"FGF8" Related Products

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Recombinant Human FGF8

Cat.No.: FGF8-28885TH
Product Overview: Recombinant full length Human FGF8. Predicted Mol Wt 22.5 kDa.
Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
Molecular Weight: 22.500kDa
Source: E. coli
Biological activity: ED50 range = 10-50 ng/mL, determined by the dose dependent proliferation of mouse BALB/3T3 cells.
Form: Lyophilised:Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely.
Purity: >95% by SDS-PAGE
Storage: Please see Notes section
Sequences of amino acids: MQVTVQSSPN FTQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF EFLNYPPFTR SLRGSQRTWA PEPR
Sequence Similarities: Belongs to the heparin-binding growth factors family.
Gene Name: FGF8 fibroblast growth factor 8 (androgen-induced) [ Homo sapiens ]
Official Symbol: FGF8
Synonyms: FGF8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8; AIGF;
Gene ID: 2253
mRNA Refseq: NM_001206389
Protein Refseq: NP_001193318
MIM: 600483
Uniprot ID: P55075
Chromosome Location: 10q25-q26
Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem;
Function: growth factor activity; growth factor activity; protein tyrosine kinase activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding;

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