FGF19 involved in several pathways and played different roles in them. We selected most pathways FGF19 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
CACNG7; GNA12A; MAP2K5; TRAF6; HRAS; PRKACB; CACNA1DA; MAP2K3; MAPK12B; PPM1BB |
| Ras signaling pathway |
MAPK10; FGFR1; RASA4; CALML3; FGF20; GAB2; PDGFRB; PLA2G12A; NRAS; PLA2G2F |
| Rap signaling pathway |
SRC; IGF1R; MAP2K2; MAPK11; PDGFRB; FGF12; FGF11; LAT; KRIT1; GRIN1 |
| PIK-Akt signaling pathway |
BAD; GH1; ANGPT1; FN1; FGF22; LAMA2; HGF; CRTC2; GNG3; FGFR1 |
| Regulation of actin cytoskeleton |
ITGB1B.2; SSH2; PIK3R3; WASLB; RAC1B; ITGA6; PAK2B; DIAPH3; WAS; MYL7 |
| Pathways in cancer |
LAMA5; PGF; MSH2; MSH6; LAMA2; IGF1R; FGF20; TGFB3; WNT9A; FGF11 |
| Melanoma |
TP53; FGF8; CCND1; PDGFC; FGF16; ARAF; MAPK1; BAD; PDGFB; PIK3R1 |
FGF19 has several biochemical functions, for example, protein binding, protein kinase binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF19 itself. We selected most functions FGF19 had, and list some proteins which have the same functions with FGF19. You can find most of the proteins on our site.
| Function |
Related Protein |
| protein binding |
SMYD2; ST8SIA5; MARK4; TMEM173; GTF2F2; P4HA1; HMGA2; ARL2BP; RND2; RAD9 |
| protein kinase binding |
TRP53; SMAD3; RPS19; PPME1; AKAP1; DNAJA3; CACNB3; BCL10; PLK1; PPP1CB |
| protein phosphatase binding |
PPME1; SHOC2; PIK3R2; ANAPC7; TRAF3; GRB2; PPP1R3C; DLG3; FGF19; STAT3 |
FGF19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF19 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF19.
Walters, JRF; et al. Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY 11:426-434(2014).
Kong, B; Guo, GL; et al. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLOS ONE 9:-(2014).
