Tnfrsf10b

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 10b

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms

    TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Avi
  • His
  • C
  • Fc
  • hFc
  • mFc
  • Fc|His
  • hIgG1
  • hIgG4
  • His|Avi
  • His|GST
  • HlgG1 Fc
  • human|IgG1|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF10B-518H Active Recombinant Human TNFRSF10B E.coli N/A
Human TNFRSF10B-460H Active Recombinant Human TNFRSF10B, Fc Chimera HEK293 Fc
Human TNFRSF10B-598H Active Recombinant Human TNFRSF10B, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF10B-28127TH Recombinant Human TNFRSF10B, Fc-tagged Fc
Human TNFRSF10B-27023TH Recombinant Human TNFRSF10B, Fc-tagged HEK293 Fc 161 amino acids
Human TNFRSF10B-884H Recombinant Human TNFRSF10B, Fc-His tagged Human Cell Fc/His
Human TNFRSF10B-309H Recombinant Human TNFRSF10B Protein, His-tagged HEK293 His
Human TNFRSF10B-28130TH Recombinant Human TNFRSF10B, Fc-tagged Fc
Human TNFRSF10B-56H Active Recombinant Human TNFRSF10B protein, Fc-tagged, FITC-labeled HEK293 Fc
Human TNFRSF10B-28129TH Recombinant Human TNFRSF10B, Fc-tagged HEK293 Fc 216 amino acids
Human TNFRSF10B-51H Recombinant Human TNFRSF10B protein(Met1-Glu182), hFc-tagged HEK293 C-hFc Met1-Glu182
Human TNFRSF10B-2350H Active Recombinant Human TNFRSF10B protein, His-tagged HEK293 His Met1-Glu182
Human TNFRSF10B-310H Recombinant Human TNFRSF10B Protein, Fc/His-tagged HEK293 Fc/His
Human TNFRSF10B-7761H Recombinant Human TNFRSF10B protein, His & GST-tagged E.coli His/GST Ser234~Ala435 (Accession # O14763)
Human TNFRSF10B-311H Recombinant Human TNFRSF10B protein E.coli N/A 132
Human TNFRSF10B-2829HCL Recombinant Human TNFRSF10B cell lysate Human Cell N/A
Human TNFRSF10B-599H Active Recombinant Human TNFRSF10B Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human TNFRSF10B-1999H Recombinant Human TNFRSF10B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNFRSF10B-377H Recombinant Human TNFRSF10B protein, Fc-tagged HEK293 human/IgG1/Fc 127
Human TNFRSF10B-1435H Recombinant Human TNFRSF10B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TNFRSF10B-2350HAF555 Recombinant Human TNFRSF10B Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 138
Human TNFRSF10B-1148H Recombinant Human TNFRSF10B Protein (Met1-Glu182), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Glu182
Human TNFRSF10B-763H Recombinant Human TNFRSF10B protein, His-Avi-tagged HEK293 His-Avi Ile56-Glu182
Human TNFRSF10B-2350HB Recombinant Human TNFRSF10B protein, His-tagged, Biotinylated HEK293 His
Human TNFRSF10B-2350HAF647 Recombinant Human TNFRSF10B Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 138
Human TNFRSF10B-884HAF555 Recombinant Human TNFRSF10B Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 375
Human TNFRSF10B-884HAF488 Recombinant Human TNFRSF10B Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 375
Human TNFRSF10B-2350HAF488 Recombinant Human TNFRSF10B Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 138
Human TNFRSF10B-2350HF Recombinant Human TNFRSF10B Protein, His-tagged, FITC conjugated HEK293 His 138
Human TNFRSF10B-462H Recombinant Human TNFRSF10B Protein, His-tagged HEK293 His 440
Human TNFRSF10B-884HAF647 Recombinant Human TNFRSF10B Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 375
Human TNFRSF10B-2136H Recombinant Human TNFRSF10B Protein, His-tagged E.coli N-His Ile56-Ser210
Human TNFRSF10B-156H Recombinant Human TNFRSF10B Protein, C-His-tagged E.coli C-His
Human TNFRSF10B-6668H Recombinant Human TNFRSF10B Protein (Ile56-Glu182), C-His tagged Mammalian cells C-His Ile56-Glu182
Human TNFRSF10B-884HF Recombinant Human TNFRSF10B Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 375
Human TNFRSF10B-15H Active Recombinant Human TNFRSF10B Protein HEK293
Human TNFRSF10B-0780H Active Recombinant Human TNFRSF10B protein, His-tagged HEK293 His Ile56-Glu182
Human TNFRSF10B-0779H Active Recombinant Human TNFRSF10B protein, Fc-tagged HEK293 Fc Ile56-Glu182
Human TNFRSF10B-5248H Recombinant Human TNFRSF10B Protein (Met1-Glu182), C-Fc tagged Mammalian cells C-Fc Met1-Glu182
Human TNFRSF10B-478H Recombinant Human TNFRSF10B Protein (Ile56-Glu186), C-mFc-tagged HEK293 C-mFc Ile56-Glu186
Human TNFRSF10B-5247H Recombinant Human TNFRSF10B Protein (Met1-Glu182), C-His tagged Mammalian cells C-His Met1-Glu182
Human TNFRSF10B-6669H Recombinant Human TNFRSF10B Protein (Asn53-Ser177), C-Fc tagged Mammalian cells C-Fc Asn53-Ser177
Human TNFRSF10B-463H Recombinant Human TNFRSF10B Protein, Fc-tagged HEK293 Fc 440
Human TNFRSF10B-1497H Recombinant Human TNFRSF10B Protein (Ser234-Ala435), N-GST tagged E.coli N-GST Ser234-Ala435
Mouse Tnfrsf10b-178M Recombinant Mouse Tnfrsf10b Sf21 Insect Cell N/A
Mouse Tnfrsf10b-3321M Active Recombinant Mouse Tnfrsf10b protein, His&hFc-tagged HEK293 His&hFc Met1-Ser177
Mouse Tnfrsf10b-7763M Recombinant Mouse Tnfrsf10b protein, His-tagged E.coli His Pro54~Lys180 (Accession # Q9QZM4)
Mouse Tnfrsf10b-3292M Active Recombinant Mouse Tnfrsf10b protein, His-tagged HEK293 His Met1-Ser177
Mouse Tnfrsf10b-7762M Recombinant Mouse Tnfrsf10b protein, His-tagged E.coli His Asp233~Ala367 (Accession # Q9QZM4)
Mouse TNFRSF10B-2397MCL Recombinant Mouse TNFRSF10B cell lysate Human Cell N/A
Mouse Tnfrsf10b-6544M Recombinant Mouse Tnfrsf10b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnfrsf10b-3321MAF555 Recombinant Mouse Tnfrsf10b Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 373
Mouse Tnfrsf10b-5750M Recombinant Mouse Tnfrsf10b Protein (Asn53-Ser177), C-Fc tagged Mammalian cells C-Fc Asn53-Ser177
Mouse Tnfrsf10b-3292MAF647 Recombinant Mouse Tnfrsf10b Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 136
Mouse Tnfrsf10b-3293M Recombinant Mouse Tnfrsf10b(Asn53-Ser177) Protein, C-Avi-6*His-tagged, Biotinylated HEK293 Avi-His
Mouse Tnfrsf10b-3292MF Recombinant Mouse Tnfrsf10b Protein, His-tagged, FITC conjugated HEK293 His 136
Mouse Tnfrsf10b-3292MAF488 Recombinant Mouse Tnfrsf10b Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 136
Mouse Tnfrsf10b-3292MAF555 Recombinant Mouse Tnfrsf10b Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 136
Mouse Tnfrsf10b-3321MAF488 Recombinant Mouse Tnfrsf10b Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 373
Mouse TNFRSF10B-0778M Active Recombinant Mouse TNFRSF10B protein, His-tagged HEK293 His Asn53-Lys180
Mouse Tnfrsf10b-3321MAF647 Recombinant Mouse Tnfrsf10b Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 373
Mouse Tnfrsf10b-3321MF Recombinant Mouse Tnfrsf10b Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 373
Rat Tnfrsf10b-2745R Recombinant Rat Tnfrsf10b Protein, His-tagged E.coli N-His Lys17-Ala336
Rhesus monkey TNFRSF10B-1637R Recombinant Rhesus Monkey TNFRSF10B Protein HEK293 N/A
Rhesus monkey TNFRSF10B-1639R Recombinant Rhesus Monkey TNFRSF10B Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey TNFRSF10B-1638R Recombinant Rhesus Monkey TNFRSF10B Protein, hIgG1-tagged HEK293 hIgG1
Cynomolgus TNFRSF10B-0777C Active Recombinant Cynomolgus TNFRSF10B protein, His-tagged HEK293 His Ile58-Ser212
Homo sapiens (Human) RFL25566HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 10B(Tnfrsf10B) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (56-440)
Chicken TNFRSF10B-5691C Recombinant Chicken TNFRSF10B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Tnfrsf10b Related Signal Pathway

Tnfrsf10b involved in several pathways and played different roles in them. We selected most pathways Tnfrsf10b participated on our site, such as Cytokine-cytokine receptor interaction, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf10b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCXCL9;IFNA1;TNFSF4;IL11RA2;CCR9;FLT3LG;INHBE;CCR7;LIFR
p signaling pathwayAPAF1;RRM2;IGFBP3;PTEN;CYCS;SIAH2L;SHISA5;CCNG1;TP53AIP1
ApoptosisXIAP;LMNB1;IL3;HMGB2;AIFM1;GAS2;BNIP3L;CAPN2B;HIST1H1B
Natural killer cell mediated cytotoxicityTYROBP;PRF1;KLRC1;ULBP2;KIR2DS5;SHC1;KLRC2;Raet1c;NFATC2
MeaslesIFNA7;CCNE2;cgr2b;IFNA21;IFNA2;PIK3R5;IL2RG;IFNG;IRAK4
Influenza APABPN1L;MAPK12;HLA-DRB4;HLA-DPB1;PRKCB;RSAD2;IL12B;TNFRSF10B;IFNA7

Tnfrsf10b has several biochemical functions, for example, TRAIL binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf10b itself. We selected most functions Tnfrsf10b had, and list some proteins which have the same functions with Tnfrsf10b. You can find most of the proteins on our site.

Function Related Protein
TRAIL bindingTNFRSF10A;Tnfrsf22;TNFRSF10D;TNFRSF10B;TNFRSF10C
protein bindingMETAP2;GAPDHS;CBX5;MED15;TEF;HADHA;ETS1;LEO1;VPS36
receptor activityNEO1;GFRA2A;PVRL1B;GFRA1B;DERL1;PAQR5A;CD160;CADM1A;SV2A
tumor necrosis factor-activated receptor activityTnfrsf26;CD40;TNFRSF8;TNFRSF10B;TNFRSF10D;NRADD;HDR;TNFRSF1B;TNFRSF14

Tnfrsf10b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf10b here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf10b.

TNFSF10

Gene Family

TNF

Research Area

Related articles

Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).
Seirafian, S; Prod'homme, V; et al. Human cytomegalovirus suppresses Fas expression and function. JOURNAL OF GENERAL VIROLOGY 95:933-939(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does TNFRSF10B activation induce apoptosis in cancer cells? 03/09/2023

Activation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.

Is TNFRSF10B involved in other diseases besides cancer? 04/19/2021

TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.

Can TNFRSF10B be used as a diagnostic marker for cancer? 03/08/2019

TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.

In what types of cancer is TNFRSF10B expression altered? 03/19/2017

TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.

Are there any side effects associated with targeting TNFRSF10B in cancer treatment? 06/06/2016

Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.

Customer Reviews (3)

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Reviews
08/11/2020

    The combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

    10/07/2018

      The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.

      03/04/2017

        The manufacturer's commitment to providing excellent technical support is highly valuable.

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