FGF13
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Official Full Name
fibroblast growth factor 13
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Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5 end results in several transcript variants encoding different isoforms with different N-termini. -
Synonyms
FGF13; fibroblast growth factor 13; FGF2; FHF2; fibroblast growth factor homologous factor 2; FGF 13; FGF 2; FGF-13; FGF13_HUMAN; FHF 2; FHF-2; OTTHUMP00000024143; OTTHUMP00000024144;
- Involved Pathway
- Protein Function
- Interacting Protein
- FGF13 Related Articles
- FGF13 Related Research Area
- FGF13 Related Signal Pathway
FGF13 involved in several pathways and played different roles in them. We selected most pathways FGF13 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MEF2CA;FGF19;FGF20B;FASLG;JUND;FGF8A;EGFRA;SRFA;ARR3A |
| Ras signaling pathway | RGL2;FLT4;PLA2G2D;AKT1;PTPN11;MAPK8;FGF22;PLA2G4D;SOS1 |
| Rap signaling pathway | ACTG1;AKT2;NGF;FLT4;MRAS;SKAP1;FGF13;NRAS;INS |
| PIK-Akt signaling pathway | ANGPT1;SOS1;GNG8;F2R;PGF;RPS6;OSMR;PPP2R5B;RBL2 |
| Regulation of actin cytoskeleton | FGF20B;MYL10;FGF5;RASSF7;ITGAV;CDC42L;ACTN4;EZRB;SOS1 |
| Pathways in cancer | TCF7;PGF;FOXO1;FIGF;AKT1;Shh;GNA11;ITGA2B;PAX8 |
| Melanoma | FGF20;PIK3R1;TRP53;AKT1;MAP2K1;IGF1;PTEN;NRAS;PDGFC |
FGF13 has several biochemical functions, for example, beta-tubulin binding, growth factor activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF13 itself. We selected most functions FGF13 had, and list some proteins which have the same functions with FGF13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-tubulin binding | ARL8B;TBCD;RANBP10;ADNP;PROL1;SNCA;SERPINB1A;SPAST;SIRT2 |
| growth factor activity | MACC1;FGF21;FGF13;AGT;Pdgfa&Pdgfb;BMP7A;FGF1;VEGFA;BMP8A |
| ion channel binding | FKBP1A;SRI;KCNB1;KCNQ3;ACTN4;YWHAH;AKAP6;KCNE2;FGF13 |
| microtubule binding | NUMA1;KCNH2A;FGF13;MTAP1A;TRPV4;CETN2;DPYSL5;SKA1;DYNC1I1 |
| protein binding | RAB1B;USP49;DAAM1;SNRPD3;CALM2;MAP3K8;CD86;TELO2;H2-AA |
| protein kinase activator activity | MT3;PIK3CA;STRADA;GPRC5B;FGF13;AGAP2;MAPK8IP2;DBF4B;NKX3-1 |
| sodium channel regulator activity | GPLD1;SCLT1;SGK2A;FXYD5;SCN3B;PKP2;YWHAH;FXYD3;AGT |
FGF13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF13 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF13.
PRNP; CLEC3B; MAPK8IP2
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