• Official Full Name

    tumor necrosis factor receptor superfamily, member 12A

  • Overview

    Fibroblast growth factor-inducible 14 (Fn14) is the receptor for Tweak, a member of the TNF receptor family. It was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Fn14 is highly expressed in glioma and some cancer cases of breast, pancreas, and liver. Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins
  • Synonyms

    TNFRSF12A; tumor necrosis factor receptor superfamily, member 12A; tumor necrosis factor receptor superfamily member 12A; CD266; FN14; TweakR; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14; tumor necrosis factor receptor superfamily, member 12;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Rhesus monkey
  • Rhesus Monkey
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • Mammalian cells
  • C
  • Fc
  • mFc
  • His(C
  • ter)
  • hFc
  • hIgG4
  • His|GST
  • N/A
  • N
  • GST
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF12A-221H Active Recombinant Human TNFRSF12A Protein, Fc-tagged HEK293 Fc
Human TNFRSF12A-41H Active Recombinant Human Fn-14, Fc-tagged HEK293 Fc
Human TNFRSF12A-709H Active Recombinant Human TNFRSF12A, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF12A-312H Recombinant Active Human TNFRSF12A Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Glu28-Trp79
Human TNFRSF12A-7734H Recombinant Human TNFRSF12A protein, His & GST-tagged E.coli His/GST Ser24~Ala126 (Accession # Q9NP84)
Human TNFRSF12A-582H Recombinant Human TNFRSF12A protein E.coli N/A 53
Human TNFRSF12A-30127TH Recombinant Human TNFRSF12A, Fc-tagged E.coli Fc
Human TNFRSF12A-2125H Recombinant Human TNFRSF12A Protein, Flag-tagged HEK293 Fc
Human TNFRSF12A-30125TH Recombinant Human TNFRSF12A, Fc-tagged HEK293 Fc 48 amino acids
Human TNFRSF12A-1560HCL Recombinant Human TNFRSF12A cell lysate Human Cell N/A
Human TNFRSF12A-441H Recombinant Human TNFRSF12A Protein, His&GST-tagged E.coli N-His&GST Ser24-Ala126
Human TNFRSF12A-151H Recombinant Human TNFRSF12A Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human TNFRSF12A-471H Recombinant Human TNFRSF12A Protein, Fc-tagged HEK293 Fc 129
Human TNFRSF12A-4829H Recombinant Human TNFRSF12A Protein (Glu28-Trp79), C-Fc tagged Mammalian cells C-Fc Glu28-Trp79
Human TNFRSF12A-1128H Recombinant Human TNFRSF12A Protein (Ser24-Ala126), N-GST tagged E.coli N-GST Ser24-Ala126
Human TNFRSF12A-737H Recombinant Human TNFRSF12A Protein (Glu28-Pro80), C-mFc-tagged HEK293 C-mFc Glu28-Pro80
Mouse Tnfrsf12a-42M Active Recombinant Mouse Fn-14, Fc-tagged HEK293 Fc
Mouse Tnfrsf12a-2085M Recombinant Mouse Tnfrsf12a, Fc Chimera HEK293 Fc
Rhesus monkey TNFRSF12A-1645R Recombinant Rhesus Monkey TNFRSF12A Protein HEK293 N/A
Rhesus monkey TNFRSF12A-1647R Recombinant Rhesus Monkey TNFRSF12A Protein, hIgG4-tagged HEK293 hIgG4
Rhesus Monkey TNFRSF12A-1646R Recombinant Rhesus Monkey TNFRSF12A Protein, hIgG1 tagged HEK293 hFc
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Tnfrsf12a Related Signal Pathway

Tnfrsf12a involved in several pathways and played different roles in them. We selected most pathways Tnfrsf12a participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf12a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCRFB16;CCL19;KDR;EDAR;TNFSF13B;CSF1;Ccl9;HGF;PRL2

Tnfrsf12a has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf12a itself. We selected most functions Tnfrsf12a had, and list some proteins which have the same functions with Tnfrsf12a. You can find most of the proteins on our site.

Function Related Protein
protein bindingZC3HC1;ZMYND10;SPSB2;FAM83A;NOL12;KTN1;AFG3L2;SIRT4;NEK3

Tnfrsf12a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf12a here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf12a.

TNFSF12; SLC30A2; TRAF2; BIRC2; fliN

Gene Family

TNF Cytokines

Research Area

  • Q&As
  • Reviews

Q&As (5)

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Can TNFRSF12A be a potential therapeutic target for cardiovascular diseases? 05/14/2022

Some studies suggest that TNFRSF12A may play a role in cardiovascular diseases, and targeting it could be a potential therapeutic strategy, but more research is needed.

Can TNFRSF12A be used as a diagnostic marker for certain diseases? 02/09/2021

Research indicates that elevated levels of TNFRSF12A may serve as a diagnostic marker for certain cancers, providing valuable information for disease detection.

Are there any FDA-approved drugs targeting TNFRSF12A? 05/10/2020

As of now, there are no FDA-approved drugs specifically targeting TNFRSF12A. However, research is ongoing to develop targeted therapies.

How is TNFRSF12A involved in inflammation? 01/31/2018

TNFRSF12A is known to modulate inflammatory responses, and dysregulation of its signaling pathways may contribute to chronic inflammatory conditions.

Can TNFRSF12A be targeted for immunotherapy in cancer treatment? 11/17/2017

TNFRSF12A is being explored as a potential target for immunotherapy in cancer, with studies investigating its role in modulating the immune response.

Customer Reviews (3)

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    The manufacturer's commitment to delivering excellent technical support further enhances the experience, offering timely resolutions to any challenges I may encounter.


      the TNFRSF12A protein surpasses expectations in terms of quality, meeting the rigorous demands of my experiments.


        With the TNFRSF12A protein and the manufacturer's support, I can confidently pursue my research goals and achieve meaningful outcomes.

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