FGF4
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Official Full Name
fibroblast growth factor 4
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Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. -
Synonyms
FGF4; fibroblast growth factor 4; heparin secretory transforming protein 1 , HSTF1; HBGF 4; HST; HST 1; human stomach cancer; transforming factor from FGF related oncogene; K FGF; kaposi sarcoma oncogene; KFGF; transforming protein KS3; FGF-4; HSTF-1; onc;
- Involved Pathway
- Protein Function
- Interacting Protein
- FGF4 Related Articles
- FGF4 Related Research Area
- FGF4 Related Signal Pathway
FGF4 involved in several pathways and played different roles in them. We selected most pathways FGF4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK8A;FLNC;CACNA1SB;TGFBR2;PAK1;GNA12A;GADD45B;ACVR1C;MAPT |
| Ras signaling pathway | ELK1;HTR7;PLA2G2A;PLA2G12B;RGL2;GNG2;KITLG;PLA2G2D;GNGT2 |
| Rap signaling pathway | P2RY1;IGF1;SRC;VEGFB;RAPGEF5;PDGFD;INS2;PIK3CA;FARP2 |
| PIK-Akt signaling pathway | IFNA2;BCL2;HSP90AA1;IFNA4;FGF14;OSM;IL2RG;TNR;GNB2 |
| Regulation of actin cytoskeleton | PDGFB;FGF7;ACTN1;VCL;PAK3;PIP5K2;APC2;SCIN;ABI2A |
| Pathways in cancer | RXRG;FGF21;CCND1;GNA11;BCL2L1;RARB;EPAS1;LAMC2;NFKBIA |
| Melanoma | BAD;PIK3R5;FGF22;Pdgfa&Pdgfb;PTEN;IGF1;HRAS;FGF3;MAPK1 |
FGF4 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF4 itself. We selected most functions FGF4 had, and list some proteins which have the same functions with FGF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor receptor binding | FGF18B;FRS3;FGF21;FGF6;FGF18A;FGF2;FGF8A;FRS2;FGF20B |
| growth factor activity | KITLG;CSPG5;FGF13;BMP3;BMP7A;NRG1;TIMP1;GDF1;IGF2A |
| heparin binding | PTPRF;WISP2;SLIT1B;Epy;APLP2;APOA5;FGF9;BMP7;LTF |
FGF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF4.
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