|Official Full Name||tumor necrosis factor receptor superfamily, member 10b|
|Background||The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]|
|Synonyms||TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer);|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
tnfrsf10b involved in several pathways and played different roles in them. We selected most pathways tnfrsf10b participated on our site, such as Cytokine-cytokine receptor interaction, p signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf10b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||CXCL6; CXCL13; IL20; CXCR6; LEPA; CXCR4B; IFNB1; CD40LG; PDGFRA; IFNB|
|p signaling pathway||CCNB1; CASP3B; SERPINB5; TSC2; THBS1; CCNB3; BIDA; CDK1; CASP9; MDM4|
|Apoptosis||CDK5RAP2; BNIP3LB; FAS; TRAF2; CTNNB1; BAXA; STK24A; CAPN2A; TNFRSF1A; BIRC5A|
|Natural killer cell mediated cytotoxicity||KIR3DL2; MICB; IFNGR1; ULBP2; KLRC4-KLRK1; KLRC2; LAT; RAET1G; SHC2; IFNGR2|
|Measles||CD3E; CD3D; STAT1; BBC3; IFNGR2; CBLB; IRF3; AKT2; IFNA14; OAS1B; IL1B|
|Influenza A||IFNAR1; FURIN; PIK3CB; MAP2K3; IL12B; IFNA12; NXF2; PIK3CA; EIF2AK4; HSPA6|
tnfrsf10b has several biochemical functions, for example, TRAIL binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf10b itself. We selected most functions tnfrsf10b had, and list some proteins which have the same functions with tnfrsf10b. You can find most of the proteins on our site.
|TRAIL binding||Tnfrsf22; TNFRSF10A; TNFRSF10B; TNFRSF10D; TNFRSF10C|
|protein binding||IL1R1; KRT6A; TET3; KCTD1; SPN; NLK; SPG11; OCRL; BCL2L10; USP36|
|receptor activity||VMN1R46; XPR1; ANTXR2A; NCR3; CD4; OGFRL2; KLRB1B; RNF139; GRIK3; KLRC4-KLRK1|
|tumor necrosis factor-activated receptor activity||TNFRSF9A; TNFRSF8; CD40; Tnfrsf26; TNFRSF11B; TNFRSF14; TNFRSF10A; TNFRSF9; TNFRSF18; FAS|
tnfrsf10b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf10b here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf10b.