|Official Full Name||tumor necrosis factor receptor superfamily, member 25|
|Background||The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]|
|Synonyms||TNFRSF25; tumor necrosis factor receptor superfamily, member 25; DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12; tumor necrosis factor receptor superfamily member 25; protein WSL-1; death receptor beta; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; lymphocyte-associated receptor of death; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein);|
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tnfrsf25 involved in several pathways and played different roles in them. We selected most pathways tnfrsf25 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||TNFRSF25; ACVR2AA; IFNA6; KITLGB; CCL13; PRP2; FLT1; CCL6; IFNA17; VEGFA|
tnfrsf25 has several biochemical functions, for example, receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf25 itself. We selected most functions tnfrsf25 had, and list some proteins which have the same functions with tnfrsf25. You can find most of the proteins on our site.
|receptor activity||IGF2R; SV2A; NRXN1; TNFRSF10A; BTLA; MED16; RTN4R; IL10RA; MED24; THBD|
|tumor necrosis factor-activated receptor activity||TNFRSF4; TNFRSF10C; TNFRSF14; TNFRSF1A; TNFRSFA; HDR; NRADD; CD40; TNFRSF18; TNFRSF10B|
tnfrsf25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf25 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf25.