FGF17
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Official Full Name
fibroblast growth factor 17 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be prominently expressed in the cerebellum and cortex. The mouse homolog of this gene was localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, which suggests a role in central nervous system, bone and vascular development.This gene was referred to as FGF-13 in reference 2, however, its amino acid sequence and chromosomal localization are identical to FGF17. -
Synonyms
FGF17;fibroblast growth factor 17;FGF 13;FGF13;FGF-17;OTTHUMP00000122553;OTTHUMP00000224730;FGF-13
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
Involved Pathway
FGF17 involved in several pathways and played different roles in them. We selected most pathways FGF17 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathways in cancer | LPAR2,SFPI1,SOS1,FGF16,PML,MAPK9,EPAS1,AXIN1,TRAF6,WNT8B |
| MAPK signaling pathway | RAP1AA,GRB2A,HSPA1B,FGFR2,CACNA2D3,MAPKAPK2A,MAPK12B,PPP3R1B,PAK2A,MKNK2B |
| Rap signaling pathway | RAP1A,FGF21,INSR,FGFR4,P2RY1,MAP2K3,CALM3,SIPA1L2,IGF1,RALGDS |
| Ras signaling pathway | FGF14,GNGT2,FASLG,Pdgfa&Pdgfb,SHC4,SHOC2,ANGPT1,FGF18,NGF,RAPGEF5 |
| Melanoma | IGF1R,FGF19,FGF3,PDGFRB,FGF21,PIK3R3,FGF6,ARAF,FGF11,Pdgfa&Pdgfb |
| Regulation of Actin Cytoskeleton | ROCK1,FGD3,MYL10,MYL12.1,INSB,BRK1,ITGA2B,FGF11A,FGF16,RAC1 |
| PIK-Akt signaling pathway | TP53,ATF4,CREB3L2,RELA,TCL1A,FGF20,HGF,SGK3,PDGFRA,FN1 |
Protein Function
FGF17 has several biochemical functions, for example, growth factor activity,type 1 fibroblast growth factor receptor binding,type 2 fibroblast growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF17 itself. We selected most functions FGF17 had, and list some proteins which have the same functions with FGF17. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| type 2 fibroblast growth factor receptor binding | FGF7,FGF18,FGF8,FGF10 |
| growth factor activity | VEGFB,PDGFD,HGF,GFER,HDGF,INHBC,EGF,BMP2,BMP2B,AMH |
| type 1 fibroblast growth factor receptor binding | NPTN,FGF8,FGF18 |
Interacting Protein
FGF17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF17 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF17.
FGF17 Related Signal Pathway
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References
- Campo, GM; Avenoso, A; et al. Beta-arrestin-2 negatively modulates inflammation response in mouse chondrocytes induced by 4-mer hyaluronan oligosaccharide. MOLECULAR AND CELLULAR BIOCHEMISTRY 399:201-208(2015).
- Bob, F; Gluhovschi, G; et al. Immunohistochemical study of tubular epithelial cells and vascular endothelial cells in glomerulonephritis. RENAL FAILURE 36:1208-1214(2014).
