FGF1
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Official Full Name
fibroblast growth factor 1 (acidic)
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Overview
Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin-binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues. -
Synonyms
FGF1; Fibroblast Growth Factor-acidic; FGF-acidic; Basic fibroblast growth factor; BFGF; FGF 2; FGF B; FGF2; FGF2 basic; FGF2_HUMAN; FGFB; Fibroblast growth factor 2 (basic); HBGF 2; HBGF-2; HBGF2; HBGH 2; HBGH2; Heparin binding growth factor 2 precursor; Heparin-binding growth factor 2; Prostatropin;
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- FGF1 Related Signal Pathway
FGF1 involved in several pathways and played different roles in them. We selected most pathways FGF1 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RPS6KA1;GRB2A;MAP3K13;MAP3K5;PPM1NB;PPM1AB;CACNG8;TGFB1;MECOM |
| Ras signaling pathway | ETS2;FGF22;PLA1A;RGL2;SHC4;GNB1;PLD2;FGF7;RAPGEF5 |
| Rap signaling pathway | FGFR4;BCAR1;MET;PDGFRA;SIPA1L1;ANGPT4;PIK3CD;FGF16;CALM3 |
| PIK-Akt signaling pathway | PIK3CG;PIK3CB;YWHAH;THBS3;FGF16;IFNA16;ITGA6;RELA;CREB3L2 |
| Hippo signaling pathway | PARD6A;SOX2;SMAD7;WNT3;WNT1;MOBKL1A;WNT9A;YWHAG;LEF1 |
| Regulation of actin cytoskeleton | ITGA7;F2R;ITGB7;FGF3;LIMK1A;MLCK2;TMSB4Y;ITGA8;WAS |
| Pathways in cancer | FGF11;GRB2;PRKCA;GNAI3;TGFBR2;PLD1;FGF9;ERBB2;HDAC1 |
| Melanoma | HGF;FGF11;PTEN;FGF21;PIK3CA;MAPK1;MDM2;Fgf15;AKT1 |
FGF1 has several biochemical functions, for example, S100 protein binding, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF1 itself. We selected most functions FGF1 had, and list some proteins which have the same functions with FGF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S100 protein binding | S100A6;DDX1;S100A1;ANXA11;FGF1A;KCNK3;AGER;ANXA2;ATP2A2 |
| fibroblast growth factor receptor binding | FGF10;FGF10B;FGF22;FGF20B;FGF10A;FGF1A;KLB;FGF6;FGF9 |
| growth factor activity | MDKA;BMP7B;PDGFC;GSDF;IL8L2;INHBB;GDF10B;TFF1;GDF10 |
| heparin binding | BSPH1;RPL22;FGFBP3;LPA;FSTL1;APOH;PF4;BMP4;SLIT1A |
| protein binding | UNC13A;MARK3;KBTBD7;MYH10;NXT1;DUSP14;RUNX3;GLTP;SH2D2A |
FGF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF1.
FGFR1; FGFR2; heparin; intg_av_b3_human; FGFR3; copper(2+); SRPK1; FGFR4; HSPG2
Research Area
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Customer Reviews (3)
Write a reviewBy using FGF1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.
The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.
As a researcher utilizing FGF1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.
Q&As (5)
Ask a questionYes, there have been clinical trials exploring the use of FGF1 in treating heart disease, specifically in promoting cardiac angiogenesis.
Yes, FGF1 is being investigated for its potential in regenerative medicine to repair damaged tissues and organs.
FGF1 has shown potential in improving insulin sensitivity and glucose regulation in preclinical studies, but further research is needed for clinical applications.
Safety concerns include the risk of uncontrolled cell growth, which could lead to cancer, and the need for precise dosing and administration.
Potential side effects may include inflammation at the application site, allergic reactions, and adverse effects related to uncontrolled cell growth.
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