FGF23
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Official Full Name
fibroblast growth factor 23
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Background
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013] -
Synonyms
FGF23; fibroblast growth factor 23; ADHR; FGFN; HYPF; HPDR2; PHPTC; phosphatonin; tumor-derived hypophosphatemia inducing factor;
- FGF23 Related Articles
- FGF23 Related Research Area
- FGF23 Related Signal Pathway
Lindberg, I; Pang, HW; et al. FGF23 is Endogenously Phosphorylated in Bone Cells. JOURNAL OF BONE AND MINERAL RESEARCH 30:431-436(2015).
Moe, SM; Chen, NX; et al. Anti-Sclerostin Antibody Treatment in a Rat Model of Progressive Renal Osteodystrophy. JOURNAL OF BONE AND MINERAL RESEARCH 30:539-549(2015).
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