FGF18 involved in several pathways and played different roles in them. We selected most pathways FGF18 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
MAPK13; MAP3K4; PAK2; CACNB3; CDC42L; MAP4K3; MAP3K13; FGF1B; MAPK12B; AKT2L |
| Ras signaling pathway |
SHC1; GNGT2; GNB1; LOC608458; VEGFA; INS1; RASAL3; GNG10; FGF13; KSR2 |
| Rap signaling pathway |
FGF4; PRKCB; IGF1R; INS2; PRKD1; PLCB3; LPAR3; PRKCZ; FGFR2; ITGA2B |
| PIK-Akt signaling pathway |
MDM2; GYS2; GYS1; IFNB1; IL7; COL6A4; CREB3L2; IFNA12; RPTOR; KRAS |
| Regulation of actin cytoskeleton |
FGF17; HRAS; ITGAL; FGFR4; PIP4K2AA; ITGA2B; FGD1; RAC1B; MAPK1; ARHGEF7 |
| Pathways in cancer |
PDGFB; LPAR3; NCOA4; WNT5A; CASP9; CXCL12; BRAF; PTGER2; WNT1; PPARD |
| Melanoma |
PDGFRA; PIK3R2; BRAF; TP53; MAPK3; FGF11; FGF2; KRAS; BAD; CDH1 |
FGF18 has several biochemical functions, for example, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF18 itself. We selected most functions FGF18 had, and list some proteins which have the same functions with FGF18. You can find most of the proteins on our site.
| Function |
Related Protein |
| growth factor activity |
TIMP1; PRL2C2; CXCL12; FGF12B; KITLG; HDGF; LFT1; AMBN; BMP8A; Artn |
| type 1 fibroblast growth factor receptor binding |
NPTN; FGF8; FGF17; FGF18 |
| type 2 fibroblast growth factor receptor binding |
FGF10; FGF18; FGF7; FGF17; FGF8 |
FGF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF18.
LYAR
Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
Portela, VM; Dirandeh, E; et al. The Role of Fibroblast Growth Factor-18 in Follicular Atresia in Cattle. BIOLOGY OF REPRODUCTION 92:-(2015).
