FGF4

  • Official Full Name

    fibroblast growth factor 4

  • Overview

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

  • Synonyms

    FGF4;fibroblast growth factor 4;heparin secretory transforming protein 1 , HSTF1;HBGF 4;HST;HST 1;human stomach cancer;transforming factor from FGF related oncogene;K FGF;kaposi sarcoma oncogene;KFGF;transforming protein KS3;FGF-4;HSTF-1;onc

Recombinant Proteins

  • Human
  • Mouse
  • Chicken
  • Cattle
  • Zebrafish
  • E.coli
  • CHO
  • Mammalian Cells
  • HEK293
  • Human Cells
  • Non
  • His
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
FGF4-520H Active Recombinant Human FGF4 Protein E.coli Human
FGF4-023E Active Recombinant Human FGF4 (54 - 206aa) E.coli Human Non
Fgf4-521M Active Recombinant Mouse Fibroblast Growth Factor 4 E.coli Mouse Non 30-202 a.a.
FGF4-01HG Active GMP Recombinant Human FGF4 Protein CHO Human
FGF4-167H Recombinant Human FGF4 protein E.coli Human Non 182
FGF4-28882TH Recombinant Human FGF4 E.coli Human Non
FGF4-3190C Recombinant Chicken FGF4 Mammalian Cells Chicken His
FGF4-5853M Recombinant Mouse FGF4 Protein Mammalian Cells Mouse His
FGF4-643C Recombinant Cattle FGF4 protein, His & GST-tagged E.coli Cattle GST&His Ser71~Leu206
FGF4-681H Recombinant Human Fibroblast Growth Factor 4 HEK293 Human Non
FGF4-9173Z Recombinant Zebrafish FGF4 Mammalian Cells Zebrafish His
FGF4-038H Active Recombinant Human FGF4 Protein E.coli Human 54-206 a.a.
FGF4-039H Recombinant Human FGF4(Ser71­-Leu206) Protein, None-tagged E.coli Human Non
FGF4-09H Active Recombinant Human FGF4 Protein, Animal Free Human Cells Human
FGF4-1495H Recombinant Human FGF4 Protein, His-tagged E.coli Human His Ala31-Leu206
Fgf4-1496M Recombinant Mouse Fgf4 Protein, His-tagged E.coli Mouse His Ala30-Leu202
FGF4-14H Recombinant Human FGF4 Protein E.coli Human
FGF4-263H Recombinant Human fibroblast growth factor 4 Protein, His tagged E.coli Human His 54-206aa
FGF4-3235M Recombinant Mouse FGF4 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
FGF4-3235M-B Recombinant Mouse FGF4 Protein Pre-coupled Magnetic Beads HEK293 Mouse
FGF4-4113H Active Recombinant Human FGF4 Protein E.coli Human Non
FGF4-413F Active Recombinant Human FGF4 Protein (177 aa) E.coli Human 177
Fgf4-520M Recombinant Mouse Fgf4(Ser67­-Leu202) Protein, None-tagged E.coli Mouse Non
FGF4-86H Recombinant Active Human FGF4 Protein, His-tagged(C-ter) E.coli Human His
FGF4-87H Active Recombinant Human FGF4 Protein E.coli Human
FGF4-96H Active Recombinant Human FGF4 Protein (Gly25-Leu206), C-His tagged, Animal-free, Carrier-free E.coli Human His Gly25-Leu206

    Involved Pathway

    FGF4 involved in several pathways and played different roles in them. We selected most pathways FGF4 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway CALML3,ITGAL,F2RL3,KIT,INSR,PDGFB,GNAO1,FGFR4,Kitl,PRKD2
    PIK-Akt signaling pathway IL4R,EIF4E1B,RXRA,IFNAR2,HSP90AB1,MCL1,GHR,PDGFRB,GYS2,NGF
    Ras signaling pathway GNG10,KSR1,ZAP70,RALGDS,PRKCB,MAPK9,ANGPT4,RHOA,CALM1,PRKACB
    MAPK signaling pathway ARRB2,RAP1AB,NTF4,CACNA1G,PRKCA,RPS6KA6,RAC3A,MAPKAPK5,FASLG,TRP53
    Regulation of Actin Cytoskeleton HRAS,RDX,ITGB1,Fgf15,GNG12,RRAS2,PIKFYVE,RASSF7,ARHGEF7B,PTK2
    Melanoma TRP53,PIK3R5,IGF1R,FGF18,PDGFRB,FGFR1,FGF9,KRAS,MITF,RB1
    Pathways in cancer AGTR1B,PRKACA,NTRK1,IGF1,STAT1,FGF17,MAPK1,TRAF1,WNT10B,ERBB2

    Protein Function

    FGF4 has several biochemical functions, for example, fibroblast growth factor receptor binding,growth factor activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF4 itself. We selected most functions FGF4 had, and list some proteins which have the same functions with FGF4. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor receptor binding FGF3,FRS3,FGF2,FGF22,FGF8A,FGF6B,FGF18A,FGF9,FGF16,FGF8
    heparin binding COL25A1,ADAMTS1,FGF12,FGF1A,SLIT1B,VEGFA,VEGFAA,WISP1A,PDCD5,RPL22
    growth factor activity IL6,BMP1,GDF3,KLK1B4,TYMP,MSTN,GMFB,MDKA,VEGFA,TGFB1A

    Interacting Protein

    FGF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF4.

    FGF4 Related Signal Pathway

    Resources

    Gene Families

    Growth Factors

    Research Area

    FGF Family
    Embryonic and Induced Pluripotent Stem Cell Markers
    Trophoblast Stem Cell Markers
    FGF Ligands
    Oncoprotein-Growth Factors

    References

    • Joo, JY; Choi, HW; et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions (vol 4, pg 7477, 2014). SCIENTIFIC REPORTS 5:-(2015).
    • Shams, S; Mohsin, S; et al. Mesenchymal Stem Cells Pretreated with HGF and FGF4 Can Reduce Liver Fibrosis in Mice. Stem Cells International :-(2015).

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