FGF5
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Official Full Name
fibroblast growth factor 5
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Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
FGF5; fibroblast growth factor 5; heparin-binding growth factor 5; HBGF-5; Smag-82;
- Involved Pathway
- Protein Function
- Interacting Protein
- FGF5 Related Articles
- FGF5 Related Research Area
- FGF5 Related Signal Pathway
FGF5 involved in several pathways and played different roles in them. We selected most pathways FGF5 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK7;TGFBR1B;FGF2;MAP4K4;BDNF;MAPK13;MEF2CB;GNA12A;MKNK2A |
| Ras signaling pathway | FGF11;KSR1;KITLG;GNGT2;MAP2K2;VEGFC;PLCE1;SOS1;MAPK1 |
| Rap signaling pathway | FGF6;ITGAL;CALM2;FGF17;SIPA1L1;PIK3CD;INSR;GRIN2A;VAV2 |
| PIK-Akt signaling pathway | GNB3;PHLPP1;PPP2CB;SPP1;FGF12;PDPK1;TNC;NFKB1;FOXO3 |
| Regulation of actin cytoskeleton | RHOAB;INS2;ACTN1;MYL5;RRAS;ARHGEF7;ITGAV;FGF6A;LIMK1 |
| Pathways in cancer | FGF22;LPAR6;PGF;FGF9;ITGA3;IKBKG;TGFA;FOXO1;MSH2 |
| Melanoma | TP53;FGF16;MITF;PDGFRA;PIK3CG;TRP53;CCND1;FGF6;KRAS |
FGF5 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF5 itself. We selected most functions FGF5 had, and list some proteins which have the same functions with FGF5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor receptor binding | FGF6A;FGF6B;KLB;FGF20A;FGF9;Fgf15;FGF22;FGF10B;FGF16 |
| growth factor activity | VEGFAA;LFT2;FGF1A;KITLG;RABEP2;FGF2;THBS4;NRTN;GH1 |
FGF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF5.
EGF; FGFR2; FGFR4; MAPK1
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