fgf19
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  • Official Full Name
  • fibroblast growth factor 19
  • Background
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
  • Synonyms
  • FGF19; fibroblast growth factor 19; FGF-19;
Cat.#:FGF19-4109HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGF19 Protein, GST-tagged
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Cat.#:FGF19-100HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 19, His-tagged
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Cat.#:FGF19-132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF19 Protein, His-tagged
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Cat.#:FGF19-238HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor 19
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Cat.#:FGF19-251HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF19, FLAG-tagged
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Cat.#:FGF19-252HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGF19, Fc-tagged
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Cat.#:FGF19-27597THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF19
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Cat.#:FGF19-27599THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF19, His-tagged
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Cat.#:FGF19-28824THTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF19 Protein, Fc-tagged
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Cat.#:FGF19-7336HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGF19, None tagged
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Cat.#:Fgf19-1815RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Fgf19 protein, His-tagged
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Cat.#:FGF19-6240CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGF19
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Cat.#:FGF19-2002ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGF19
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Cat.#:FGF19-6244HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human FGF19 293 Cell Lysate
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Involved Pathway

FGF19 involved in several pathways and played different roles in them. We selected most pathways FGF19 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG6; FGF1B; PPM1BA; PRKACAA; HRASA; MYCB; KCNA3; PDGFRB; GADD45BB; NTRK1
Ras signaling pathway
CDC42; HTR7; RASAL3; IKBKB; PLCG2; PLA2G4D; RASA1; FLT1; HRAS; ANGPT1
Rap signaling pathway
INS; FGF16; KIT; GNAS; ITGB1; MAP2K2; FGF5; FLT4; MAP2K1; Itgam&Itgb2
PIK-Akt signaling pathway
GHR; FGF14; FGF4; MAPK1; ANGPT2; RPS6KB2; FASLG; ITGA5; CCND1; ITGB4
Regulation of actin cytoskeleton
ACTB; RHOA; PIK3R2; RRAS; INS2; FGF11; ITGA3B; PIP4K2C; PIK3R1; PFN3
Pathways in cancer
WNT10B; PIK3R2; WNT4; NFKB1; MSH3; FGF1; XIAP; WNT9A; PIK3R5; WNT8A
Melanoma
FGF7; FGFR1; CCND1; FGF10; NRAS; FGF6; CDH1; HRAS; MDM2; FGF2

Protein Function

FGF19 has several biochemical functions, for example, protein binding, protein kinase binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF19 itself. We selected most functions FGF19 had, and list some proteins which have the same functions with FGF19. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein P2RY6; GTPBP10; DDX42; CD2AP; LOXL2; EFEMP2; OLFM4; IFT88; PRADC1; RORA
Function protein kinase binding
Related Protein GRB2; KIF11; PIWIL1; TPCN2; TRAF6; PPME1; FGF19; CDC25C; HSP90AB1; FAM83E
Function protein phosphatase binding
Related Protein MAP2K7; JAK3; EIF2AK3; TRAF2; JUPA; MVP; ROS1; PPP6R3; EGFR; HSF4

FGF19 Related Articles

Walters, JRF; et al. Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY 11:426-434(2014).
Kong, B; Guo, GL; et al. Soluble Expression of Disulfide Bond Containing Proteins FGF15 and FGF19 in the Cytoplasm of Escherichia coli. PLOS ONE 9:-(2014).