| Official Full Name | tumor necrosis factor receptor superfamily, member 18 |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased;expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance;maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in;the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported. |
| Synonyms | TNFRSF18; tumor necrosis factor receptor superfamily, member 18; tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; AITR; Gitr |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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tnfrsf18 involved in several pathways and played different roles in them. We selected most pathways tnfrsf18 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with tnfrsf18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CSF2RB; TGFBR2; LIFR; LEPA; LTBR; CXCL5; IL10RB; CD27; GH1; CCR10 |
tnfrsf18 has several biochemical functions, for example, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by tnfrsf18 itself. We selected most functions tnfrsf18 had, and list some proteins which have the same functions with tnfrsf18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tumor necrosis factor-activated receptor activity | FAS; TNFRSF10C; HDR; TNFRSF1B; TNFRSF10B; TNFRSF21; TNFRSF4; TNFRSF10A; EDA2R; TNFRSF6B |
tnfrsf18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with tnfrsf18 here. Most of them are supplied by our site. Hope this information will be useful for your research of tnfrsf18.
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