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TNFRSF4

Official Full Name

tumor necrosis factor receptor superfamily, member 4
Overview

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes
Synonyms

TNFRSF4; tumor necrosis factor receptor superfamily, member 4; tumor necrosis factor receptor superfamily member 4; OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1; Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L;

Type

Recombinant Proteins
Cell & Tissue Lysates
GMP Proteins
Protein Pre-coupled Magnetic Beads
Chromatography Reagents

Species

Cynomolgus / Rhesus macaque
Cynomolgus/Rhesus macaque
Homo sapiens (Human)
Human
Marmoset
Monkey
Mouse
Mus musculus (Mouse)
Rabbit
Rat
Rattus norvegicus (Rat)
Rhesus
Rhesus macaque
Rhesus monkey

Source

CHO
E.coli
E.coli expression system
HEK293
HEK293T
Human Cell
Human cells
Insect Cell
Mammalian Cell
Mammalian cells
NS0

Tag

Fc
Avi
Flag
hIgG4
His
SUMO
LEVLFQ
mFc
Myc
DDK
Non
rFc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TNFRSF4-523H	Active Recombinant Human TNFRSF4 Protein, His-tagged	CHO	His		Inquiry
Human	TNFRSF4-441H	Active Recombinant Human TNFRSF4, Fc-tagged	HEK293	Fc		Inquiry
Human	TNFRSF4-3247H	Active Recombinant Human TNFRSF4 protein, His-tagged	HEK293	His	Leu 29 - Ala 216	$393.0 ~~$786~~ / 100μg
Human	TNFRSF4-521H	Active Recombinant Human TNFRSF4, HIgG1 Fc-tagged	CHO	Fc		Inquiry
Human	TNFRSF4-522H	Active Recombinant Human TNFRSF4 Protein, Fc-tagged	CHO	Fc		Inquiry
Human	TNFRSF4-520H	Active Recombinant Human TNFRSF4, MIgG2a Fc-tagged	CHO	Fc		$198 / 10μg
Human	TNFRSF4-1826H	Active Recombinant Human TNFRSF4 protein, His & Avi-tagged, Biotinylated	HEK293	His&Avi	AA Leu 29 - Ala 216	$798 / 25µg
Human	TNFRSF4-659H	Active Recombinant Human TNFRSF4, Fc-tagged, Biotinylated	Human Cell	Fc		Inquiry
Human	TNFRSF4-19H	Active Recombinant Human TNFRSF4 Protein, Fc-tagged, Alexa Fluor® 488 conjugated	NS0	Fc		Inquiry
Human	TNFRSF4-20H	Active Recombinant Human TNFRSF4 Protein, Fc-tagged, Alexa Fluor® 647 conjugated	NS0	Fc		Inquiry
Human	TNFRSF4-871H	Recombinant Human TNFRSF4 Protein, DDK/His-tagged	HEK293	His&Flag		Inquiry
Human	TNFRSF4-455H	Recombinant Human TNFRSF4, Fc Chimera	HEK293	Fc	93-330 a.a.	Inquiry
Human	TNFRSF4-670H	Recombinant Human TNFRSF4 protein, Fc-tagged	HEK293	Fc	Leu 29 - Ala 216	Inquiry
Human	TNFRSF4-967H	Recombinant Human TNFRSF4	Insect Cell	Non		Inquiry
Human	TNFRSF4-3246H	Recombinant Human TNFRSF4, Fc-His tagged	Human Cell	His&Fc		$498 / 50µg
Human	TNFRSF4-27215TH	Recombinant Human TNFRSF4, Fc-tagged		Fc		Inquiry
Human	TNFRSF4-2422HCL	Recombinant Human TNFRSF4 cell lysate	Human Cell	Non		Inquiry
Human	TNFRSF4-0595H	Active Recombinant Human TNFRSF4 protein, Fc-tagged	HEK293	Fc	Leu29-Ala216	Inquiry
Human	TNFRSF4-1153H	Recombinant Human TNFRSF4 Protein (Met1-Ala216), HlgG1 Fc-tagged	HEK293	Fc	Met1-Ala216	Inquiry
Human	TNFRSF4-2221H	Recombinant Human TNFRSF4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	TNFRSF4-681H	Recombinant Human TNFRSF4 Protein (Leu29-Ala216), C-hFc and 6×His-tagged	HEK293	His&Fc	Leu29-Ala216	Inquiry
Human	TNFRSF4-5154H	Recombinant Human TNFRSF4 Protein (Met1-Ala216), C-His tagged	Mammalian cells	His	Met1-Ala216	Inquiry
Human	TNFRSF4-115HG	Active GMP Recombinant Human TNFRSF4 protein	HEK293		DNA sequence encoding Human OX40(NCBI Reference Sequence: NP_003318.1) was expressed with His tag at the C-terminal.	Inquiry
Human	TNFRSF4-442H	Active Recombinant Human TNFRSF4 protein, Fc-Avi-tagged, Biotinylated	HEK293	Fc&Avi	Leu 29 - Ala 216	$798 / 25µg
Human	TNFRSF4-2221H-B	Recombinant Human TNFRSF4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	TNFRSF4-393H	Active Recombinant Human TNFRSF4 Protein (Met1-Ala216), His-tagged, Biotinylated	HEK293	His	Met1-Ala216	Inquiry
Human	TNFRSF4-05H	Active Recombinant Human TNFRSF4 Protein, hIgG/His-tagged	Insect Cell	His&Fc		Inquiry
Human	TNFRSF4-339H	Recombinant Human TNFRSF4 protein, Fc-tagged	HEK293	Fc	188	$786 / 100µg
Human	TNFRSF4-152H	Recombinant Human TNFRSF4 Protein, DYKDDDDK-tagged	Human cells	Flag		Inquiry
Human	TNFRSF4-3246HF	Recombinant Human TNFRSF4 Protein, Fc/His-tagged, FITC conjugated	HEK293	His&Fc	436	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-3246HAF555	Recombinant Human TNFRSF4 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated	HEK293	His&Fc	436	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-345H	Recombinant Human TNFRSF4 protein, His-Avi-tagged	HEK293	His&Avi	29-216 a.a.	Inquiry
Human	TNFRSF4-3247HAF488	Recombinant Human TNFRSF4 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	Leu29-Ala216	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-982HFL	Recombinant Full Length Human TNFRSF4 Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	TNFRSF4-3247HAF555	Recombinant Human TNFRSF4 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	Leu29-Ala216	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-4989H	Recombinant Human TNFRSF4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	TNFRSF4-5155H	Recombinant Human TNFRSF4 Protein (Leu29-Ala216), C-Fc tagged	Mammalian cells	Fc	Leu29-Ala216	Inquiry
Human	TNFRSF4-3246HAF488	Recombinant Human TNFRSF4 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated	HEK293	His&Fc	436	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-3246HAF647	Recombinant Human TNFRSF4 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated	HEK293	His&Fc	436	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-338H	Active Recombinant Human TNFRSF4 protein, mFc-tagged	HEK293	mFc	Leu 29 - Ala 216	Inquiry
Human	TNFRSF4-3247HAF647	Recombinant Human TNFRSF4 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	Leu29-Ala216	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-2034H	Recombinant Human TNFRSF4 Protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	TNFRSF4-3247HF	Recombinant Human TNFRSF4 Protein, His-tagged, FITC conjugated	HEK293	His	Leu29-Ala216	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF4-239H	Recombinant Human TNFRSF4 Protein, hIgG-His-tagged	Insect Cell	His&Fc	29-214aa	Inquiry
Human	TNFRSF4-680H	Recombinant Human TNFRSF4 Protein	HEK293		277	Inquiry
Human	TNFRSF4-2764H	Recombinant Human TNFRSF4 protein(141-210 aa), C-His-tagged	E.coli	His	141-210 aa	Inquiry
Mouse	Tnfrsf4-7075M	Recombinant Mouse Tnfrsf4 protein, His-tagged	E.coli	His	Lys29~Gly210 (Accession # P47741)	Inquiry
Mouse	Tnfrsf4-4200M	Active Recombinant Mouse Tnfrsf4 protein, His-tagged	HEK293	His	Val 20 - Pro 211	$658 / 100µg
Mouse	Tnfrsf4-7400M	Recombinant Mouse Tnfrsf4 protein, Fc-tagged	HEK293	Fc	Val20-Pro211	$798 / 100µg
Mouse	TNFRSF4-1762MCL	Recombinant Mouse TNFRSF4 cell lysate	Human Cell	Non		Inquiry
Mouse	Tnfrsf4-547M	Recombinant Mouse Tnfrsf4 Protein	HEK293	Non	Met1-Pro211	$658 / 50µg
Mouse	Tnfrsf4-6548M	Recombinant Mouse Tnfrsf4 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	TNFRSF4-0592M	Active Recombinant Mouse TNFRSF4 protein, Fc-tagged	HEK293	Fc	Val20-Pro211	Inquiry
Mouse	TNFRSF4-341M	Active Recombinant Mouse TNFRSF4 Protein, His & Avi-tagged, Biotinylated	HEK293	His&Avi	Val 20 - Pro 211	$798 / 25µg
Mouse	Tnfrsf4-547MAF647	Recombinant Mouse Tnfrsf4 Protein, Alexa Fluor 647 conjugated	HEK293	LEVLFQ	Met1-Pro211， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Tnfrsf4-3602M	Recombinant Mouse Tnfrsf4 protein, His-SUMO-tagged	E.coli	His&SUMO	20-211aa	Inquiry
Mouse	TNFRSF4-683M	Recombinant Mouse TNFRSF4 Protein, Fc-tagged	HEK293	Fc	272	Inquiry
Mouse	Tnfrsf4-547MAF488	Recombinant Mouse Tnfrsf4 Protein, Alexa Fluor 488 conjugated	HEK293	LEVLFQ	Met1-Pro211， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Tnfrsf4-547MAF555	Recombinant Mouse Tnfrsf4 Protein, Alexa Fluor 555 conjugated	HEK293	LEVLFQ	Met1-Pro211， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	TNFRSF4-686M	Recombinant Mouse TNFRSF4 Protein	HEK293		272	Inquiry
Mouse	Tnfrsf4-7400MAF555	Recombinant Mouse Tnfrsf4 Protein, hFc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	Val20-Pro211	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Tnfrsf4-7400MAF647	Recombinant Mouse Tnfrsf4 Protein, hFc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	Val20-Pro211	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Tnfrsf4-5752M	Recombinant Mouse Tnfrsf4 Protein (Val20-Pro211), C-Fc tagged	Mammalian cells	Fc	Val20-Pro211	Inquiry
Mouse	TNFRSF4-687M	Recombinant Mouse TNFRSF4 Protein, Fc-tagged	HEK293	Fc	272	Inquiry
Mouse	Tnfrsf4-7400MF	Recombinant Mouse Tnfrsf4 Protein, hFc-tagged, FITC conjugated	HEK293	Fc	Val20-Pro211	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	TNFRSF4-843M	Recombinant Mouse TNFRSF4 Protein (Met1-Pro211), RlgG Fc-tagged	HEK293	rFc	Met1-Pro211	$498 / 50µg
Mouse	Tnfrsf4-547MF	Recombinant Mouse Tnfrsf4 Protein, FITC conjugated	HEK293	LEVLFQ	Met1-Pro211， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Mouse	Tnfrsf4-6763M	Recombinant Mouse Tnfrsf4 Protein (Val20-Pro211), C-His tagged	Mammalian cells	His	Val20-Pro211	Inquiry
Mouse	TNFRSF4-682M	Recombinant Mouse TNFRSF4 Protein	HEK293		272	Inquiry
Mouse	Tnfrsf4-6764M	Recombinant Mouse Tnfrsf4 Protein (Val20-Pro211), N-Fc tagged	Mammalian cells	Fc	Val20-Pro211	Inquiry
Mouse	Tnfrsf4-7400MAF488	Recombinant Mouse Tnfrsf4 Protein, hFc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	Val20-Pro211	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rat	TNFRSF4-6200R	Recombinant Rat TNFRSF4 Protein	Mammalian Cell	His		Inquiry
Rat	Tnfrsf4-349R	Recombinant Rat Tnfrsf4 protein, Fc-tagged	HEK293	Fc	191	$798 / 100µg
Rat	TNFRSF4-1922R	Active Recombinant Rat TNFRSF4 protein, His-tagged	HEK293	His	Val 20 - Pro 210	Inquiry
Rat	TNFRSF4-5857R-B	Recombinant Rat TNFRSF4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Tnfrsf4-450R	Recombinant Rat Tnfrsf4 Protein, His-tagged	E.coli	His	Lys29-Gly210	Inquiry
Rat	TNFRSF4-0593R	Recombinant Rat TNFRSF4 protein, Fc-tagged	HEK293	Fc	Val20-Pro210	Inquiry
Rat	TNFRSF4-192M	TNFRSF4 protein-coupled magnetic MicroBeads				Inquiry
Rat	TNFRSF4-5857R	Recombinant Rat TNFRSF4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	TNFRSF4-685R	Recombinant Rat TNFRSF4 Protein, Fc-tagged	HEK293	Fc	271	Inquiry
Monkey	TNFRSF4-548RAF488	Recombinant Monkey TNFRSF4 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	Met1-Ala216， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-548RF	Recombinant Monkey TNFRSF4 Protein, His-tagged, FITC conjugated	HEK293	His	Met1-Ala216， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-549RAF488	Recombinant Monkey TNFRSF4 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	Met1-Ala216， 426	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-549RF	Recombinant Monkey TNFRSF4 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	Met1-Ala216， 426	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-548RAF555	Recombinant Monkey TNFRSF4 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	Met1-Ala216， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-549RAF555	Recombinant Monkey TNFRSF4 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	Met1-Ala216， 426	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-548RAF647	Recombinant Monkey TNFRSF4 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	Met1-Ala216， 199	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Monkey	TNFRSF4-549RAF647	Recombinant Monkey TNFRSF4 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	Met1-Ala216， 426	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Rhesus monkey	TNFRSF4-1566R	Recombinant Rhesus Monkey TNFRSF4 Protein, hIgG4-tagged	HEK293	hIgG4		Inquiry
Rhesus monkey	TNFRSF4-1565R	Recombinant Rhesus Monkey TNFRSF4 Protein	HEK293	Non		Inquiry
Rabbit	TNFRSF4-115R	Recombinant Rabbit TNFRSF4 protein, Fc-tagged	HEK293	Fc	190	Inquiry
Rabbit	TNFRSF4-0594R	Recombinant Rabbit TNFRSF4 protein, Fc-tagged	HEK293	Fc	Ala19-Gln208	Inquiry
Rabbit	TNFRSF4-684R	Recombinant Rabbit TNFRSF4 Protein, Fc-tagged	HEK293	Fc	267	Inquiry
Rabbit	TNFRSF4-1907R	Recombinant Rabbit TNFRSF4 protein, His-tagged	HEK293	His	Ala 19 - Gln 208	Inquiry
Cynomolgus / Rhesus macaque	TNFRSF4-0591C	Active Recombinant Cynomolgus / Rhesus macaque TNFRSF4 protein, His-Avi-tagged, Biotinylated	HEK293	His&Avi	Lys28-Ala214	Inquiry
Cynomolgus/Rhesus macaque	TNFRSF4-103M	Active Recombinant Cynomolgus/Rhesus macaque TNFRSF4 protein, His-tagged	HEK293	His	Lys 28 - Ala 214	Inquiry
Homo sapiens (Human)	RFL34482HF	Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 4(Tnfrsf4) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (29-277)	Inquiry
Marmoset	TNFRSF4-340M	Active Recombinant Marmoset TNFRSF4 protein, His-tagged	HEK293	His	Leu 29 - Ala 214	Inquiry
Mus musculus (Mouse)	RFL10978MF	Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 4(Tnfrsf4) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (20-272)	Inquiry
Rattus norvegicus (Rat)	RFL13373RF	Recombinant Full Length Rat Tumor Necrosis Factor Receptor Superfamily Member 4(Tnfrsf4) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (20-271)	Inquiry
Rhesus	TNFRSF4-549R	Recombinant Rhesus TNFRSF4 Protein, Fc-tagged	HEK293	Fc	Met1-Ala216	Inquiry
Rhesus	TNFRSF4-548R	Recombinant Rhesus TNFRSF4 Protein, His-tagged	HEK293	His	Met1-Ala216	Inquiry
Rhesus macaque	TNFRSF4-102M	Recombinant Rhesus macaque TNFRSF4 protein, Fc-tagged	HEK293	Fc	187	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
TNFRSF4 Related Signal Pathway

TNFRSF4 involved in several pathways and played different roles in them. We selected most pathways TNFRSF4 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	OSTN;IL10RA;PLEKHO2;FASLG;IFNA12;THPO;INHBB;GM13304;IL9R

TNFRSF4 has several biochemical functions, for example, tumor necrosis factor-activated receptor activity, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF4 itself. We selected most functions TNFRSF4 had, and list some proteins which have the same functions with TNFRSF4. You can find most of the proteins on our site.

Function	Related Protein
tumor necrosis factor-activated receptor activity	TNFRSF25;TNFRSF10A;TNFRSF14;TNFRSF18;FAS;TNFRSF1A;NGFRB;TNFRSF11A;TNFRSF10C
virus receptor activity	CD86;LDLR;NCAM1;CD4;SERPINB4;ITGB5;SELPLG;SERPINB3;HLA-DRB1

TNFRSF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF4.

Research Area

Cancer Drug Targets

Immune Checkpoints

T Cell Markers

Co-stimulatory TNF Superfamily Molecules

T Follicular Helper (Tfh) Cells

B Cell CD Antigen

CD Antigen (Regulatory T Cells)

TNF Receptor

Co-stimulatory Molecules

Autoimmune Disease Therapeutic Targets

Lambracht-Washington, D; Rosenberg, RN; et al. Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+T cells (Tregs) in a mouse study for active DNA A beta 42 immunotherapy. JOURNAL OF NEUROIMMUNOLOGY 278:90-99(2015).

Aranda, F; Vacchelli, E; et al. Immunostimulatory monoclonal antibodies in cancer therapy. ONCOIMMUNOLOGY 3:-(2014).