tumor necrosis factor receptor superfamily, member 1B
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
TNFRSF1B involved in several pathways and played different roles in them. We selected most pathways TNFRSF1B participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
TNFRSF1B has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1B itself. We selected most functions TNFRSF1B had, and list some proteins which have the same functions with TNFRSF1B. You can find most of the proteins on our site.
TNFRSF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1B.