tnfrsf8

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tnfrsf8

Official Full Name Tumor Necrosis Factor Receptor Superfamily, Member 8
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms CD 30; CD153 antibodyCD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki-1 antigen; KI1; Lymphocyte activation; antigen CD30; TNFRSF8; Tumor Necrosis Factor Receptor Superfamily Member 8; Iratumumab; 640735-09-7; Brentuximab vedotin; 914088-09-8; CD30; Ki-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • Fc
    • Fc Chimera
    • His
    • hIgG1
    • hIgG4
    • Avi
    • LIgG2b Fc
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse TNFRSF8-1155M Recombinant Mouse TNFRSF8 Protein (Met1-Thr258), His-tagged HEK293 His
    Human TNFRSF8-1594HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled NS0 Fc
    Human TNFRSF8-1594HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled NS0 Fc
    Human TNFRSF8-263HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled NS0 Fc
    Human TNFRSF8-263HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled NS0 Fc
    Human TNFRSF8-373H Recombinant Human TNFRSF8 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc
    Human TNFRSF8-434H Recombinant Human TNFRSF8 Protein (Met1-Lys379), His-tagged, Biotinylated HEK293 His
    Human TNFRSF8-641HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled HEK293 Fc
    Human TNFRSF8-641HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human TNFRSF8-642HA Recombinant Human TNFRSF8 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
    Human TNFRSF8-642HP Recombinant Human TNFRSF8 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
    Human TNFRSF8-1594H Recombinant Human TNFRSF8, Fc-tagged NSO Fc
    Human TNFRSF8-1821H Recombinant Human TNFRSF8 protein, His & Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNFRSF8-2027H Recombinant Human TNFRSF8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TNFRSF8-2031H Recombinant Human TNFRSF8 Protein, DDK-tagged Insect Cell DDK
    Human TNFRSF8-2097HCL Recombinant Human TNFRSF8 cell lysate Human Cell N/A
    Human TNFRSF8-263H Recombinant Human TNFRSF8, Fc Chimera NS0 Fc Chimera
    Human TNFRSF8-26927TH Recombinant Human TNFRSF8 Wheat Germ N/A
    Human TNFRSF8-377H Recombinant Human TNFRSF8 Protein, His-tagged Insect Cell His
    Human TNFRSF8-563H Recombinant Human TNFRSF8, His tagged Human Cell His
    Human TNFRSF8-641H Recombinant Human TNFRSF8 Protein, Fc-tagged HEK293 Fc
    Human TNFRSF8-642H Recombinant Human TNFRSF8, Fc-His tagged Human Cell Fc/His
    Human TNFRSF8-7532H Recombinant Human TNFRSF8, His-tagged E.coli His
    Human TNFRSF8-889H Recombinant Human TNFRSF8 Protein, DDK-tagged Sf9 Insect Cell DDK
    Mouse Tnfrsf8-1713M Recombinant Mouse Tnfrsf8 NSO N/A
    Rat TNFRSF8-6201R Recombinant Rat TNFRSF8 Protein Mammalian Cell His
    Rhesus monkey TNFRSF8-1691R Recombinant Rhesus Monkey TNFRSF8 Protein HEK293 N/A
    Rhesus monkey TNFRSF8-1720R Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey TNFRSF8-1721R Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG4-tagged HEK293 hIgG4
    Chicken TNFRSF8-6014C Recombinant Chicken TNFRSF8 Mammalian Cell His

    tnfrsf8 involved in several pathways and played different roles in them. We selected most pathways tnfrsf8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CNTF; IL12RB1; IL25; CLCF1; CSF3; TNFRSF19; TNFRSF1A; CXCL2; CXCL10; CXCL12

    tnfrsf8 has several biochemical functions, for example, transmembrane signaling receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf8 itself. We selected most functions tnfrsf8 had, and list some proteins which have the same functions with tnfrsf8. You can find most of the proteins on our site.

    Function Related Protein
    transmembrane signaling receptor activity CD300C; FZD8A; TNFRSF11A; KIR2DS2; Cd79a, Cd79b; GHRHRA; SLC22A17; CR2; CD97; NPC1
    tumor necrosis factor-activated receptor activity TNFRSF9; TNFRSF14; TNFRSF1B; NGFRB; TNFRSFA; TNFRSF1A; LTBR; NRADD; TNFRSF4; RELT

    tnfrsf8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf8 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf8.

    Traf1; Traf2; BCL6

    Slack, GW; Steidl, C; et al. CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia. BRITISH JOURNAL OF HAEMATOLOGY 167:608-617(2014).
    Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).

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