TNFRSF1B

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 1B

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
  • Synonyms

    TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Transfected Stable Cell Lines
  • Chicken
  • Cynomolgus Monkey
  • Cynomolgus/Rhesus
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E. coil
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • C
  • hFc
  • His
  • Fc
  • Fc Chimera
  • Fc|His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • mFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF1B-2349H Active Recombinant Human TNFRSF1B, Fc-His Human Cell Fc
Human TNFRSF1B-164H Active Recombinant Human TNFRSF1B E.coli N/A
Human TNFRSF1B-153H Active Recombinant Human TNFRSF1B, Fc Chimera HEK293 Fc
Human TNFRSF1B-165H Active Recombinant Human TNFRSF1B, Fc Chimera Mammalian cells Fc Chimera
Human TNFRSF1B-178H Active Recombinant Human TNFRSF1B protein(Met1-Asp257), His&hFc-tagged HEK293 C-His&hFc Met1-Asp257
Human TNFRSF1B-193H Active Recombinant Human TNFRSF1B protein, His-tagged HEK293 His Met1-Arg268
Human TNFRSF1B-249H Active Recombinant Human TNFRSF1B protein E.coli N/A Pro 24-Thr206
Human TNFRSF1B-708H Active Recombinant Human TNFRSF1B, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF1B-446H Active Recombinant Human TNFRSF1B protein, His-GST-tagged E.coli His/GST Ala298~Leu441
Human TNFRSF1B-1261H Active Recombinant Human TNFRSF1B protein, His-tagged HEK293 His Leu 23 - Asp 257
Human TNFRSF1B-285H Recombinant Human TNFRSF1B protein, His-tagged, Biotinylated HEK293 His Met1-Asp257
Human TNFRSF1B-76H Recombinant Human TNFRSF1B CHO N/A
Human TNFRSF1B-62H Recombinant Human TNFRSF1B protein, His-tagged Insect Cell His
Human TNFRSF1B-7055H Recombinant Human TNFRSF1B protein, His & GST-tagged E.coli His/GST Ala298~Leu441 (Accession# P20333)
Human TNFRSF1B-31575TH Recombinant Human TNFRSF1B, His-tagged E.coli His
Human TNFRSF1B-5270H Recombinant Human TNFRSF1B protein E.coli N/A 184
Human TNFRSF1B-125H Recombinant Human soluble tumor necrosis factor receptor superfamily, member 1B, His-tagged E.coli His
Human TNFRSF1B-80H Recombinant Human TNF Receptor 2 protein, His-tagged E.coli His 184 amino acids
Human TNFRSF1B-180H Recombinant Human TNFRSF1B E.coli N/A
Human TNFRSF1B-66H Recombinant Human TNF-R2, Fc-tagged HEK293 Fc
Human TNFRSF1B-386H Recombinant Human TNFRSF1B Mammalian Cell His
Human TNFRSF1B-1689H Recombinant Human TNFRSF1B, Fc&His-tagged Mammalian cells Fc/His
Human TNFRSF1B-851HCL Recombinant Human TNFRSF1B cell lysate Human Cell N/A
Human TNFRSF1B-2632HCL Recombinant Human TNFRSF1B cell lysate Human Cell N/A
Human TNFRSF1B-1318H Active Recombinant Human TNFRSF1B protein, His&Avi-tagged, Biotinylated HEK293 His&Avi Met1-Asp257
Human TNFRSF1B-01H Active Recombinant Human TNFRSF1B Protein E. coil 184
Human TNFRSF1B-333H Recombinant Human TNFR2 Protein, mFc-tagged HEK293 mFc Leu23-Asp257
Human TNFRSF1B-1482H Recombinant Human TNFRSF1B Protein (Leu23-Asp257), N-His tagged E.coli N-His Leu23-Asp257
Human TNFRSF1B-211H-B Recombinant Human TNFRSF1B Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF1B-5142H Recombinant Human TNFRSF1B Protein (Met1-Asp257), C-His tagged Mammalian cells C-His Met1-Asp257
Human TNFRSF1B-126H Human Soluble Tumor Necrosis Receptor factor Type II (rDNA derived) Reference standard N/A
Human TNFRSF1B-458H Recombinant Human TNFRSF1B Protein, His-tagged HEK293 His 461
Human TNFRSF1B-5536H Recombinant Human TNFRSF1B protein, His-tagged Yeast His 23-257aa
Human TNFRSF1B-211H Recombinant Human TNFRSF1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF1B-3600H Recombinant Human TNFRSF1B protein, GST-tagged E.coli GST 27-203aa
Human TNFRSF1B-6477H Recombinant Human TNFRSF1B Protein (Pro24-Thr206), C-His tagged E.coli C-His Pro24-Thr206
Human TNFRSF1B-6478H Recombinant Human TNFRSF1B Protein (Lys288-Ser461), C-His tagged Mammalian cells C-His Lys288-Ser461
Mouse Tnfrsf1b-3274M Active Recombinant Mouse Tnfrsf1b protein, His-tagged HEK293 His Met1-Gly258
Mouse Tnfrsf1b-7056M Recombinant Mouse Tnfrsf1b protein, His-tagged E.coli His His303~Ala474 (Accession# P25119)
Mouse Tnfrsf1b-3259M Recombinant Mouse Tnfrsf1b protein(Met1-Gly258), hFc-tagged HEK293 C-hFc Met1-Gly258
Mouse TNFRSF1B-2192MCL Recombinant Mouse TNFRSF1B cell lysate Human Cell N/A
Mouse TNFRSF1B-194H Recombinant Mouse TNFRSF1B(Val23-Gly258) Protein, C-6*His-Avi-tagged, Biotinylated HEK293 His-Avi
Mouse Tnfrsf1b-847M Recombinant Mouse Tnfrsf1b protein E.coli N/A 236
Mouse Tnfrsf1b-447M Recombinant Mouse Tnfrsf1b Protein, His-tagged HEK293F N-His Val23-Gly258
Mouse Tnfrsf1b-6828M Recombinant Mouse Tnfrsf1b Protein (Val23-Gly258), C-His tagged Mammalian cells C-His Val23-Gly258
Rat TNFRSF1B-6198R Recombinant Rat TNFRSF1B Protein Mammalian Cell His
Rat Tnfrsf1b-7057R Recombinant Rat Tnfrsf1b protein, His & T7-tagged E.coli His/T7 Ala25~Met229 (Accession # Q80WY6)
Rat Tnfrsf1b-448R Recombinant Rat Tnfrsf1b Protein, His-tagged HEK293F N-His Val23-Gly258
Rat TNFRSF1B-5855R Recombinant Rat TNFRSF1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TNFRSF1B-5855R-B Recombinant Rat TNFRSF1B Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey TNFRSF1B-70C Recombinant Cynomolgus TNFRSF1B, Fc tagged Human Cell Fc/His
Cynomolgus Monkey TNFRSF1B-8828C Recombinant Cynomolgus TNFRSF1B, His tagged Human Cell His
Cynomolgus Monkey TNFRSF1B-1048CCL Recombinant Cynomolgus TNFRSF1B cell lysate Human Cell N/A
Cynomolgus/Rhesus TNFRSF1B-2184C Active Recombinant Cynomolgus/Rhesus TNFRSF1B protein, hFc-tagged HEK293 hFc Met1-Asp257
Cynomolgus/Rhesus TNFRSF1B-0765C Recombinant Cynomolgus/Rhesus TNFRSF1B protein(Met1-Asp257), His-tagged HEK293 C-His Met1-Asp257
Homo sapiens (Human) RFL14909HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 1B(Tnfrsf1B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-461)
Mus musculus (Mouse) RFL26484MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 1B(Tnfrsf1B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (23-474)
Rhesus Macaque TNFRSF1B-4869R Recombinant Rhesus monkey TNFRSF1B Protein, His-tagged Mammalian Cell His
Rhesus Macaque TNFRSF1B-4683R-B Recombinant Rhesus Macaque TNFRSF1B Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque TNFRSF1B-4683R Recombinant Rhesus Macaque TNFRSF1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TNFRSF1B-482R Recombinant Rhesus Macaque TNFRSF1B(Leu23-Asp257) Protein, C-6*His-tagged HEK293 His
Rhesus Macaque TNFRSF1B-4870R Recombinant Rhesus Macaque TNFRSF1B(Leu23-Asp257) Protein, C-Fc-tagged HEK293 Fc
Zebrafish TNFRSF1B-5605Z Recombinant Zebrafish TNFRSF1B Mammalian Cell His
Chicken TNFRSF1B-6009C Recombinant Chicken TNFRSF1B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF1B Related Signal Pathway

TNFRSF1B involved in several pathways and played different roles in them. We selected most pathways TNFRSF1B participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCCL6;IL22RA1;CXCR4B;IL11RA2;CCL19;TNFSF8;CXCL6;INHBA;CCL11
TNF signaling pathwayMLKL;ICAM1;CXCL5;MAP3K14;LTA;TNFRSF1B;PIK3CA;TNF;MAPK10
Adipocytokine signaling pathwaySLC2A1;CPT1A;PCK2;PTPN11;TNFRSF1B;ACSL1B;ADIPOR1B;RXRGA;SLC2A4
Amyotrophic lateral sclerosis (ALS)PPP3R2;TNFRSF1B;TNFRSF1A;MAP3K5;SOD1;PRPH;TNF;CASP9;CYCS

TNFRSF1B has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1B itself. We selected most functions TNFRSF1B had, and list some proteins which have the same functions with TNFRSF1B. You can find most of the proteins on our site.

Function Related Protein
protein bindingKRTAP3-3;KLRC2;ETV1;ERCC3;HIST1H4L;SCN5A;LRRK1;GCKR;GAB2
tumor necrosis factor-activated receptor activityTnfrsf26;TNFRSFA;RELT;CD40;FAS;TNFRSF14;TNFRSF21;TNFRSF10C;TNFRSF1B
ubiquitin protein ligase bindingFLJ11011L;PRR5L;UBE2J2;GABARAPL2;MYOD1;RPA2;HIF1A;TMEM189;UBE2A

TNFRSF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1B.

GRN; TNF; TRAF2; TNF; TUBB3; HAX1; IRS4; CDIPT; XPO1; ATP2A1; IPO8; PHGDH; XPOT

Gene Family

TNF Cytokines

Research Area

Related articles

Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).
Kolorz, M; Wroblova, K; et al. Pharmacogenomics of infliximab therapy, impact of TNFRSF1A and TNFRSF1B gene polymorphisms. BIOMEDICAL PAPERS-OLOMOUC 157:S75-S78(2013).
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