FGF18

  • Official Full Name

    fibroblast growth factor 18

  • Overview

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
  • Synonyms

    FGF18; fibroblast growth factor 18; ZFGF5; FGF-18;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • N
  • hFc
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGF18-522H Active Recombinant Human FGF18 E.coli N/A
Human FGF18-504H Active Recombinant Human FGF18 Protein, His-tagged HEK293 His Met 1-Ala 207
Human FGF18-655H Recombinant Human FGF18 Mammalian Cell His
Human FGF18-183H Recombinant Human FGF18 protein, His/S-tagged E.coli His/S
Human FGF18-12867H Recombinant Human FGF18, GST-tagged E.coli GST 1-207a.a.
Human FGF18-224H Active Recombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged CHO Fc
Human FGF18-171H Recombinant Human Fibroblast Growth Factor 18 E.coli N/A
Human FGF18-223H Active Recombinant Human Fibroblast Growth Factor 18, MIgG2a Fc-tagged CHO Fc
Human FGF18-222H Active Recombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged, mutant CHO Fc
Human FGF18-1660HCL Recombinant Human FGF18 cell lysate Human Cell N/A
Human FGF18-1482H Recombinant Human FGF18 Protein, His-tagged E.coli N-His Cys10-Arg199
Human FGF18-4817HF Recombinant Full Length Human FGF18 Protein, GST-tagged In Vitro Cell Free System GST 207 amino acids
Human FGF18-3222H Recombinant Human FGF18 Protein (Cys10-Arg199), His tagged E.coli His Cys10-Arg199
Human FGF18-4108H Recombinant Human FGF18 Protein, GST-tagged Wheat Germ GST
Human FGF18-1483H Recombinant Human FGF18 Protein, His-tagged E.coli N-His Glu28-Ala207
Human FGF18-2946H-B Recombinant Human FGF18 Protein Pre-coupled Magnetic Beads HEK293
Human FGF18-12H Recombinant Human FGF18 Protein (28-207), N-hFc-tagged HEK293 N-hFc 28-207
Human FGF18-031H Active Recombinant Human FGF18 Protein E.coli
Human FGF18-2946H Recombinant Human FGF18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGF18-418F Active Recombinant Human FGF18 Protein (174 aa) E.coli 174
Human FGF18-308H Active Recombinant Human FGF18 Protein (Ala27-Arg199), C-His tagged, Animal-free, Carrier-free E.coli C-His Ala27-Arg199
Mouse Fgf18-184M Recombinant Mouse Fgf18 protein, His/S-tagged E.coli His/S
Mouse Fgf18-562M Recombinant Mouse Fgf18 protein E.coli N/A 180
Mouse Fgf18-491M Recombinant Mouse FGF18 protein(Met1-Gly207), His-tagged HEK293 C-His Met1-Gly207
Mouse FGF18-2430MCL Recombinant Mouse FGF18 cell lysate Human Cell N/A
Mouse Fgf18-417F Active Recombinant Mouse Fgf18 Protein (172 aa) E.coli 172
Rat Fgf18-588R Recombinant Rat Fgf18 protein E.coli N/A 180
Rat FGF18-2330R Recombinant Rat FGF18 Protein Mammalian Cell His
Rat Fgf18-185R Recombinant Rat Fgf18 protein, His/S-tagged E.coli His/S
Rat FGF18-1987R Recombinant Rat FGF18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FGF18-1987R-B Recombinant Rat FGF18 Protein Pre-coupled Magnetic Beads HEK293
Rat Fgf18-416F Active Recombinant Rat Fgf18 Protein (172 aa) E.coli 172
Chicken FGF18-6279C Recombinant Chicken FGF18 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FGF18 Related Signal Pathway

FGF18 involved in several pathways and played different roles in them. We selected most pathways FGF18 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPRKACBA;HRAS;GNG12;CACNA1SA;NFATC3;IL1A;TNFRSF1A;FGF13B;FGF19
Ras signaling pathwayFGFR1;KIT;NGFR;FGF18;GRIN2B;PDGFRA;FGF19;ANGPT2;GNG12
Rap signaling pathwayRAP1GAP;ITGAM;PRKCZ;KLK1B4;FGFR4;INS1;FGF1;APBB1IP;PRKD3
PIK-Akt signaling pathwayIL2RA;PTK2;CREB5;PPP2R5A;PDGFD;MDM2;MTCP1;TSC2;PIK3CA
Regulation of actin cytoskeletonMAP2K2;RAC1;ARHGEF7;KRAS;RHOAA;PPP1R12C;CD14;FGF9;PDGFA
Pathways in cancerPPARG;LPAR3;GNG3;PLCB1;FGF18;FAS;LAMB2;STAT1;HDAC1
MelanomaMDM2;FGF16;MAP2K2;PIK3CB;FGF4;AKT1;FGF1;FGF17;PIK3R5

FGF18 has several biochemical functions, for example, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF18 itself. We selected most functions FGF18 had, and list some proteins which have the same functions with FGF18. You can find most of the proteins on our site.

Function Related Protein
growth factor activityFGF6;IL10;THBS4B;FIGF;FGF8B;FGF20B;IL5;GPI1;GRN
type 1 fibroblast growth factor receptor bindingFGF18;FGF17;NPTN;FGF8
type 2 fibroblast growth factor receptor bindingFGF17;FGF7;FGF10;FGF8;FGF18

FGF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF18.

LYAR

Research Area

Related articles

Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
Portela, VM; Dirandeh, E; et al. The Role of Fibroblast Growth Factor-18 in Follicular Atresia in Cattle. BIOLOGY OF REPRODUCTION 92:-(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are the potential side effects of FGF18 therapy? 12/04/2021

While generally considered safe, potential side effects may include local reactions at the injection site. Comprehensive studies are ongoing to assess long-term safety.

Is FGF18 only applicable to bone-related conditions? 05/04/2021

While its primary focus is on musculoskeletal conditions, FGF18's role in cellular growth and repair suggests potential applications in other medical fields.

How does FGF18 compare to other growth factors in terms of clinical applications? 07/03/2020

Comparative studies are underway to evaluate the effectiveness and safety of FGF18 against other growth factors in various clinical scenarios.

Are there any ongoing clinical trials involving FGF18? 12/22/2019

Yes, there are several clinical trials exploring the safety and efficacy of FGF18 in various musculoskeletal disorders and conditions.

How does FGF18 contribute to the treatment of osteoarthritis? 07/08/2017

FGF18 has shown promise in promoting cartilage repair and regeneration, making it a potential candidate for the development of therapies for osteoarthritis.

Customer Reviews (3)

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Reviews
01/09/2022

    the FGF18 protein exhibits remarkable stability, enabling it to maintain its structural integrity and functionality throughout the experimental process.

    05/30/2021

      The FGF18 protein offers exceptional quality and purity, which is crucial for ensuring reliable and reproducible experimental outcomes.

      12/08/2017

        As a researcher utilizing the FGF18 protein, I am fortunate to benefit from its numerous advantages in trials.

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