Fgf22
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Official Full Name
fibroblast growth factor 22 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. -
Synonyms
FGF22;fibroblast growth factor 22;FGF-22
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Fc
- Non
- SUMO
- Avi
Involved Pathway
Fgf22 involved in several pathways and played different roles in them. We selected most pathways Fgf22 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgf22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | PLA1A,FGF14,RASAL1,SHC1,FLT1,PAK1,RHOA,CALML5,FGF5,ABL2 |
| PIK-Akt signaling pathway | PIK3R3,IFNA4,FGF18,IL4R,FLT4,RBL2,FGFR1,TNR,FGF16,Fgf15 |
| MAPK signaling pathway | CACNA1SA,GNG12A,TRAF2,MAPT,MAPK8IP2,MAPK8,RPS6KA2,HRASB,GNA12,NFKB1 |
| Melanoma | FGF10,MDM2,Fgf15,BRAF,NRAS,FGF11,PDGFD,PIK3R2,PIK3R1,FGF5 |
| Rap signaling pathway | RRAS,FGFR1,FGF21,KLK1B4,RAP1A,RAF1,CALM1,MAP2K2,ITGB3,KITLG |
| Pathways in cancer | SOS1,LPAR5,PLCG2,LAMA4,LAMA3,AXIN1,RALB,NOS2,GNG3,ITGA6 |
| Regulation of Actin Cytoskeleton | FGF11,FGF14,PIK3R5,PAK3,PDGFRA,FGF18,ROCK2B,MAP2K2A,ACTG1,RAF1B |
Protein Function
Fgf22 has several biochemical functions, for example, fibroblast growth factor receptor binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgf22 itself. We selected most functions Fgf22 had, and list some proteins which have the same functions with Fgf22. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| fibroblast growth factor receptor binding | FGF20A,FGF6,FGF8,FGF5,FGF18B,FGF20B,FRS3,FGF4,KLB,FGF1A |
| growth factor activity | NRG3,IGF2A,FGF6B,NTF7,TGFA,PDGFC,AMELX,PDGFAB,GPR19,JAG2 |
Interacting Protein
Fgf22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgf22 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgf22.
Fgf22 Related Signal Pathway
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References
- Yemisci, M; Caban, S; et al. Systemically administered brain-targeted nanoparticles transport peptides across the blood-brain barrier and provide neuroprotection. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 35:469-475(2015).
- Rashid, H; Ma, CY; et al. Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. CONNECTIVE TISSUE RESEARCH 55:83-87(2014).
