• Official Full Name

    fibroblast growth factor 19

  • Overview

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
  • Synonyms

    FGF19; fibroblast growth factor 19; FGF-19;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGF19-238H Recombinant Human FGF19 protein E.coli N/A 195
Human FGF19-27597TH Recombinant Human FGF19 E.coli N/A
Human FGF19-7336H Recombinant Human FGF19 protein(Phe27-Lys216) E.coli N/A Phe27-Lys216
Human FGF19-27599TH Recombinant Human FGF19, His-tagged E.coli His
Human FGF19-28824TH Recombinant Human FGF19 Protein, Fc-tagged E.coli Fc aa 1-216
Human FGF19-252H Active Recombinant Human FGF19, Fc-tagged HEK293 Fc Leu 25 - Lys 216
Human FGF19-132H Recombinant Human FGF19 Protein, His-tagged E.coli His
Human FGF19-251H Recombinant Human FGF19, FLAG-tagged HEK293 Flag
Human FGF19-100H Recombinant Human Fibroblast Growth Factor 19, His-tagged E.coli His
Human FGF19-6244HCL Recombinant Human FGF19 293 Cell Lysate HEK293 N/A
Human FGF19-3206H Recombinant Human FGF19 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FGF19-4109H Recombinant Human FGF19 Protein, GST-tagged Wheat Germ GST
Human FGF19-4819HF Recombinant Full Length Human FGF19 Protein, GST-tagged In Vitro Cell Free System GST 216 amino acids
Human FGF19-48H Recombinant Human FGF19 Protein, His-tagged HEK293 His aa 25-216
Human FGF19-3970H Recombinant Human FGF19 protein, His-tagged E.coli His 30-216 aa
Human FGF19-032H Recombinant Human FGF19 Protein E.coli
Human FGF19-121F Active Recombinant Human FGF19 Protein (195 aa) E.coli 195
Human FGF19-5231H Recombinant Human FGF19 protein, GST-tagged E.coli GST 32-216aa
Human FGF19-1485H Recombinant Human FGF19 Protein, His-tagged E.coli N-His Leu25-Lys216
Human FGF19-906H Recombinant Human FGF19 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGF19-906H-B Recombinant Human FGF19 Protein Pre-coupled Magnetic Beads HEK293
Human FGF19-1484H Recombinant Human FGF19 Protein, His-tagged E.coli N-His Gly4-Lys216
Human FGF19-75H Recombinant Active Human FGF19 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human FGF19-3331H Recombinant Human FGF19 Protein (Phe27-Lys216), N-His tagged E.coli N-His Phe27-Lys216
Human FGF19-3332H Recombinant Human FGF19 Protein (Gly4-Lys216), His tagged E.coli His Gly4-Lys216
Human FGF19-01H Recombinant Human FGF-19 Protein, His-Tagged HEK293 His 205aa
Human FGF19-857HFL Recombinant Full Length Human FGF19 Protein, C-Flag-tagged Mammalian cells Flag
Human FGF19-325H Active Recombinant Human FGF19 Protein (Arg23-Lys216), C-His tagged, Animal-free, Carrier-free E.coli C-His Arg23-Lys216
Rat Fgf19-1815R Recombinant Rat Fgf19 protein, His-tagged E.coli His Gly25~Lys218
Zebrafish FGF19-2002Z Recombinant Zebrafish FGF19 Mammalian Cell His
Chicken FGF19-6240C Recombinant Chicken FGF19 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FGF19 Related Signal Pathway

FGF19 involved in several pathways and played different roles in them. We selected most pathways FGF19 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFGF2;CALML5;GNGT2;PLCG1;FGF14;IGF1;PAK3;PIK3CG;PRKCA
Rap signaling pathwayPRKCG;PIK3R2;GRIN1;FGF2;Fgf15;PARD6A;KRAS;PDGFRA;RAP1B
PIK-Akt signaling pathwayITGB3;RBL2;INS;PRL;LAMB3;PHLPP1;TEK;CD19;IFNA6
Regulation of actin cytoskeletonWASB;MAPK1;ITGA1;ACTN1;ROCK1;GNG12;MAPK3;FGFR1;SRC
Pathways in cancerGNAI2;SPI1;Casp3;TCEB2;GNAQ;BAX;PIK3R2;PDGFB;CSF1R

FGF19 has several biochemical functions, for example, protein binding, protein kinase binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF19 itself. We selected most functions FGF19 had, and list some proteins which have the same functions with FGF19. You can find most of the proteins on our site.

Function Related Protein
protein bindingKL;RPS27;TIMM8A;FIG4;RAB1A;ZMYND10;MAP4K5;ELMO2;EMD
protein kinase bindingYWHAZ;MAPKAP1;TCTN2;SNAP91;SKAP1;CNTLN;CCNL2;MAP2K3;RPS6
protein phosphatase bindingCSF1R;CDC27;PPARG;GRB2;MAP3K5;CDKN1B;MAPK14;Itga10&Itgb1;TRP53

FGF19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF19 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF19.

Research Area

Related articles

Walters, JRF; et al. Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY 11:426-434(2014).
Kong, B; Guo, GL; et al. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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How is FGF19 gene expression regulated, and what factors influence its secretion and activity in various tissues? 09/12/2021

FGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.

Can you discuss the potential therapeutic applications of targeting FGF19 in metabolic disorders, and what challenges exist in developing such interventions? 05/20/2020

Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.

Can you explain the role of FGF19 in the enterohepatic circulation of bile acids and its implications for metabolic health? 04/05/2019

FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.

What is the role of FGF19 in the regulation of gut hormone secretion, and how does this contribute to its effects on metabolic processes? 02/02/2019

FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.

What is the significance of FGF19 in metabolic diseases, and how does dysregulation contribute to conditions like obesity and non-alcoholic fatty liver disease (NAFLD)? 12/29/2018

Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.

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