FGF4 involved in several pathways and played different roles in them. We selected most pathways FGF4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
NRAS; NTF4; FGFR3; RAF1B; RAP1A; MRAS; ARR3B; CACNG6A; MKNK1; MAPK8 |
| Ras signaling pathway |
KLK1B4; Kitl; FOXO4; FGFR3; RASAL2; RELA; RASSF1; KSR2; PTPN11; PIK3CB |
| Rap signaling pathway |
FGF22; PIK3R5; KIT; RAP1A; LPAR2; PIK3CB; FGF8; PDGFRB; PLCG1; INS1 |
| PIK-Akt signaling pathway |
COL24A1; EIF4E2; BRCA1; FGF10; LAMC1; CREB3L1; PTEN; SOS1; IFNA12; SPP1 |
| Regulation of actin cytoskeleton |
MOS; MYLK; MAP2K2; FGF2; MAPK6; PIP4K2C; INS2; TMSB; ITGA8; ITGB5 |
| Pathways in cancer |
TCF7; FZD6; GNG12; FGF7; TCEB1; EGLN2; HHIP; LEF1; PTGER4; ARNT2 |
| Melanoma |
FGF12; TP53; FGF6; RB1; FGF5; PTEN; FGF1; Pdgfa&Pdgfb; PIK3R3; FGF8 |
FGF4 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF4 itself. We selected most functions FGF4 had, and list some proteins which have the same functions with FGF4. You can find most of the proteins on our site.
| Function |
Related Protein |
| fibroblast growth factor receptor binding |
FGF10; KLB; FGF8A; FGF10A; FGF6; FGF3; FGF6B; FGF2; FGF22; FRS3 |
| growth factor activity |
FGF9; RABEP1; MIA1; GDF2; MIA; FGF11; LEFTY2; EGF; CD320; THBS4 |
| heparin binding |
VTN; PRELP; SMOC2; SELL; MDK; ABP1; APPA; CCL15; KAL1; SLIT1B |
FGF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF4.
Joo, JY; Choi, HW; et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions (vol 4, pg 7477, 2014). SCIENTIFIC REPORTS 5:-(2015).
Shams, S; Mohsin, S; et al. Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice. Stem Cells International :-(2015).
