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Official Full Name tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
Background TNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
Synonyms TNFRSF14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; CD40-like protein; OTTHUMP00000000866; OTTHUMP00000204095; OTTHUMP00000204096; OTTHUMP00000204097; herpesvirus entry mediator A; herpes virus entry mediator A; tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2; CD270
    • Species :
    • Cynomolgus
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Hi-5 Insect Cell
    • Human
    • Human Cell
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • NSO
    • Pichia. Pastoris.
    • Tag :
    • Avi
    • Fc
    • DDK
    • His
    • HlgG1 Fc
    • human
    • IgG1
    • Mouse
    • IgG2a
    • Myc/DDK
    • Myc
    • N/A
    • Strep
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF14-152H Recombinant Human TNFRSF14 Protein, His-tagged Human Cells His
    Human TNFRSF14-1150H Recombinant Human TNFRSF14 Protein (Met1-Val202), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Human TNFRSF14-1151H Recombinant Human TNFRSF14 Protein (Met1-Val202), AVI-Fc-tagged, Biotinylated HEK293 Avi/Fc
    Human TNFRSF14-115HG GMP Recombinant Human TNFRSF14 protein, Fc-tagged HEK293 Fc
    Human TNFRSF14-1691H Recombinant Human TNFRSF14, Fc-His NSO Fc/His
    Human TNFRSF14-1991H Recombinant Human TNFRSF14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TNFRSF14-1996H Recombinant Human TNFRSF14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TNFRSF14-2155HCL Recombinant Human TNFRSF14 cell lysate Human Cell N/A
    Human TNFRSF14-2443H Recombinant human TNFRSF14, His-tagged E.coli His
    Human TNFRSF14-30480TH Recombinant Human TNFRSF14, Fc-tagged Fc
    Human TNFRSF14-371H Recombinant Human TNFRSF14 Protein (Met1-Val202), His-Fc-tagged, Biotinylated HEK293 His/Fc
    Human TNFRSF14-372H Recombinant Human TNFRSF14 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
    Human TNFRSF14-373H Recombinant Human TNFRSF14 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human TNFRSF14-374H Recombinant Human TNFRSF14 protein, Strep-tagged HEK293 Strep
    Human TNFRSF14-389H Recombinant Human TNFRSF14 protein Pichia. Pastoris. N/A
    Human TNFRSF14-5144H Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 14 (Herpesvirus Entry Mediator) Human N/A
    Human TNFRSF14-555H Recombinant Human TNFRSF14 protein, His-tagged HEK293 His
    Human TNFRSF14-555HB Recombinant Human TNFRSF14 protein, His-tagged, Biotinylated HEK293 His
    Human TNFRSF14-613H Recombinant Human TNFRSF14 Mammalian Cell His
    Human TNFRSF14-624H Recombinant Human TNFRSF14, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFRSF14-625H Recombinant Human TNFRSF14 Protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc
    Human TNFRSF14-756H Recombinant Human TNFRSF14, Fc-His tagged Human Cell Fc/His
    Human TNFRSF14-877H Recombinant Human TNFRSF14 Protein, DDK/His-tagged HEK293 DDK/His
    Human TNFRSF14-878H Recombinant Human TNFRSF14 Protein, Fc-tagged Hi-5 Insect Cell Fc
    Human TNFRSF14-945H Recombinant Human TNFRSF14, Fc Chimera Insect Cell Fc
    Mouse TNFRSF14-001MCL Recombinant Mouse TNFRSF14 cell lysate CHO N/A
    Mouse Tnfrsf14-1062M Recombinant Mouse Tnfrsf14 protein, His-tagged E.coli His
    Mouse TNFRSF14-2420MCL Recombinant Mouse TNFRSF14 cell lysate Human Cell N/A
    Mouse Tnfrsf14-428M Recombinant Mouse Tnfrsf14, His-Fc tagged CHO Fc/His
    Mouse Tnfrsf14-6546M Recombinant Mouse Tnfrsf14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tnfrsf14-756M Recombinant Mouse Tnfrsf14 protein (Met1-Gln206), His-tagged HEK293 His
    Mouse Tnfrsf14-757M Recombinant Mouse Tnfrsf14, Fc-His tagged Human Cell Fc/His
    Mouse Tnfrsf14-869M Recombinant Mouse Tnfrsf14 Protein, Fc Chimera CHO Fc
    Cynomolgus Monkey TNFRSF14-1133CCL Recombinant Cynomolgus TNFRSF14 cell lysate Human Cell N/A
    Cynomolgus Monkey TNFRSF14-75C Recombinant Cynomolgus TNFRSF14, Fc tagged Human Cell His
    Cynomolgus TNFRSF14-986C Recombinant Cynomolgus TNFRSF14 Protein (Met1-Arg201), His-tagged Insect Cell His
    Rhesus Macaque TNFRSF14-4868R Recombinant Rhesus monkey TNFRSF14 Protein, His-tagged Mammalian Cell His

    tnfrsf14 involved in several pathways and played different roles in them. We selected most pathways tnfrsf14 participated on our site, such as Cytokine-cytokine receptor interaction, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction GHRA; VEGFB; CCL3L3; LTBR; TNFRSF11A; TNFSF11; CLCF1; OSMR; MET; Ccl21a
    Herpes simplex infection PTPN11A; EIF2S1B; Casp3; TBP; MED8; RNASEL; IFNA7; POLR2A; IFNGR2; HNRPK

    tnfrsf14 has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf14 itself. We selected most functions tnfrsf14 had, and list some proteins which have the same functions with tnfrsf14. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CACYBP; MORF4L2; ZMYM2; EPHB6; ANKHD1; LRRC26; LSM11; RAB18; HSPA4L; DYNLRB1
    tumor necrosis factor-activated receptor activity TNFRSF10C; TNFRSF11A; CD27; CD40; TNFRSF10D; NGFR; LTBR; RELT; NRADD; NGFRB
    ubiquitin protein ligase binding DERL1; TOLLIP; PRKAR2A; GRIK2; CUL2; UBE2S; UBE2R2; ANAPC2; PRKACB; FZD5
    virus receptor activity MRC1; CD86; GYPA; CXCR4; F11R; SCARB2; TFRC; ITGB5; HLA-DRB1; PVR

    tnfrsf14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf14 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf14.

    TRAF5; TRAF2; TNFSF14; TRAF2; gD; q65zq1_human; PER2

    del Rio, ML; Fernandez-Renedo, C; et al. Therapeutic Blockade of LIGHT Interaction With Herpesvirus Entry Mediator and Lymphotoxin beta Receptor Attenuates In Vivo Cytotoxic Allogeneic Responses. TRANSPLANTATION 98:1165-1174(2014).
    Herraez, DL; Martinez-Bueno, M; et al. Rheumatoid Arthritis in Latin Americans Enriched for Amerindian Ancestry is Associated With Loci in Chromosomes 1, 12, and 13, and the HLA Class II Region. ARTHRITIS AND RHEUMATISM 65:1457-1467(2013).

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