FGF19
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Official Full Name
fibroblast growth factor 19
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Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] -
Synonyms
FGF19; fibroblast growth factor 19; FGF-19;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- Flag
- GST
- His
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- FGF19 Related Signal Pathway
FGF19 involved in several pathways and played different roles in them. We selected most pathways FGF19 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | Fasl;MAPK7;NLK;Pdgfa&Pdgfb;RRAS;ECSIT;AKT1;ARRB2B;NGF |
| Ras signaling pathway | ARF6;RELA;PLA2G5;PLA2G12A;GAB1;LAT;MAP2K2;RHOA;PLCE1 |
| Rap signaling pathway | VEGFA;MAP2K1;ITGAM;INSR;ITGA2B;ANGPT1;FGF12;BCAR1;NRAS |
| PIK-Akt signaling pathway | TNC;CCNE2;Reln;INS2;GYS1;CCNE1;PKN3;COL27A1;ANGPT2 |
| Regulation of actin cytoskeleton | PAK2;PIP5K1A;RAC1A;MYLK4;RDX;CFL2L;SRC;ACTG1;MYLK |
| Pathways in cancer | GRB2;TCF7;FGF20;Flt3l;CSF1R;CCNA1;CASP9;CBLB;RHOA |
| Melanoma | PTEN;RAF1;PDGFA;FGF4;AKT1;FGF20;HGF;PIK3CA;PIK3CB |
FGF19 has several biochemical functions, for example, protein binding, protein kinase binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF19 itself. We selected most functions FGF19 had, and list some proteins which have the same functions with FGF19. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PDE4D;CISH;ACTN1;TM4SF4;ZFHX3;THAP10;GGT1;RMND5A;MMS22L |
| protein kinase binding | CDKN2D;KIF11;JTB;IFNAR2;STK11IP;IRS2;CNTLN;TRAP1;DVL1 |
| protein phosphatase binding | TRP53;GNB2L1;ANAPC7;STAT6;FGF19;PARD3;KAT2A;SKAP1;PIK3R1 |
FGF19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF19 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF19.
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Q&As (5)
Ask a questionFGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.
Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.
FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.
FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.
Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.
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