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TNFRSF10A

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 10a

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
  • Synonyms

    TNFRSF10A; tumor necrosis factor receptor superfamily, member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Homo sapiens (Human)
  • Human
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • C
  • His
  • Fc
  • Fc Chimera
  • Fc|His
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF10A-597H Active Recombinant Human TNFRSF10A, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF10A-248H Active Recombinant Human TNFRSF10A, Fc Chimera Sf21 Insect Cell Fc Chimera
Human TNFRSF10A-312H Active Recombinant Human TNFRSF10A Protein E.coli N/A
Human TNFRSF10A-524H Active Recombinant Human TNFRSF10A, Fc-tagged HEK293 Fc
Human TNFRSF10A-249H Active Recombinant Human TNFRSF10A, Fc Chimera CHO Fc Chimera
Human TNFRSF10A-112H Recombinant Human TNFRSF10A E.coli N/A
Human TNFRSF10A-49H Recombinant Human TRAIL-R1, Fc Chimera HEK293 Fc
Human TNFRSF10A-3168H Recombinant Human TNFRSF10A protein(Met1-Asn239), His-tagged HEK293 C-His Met1-Asn239
Human TNFRSF10A-883H Recombinant Human TNFRSF10A, Fc-His tagged Human Cell Fc/His
Human TNFRSF10A-3131H Recombinant Human TNFRSF10A, Fc tagged Human Cell Fc
Human TNFRSF10A-27024TH Recombinant Human TNFRSF10A, Fc-tagged Fc
Human TNFRSF10A-2180HCL Recombinant Human TNFRSF10A cell lysate Human Cell N/A
Human TNFRSF10A-3168HAF488 Recombinant Human TNFRSF10A Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 142
Human TNFRSF10A-212H Recombinant Human TNFRSF10A protein, His-Avi-tagged HEK293 His-Avi It contains Pro34-Asn 239.
Human TNFRSF10A-3131HAF555 Recombinant Human TNFRSF10A Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 372
Human TNFRSF10A-212HB Recombinant Human TNFRSF10A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi It contains Pro34-Asn 239.
Human TNFRSF10A-461H Recombinant Human TNFRSF10A Protein, Fc-tagged HEK293 Fc 468
Human TNFRSF10A-883HAF488 Recombinant Human TNFRSF10A Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 378
Human TNFRSF10A-3168HAF555 Recombinant Human TNFRSF10A Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 142
Human TNFRSF10A-3131HAF488 Recombinant Human TNFRSF10A Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 372
Human TNFRSF10A-883HAF555 Recombinant Human TNFRSF10A Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 378
Human TNFRSF10A-460H Recombinant Human TNFRSF10A Protein, His-tagged HEK293 His 468
Human TNFRSF10A-3131HAF647 Recombinant Human TNFRSF10A Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 372
Human TNFRSF10A-0739H Active Recombinant Human TNFRSF10A protein, His-tagged HEK293 His Ala24-Asn239
Human TNFRSF10A-3168HAF647 Recombinant Human TNFRSF10A Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 142
Human TNFRSF10A-883HAF647 Recombinant Human TNFRSF10A Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 378
Human TNFRSF10A-3131HF Recombinant Human TNFRSF10A Protein, Fc-tagged, FITC conjugated HEK293 Fc 372
Human TNFRSF10A-3168HF Recombinant Human TNFRSF10A Protein, His-tagged, FITC conjugated HEK293 His 142
Human TNFRSF10A-883HF Recombinant Human TNFRSF10A Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 378
Human TNFRSF10A-5249H Recombinant Human TNFRSF10A Protein (Met1-Asn239), C-His tagged Mammalian cells C-His Met1-Asn239
Homo sapiens (Human) RFL3235HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 10A(Tnfrsf10A) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-468)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF10A Related Signal Pathway

TNFRSF10A involved in several pathways and played different roles in them. We selected most pathways TNFRSF10A participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF10A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCL2;INHBA;NT5C3;TNFSF12;IL17RA;CD70;LTBR;PRLR;ACVR1B
ApoptosisVIML;IL1B2;DSG2;DBNLA;IL3RA;AKT3A;HMGB2;BADB;PPP3R1
Natural killer cell mediated cytotoxicityMAP2K1;TYROBP;IFNGR2;KIR2DS2;IFNA7;FCER1G;KIR2DL1;HLA-C;ARAF
MeaslesPIK3CB;IL2RG;IFNB1;IL12A;PIK3CG;RAB9B;IFNA2;IFNA21;TRP53
Influenza ATRIM25;AKT1;TMPRSS4;BLB1;HLA-DPA1;CASP9;IL33;MAPK9;EP300

TNFRSF10A has several biochemical functions, for example, TRAIL binding, death receptor activity, protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF10A itself. We selected most functions TNFRSF10A had, and list some proteins which have the same functions with TNFRSF10A. You can find most of the proteins on our site.

Function Related Protein
TRAIL bindingTNFRSF10B;TNFRSF10C;TNFRSF10A;TNFRSF10D;Tnfrsf22
death receptor activityNGFR;TNFRSF10A
protease bindingRYR1;CD70;SERPINF2;CCBE1;ITGB1;FAP;Serpina1c;ADAM8A;INS2
protein bindingDGCR6L;IKBIP;SLC48A1;SKP1;LAMP2;COX6B2;IGF1;SETBP1;PPP1CC
receptor activityMED14;CD244;EDAR;RET;GRIN1A;GRIA4A;TRAM1;NLGN4X;ANTXR2B
transcription factor bindingPER1;MED1;ERCC3;E2F5;DR1;HDAC11;EP300;NFIA;PIAS2
tumor necrosis factor-activated receptor activityTNFRSF4;TNFRSF14;TNFRSF11B;NGFR;TNFRSF10A;TNFRSF1B;TNFRSF25;TNFRSF19;TNFRSF8

TNFRSF10A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF10A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF10A.

CASP8; TNFSF10; ARAP1

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