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TNFRSF8

Official Full Name

Tumor Necrosis Factor Receptor Superfamily, Member 8
Overview

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms

CD 30; CD153 antibodyCD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki-1 antigen; KI1; Lymphocyte activation; antigen CD30; TNFRSF8; Tumor Necrosis Factor Receptor Superfamily Member 8; Iratumumab; 640735-09-7; 914088-09-8; CD30; Ki-1;

Type

Recombinant Proteins
Cell & Tissue Lysates
GMP Proteins
Protein Pre-coupled Magnetic Beads
Chromatography Reagents

Species

Canine
Chicken
Cynomolgus
Homo sapiens (Human)
Human
Mouse
Rat
Rattus norvegicus (Rat)
Rhesus monkey

Source

E.coli
E.coli expression system
HEK293
HEK293 cells
HEK293T
Human Cell
Insect Cell
Insect cells
Insect Cells
Mammalian Cell
Mammalian cells
Sf9 Insect Cell
Wheat Germ

Tag

C
His
Fc
Avi
Flag
hIgG4
GST
lIgG2b
mFc
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TNFRSF8-1821H	Active Recombinant Human TNFRSF8 protein, His & Avi-tagged, Biotinylated	HEK293	His&Avi	AA Phe 19 - Lys 379	Inquiry
Human	TNFRSF8-051H	Active Recombinant Human TNFRSF8 protein, His/Avi-tagged, Biotinylated	HEK293 cells	His&Avi	Phe19-Lys379	Inquiry
Human	TNFRSF8-263HAF555	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated	Mammalian cells	Fc		$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-263HAF488	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated	Mammalian cells	Fc		$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-973H	Active Recombinant Human TNFRSF8 Protein, His & hFc-tagged	HEK293	His&Fc	Met 1-Lys 379	Inquiry
Human	TNFRSF8-052H	Active Recombinant Human TNFRSF8 protein, Fc/Avi-tagged, Biotinylated	HEK293 cells	Fc&Avi	Phe19-Lys379	Inquiry
Human	TNFRSF8-1594HAF647	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated	Mammalian cells	Fc	1-379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-263HAF647	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated	Mammalian cells	Fc		$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-1594HF	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated	Mammalian cells	Fc	1-379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-1594HAF488	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated	Mammalian cells	Fc	1-379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-263HF	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated	Mammalian cells	Fc		$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD30-3072H	Active Recombinant Human CD30 protein, His-tagged, FITC-Labeled	HEK293	His	Phe 19-Lys 379	Inquiry
Human	TNFRSF8-1594HAF555	Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated	Mammalian cells	Fc	1-379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	CD30-3074H	Active Recombinant Human CD30 protein, Fc-tagged,FITC-Labeled	HEK293	Fc	Phe 19-Lys 379	Inquiry
Human	TNFRSF8-642HP	Recombinant Human TNFRSF8 protein, Fc-His-tagged, R-PE labeled	HEK293	His&Fc		Inquiry
Human	TNFRSF8-563H	Recombinant Human TNFRSF8, His tagged	Human Cell	His	Met1-Lys379	$568 / 100 µg
Human	TNFRSF8-26927TH	Recombinant Human TNFRSF8	Wheat Germ	Non	113 amino acids	Inquiry
Human	TNFRSF8-642H	Active Recombinant Human TNFRSF8, Fc-His tagged	Human Cell	His&Fc	Met1-Lys379	$629 / 100 µg
Human	TNFRSF8-1594H	Active Recombinant Human TNFRSF8, Fc-tagged	Mammalian cells	Fc	1-379	Inquiry
Human	TNFRSF8-7532H	Recombinant Human TNFRSF8, His-tagged	E.coli	His	19-379aa	Inquiry
Human	TNFRSF8-641H	Recombinant Human TNFRSF8 Protein, Fc-tagged	HEK293	Fc	Phe 19 - Lys 379	Inquiry
Human	TNFRSF8-377H	Recombinant Human TNFRSF8 Protein, His-tagged	Insect Cell	His		Inquiry
Human	TNFRSF8-889H	Recombinant Human TNFRSF8 Protein, DDK-tagged	Sf9 Insect Cell	Flag	Met-Phe19	Inquiry
Human	TNFRSF8-2097HCL	Recombinant Human TNFRSF8 cell lysate	Human Cell	Non		Inquiry
Human	TNFRSF8-641HAF488	Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated	HEK293	Fc	Phe 19-Lys 379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-563HAF647	Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 647 conjugated	HEK293	His	372	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-641HA	Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled	HEK293	Fc	Met1-Lys379	Inquiry
Human	TNFRSF8-451H	Recombinant Human TNFRSF8 Protein, His-tagged	E.coli	His	Met464-Lys595	Inquiry
Human	TNFRSF8-2027H	Recombinant Human TNFRSF8 Protein, MYC/DDK-tagged	HEK293	Myc&DDK		Inquiry
Human	TNFRSF8-444H	Recombinant Human TNFRSF8 Protein, His-Avi-tagged	HEK293	His&Avi	Phe19-Lys379	Inquiry
Human	TNFRSF8-642HA	Recombinant Human TNFRSF8 protein, Fc-His-tagged, APC labeled	HEK293	His&Fc		Inquiry
Human	TNFRSF8-08H	Recombinant Human TNFRSF8 Protein, C-6His-Avi tagged, Biotinylated	Human Cell	His&Avi	Gln24-Lys265(Met115Thr)	Inquiry
Human	TNFRSF8-1594HA	Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled	Mammalian cells	Fc		Inquiry
Human	TNFRSF8-563HAF488	Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 488 conjugated	HEK293	His	372	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-641HAF555	Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated	HEK293	Fc	Phe 19-Lys 379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-150H	Recombinant Human TNFRSF8 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	TNFRSF8-434H	Recombinant Human TNFRSF8 Protein (Met1-Lys379), His-tagged, Biotinylated	HEK293	His	Met1-Lys379	Inquiry
Human	TNFRSF8-642HAF488	Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated	HEK293	His&Fc	609	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-642HAF555	Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated	HEK293	His&Fc	609	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-0270H	Recombinant Human TNFRSF8 protein, His&Avi-tagged, Biotinylated	HEK293	His&Avi	Met1-Lys379	Inquiry
Human	TNFRSF8-908H	Recombinant Human TNFRSF8 protein, mFc-tagged	HEK293	mFc	Phe19-Lys379	Inquiry
Human	TNFRSF8-563HF	Recombinant Human TNFRSF8 Protein, His-tagged, FITC conjugated	HEK293	His	372	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-641HAF647	Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated	HEK293	Fc	Phe 19-Lys 379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-2031H	Recombinant Human TNFRSF8 Protein, DDK-tagged	Insect Cell	Flag		Inquiry
Human	TNFRSF8-567HG	Active GMP Recombinant Human TNFRSF8 protein	HEK293		DNA sequence encoding Human CD30(UniProtKB - P28908 ) was expressed with His tag at the C-terminal.	Inquiry
Human	TNFRSF8-180H	Recombinant Human TNFRSF8 Protein, His\Avi-tagged	Human Cell	His&Avi	Gln24-Lys265	Inquiry
Human	TNFRSF8-642HAF647	Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated	HEK293	His&Fc	609	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-1594HP	Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled	HEK293	Fc	Met1-Lys379	Inquiry
Human	TNFRSF8-2788H	Recombinant Human TNFRSF8 protein, His-tagged	E.coli	His	19-246 aa	$319 / 25μg
Human	TNFRSF8-145H	Recombinant Human TNFRSF8 Protein, His-tagged	HEK293	His	595	Inquiry
Human	TNFRSF8-642HF	Recombinant Human TNFRSF8 Protein, Fc/His-tagged, FITC conjugated	HEK293	His&Fc	609	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-641HP	Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled	HEK293	Fc		Inquiry
Human	TNFRSF8-563HAF555	Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 555 conjugated	HEK293	His	372	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-150H-B	Recombinant Human TNFRSF8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	TNFRSF8-2637H	Active Recombinant Human TNFRSF8 protein, His-tagged	HEK293	His	Phe19-Lys379	Inquiry
Human	TNFRSF8-373H	Active Recombinant Human TNFRSF8 Protein, LIgG2b Fc-tagged, low endotoxin	HEK293	lIgG2b	Phe 19 - Lys 379	Inquiry
Human	TNFRSF8-146H	Recombinant Human TNFRSF8 Protein, Fc-tagged	HEK293	Fc	595	Inquiry
Human	TNFRSF8-4659H	Active Recombinant Human TNFRSF8 Protein, His-tagged, Site-specific PE-Labeled	HEK293	C-His	Phe 19 - Lys 379	Inquiry
Human	TNFRSF8-561H	Recombinant Human TNFRSF8 Protein (Phe19-Lys379), C-6×His-tagged	HEK293	His	Phe19-Lys379	Inquiry
Human	Tnfrsf8-058M	Recombinant Mouse Tnfrsf8 Protein, hFc-tagged	HEK293	Fc	Met1-Thr258	Inquiry
Human	TNFRSF8-641HF	Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated	HEK293	Fc	Phe 19-Lys 379	$798 / 20μg $1,298 / 50μg $1,998 / 100μg
Human	TNFRSF8-0272H	Recombinant Human TNFRSF8 protein, His-tagged, Biotinylated	HEK293	His	Met1-Lys379	Inquiry
Human	TNFRSF8-5335H	Recombinant Human TNFRSF8 Protein (Met1-Lys379), C-His tagged	Mammalian cells	His	Met1-Lys379	Inquiry
Human	CD30-492M	CD30 protein-coupled magnetic MicroBeads				Inquiry
Mouse	Tnfrsf8-1713M	Recombinant Mouse Tnfrsf8	Mammalian cells	Non		Inquiry
Mouse	Tnfrsf8-038M	Recombinant Mouse Tnfrsf8 Protein, hIgG/His-tagged	Insect cells	His&Fc		Inquiry
Mouse	Tnfrsf8-10625M	Recombinant Mouse Tnfrsf8 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	TNFRSF8-1156M	Recombinant Mouse TNFRSF8 protein(Met1-Thr258), hFc-tagged	HEK293	Fc	Met1-Thr258	Inquiry
Mouse	TNFRSF8-1155M	Recombinant Mouse TNFRSF8 Protein (Met1-Thr258), His-tagged	HEK293	His	Met1-Thr258	Inquiry
Mouse	Tnfrsf8-6549M	Recombinant Mouse Tnfrsf8 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	Tnfrsf8-006M	Recombinant Mouse Tnfrsf8 Protein, hIgG/His-tagged	Insect Cells	His&Fc	19-258aa	Inquiry
Mouse	TNFRSF8-2405M	Recombinant Mouse TNFRSF8 protein(Met1-Thr258), hFc-tagged	HEK293	Fc	Met1-Thr258	Inquiry
Mouse	Tnfrsf8-10625M-B	Recombinant Mouse Tnfrsf8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	TNFRSF8-6201R	Recombinant Rat TNFRSF8 Protein	Mammalian Cell	His		Inquiry
Rat	TNFRSF8-5858R	Recombinant Rat TNFRSF8 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	TNFRSF8-5858R-B	Recombinant Rat TNFRSF8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Tnfrsf8-452R	Recombinant Rat Tnfrsf8 Protein, His&GST-tagged	E.coli	His&GST	Asn43-Leu201	Inquiry
Rhesus monkey	TNFRSF8-1720R	Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG1-tagged	HEK293	Fc	29-393	Inquiry
Rhesus monkey	TNFRSF8-1691R	Recombinant Rhesus Monkey TNFRSF8 Protein	HEK293	Non	29-393	Inquiry
Rhesus monkey	TNFRSF8-1721R	Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG4-tagged	HEK293	hIgG4	29-393	Inquiry
Canine	CD30-3073C	Recombinant Canine CD30 protein, His-tagged	HEK293	His	Met 1-Gly 284	Inquiry
Cynomolgus	TNFRSF8-045C	Recombinant Cynomolgus TNFRSF8 protein, His-tagged	HEK293	His	Met1-Gly194	Inquiry
Homo sapiens (Human)	RFL31646HF	Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 8(Tnfrsf8) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-595)	Inquiry
Rattus norvegicus (Rat)	RFL12946RF	Recombinant Full Length Rat Tumor Necrosis Factor Receptor Superfamily Member 8(Tnfrsf8) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (19-493)	Inquiry
Chicken	TNFRSF8-6014C	Recombinant Chicken TNFRSF8	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource
TNFRSF8 Related Signal Pathway

TNFRSF8 involved in several pathways and played different roles in them. We selected most pathways TNFRSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cytokine-cytokine receptor interaction	LIFRA;LIF;IL10RA;AMHR2;IFNW1;PF4V1;IL20;CXCL12B;IL12A

TNFRSF8 has several biochemical functions, for example, transmembrane signaling receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF8 itself. We selected most functions TNFRSF8 had, and list some proteins which have the same functions with TNFRSF8. You can find most of the proteins on our site.

Function	Related Protein
transmembrane signaling receptor activity	OR12D2;LGR6;OR103-4;KIR2DS2;TLR7;OR6K3;NFAM1;FZD8A;TLR10
tumor necrosis factor-activated receptor activity	TNFRSF21;FAS;RELT;TNFRSFA;TNFRSF9A;CD27;TNFRSF11B;TNFRSF18;TNFRSF25

TNFRSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF8.

Traf1; Traf2; BCL6

Research Area

Cancer Drug Targets

CAR-T Cell Therapy Targets

Embryonic and Induced Pluripotent Stem Cell Markers

Co-stimulatory TNF Superfamily Molecules

T Follicular Helper (Tfh) Cells

CD Antigen (Dendritic Cell Co-stimulatory Molecules)

CD Antigen (Helper T Cells)

TNF Receptor

Co-stimulatory Molecules

Natural Killer Cell (NK Cell)

Slack, GW; Steidl, C; et al. CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia. BRITISH JOURNAL OF HAEMATOLOGY 167:608-617(2014).

Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).