TNFRSF14

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)

  • Overview

    TNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
  • Synonyms

    TNFRSF14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; CD40-like protein; OTTHUMP00000000866; OTTHUMP00000204095; OTTHUMP00000204096; OTTHUMP00000204097; herpesvirus entry mediator A; herpes virus entry mediator A; tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; CD270;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Monkey
  • Mouse
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Hi-5 Insect Cell
  • Human
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Pichia. Pastoris.
  • SF9 insect cells
  • Avi|Fc
  • C
  • Fc
  • His
  • hFc
  • DDK|His
  • Fc|His
  • His(C
  • ter)
  • Flag
  • His (Fc)
  • Avi
  • His|Fc
  • HlgG1 Fc
  • human|IgG1|Fc
  • Mouse|IgG2a|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF14-5144H Active Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) Human N/A
Human TNFRSF14-878H Active Recombinant Human TNFRSF14 Protein, Fc-tagged Hi-5 Insect Cell Fc
Human TNFRSF14-625H Active Recombinant Human TNFRSF14 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
Human TNFRSF14-624H Active Recombinant Human TNFRSF14, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF14-613H Recombinant Human TNFRSF14 Mammalian Cell His
Human TNFRSF14-877H Recombinant Human TNFRSF14 Protein, DDK/His-tagged HEK293 DDK/His
Human TNFRSF14-1691H Recombinant Human TNFRSF14, Fc-His Mammalian cells Fc/His
Human TNFRSF14-945H Recombinant Human TNFRSF14, Fc Chimera Insect Cell Fc
Human TNFRSF14-756H Recombinant Human TNFRSF14, Fc-His tagged Human Cell Fc/His
Human TNFRSF14-2443H Recombinant human TNFRSF14, His-tagged E.coli His
Human TNFRSF14-30480TH Recombinant Human TNFRSF14, Fc-tagged Fc
Human TNFRSF14-555H Recombinant Human TNFRSF14 protein, His-tagged HEK293 His
Human TNFRSF14-2155HCL Recombinant Human TNFRSF14 cell lysate Human Cell N/A
Human TNFRSF14-2171H Active Recombinant Human TNFRSF14 protein, His-tagged HEK293 His
Human TNFRSF14-313H Recombinant Human TNFRSF14 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Human TNFRSF14-1996H Recombinant Human TNFRSF14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNFRSF14-236H-B Recombinant Human TNFRSF14 Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF14-373H Recombinant Human TNFRSF14 protein, Fc-tagged HEK293 human/IgG1/Fc
Human TNFRSF14-669H Recombinant Human TNFRSF14 Protein HEK293
Human TNFRSF14-371H Recombinant Human TNFRSF14 Protein (Met1-Val202), His-Fc-tagged, Biotinylated HEK293 His/Fc
Human TNFRSF14-1190H Recombinant Human TNFRSF14 Protein (Met1-Val202), C-His tagged Mammalian cells C-His
Human TNFRSF14-389H Recombinant Human TNFRSF14 protein Pichia. Pastoris. N/A
Human TNFRSF14-670H Recombinant Human TNFRSF14 Protein, Fc-tagged HEK293 Fc
Human TNFRSF14-1150H Recombinant Human TNFRSF14 Protein (Met1-Val202), HlgG1 Fc-tagged HEK293 HlgG1 Fc
Human TNFRSF14-555HAF488 Recombinant Human TNFRSF14 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human TNFRSF14-756HAF488 Recombinant Human TNFRSF14 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Human TNFRSF14-671H Recombinant Human TNFRSF14 Protein, Strep-tagged HEK293 Strep
Human TNFRSF14-1151H Recombinant Human TNFRSF14 Protein (Met1-Val202), AVI-Fc-tagged, Biotinylated HEK293 Avi/Fc
Human TNFRSF14-442H Recombinant Human TNFRSF14 Protein, His-tagged E.coli N-His
Human TNFRSF14-115HG Active GMP Recombinant Human TNFRSF14 protein, Fc-tagged HEK293 Fc
Human TNFRSF14-555HF Recombinant Human TNFRSF14 Protein, His-tagged, FITC conjugated HEK293 His
Human TNFRSF14-555HB Recombinant Human TNFRSF14 protein, His-tagged, Biotinylated HEK293 His
Human TNFRSF14-141T Active Recombinant Human TNFRSF14 Protein (376 aa), Fc-tagged SF9 insect cells Fc
Human TNFRSF14-152H Recombinant Human TNFRSF14 Protein, His-tagged Human Cells His
Human TNFRSF14-1991H Recombinant Human TNFRSF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TNFRSF14-555HAF555 Recombinant Human TNFRSF14 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human TNFRSF14-372H Recombinant Human TNFRSF14 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
Human TNFRSF14-756HAF555 Recombinant Human TNFRSF14 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Human TNFRSF14-374H Recombinant Human TNFRSF14 protein, Strep-tagged HEK293 Strep
Human TNFRSF14-555HAF647 Recombinant Human TNFRSF14 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human TNFRSF14-756HAF647 Recombinant Human TNFRSF14 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Human TNFRSF14-756HF Recombinant Human TNFRSF14 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Human TNFRSF14-928HFL Recombinant Full Length Human TNFRSF14 Protein, C-Flag-tagged Mammalian cells Flag
Human TNFRSF14-236H Recombinant Human TNFRSF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF14-2611H Active Recombinant Human TNFRSF14 protein, hFc&His-tagged HEK293 hFc&His
Human TNFRSF14-1538H Active Recombinant Human TNFRSF14 protein, Fc-tagged HEK293 Fc
Mouse Tnfrsf14-869M Active Recombinant Mouse Tnfrsf14 Protein, Fc Chimera CHO Fc
Mouse Tnfrsf14-1062M Recombinant Mouse Tnfrsf14 protein, His-tagged E.coli His
Mouse Tnfrsf14-757M Recombinant Mouse Tnfrsf14, Fc-His tagged Human Cell Fc/His
Mouse Tnfrsf14-428M Active Recombinant Mouse Tnfrsf14 protein(Met1-Gln206), His&hFc-tagged HEK293 C-His&hFc
Mouse TNFRSF14-001MCL Recombinant Mouse TNFRSF14 cell lysate CHO N/A
Mouse TNFRSF14-2420MCL Recombinant Mouse TNFRSF14 cell lysate Human Cell N/A
Mouse Tnfrsf14-756M Recombinant Mouse Tnfrsf14 protein (Met1-Gln206), His-tagged HEK293 His
Mouse Tnfrsf14-5764M Recombinant Mouse Tnfrsf14 Protein (Gln39-Val207), C-Fc tagged Mammalian cells C-Fc
Mouse Tnfrsf14-757MAF488 Recombinant Mouse Tnfrsf14 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
Mouse Tnfrsf14-757MAF555 Recombinant Mouse Tnfrsf14 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
Mouse Tnfrsf14-428MAF555 Recombinant Mouse Tnfrsf14 Protein, His-Fc-tagged, Alexa Fluor 555 conjugated CHO His/Fc
Mouse Tnfrsf14-428MAF647 Recombinant Mouse Tnfrsf14 Protein, His-Fc-tagged, Alexa Fluor 647 conjugated CHO His/Fc
Mouse Tnfrsf14-758M Recombinant Mouse Tnfrsf14 protein, Fc-tagged HEK293 Fc
Mouse Tnfrsf14-428MF Recombinant Mouse Tnfrsf14 Protein, His-Fc-tagged, FITC conjugated CHO His/Fc
Mouse Tnfrsf14-757MF Recombinant Mouse Tnfrsf14 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
Mouse Tnfrsf14-6546M Recombinant Mouse Tnfrsf14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnfrsf14-757MAF647 Recombinant Mouse Tnfrsf14 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
Mouse Tnfrsf14-428MAF488 Recombinant Mouse Tnfrsf14 Protein, His-Fc-tagged, Alexa Fluor 488 conjugated CHO His/Fc
Monkey TNFRSF14-75CAF488 Recombinant Monkey TNFRSF14 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Monkey TNFRSF14-75CAF647 Recombinant Monkey TNFRSF14 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Monkey TNFRSF14-75CF Recombinant Monkey TNFRSF14 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Monkey TNFRSF14-75CAF555 Recombinant Monkey TNFRSF14 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Cynomolgus TNFRSF14-986C Recombinant Cynomolgus TNFRSF14 Protein (Met1-Arg201), His-tagged Insect Cell His
Cynomolgus TNFRSF14-989C Recombinant Cynomolgus TNFRSF14 protein, hFc-tagged HEK293 hFc
Cynomolgus Monkey TNFRSF14-75C Recombinant Cynomolgus TNFRSF14, Fc tagged Human Cell His
Cynomolgus Monkey TNFRSF14-1133CCL Recombinant Cynomolgus TNFRSF14 cell lysate Human Cell N/A
Rhesus Macaque TNFRSF14-4868R Recombinant Rhesus monkey TNFRSF14 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFRSF14-4682R-B Recombinant Rhesus Macaque TNFRSF14 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TNFRSF14-4682R Recombinant Rhesus Macaque TNFRSF14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNFRSF14 Related Articles
  • TNFRSF14 Related Gene Family
  • TNFRSF14 Related Signal Pathway

TNFRSF14 involved in several pathways and played different roles in them. We selected most pathways TNFRSF14 participated on our site, such as Cytokine-cytokine receptor interaction, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCNTFR;BMPR2A;IL18R1;GHR;CCL15;KITB;TNFRSF21;TNFSF13;CSF1
Herpes simplex infectionDAXX;TRAF6;IKBKB;IFNG;TBPL1;IFNA16;PER3;POU2F3;TNFSF14

TNFRSF14 has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF14 itself. We selected most functions TNFRSF14 had, and list some proteins which have the same functions with TNFRSF14. You can find most of the proteins on our site.

Function Related Protein
protein bindingGINS2;ABCB1;GM5506;FREM2;BCCIP;SPACA3;Raet1a;PRMT3;UBL4A
tumor necrosis factor-activated receptor activityRELT;FAS;CD40;CD27;TNFRSF25;TNFRSF9;TNFRSF1B;TNFRSF11A;TNFRSF10B
ubiquitin protein ligase bindingPRKAR2A;GGN;KCNH2;GRIK2;TP53;PIAS1;CDKN1A;C10orf46;CUL3
virus receptor activityCD46;DPP4;EFNB3;CD209;HYAL2;MOG;ANPEP;CXADR;NCAM1

TNFRSF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF14.

TRAF5; TRAF2; TNFSF14; TRAF2; gD; q65zq1_human; PER2

del Rio, ML; Fernandez-Renedo, C; et al. Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin beta Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. TRANSPLANTATION 98:1165-1174(2014).
Herraez, DL; Martinez-Bueno, M; et al. Rheumatoid Arthritis in Latin Americans Enriched for Amerindian Ancestry is Associated With Loci in Chromosomes 1, 12, and 13, and the HLA Class II Region. ARTHRITIS AND RHEUMATISM 65:1457-1467(2013).
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