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Tnfrsf18

  • Official Full Name

    tumor necrosis factor receptor superfamily, member 18

  • Overview

    This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased;expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance;maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in;the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported.
  • Synonyms

    TNFRSF18; tumor necrosis factor receptor superfamily, member 18; tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; AITR; Gitr;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus macaque
  • Rhesus monkey
  • Zebrafish
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human cells
  • Insect Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • Fc
  • His
  • mFc
  • 6×His
  • DYKDDDDK
  • Avi
  • Flag
  • GST
  • hFc
  • hIgG1
  • hIgG4
  • His (Fc)
  • His|GST
  • His|HIgG
  • human|IgG1|Fc
  • MlgG1 Fc
  • Mouse|IgG2a|Fc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF18-618H Active Recombinant Human TNFRSF18, Fc-tagged, Biotinylated Human Cell Fc
Human TNFRSF18-925H Active Recombinant Human TNFRSF18 E.coli N/A
Human TNFRSF18-051H Active Recombinant Human TNFRSF18 protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi Gln26-Glu161
Human TNFRSF18-4602H Active Recombinant Human TNFRSF18 protein, hFc-tagged Mammalian cell hFc 26-161aa
Human TNFRSF18-2090H Active Recombinant Human TNFRSF18 protein, His-tagged HEK293 His Met1-Glu161
Human TNFRSF18-1621H Recombinant Human TNFRSF18, Fc Chimera Mammalian cells Fc
Human TNFRSF18-39H Recombinant Human TNFRSF18 protein, hIgG-His-tagged Insect Cell His/HIgG
Human TNFRSF18-554H Recombinant Human TNFRSF18, Fc tagged Human Cell His/GST
Human TNFRSF18-370H Recombinant Human TNFRSF18 Protein, His-tagged Insect Cell His
Human TNFRSF18-2086H Recombinant Human TNFRSF18 protein, Fc-tagged HEK293 human/IgG1/Fc Gln26-Glu161
Human TNFRSF18-1143HCL Recombinant Human TNFRSF18 cell lysate Human Cell N/A
Human TNFRSF18-2091H Active Recombinant Human TNFRSF18 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln26-Glu161
Human TNFRSF18-619H Active Recombinant Human TNFRSF18 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Gln26-Glu161
Human TNFRSF18-1995H Recombinant Human TNFRSF18 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNFRSF18-330H Recombinant Human TNFRSF18 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc 136
Human TNFRSF18-2090HB Recombinant Human TNFRSF18 protein, His-tagged, Biotinylated HEK293 His
Human TNFRSF18-101HG Active GMP Recombinant Human TNFRSF18 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human GITR(NCBI Reference Sequence: NP_683700.1) was expressed with Fc tag at the C-terminal.
Human TNFRSF18-329H Recombinant Human TNFRSF18 protein, His-tagged HEK293 His 136
Human TNFRSF18-6214H Recombinant Human TNFRSF18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TNFRSF18-301498H Recombinant Human TNFRSF18 protein, GST-tagged E.coli GST Gln26-Pro130
Human TNFRSF18-1320HFL Recombinant Full Length Human TNFRSF18 Protein, C-Flag-tagged Mammalian cells Flag
Human TNFRSF18-151H Recombinant Human TNFRSF18 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human TNFRSF18-554HAF488 Recombinant Human TNFRSF18 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 377
Human TNFRSF18-554HAF555 Recombinant Human TNFRSF18 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 377
Human TNFRSF18-1479H Active Recombinant Human TNFRSF18 protein, Fc-tagged HEK293 Fc Gln26-Glu161
Human TNFRSF18-661H Recombinant Human TNFRSF18 Protein HEK293 241
Human TNFRSF18-1478H Active Recombinant Human TNFRSF18 protein, mFc-tagged HEK293 mFc Gln26-Glu161
Human TNFRSF18-154H Recombinant Human TNFRSF18 Protein, C-His-tagged E.coli C-His
Human TNFRSF18-6662H Recombinant Human TNFRSF18 Protein (26-161), His tagged E.coli His 26-161
Human TNFRSF18-5242H Recombinant Human TNFRSF18 Protein (Met1-Glu161), C-His tagged Mammalian cells C-His Met1-Glu161
Human TNFRSF18-554HAF647 Recombinant Human TNFRSF18 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 377
Human TNFRSF18-148H-B Recombinant Human TNFRSF18 Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF18-6663H Recombinant Human TNFRSF18 Protein (Gln26-Gln161), C-Fc tagged Mammalian cells C-Fc Gln26-Gln161
Human TNFRSF18-0682H Recombinant Human TNFRSF18 Protein (Gln26-Glu161), N-His tagged E.coli N-His Gln26-Glu161
Human TNFRSF18-554HF Recombinant Human TNFRSF18 Protein, Fc-tagged, FITC conjugated HEK293 Fc 377
Human TNFRSF18-601H Recombinant Human TNFRSF18 Protein (Gln26-Pro162), C-mFc and 6×His-tagged HEK293 C-mFc and 6×His Gln26-Pro162
Human TNFRSF18-2769H Recombinant Human TNFRSF18 Protein, His-tagged E.coli N-His Leu39-Val152
Human TNFRSF18-148H Recombinant Human TNFRSF18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNFRSF18-17159M Recombinant Mouse TNFRSF18 Protein Mammalian Cell His
Mouse Tnfrsf18-15M Recombinant Mouse Tnfrsf18 protein, His-tagged HEK293 His 132
Mouse Tnfrsf18-2087M Recombinant Mouse Tnfrsf18, Fc Chimera HEK293 Fc
Mouse Tnfrsf18-5751M Recombinant Mouse Tnfrsf18 Protein (Ser22-His153), C-Fc-His tagged Mammalian cells C-Fc-His Ser22-His153
Mouse Tnfrsf18-6547M Recombinant Mouse Tnfrsf18 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Tnfrsf18-2770M Recombinant Mouse Tnfrsf18 Protein, His-tagged E.coli N-His Gln20-His153
Mouse TNFRSF18-331M Recombinant Mouse TNFRSF18 protein, Fc-tagged HEK293 human/IgG1/Fc 132
Mouse TNFRSF18-9477M-B Recombinant Mouse TNFRSF18 Protein Pre-coupled Magnetic Beads HEK293
Mouse TNFRSF18-894M Recombinant Mouse TNFRSF18 Protein (Met1-His153), MlgG1 Fc-tagged HEK293 MlgG1 Fc Met1-His153
Mouse TNFRSF18-662M Recombinant Mouse TNFRSF18 Protein HEK293 250
Mouse TNFRSF18-9477M Recombinant Mouse TNFRSF18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse TNFRSF18-663M Recombinant Mouse TNFRSF18 Protein, Fc-tagged HEK293 Fc 250
Rat Tnfrsf18-8735R Recombinant Rat Tnfrsf18 protein, Fc-tagged HEK293 human/IgG1/Fc Gln20-Lys121
Rat TNFRSF18-1245RCL Recombinant Rat TNFRSF18 cell lysate Human Cell N/A
Rat TNFRSF18-1481R Recombinant Rat TNFRSF18 protein, Fc-tagged HEK293 Fc Gln20-Lys121
Rat TNFRSF18-665R Recombinant Rat TNFRSF18 Protein, Fc-tagged HEK293 Fc 121
Rat Tnfrsf18-8735RAF555 Recombinant Rat Tnfrsf18 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Gln20-Lys121
Rat TNFRSF18-664R Recombinant Rat TNFRSF18 Protein HEK293 121
Rat Tnfrsf18-8735RAF647 Recombinant Rat Tnfrsf18 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Gln20-Lys121
Rat Tnfrsf18-8735RF Recombinant Rat Tnfrsf18 Protein, hFc-tagged, FITC conjugated HEK293 hFc Gln20-Lys121
Rat Tnfrsf18-8735RAF488 Recombinant Rat Tnfrsf18 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Gln20-Lys121
Rat TNFRSF18-332R Recombinant Rat TNFRSF18 protein, His-tagged HEK293 His 102
Rhesus monkey TNFRSF18-1785R Recombinant Rhesus Monkey TNFRSF18 Protein HEK293 N/A
Rhesus monkey TNFRSF18-1786R Recombinant Rhesus Monkey TNFRSF18 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TNFRSF18-1787R Recombinant Rhesus Monkey TNFRSF18 Protein, hIgG4-tagged HEK293 hIgG4
Canine TNFRSF18-2511C Recombinant Canine TNFRSF18 protein, His-tagged HEK293 His Gly23-Pro154
Cynomolgus TNFRSF18-1019C Recombinant Cynomolgus TNFRSF18 Protein (Met1-Glu155), His-tagged HEK293 His Met1-Glu155
Cynomolgus Monkey Tnfrsf18-01C Recombinant cynomolgus TNFRSF18 protein, His-tagged HEK293 His
Mus musculus (Mouse) RFL2236MF Recombinant Full Length Mouse Tumor Necrosis Factor Receptor Superfamily Member 18(Tnfrsf18) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-228)
Rhesus macaque TNFRSF18-29R Recombinant Rhesus macaque TNFRSF18 protein, Fc-tagged HEK293 human/IgG1/Fc 136
Rhesus macaque Tnfrsf18-666R Recombinant Rhesus macaque Tnfrsf18 Protein, Fc-tagged HEK293 Fc 234
Rhesus macaque TNFRSF18-1480R Recombinant Rhesus macaque TNFRSF18 protein, Fc-tagged HEK293 Fc Gln26-Glu161
Zebrafish TNFRSF18-6312Z Recombinant Zebrafish TNFRSF18 Mammalian Cell His
Chicken TNFRSF18-2565C Recombinant Chicken TNFRSF18 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Tnfrsf18 Related Signal Pathway

Tnfrsf18 involved in several pathways and played different roles in them. We selected most pathways Tnfrsf18 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFRSF10A;IL12RB1;CXCR4A;IFNPHI1;CCR3;TNFRSF12A;TNFRSF14;KITLGB;CCL28

Tnfrsf18 has several biochemical functions, for example, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf18 itself. We selected most functions Tnfrsf18 had, and list some proteins which have the same functions with Tnfrsf18. You can find most of the proteins on our site.

Function Related Protein
tumor necrosis factor-activated receptor activityTNFRSF8;TNFRSF25;TNFRSF10C;Tnfrsf26;LTBR;TNFRSFA;TNFRSF10D;NRADD;TNFRSF4

Tnfrsf18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf18 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf18.

MYC

  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are some current clinical trials involving TNFRSF18-targeted therapies in cancer treatment? 12/20/2022

Clinical trials are investigating TNFRSF18 agonists, such as monoclonal antibodies, in combination with other cancer treatments in various cancer types.

Are there any approved TNFRSF18-targeted therapies for cancer treatment? 06/29/2019

As of my knowledge cutoff date in January 2022, there were no approved TNFRSF18-targeted therapies for cancer. However, this may have changed since then.

Are there potential side effects associated with TNFRSF18-targeted therapies? 12/30/2018

Side effects may include immune-related adverse events, similar to those seen with other immunotherapies, and can range from mild to severe.

How can TNFRSF18-targeted therapies potentially improve cancer outcomes? 05/05/2018

TNFRSF18-targeted therapies may enhance the body's immune response against cancer cells, leading to better tumor control and improved patient outcomes.

Can TNFRSF18-targeted therapies be used in combination with other immunotherapies? 05/20/2016

Yes, combination therapies involving TNFRSF18 agonists and other immunotherapies are under investigation to improve treatment efficacy.

Customer Reviews (3)

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Reviews
12/20/2021

    This flexibility enables researchers like myself to tailor TNFRSF18 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.

    03/05/2020

      Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.

      10/01/2017

        The TNFRSF18 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

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