• Official Full Name

    fibroblast growth factor 4

  • Background

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
  • Synonyms

    FGF4; fibroblast growth factor 4; heparin secretory transforming protein 1 , HSTF1; HBGF 4; HST; HST 1; human stomach cancer; transforming factor from FGF related oncogene; K FGF; kaposi sarcoma oncogene; KFGF; transforming protein KS3; FGF-4; HSTF-1; onc;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • CHO-K1
    • E. coli
    • E.coli
    • HEK293
    • Human cells
    • Mammalian Cell
    • Tag :
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|GST
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cattle FGF4-643C Recombinant Cattle FGF4 protein, His & GST-tagged E.coli His/GST
    Chicken FGF4-3190C Recombinant Chicken FGF4 Mammalian Cell His
    Human FGF4-039H Recombinant Human FGF4(Ser71­-Leu206) Protein, None-tagged E.coli N/A
    Human FGF4-023E Active Recombinant Human FGF4 (54 - 206aa) E.coli N/A
    Human FGF4-4113H Recombinant Human FGF4 Protein E.coli N/A
    Human FGF4-167H Recombinant Human FGF4 protein E.coli N/A
    Human FGF4-1495H Recombinant Human FGF4 Protein, His-tagged E.coli N-His
    Human FGF4-038H Recombinant Human FGF4 Protein E. coli
    Human FGF4-14H Recombinant Human FGF4 Protein E.coli
    Human FGF4-86H Recombinant Active Human FGF4 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human FGF4-01HG Active GMP Recombinant Human FGF4 Protein CHO-K1
    Human FGF4-87H Recombinant Human FGF4 Protein E.coli
    Human FGF4-09H Recombinant Human FGF4 Protein, Animal Free Human cells
    Human FGF4-413F Recombinant Human FGF4 Protein (177 aa) E.coli
    Human FGF4-28882TH Recombinant Human FGF4 E.coli N/A
    Human FGF4-681H Recombinant Human Fibroblast Growth Factor 4 HEK293 N/A
    Mouse FGF4-3235M-B Recombinant Mouse FGF4 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Fgf4-521M Active Recombinant Mouse Fibroblast Growth Factor 4 E.coli N/A
    Mouse Fgf4-1496M Recombinant Mouse Fgf4 Protein, His-tagged E.coli N-His
    Mouse FGF4-3235M Recombinant Mouse FGF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse FGF4-5853M Recombinant Mouse FGF4 Protein Mammalian Cell His
    Mouse Fgf4-520M Recombinant Mouse Fgf4(Ser67­-Leu202) Protein, None-tagged E.coli N/A
    Zebrafish FGF4-9173Z Recombinant Zebrafish FGF4 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • FGF4 Related Articles
    • FGF4 Related Research Area
    • FGF4 Related Signal Pathway

    FGF4 involved in several pathways and played different roles in them. We selected most pathways FGF4 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathwayELK1;HTR7;PLA2G2A;PLA2G12B;RGL2;GNG2;KITLG;PLA2G2D;GNGT2
    Rap signaling pathwayP2RY1;IGF1;SRC;VEGFB;RAPGEF5;PDGFD;INS2;PIK3CA;FARP2
    PIK-Akt signaling pathwayIFNA2;BCL2;HSP90AA1;IFNA4;FGF14;OSM;IL2RG;TNR;GNB2
    Regulation of actin cytoskeletonPDGFB;FGF7;ACTN1;VCL;PAK3;PIP5K2;APC2;SCIN;ABI2A
    Pathways in cancerRXRG;FGF21;CCND1;GNA11;BCL2L1;RARB;EPAS1;LAMC2;NFKBIA

    FGF4 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF4 itself. We selected most functions FGF4 had, and list some proteins which have the same functions with FGF4. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor receptor bindingFGF18B;FRS3;FGF21;FGF6;FGF18A;FGF2;FGF8A;FRS2;FGF20B
    growth factor activityKITLG;CSPG5;FGF13;BMP3;BMP7A;NRG1;TIMP1;GDF1;IGF2A
    heparin bindingPTPRF;WISP2;SLIT1B;Epy;APLP2;APOA5;FGF9;BMP7;LTF

    FGF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF4.

    Joo, JY; Choi, HW; et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions (vol 4, pg 7477, 2014). SCIENTIFIC REPORTS 5:-(2015).
    Shams, S; Mohsin, S; et al. Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice. Stem Cells International :-(2015).
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