fgf4

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fgf4

Official Full Name fibroblast growth factor 4
Background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
Synonyms FGF4; fibroblast growth factor 4; heparin secretory transforming protein 1 , HSTF1; HBGF 4; HST; HST 1; human stomach cancer; transforming factor from FGF related oncogene; K FGF; kaposi sarcoma oncogene; KFGF; transforming protein KS3; FGF-4; HSTF-1; onc
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGF4-023E Recombinant Human FGF4 (54 - 206aa) E.coli N/A
    Human FGF4-167H Recombinant Human FGF4 protein E.coli N/A
    Human FGF4-28882TH Recombinant Human FGF4 E.coli N/A
    Human FGF4-4113H Recombinant Human FGF4 Protein E.coli N/A
    Human FGF4-681H Recombinant Human Fibroblast Growth Factor 4 HEK293 N/A
    Mouse Fgf4-521M Recombinant Mouse Fibroblast Growth Factor 4 E.coli N/A
    Mouse FGF4-5853M Recombinant Mouse FGF4 Protein Mammalian Cell His
    Mouse Fgf4-635M Recombinant Mouse Fgf4 E.coli N/A
    Chicken FGF4-3190C Recombinant Chicken FGF4 Mammalian Cell His
    Zebrafish FGF4-9173Z Recombinant Zebrafish FGF4 Mammalian Cell His
    Cattle FGF4-643C Recombinant Cattle FGF4 protein, His & GST-tagged E.coli His/GST

    fgf4 involved in several pathways and played different roles in them. We selected most pathways fgf4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with fgf4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FLNA; MAPK14B; RRAS; MAP3K4; CACNA1DA; RAC1; MEF2CB; CACNA1SB; ARRB2B; PDGFRB
    Ras signaling pathway MAPK8; KLK1B4; FGF1; FGF4; PLA2G12A; LAT; PLA2G2D; HTR7; FLT1; FLT4
    Rap signaling pathway GNAI2; ITGB2L; RAC3; RAP1A; LCP2; PIK3R1; Fgf15; IGF1R; HRAS; SRC
    PIK-Akt signaling pathway TLR2; FGF20; F2R; Kitl; LAMC1; G6PC3; IFNA13; TCL1A; TP53; DDIT4
    Regulation of actin cytoskeleton FGF22; PAK6; ACTN3; VAV1; ITGA2; ITGA3B; PAK2; ITGAL; ARPC5LA; FGF18A
    Pathways in cancer GNG13; TRAF3; Ar; FZD10; RUNX1; Casp3; GNB3; FH; EGLN1; PLCG2
    Melanoma IGF1R; BRAF; FGF12; TP53; FGF9; RAF1; PDGFD; PDGFB; PDGFRB; NRAS

    fgf4 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by fgf4 itself. We selected most functions fgf4 had, and list some proteins which have the same functions with fgf4. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor receptor binding FGF18B; FGF22; FGF20A; FGF8A; FGF10B; FGF10; FGF20B; KLB; FGF5; FGF9
    growth factor activity CSPG5; BMP3; GDF3; GMFB; NDR1; ANGPTL3; IL9; CDNF; BMP15; VEGFA
    heparin binding SELL; TENM1; CCL7; SLIT1B; FN1; ADAMTS3; PLA2G2D; FGFR1; LPL; APOE

    fgf4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fgf4 here. Most of them are supplied by our site. Hope this information will be useful for your research of fgf4.

    Joo, JY; Choi, HW; et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions (vol 4, pg 7477, 2014). SCIENTIFIC REPORTS 5:-(2015).
    Shams, S; Mohsin, S; et al. Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice. Stem Cells International :-(2015).

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