FGF10
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Official Full Name
fibroblast growth factor 10 -
Overview
Fibroblast Growth Factor-10 (also called KGF-2) is a heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. FGF-10 is mostly related to FGF-7/KGF and is expressed during development and preferen -
Synonyms
FGF10;fibroblast growth factor 10;FGF-10;keratinocyte growth factor 2;produced by fibroblasts of urinary bladder lamina propria
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Cynomolgus
- Chicken
- E.coli
- CHO
- Mammalian Cells
- HEK293
- Human
- Wheat Germ
- In Vitro Cell Free System
- Non
- Fc
- His
- GST
- S
- Avi
- SUMO
Involved Pathway
FGF10 involved in several pathways and played different roles in them. We selected most pathways FGF10 participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Melanoma | FGF3,PIK3R2,BRAF,MAP2K2,PIK3R3,MDM2,MITF,MAPK1,FGF12,KRAS |
| PIK-Akt signaling pathway | PCK1,G6PC,BRCA1,ITGA9,IFNA13,IFNA5,ITGA2B,IFNA10,GNG5,PPP2R5C |
| Pathways in cancer | PIK3R1,ITGAV,MDM2,CCNA1,FZD2,BDKRB2,RAD51,PRKACB,PTGER4,HRAS |
| Ras signaling pathway | FGF9,GRIN2A,GNB1,SHC3,PLA2G4C,RAPGEF5,MET,VEGFA,FGFR4,SHC4 |
| Regulation of Actin Cytoskeleton | Itgam&Itgb2,PIP4K2A,PIP5K1B,PIP5KL1,ARPC5LA,PDGFB,PIK3CG,PDGFAA,MYL9B,BDKRB2 |
| MAPK signaling pathway | RASA2,PRKCA,CACNG8,NFATC1,GNA12,MAPK11,KCNA3,TAOK1,RAP1A,CACNA2D4 |
| Rap signaling pathway | FGF19,ANGPT2,PLCB2,LPAR2,FLT4,RASSF5,ITGB2L,AKT2,RASGRP3,PRKCG |
Protein Function
FGF10 has several biochemical functions, for example, chemoattractant activity,fibroblast growth factor receptor binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF10 itself. We selected most functions FGF10 had, and list some proteins which have the same functions with FGF10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAP2K5,DULLARD,RPS19,USP36,ZNF550,VPS25,HSP90AA1.1,MRTO4,PNKP,SMAD4 |
| fibroblast growth factor receptor binding | FGF2,Fgf15,FGF16,FGF21,FGF3,FGF10A,FGF18B,FGF8B,FGF22,FGF20 |
| heparin binding | RPL22,GM4980,C6orf25,CLEC3B,CRISPLD2,HDGF,SERPIND1,SERPINC1,OGN,ZNF146 |
| type 2 fibroblast growth factor receptor binding | FGF7,FGF8,FGF17,FGF18 |
| chemoattractant activity | CXCL12A,PDGFB,MIF,CCL5,CXCL12,HGF,NTF3,SAA3,CCL16,VEGFC |
| growth factor activity | GDF2,IL10,MIA1,AREG,GDNFA,CSF1,BMP7A,PDGFAA,TYMP,LEFTY2 |
Interacting Protein
FGF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF10.
FGFR2
FGF10 Related Signal Pathway
Resources
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References
- Yao, N; Xia, JX; et al. Topical application of a new monoclonal antibody against fibroblast growth factor 10 (FGF 10) mitigates propranolol-induced psoriasis-like lesions in guinea pigs. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 18:1085-1091(2014).
- Xia, JX; Mei, XL; et al. Effect of FGF10 monoclonal antibody on psoriasis-like model in guinea pigs. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:2219-2228(2014).
