Tumor Necrosis Factor Receptor Superfamily, Member 8
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
TNFRSF8 involved in several pathways and played different roles in them. We selected most pathways TNFRSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
TNFRSF8 has several biochemical functions, for example, transmembrane signaling receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF8 itself. We selected most functions TNFRSF8 had, and list some proteins which have the same functions with TNFRSF8. You can find most of the proteins on our site.
TNFRSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF8.
Traf1; Traf2; BCL6
Slack, GW; Steidl, C; et al. CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia. BRITISH JOURNAL OF HAEMATOLOGY 167:608-617(2014).
Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
