TNFRSF10C
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Official Full Name
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -
Overview
Tumor necrosis factor receptor superfamily member 10C is a protein that in humans is encoded by the TNFRSF10C gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. -
Synonyms
TNFRSF10C;CD263;DCR1;DCR1-TNFR;LIT;TRAIL-R3;TRAILR3;TRID;tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Recombinant Proteins
- Human
- Rhesus macaque
- Human Cells
- HEK293
- Mammalian Cells
- E.coli
- Fc
- His
- Non
- GST
- Avi
Involved Pathway
TNFRSF10C involved in several pathways and played different roles in them. We selected most pathways TNFRSF10C participated on our site, such as Cytokine-cytokine receptor interaction,Apoptosis,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF10C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Influenza A | EIF2AK1,PIK3R2,MAPK1,NUP98,KPNA2,Fasl,PLG,HLA-DPB1,NFKBIB,IFNA16 |
| Apoptosis | IRAK4,DIABLO,IRAK2,PRKAR2AB,CASP6,CSF2RB,PLECA,DIABLOB,HDR,APAF1 |
| Measles | CD3E,IFNA10,IL4,EIF2AK3,IFNAR1,HSPA8,IL12A,BBC3,EIF2AK1,NFKB1 |
| Natural killer cell mediated cytotoxicity | IFNA6,BID,KLRK1,MICB,PLCG1,TNFRSF10D,PIK3CD,SAMD3,RAC1,IFNB1 |
| Cytokine-cytokine receptor interaction | IL21R.1,CCR6,IL18,GM1987,TNFRSF10A,GHRA,PRLRA,Pdgfa&Pdgfb,IL17RA,CCR1 |
Protein Function
TNFRSF10C has several biochemical functions, for example, TRAIL binding,transmembrane signaling receptor activity,tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF10C itself. We selected most functions TNFRSF10C had, and list some proteins which have the same functions with TNFRSF10C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | TLR6,TLR4,THBD,OR2A4,NRXN3,GPR124,DARC,SORL1,CD5,KLRB1 |
| TRAIL binding | TNFRSF10D,TNFRSF10B,Tnfrsf22,TNFRSF10A |
| tumor necrosis factor-activated receptor activity | NRADD,TNFRSF8,TNFRSF11A,RELT,Tnfrsf26,EDA2R,TNFRSF10B,TNFRSF4,NGFRB,TNFRSF9 |
Interacting Protein
TNFRSF10C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF10C here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF10C.
TNFSF10;SRPK2;SRPK1;APOA1;SLC25A6;LRSAM1;FAM101B;ZHX1
TNFRSF10C Related Signal Pathway
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References
- Li, ZB; Guo, XW; et al. Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients. BREAST CANCER RESEARCH AND TREATMENT 149:767-779(2015).
- Ratzinger, G; Mitteregger, S; et al. Association of TNFRSF10D DNA-Methylation with the Survival of Melanoma Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15:11984-11995(2014).
