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  • Official Full Name

    tumor necrosis factor receptor superfamily, member 25

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
  • Synonyms

    TNFRSF25; tumor necrosis factor receptor superfamily, member 25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12; tumor necrosis factor receptor superfamily member 25; protein WSL-1; death receptor beta; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; lymphocyte-associated receptor of death; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Cynomolgus monkey
  • Human
  • Mouse
  • Rat
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • Fc
  • Fc Chimera
  • hIgG1
  • hIgG4
  • His
  • His (Fc)
  • Avi
  • His|T7
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF25-596H Active Recombinant Human TNFRSF25, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF25-2081H Recombinant Human TNFRSF25, Fc Chimera HEK293 Fc
Human TNFRSF25-568H Recombinant Human TNFRSF25, Fc tagged Human Cell Fc
Human TNFRSF25-2154HCL Recombinant Human TNFRSF25 cell lysate Human Cell N/A
Human TNFRSF25-2154H Recombinant Human TNFRSF25 Protein (25-199 aa), His-tagged E.coli His 25-199 aa
Human TNFRSF25-205H Recombinant Human TNFRSF25 Protein, Fc-tagged HEK293 Fc 417
Human TNFRSF25-449H Recombinant Human TNFRSF25 Protein, His-tagged E.coli N-His Thr28-Cys176
Human TNFRSF25-2142H Recombinant Human TNFRSF25 protein, His-tagged HEK293 His Gln 25 - Gln 199
Mouse Tnfrsf25-369M Active Recombinant Mouse Tnfrsf25, Fc Chimera Mammalian cells Fc Chimera
Mouse TNFRSF25-300M Active Recombinant Mouse TNFRSF25, MIgG2a Fc-tagged CHO Fc
Mouse Tnfrsf25-150M-B Recombinant Mouse Tnfrsf25 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfrsf25-150M Recombinant Mouse Tnfrsf25 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Tnfrsf25-1067R Recombinant Rat Tnfrsf25 protein, His & T7-tagged E.coli His/T7 Cys38~Gly167 (Accession # D4ADP7)
Rhesus monkey TNFRSF25-1810R Recombinant Rhesus Monkey TNFRSF25 Protein HEK293 N/A
Rhesus monkey TNFRSF25-1811R Recombinant Rhesus Monkey TNFRSF25 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TNFRSF25-1812R Recombinant Rhesus Monkey TNFRSF25 Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus TNFRSF25-369C Recombinant Cynomolgus TNFRSF25 protein, Fc-tagged HEK293 human/IgG1/Fc 184
Cynomolgus monkey TNFRSF25-204C Recombinant Cynomolgus monkey TNFRSF25 Protein, Fc-tagged HEK293 Fc 421
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • TNFRSF25 Related Signal Pathway

TNFRSF25 involved in several pathways and played different roles in them. We selected most pathways TNFRSF25 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionPLEKHO2;PPBP;CCL26;PRP2;GH2;IFNAR1;EDA;TNFRSF1B;CCL5

TNFRSF25 has several biochemical functions, for example, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF25 itself. We selected most functions TNFRSF25 had, and list some proteins which have the same functions with TNFRSF25. You can find most of the proteins on our site.

Function Related Protein
tumor necrosis factor-activated receptor activityCD40;TNFRSFA;CD27;TNFRSF10A;TNFRSF11A;TNFRSF9A;TNFRSF11B;TNFRSF1A;TNFRSF8

TNFRSF25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF25 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF25.

Gene Family


Research Area

Related articles

Gorczynski, R; Chen, ZQ; et al. Long-Term Tolerance and Skin Allograft Survival in CD200(tg) Mice After Autologous Marrow Transplantation. TRANSPLANTATION 98:1271-1278(2014).
Xu, LX; Grimaldo, S; et al. Death receptor 3 mediates TNFSF15-and TNF alpha-induced endothelial cell apoptosis. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 55:109-118(2014).
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