fgf5

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fgf5

Official Full Name fibroblast growth factor 5
Background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms FGF5; fibroblast growth factor 5; heparin-binding growth factor 5; HBGF-5; Smag-82
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGF5-172H Recombinant Human Fibroblast Growth Factor 5 E.coli N/A
    Human FGF5-28880TH Recombinant Human FGF5 E.coli N/A
    Human FGF5-4114H Recombinant Human FGF5 Protein, GST-tagged Wheat Germ GST
    Human FGF5-501H Recombinant Human FGF5 Protein, His/GST-tagged E.coli His/GST
    Human FGF5-6238HCL Recombinant Human FGF5 293 Cell Lysate HEK293 N/A
    Human FGF5-6239HCL Recombinant Human FGF5 293 Cell Lysate HEK293 N/A
    Mouse FGF5-5854M Recombinant Mouse FGF5 Protein Mammalian Cell His
    Rat FGF5-2334R Recombinant Rat FGF5 Protein Mammalian Cell His
    Zebrafish FGF5-1951Z Recombinant Zebrafish FGF5 Mammalian Cell His

    fgf5 involved in several pathways and played different roles in them. We selected most pathways fgf5 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with fgf5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF6A; CACNA2D3; FGF6B; FGF20; PRKACBA; PAK1; FLNC; MAP2K5; HSPA6; NLK1
    Ras signaling pathway HRAS; PDGFRA; CDC42; GNG8; GAB2; REL; RASAL2; RAC2; PLCG1; MAP2K2
    Rap signaling pathway NRAS; GRIN1; GNAI3; FGF9; BCAR1; PIK3R2; ARAP3; MAPK12; MAPK11; PARD6B
    PIK-Akt signaling pathway FGF20; PTK2; RPS6KB1; COL4A1; LAMC1; MLST8; OSM; NFKB1; FGF1; PTEN
    Regulation of actin cytoskeleton PPP1CBL; FGF13B; ITGB5; FGF7; FN1A; FGF17; ITGAV; KRAS; BCAR1; ROCK2B
    Pathways in cancer CASP8; FZD6; FGF22; WNT8B; HSP90AB1; PAX8; FGF11; FGF2; PIK3CD; TRAF3
    Melanoma FGF12; MAPK1; IGF1; FGF8; FGF19; PIK3R3; Pdgfa&Pdgfb; MAP2K1; BRAF; RAF1

    fgf5 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by fgf5 itself. We selected most functions fgf5 had, and list some proteins which have the same functions with fgf5. You can find most of the proteins on our site.

    Function Related Protein
    fibroblast growth factor receptor binding FGF2; FGF8; FGF10B; FGF22; FGF21; Fgf15; FGF3; FGF20A; FGF6A; FRS2
    growth factor activity F2; FGF18; CSF2; PRL2C2; NGF; MDKB; FGF14; BMP7; FGF6B; VEGFC

    fgf5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fgf5 here. Most of them are supplied by our site. Hope this information will be useful for your research of fgf5.

    EGF; FGFR2; FGFR4; MAPK1

    Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).
    Hirano, K; Van Kuppevelt, TH; et al. The transition of mouse pluripotent stem cells from the naive to the primed state requires Fas signaling through 3-O sulfated heparan sulfate structures recognized by the HS4C3 antibody. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 430:1175-1181(2013).

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