FGF5 involved in several pathways and played different roles in them. We selected most pathways FGF5 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
MAPK14A; MAP3K14; RAP1AB; MAP3K5; GNG12; CACNA1DA; BDNF; TGFB1A; HRAS; MAPK11 |
| Ras signaling pathway |
GNG2; KITLG; PDGFC; PLA2G10; RAF1; GNB4; KSR1; RASGRF2; FGF14; IGF1R |
| Rap signaling pathway |
RRAS; MAGI1; PDGFC; SIPA1L1; PIK3CG; PLCB3; GNAI3; INS2; GNAS; RASGRP3 |
| PIK-Akt signaling pathway |
IBSP; LPAR6; AKT2; GNG7; FGFR2; PPP2R2D; FGF11; ITGB5; TNC; HRAS |
| Regulation of actin cytoskeleton |
RHOAA; ABI2A; ARPC5LA; FGF8; INS1; RAC3; ARHGEF1; FGFR1; FGF1A; ITGB4 |
| Pathways in cancer |
WNT8B; FZD3; BIRC5; GNB3; AXIN1; ABL1; FGF16; RALB; FAS; MSH6 |
| Melanoma |
PTEN; CDH1; RAF1; FGF20; TP53; AKT2; FGF14; FGF19; PIK3R2; HRAS |
FGF5 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF5 itself. We selected most functions FGF5 had, and list some proteins which have the same functions with FGF5. You can find most of the proteins on our site.
| Function |
Related Protein |
| fibroblast growth factor receptor binding |
FRS3; FGF8A; FGF3; FGF10; FGF18B; FGF20; FGF2; FGF4; FGF5; FGF20A |
| growth factor activity |
GDNFA; FBRS; NDP; BMP15; TIMP1; PDGFD; BMP7A; CXCL1; FGF6B; BMP2B |
FGF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF5.
EGF; FGFR2; FGFR4; MAPK1
Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).
Hirano, K; Van Kuppevelt, TH; et al. The transition of mouse pluripotent stem cells from the naive to the primed state requires Fas signaling through 3-O sulfated heparan sulfate structures recognized by the HS4C3 antibody. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430:1175-1181(2013).
