Tnfrsf12a
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Official Full Name
tumor necrosis factor receptor superfamily, member 12A
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Overview
Fibroblast growth factor-inducible 14 (Fn14) is the receptor for Tweak, a member of the TNF receptor family. It was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Fn14 is highly expressed in glioma and some cancer cases of breast, pancreas, and liver. Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins -
Synonyms
TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; tumor necrosis factor receptor superfamily member 12A; CD266; FN14; TweakR; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14; tumor necrosis factor receptor superfamily, member 12;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Rhesus monkey
- Rhesus Monkey
- E.coli
- HEK293
- Human Cell
- Human Cells
- Mammalian cells
- Fc
- Flag
- GST
- hIgG4
- His
- mFc
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- Tnfrsf12a Related Signal Pathway
Tnfrsf12a involved in several pathways and played different roles in them. We selected most pathways Tnfrsf12a participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf12a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | BMP7B;PLEKHO2;CCL25B;IL18;CCL24;LIFR;CNTFR;TNFRSF12A;EGFRA |
Tnfrsf12a has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf12a itself. We selected most functions Tnfrsf12a had, and list some proteins which have the same functions with Tnfrsf12a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SRSF10;NEDD8;OSBPL2;FXR2;ZBTB22;TIMM23;SNX10;NRAP;ITGB3BP |
Tnfrsf12a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf12a here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf12a.
TNFSF12; SLC30A2; TRAF2; BIRC2; fliN
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe manufacturer's commitment to delivering excellent technical support further enhances the experience, offering timely resolutions to any challenges I may encounter.
the TNFRSF12A protein surpasses expectations in terms of quality, meeting the rigorous demands of my experiments.
With the TNFRSF12A protein and the manufacturer's support, I can confidently pursue my research goals and achieve meaningful outcomes.
Q&As (5)
Ask a questionSome studies suggest that TNFRSF12A may play a role in cardiovascular diseases, and targeting it could be a potential therapeutic strategy, but more research is needed.
Research indicates that elevated levels of TNFRSF12A may serve as a diagnostic marker for certain cancers, providing valuable information for disease detection.
As of now, there are no FDA-approved drugs specifically targeting TNFRSF12A. However, research is ongoing to develop targeted therapies.
TNFRSF12A is known to modulate inflammatory responses, and dysregulation of its signaling pathways may contribute to chronic inflammatory conditions.
TNFRSF12A is being explored as a potential target for immunotherapy in cancer, with studies investigating its role in modulating the immune response.
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