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Official Full Name tumor necrosis factor receptor superfamily, member 1B
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Synonyms TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • Fc Chimera
    • His
    • GST
    • T7
    • mFc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF1B-125H Recombinant Human soluble tumor necrosis factor receptor superfamily, member 1B, His-tagged E.coli His
    Human TNFRSF1B-126H Human Soluble Tumor Necrosis Receptor factor Type II (rDNA derived) Reference standard N/A
    Human TNFRSF1B-153H Recombinant Human TNFRSF1B, Fc Chimera HEK293 Fc
    Human TNFRSF1B-164H Recombinant Human TNFRSF1B E.coli N/A
    Human TNFRSF1B-165H Recombinant Human TNFRSF1B, Fc Chimera Mammalian cells Fc Chimera
    Human TNFRSF1B-1689H Recombinant Human TNFRSF1B, Fc&His-tagged Mammalian cells Fc/His
    Human TNFRSF1B-178H Recombinant Human TNFRSF1B, Fc-His tagged Human Cell Fc/His
    Human TNFRSF1B-180H Recombinant Human TNFRSF1B E.coli N/A
    Human TNFRSF1B-193H Recombinant Human TNFRSF1B, His tagged Human Cell His
    Human TNFRSF1B-2349H Recombinant Human TNFRSF1B, Fc-His Human Cell Fc
    Human TNFRSF1B-249H Recombinant Human TNFRSF1B protein E.coli N/A
    Human TNFRSF1B-2632HCL Recombinant Human TNFRSF1B cell lysate Human Cell N/A
    Human TNFRSF1B-285H Recombinant Human TNFRSF1B, His tagged Human Cell His
    Human TNFRSF1B-31575TH Recombinant Human TNFRSF1B, His-tagged E.coli His
    Human TNFRSF1B-333H Recombinant Human TNFR2 Protein, mFc-tagged HEK293 mFc
    Human TNFRSF1B-386H Recombinant Human TNFRSF1B Mammalian Cell His
    Human TNFRSF1B-5270H Recombinant Human TNFRSF1B protein E.coli N/A
    Human TNFRSF1B-62H Recombinant Human TNFRSF1B protein, His-tagged Insect Cell His
    Human TNFRSF1B-66H Recombinant Human TNF-R2, Fc-tagged HEK293 Fc
    Human TNFRSF1B-7055H Recombinant Human TNFRSF1B protein, His & GST-tagged E.coli His/GST
    Human TNFRSF1B-708H Recombinant Human TNFRSF1B, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFRSF1B-76H Recombinant Human TNFRSF1B CHO N/A
    Human TNFRSF1B-80H Recombinant Human TNF Receptor 2 protein, His-tagged E.coli His
    Human TNFRSF1B-851HCL Recombinant Human TNFRSF1B cell lysate Human Cell N/A
    Mouse TNFRSF1B-2192MCL Recombinant Mouse TNFRSF1B cell lysate Human Cell N/A
    Mouse Tnfrsf1b-3259M Recombinant Mouse Tnfrsf1b, Fc tagged Human Cell Fc
    Mouse Tnfrsf1b-3274M Recombinant Mouse Tnfrsf1b, His tagged Human Cell His
    Mouse Tnfrsf1b-7056M Recombinant Mouse Tnfrsf1b protein, His-tagged E.coli His
    Mouse Tnfrsf1b-847M Recombinant Mouse Tnfrsf1b protein E.coli N/A
    Rat TNFRSF1B-6198R Recombinant Rat TNFRSF1B Protein Mammalian Cell His
    Rat Tnfrsf1b-7057R Recombinant Rat Tnfrsf1b protein, His & T7-tagged E.coli His/T7
    Cynomolgus Monkey TNFRSF1B-1048CCL Recombinant Cynomolgus TNFRSF1B cell lysate Human Cell N/A
    Cynomolgus Monkey TNFRSF1B-70C Recombinant Cynomolgus TNFRSF1B, Fc tagged Human Cell Fc/His
    Cynomolgus Monkey TNFRSF1B-8828C Recombinant Cynomolgus TNFRSF1B, His tagged Human Cell His
    Rhesus Macaque TNFRSF1B-4869R Recombinant Rhesus monkey TNFRSF1B Protein, His-tagged Mammalian Cell His
    Chicken TNFRSF1B-6009C Recombinant Chicken TNFRSF1B Mammalian Cell His
    Zebrafish TNFRSF1B-5605Z Recombinant Zebrafish TNFRSF1B Mammalian Cell His

    tnfrsf1b involved in several pathways and played different roles in them. We selected most pathways tnfrsf1b participated on our site, such as Cytokine-cytokine receptor interaction, TNF signaling pathway, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf1b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction TNFSF12; IL10RA; IFNPHI1; CCR8; CCL19; TNF; PDGFAB; IL2RB; IL7; VEGFA
    TNF signaling pathway CASP10; SELE; CREB3L1; LTA; ATF4; FOS; PIK3CB; CASP8; MMP9; CXCL2
    Adipocytokine signaling pathway IRS4; CAMKK1; IKBKB; NFKBIAA; TNFRSF1A; MAPK8; G6PCA.2; LEPB; ACSL3B; PRKAG3B
    Amyotrophic lateral sclerosis (ALS) GRIN2D; BCL2; BID; SLC1A2; GRIA2; TNF; MAPK12; PPP3CA; NEFL; PPP3R2

    tnfrsf1b has several biochemical functions, for example, protein binding, tumor necrosis factor-activated receptor activity, ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf1b itself. We selected most functions tnfrsf1b had, and list some proteins which have the same functions with tnfrsf1b. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TRIM2; ZNF131; EEA1; AGFG1; GPR77; HIP1R; CARD10; NME7; KCNE1; SETDB2
    tumor necrosis factor-activated receptor activity TNFRSF10D; Tnfrsf26; TNFRSF9; EDA2R; CD40; TNFRSF1A; NGFRB; NRADD; TNFRSF21; TNFRSF6B
    ubiquitin protein ligase binding PARK2; PCBP2; RNF20; ATP6V0C; HSPA1L; UBE2G1; CLU; AKTIP; WASH; UBE2U

    tnfrsf1b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf1b here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf1b.


    Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).
    Kolorz, M; Wroblova, K; et al. Pharmacogenomics of infliximab therapy, impact of TNFRSF1A and TNFRSF1B gene polymorphisms. BIOMEDICAL PAPERS-OLOMOUC 157:S75-S78(2013).

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