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Official Full Name tumor necrosis factor receptor superfamily, member 10b
Background The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Synonyms TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Tag :
    • Fc
    • His
    • hIgG1
    • hIgG4
    • Avi
    • GST
    • His-Avi
    • HlgG1 Fc
    • human
    • IgG1
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TNFRSF10B-1148H Recombinant Human TNFRSF10B Protein (Met1-Glu182), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Human TNFRSF10B-1435H Recombinant Human TNFRSF10B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human TNFRSF10B-1999H Recombinant Human TNFRSF10B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human TNFRSF10B-2350H Recombinant Human TNFRSF10B, His tagged Human Cell His
    Human TNFRSF10B-2350HB Recombinant Human TNFRSF10B protein, His-tagged, Biotinylated HEK293 His
    Human TNFRSF10B-27023TH Recombinant Human TNFRSF10B, Fc-tagged HEK293 Fc
    Human TNFRSF10B-28127TH Recombinant Human TNFRSF10B, Fc-tagged Fc
    Human TNFRSF10B-28129TH Recombinant Human TNFRSF10B, Fc-tagged HEK293 Fc
    Human TNFRSF10B-28130TH Recombinant Human TNFRSF10B, Fc-tagged Fc
    Human TNFRSF10B-2829HCL Recombinant Human TNFRSF10B cell lysate Human Cell N/A
    Human TNFRSF10B-309H Recombinant Human TNFRSF10B Protein, His-tagged HEK293 His
    Human TNFRSF10B-310H Recombinant Human TNFRSF10B Protein, Fc/His-tagged HEK293 Fc/His
    Human TNFRSF10B-311H Recombinant Human TNFRSF10B protein E.coli N/A
    Human TNFRSF10B-377H Recombinant Human TNFRSF10B protein, Fc-tagged HEK293 human/IgG1/Fc
    Human TNFRSF10B-460H Recombinant Human TNFRSF10B, Fc Chimera HEK293 Fc
    Human TNFRSF10B-518H Recombinant Human TNFRSF10B E.coli N/A
    Human TNFRSF10B-51H Recombinant Human TRAIL-R2, Fc Chimera HEK293 Fc
    Human TNFRSF10B-56H Recombinant Human TNFRSF10B protein, Fc-tagged, FITC-labeled HEK293 Fc
    Human TNFRSF10B-598H Recombinant Human TNFRSF10B, Fc-tagged, Biotinylated Human Cell Fc
    Human TNFRSF10B-599H Recombinant Human TNFRSF10B Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human TNFRSF10B-763H Recombinant Human TNFRSF10B protein, His-Avi-tagged HEK293 His-Avi
    Human TNFRSF10B-7761H Recombinant Human TNFRSF10B protein, His & GST-tagged E.coli His/GST
    Human TNFRSF10B-884H Recombinant Human TNFRSF10B, Fc-His tagged Human Cell Fc/His
    Mouse Tnfrsf10b-178M Recombinant Mouse Tnfrsf10b Sf21 Insect Cell N/A
    Mouse TNFRSF10B-2397MCL Recombinant Mouse TNFRSF10B cell lysate Human Cell N/A
    Mouse Tnfrsf10b-3292M Recombinant Mouse Tnfrsf10b, His tagged Human Cell His
    Mouse Tnfrsf10b-3321M Recombinant Mouse Tnfrsf10b, Fc-His tagged Human Cell Fc/His
    Mouse Tnfrsf10b-6544M Recombinant Mouse Tnfrsf10b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Tnfrsf10b-7762M Recombinant Mouse Tnfrsf10b protein, His-tagged E.coli His
    Mouse Tnfrsf10b-7763M Recombinant Mouse Tnfrsf10b protein, His-tagged E.coli His
    Rhesus monkey TNFRSF10B-1637R Recombinant Rhesus Monkey TNFRSF10B Protein HEK293 N/A
    Rhesus monkey TNFRSF10B-1638R Recombinant Rhesus Monkey TNFRSF10B Protein, hIgG1-tagged HEK293 hIgG1
    Rhesus monkey TNFRSF10B-1639R Recombinant Rhesus Monkey TNFRSF10B Protein, hIgG4-tagged HEK293 hIgG4
    Chicken TNFRSF10B-5691C Recombinant Chicken TNFRSF10B Mammalian Cell His

    tnfrsf10b involved in several pathways and played different roles in them. We selected most pathways tnfrsf10b participated on our site, such as Cytokine-cytokine receptor interaction, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf10b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CXCL6; CXCL13; IL20; CXCR6; LEPA; CXCR4B; IFNB1; CD40LG; PDGFRA; IFNB
    p signaling pathway CCNB1; CASP3B; SERPINB5; TSC2; THBS1; CCNB3; BIDA; CDK1; CASP9; MDM4
    Natural killer cell mediated cytotoxicity KIR3DL2; MICB; IFNGR1; ULBP2; KLRC4-KLRK1; KLRC2; LAT; RAET1G; SHC2; IFNGR2
    Measles CD3E; CD3D; STAT1; BBC3; IFNGR2; CBLB; IRF3; AKT2; IFNA14; OAS1B; IL1B
    Influenza A IFNAR1; FURIN; PIK3CB; MAP2K3; IL12B; IFNA12; NXF2; PIK3CA; EIF2AK4; HSPA6

    tnfrsf10b has several biochemical functions, for example, TRAIL binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf10b itself. We selected most functions tnfrsf10b had, and list some proteins which have the same functions with tnfrsf10b. You can find most of the proteins on our site.

    Function Related Protein
    TRAIL binding Tnfrsf22; TNFRSF10A; TNFRSF10B; TNFRSF10D; TNFRSF10C
    protein binding IL1R1; KRT6A; TET3; KCTD1; SPN; NLK; SPG11; OCRL; BCL2L10; USP36
    receptor activity VMN1R46; XPR1; ANTXR2A; NCR3; CD4; OGFRL2; KLRB1B; RNF139; GRIK3; KLRC4-KLRK1
    tumor necrosis factor-activated receptor activity TNFRSF9A; TNFRSF8; CD40; Tnfrsf26; TNFRSF11B; TNFRSF14; TNFRSF10A; TNFRSF9; TNFRSF18; FAS

    tnfrsf10b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf10b here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf10b.


    Meng, XW; Koh, BD; et al. Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression. JOURNAL OF BIOLOGICAL CHEMISTRY 289:20543-20558(2014).
    Seirafian, S; Prod'homme, V; et al. Human cytomegalovirus suppresses Fas expression and function. JOURNAL OF GENERAL VIROLOGY 95:933-939(2014).


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