FGF3
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Official Full Name
fibroblast growth factor 3 -
Overview
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. -
Synonyms
FGF3;fibroblast growth factor 3;fibroblast growth factor 3 (murine mammary tumor virus integration site (v int 2) oncogene homolog) , INT2;HBGF 3;INT 2 proto oncogene protein;murine mammary tumor virus integration site 2;mouse;oncogene INT2;V INT2
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Non
- His
- Avi
- Fc
- Myc
Involved Pathway
FGF3 involved in several pathways and played different roles in them. We selected most pathways FGF3 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | PIK3R5,IFNAR2,TRP53,IFNA16,TNC,PKN2,GNGT2,CCND1,BRCA1,MDM2 |
| Pathways in cancer | MAPK1,FZD8,GNGT1,NTRK1,EPAS1,GNAQ,MSH3,PLCB3,SKP2,NRAS |
| Regulation of Actin Cytoskeleton | GNA12,RAF1,ITGA2,FGF4,FGF8A,PIP5K2,FGF7,ITGA4,ARHGEF7A,FGF17 |
| MAPK signaling pathway | RAP1B,MAPKAPK2A,FGF2,FLNC,FGF1A,PRKACAA,CACNG2A,FGF18A,GADD45AA,CDC42L |
| Rap signaling pathway | NGF,GNAQ,RAC3,MAPK13,PFN3,SIPA1L1,ITGB3,F2RL3,FGFR4,RAPGEF6 |
| Melanoma | HGF,MDM2,PDGFA,PIK3R1,RAF1,PIK3CD,Pdgfa&Pdgfb,PDGFB,FGF17,KRAS |
| Ras signaling pathway | EFNA4,ZAP70,AKT1,Pdgfa&Pdgfb,INS,ANGPT1,KITLG,PAK7,SHC2,CALML5 |
Protein Function
FGF3 has several biochemical functions, for example, fibroblast growth factor receptor binding,growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF3 itself. We selected most functions FGF3 had, and list some proteins which have the same functions with FGF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | HSD17B8,PRC1,2610109H07Rik,SYMPK,LSM11,POLR3C,HIRIP3,PSMD4,ACTN3,ERCC5 |
| fibroblast growth factor receptor binding | FGF8,FGF2,FGF8A,FGF21,FGF9,FGF20A,FGF10,FGF1,FGF6A,FGF5 |
| growth factor activity | IL6,IL5,Artn,BMP7B,FGF7,GDF7,GDF6,AMELX,GFER,NRTN |
Interacting Protein
FGF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF3.
FGF3 Related Signal Pathway
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References
- Rashid, H; Ma, CY; et al. Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. CONNECTIVE TISSUE RESEARCH 55:83-87(2014).
- Nakao, Y; Mitsuyasu, T; et al. Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway. INTERNATIONAL JOURNAL OF ONCOLOGY 43:1377-1384(2013).
