Human 4-1BB Ligand Receptor, also known as the Tumor Necrosis Factor Receptor Superfamily Member 9, is a 255 amino acid cytokine protein implicated in T-cell activation pathways. After initial synthesis of the peptide, the cytokine is proteolytically cleaved by proteases, thus separating the 23 residue signal sequence from the actual mature 232 residue 4-1BB Receptor sequence. The protein is expressed from the TNFRSF9 gene located at locus 1p36 on chromosome 1. The 4-1BB receptor or TNFRSF9 inherently has high affinity binding for the 4-1BB ligand such that upon binding, the receptor contributes to clonal expansion, survival and development of T-cells. It can also induce proliferation in peripheral monocytes, enhance T-cell apoptosis induced by TCR/CD3 triggered activation and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins such as TRAF1, TRAF2 and TRAF 3 have been shown to bind to this receptor and transducer the signals leading to activation of NF-κB.
TNFRSF9; 4-1BB; CD137; CDw137; ILA; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; tumor necrosis factor receptor superfamily member 9;
TNFRSF9 involved in several pathways and played different roles in them. We selected most pathways TNFRSF9 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
TNFRSF9 has several biochemical functions, for example, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF9 itself. We selected most functions TNFRSF9 had, and list some proteins which have the same functions with TNFRSF9. You can find most of the proteins on our site.
TNFRSF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF9.
Campana, D; Schwarz, H; et al. 4-1BB Chimeric Antigen Receptors. CANCER JOURNAL 20:134-140(2014).
Song, C; Sadashivaiah, K; et al. Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy. ONCOIMMUNOLOGY 3:-(2014).