FGF18
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Official Full Name
fibroblast growth factor 18
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Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008] -
Synonyms
FGF18; fibroblast growth factor 18; ZFGF5; FGF-18;
- Involved Pathway
- Protein Function
- Interacting Protein
- FGF18 Related Articles
- FGF18 Related Research Area
- FGF18 Related Signal Pathway
FGF18 involved in several pathways and played different roles in them. We selected most pathways FGF18 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | Fasl;HSPA1A;MAPK3;PAK2A;GADD45BA;TAOK2;RASA2;CACNG7A;FGF17 |
| Ras signaling pathway | GNG10;PLD2;MAP2K2;PIK3R5;FGF9;RASAL3;ABL1;PTPN11;PIK3R2 |
| Rap signaling pathway | MAPK11;PDGFRB;NGFR;FGF5;ITGB3;AKT2;FGFR3;ANGPT4;PLCG1 |
| PIK-Akt signaling pathway | PDGFD;PIK3R5;IKBKG;PDPK1;FGF21;FGF13;FGF12;PDGFRB;GNGT2 |
| Regulation of actin cytoskeleton | GNG12A;MAPK3;SLC9A1;ROCK2;FGF6B;ITGA10;PTK2AB;MYLPF;ITGA8 |
| Pathways in cancer | FZD1;BCR;WNT7A;MAP2K1;RXRG;PTEN;PTK2;TGFBR2;LPAR3 |
| Melanoma | FGF14;BRAF;FGF18;Fgf15;FGF20;HGF;FGF10;PDGFA;HRAS |
FGF18 has several biochemical functions, for example, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF18 itself. We selected most functions FGF18 had, and list some proteins which have the same functions with FGF18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| growth factor activity | VEGFAA;EREG;FGF12A;FGF1B;CSF1B;HBEGFA;BMP2B;SPAW;FGF2 |
| type 1 fibroblast growth factor receptor binding | FGF18;FGF8;NPTN;FGF17 |
| type 2 fibroblast growth factor receptor binding | FGF18;FGF10;FGF8;FGF17;FGF7 |
FGF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF18.
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