FGF18 Protein


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Official Full Name fibroblast growth factor 18
Background The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Synonyms FGF18; fibroblast growth factor 18; ZFGF5; FGF-18;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • S
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGF18-222H Recombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged, mutant CHO Fc
    Human FGF18-223H Recombinant Human Fibroblast Growth Factor 18, MIgG2a Fc-tagged CHO Fc
    Human FGF18-224H Recombinant Human Fibroblast Growth Factor 18, HIgG1 Fc-tagged CHO Fc
    Human FGF18-504H Recombinant Human FGF18 Protein, His-tagged HEK293 His
    Human FGF18-522H Recombinant Human FGF18 E.coli N/A
    Human FGF18-12867H Recombinant Human FGF18, GST-tagged E.coli GST
    Human FGF18-171H Recombinant Human Fibroblast Growth Factor 18 E.coli N/A
    Human FGF18-183H Recombinant Human FGF18 protein, His/S-tagged E.coli His/S
    Human FGF18-655H Recombinant Human FGF18 Mammalian Cell His
    Mouse Fgf18-184M Recombinant Mouse Fgf18 protein, His/S-tagged E.coli His/S
    Mouse Fgf18-491M Recombinant Mouse Fgf18, His tagged Human Cell His
    Mouse Fgf18-562M Recombinant Mouse Fgf18 protein E.coli N/A
    Rat Fgf18-185R Recombinant Rat Fgf18 protein, His/S-tagged E.coli His/S
    Rat FGF18-2330R Recombinant Rat FGF18 Protein Mammalian Cell His
    Rat Fgf18-588R Recombinant Rat Fgf18 protein E.coli N/A
    Chicken FGF18-6279C Recombinant Chicken FGF18 Mammalian Cell His
    Human FGF18-1660HCL Recombinant Human FGF18 cell lysate Human Cell N/A
    Mouse FGF18-2430MCL Recombinant Mouse FGF18 cell lysate Human Cell N/A
    Human FGF18-031H Recombinant Human FGF18 Protein E. coli
    Human FGF18-1482H Recombinant Human FGF18 Protein, His-tagged E.coli N-His
    Human FGF18-1483H Recombinant Human FGF18 Protein, His-tagged E.coli N-His
    Human FGF18-4817HF Recombinant Full Length Human FGF18 Protein, GST-tagged In Vitro Cell Free System GST
    Human FGF18-4108H Recombinant Human FGF18 Protein, GST-tagged Wheat Germ GST

    FGF18 involved in several pathways and played different roles in them. We selected most pathways FGF18 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP2K1; ARRB2A; GADD45B; ELK1; RAC3; RAC1; HRASB; MAPK8IP2; RAP1B; PRKCBA
    Ras signaling pathway PDGFRB; MRAS; RASA1; EFNA4; PAK3; RHOA; SHC1; MAPK1; RAB5C; FASLG
    Rap signaling pathway FGF9; Fgf15; FGF10; GNAI2; MRAS; MAGI1; PARD3; BRAF; PDGFD; LAT
    PIK-Akt signaling pathway PCK1; PDGFA; TEK; ITGB1; FGF14; LAMA3; LPAR5; EIF4E2; GYS1; TP53
    Regulation of actin cytoskeleton FGD3; ITGB3; ITGB5; RDX; APC; PPP1CBL; HRASA; SLC9A1; SSH2; WASF1
    Pathways in cancer FAS; STAT5B; SUFU; SMAD2; AKT1; PTGER3; TRAF3; BDKRB2; LAMB2; F2R

    FGF18 has several biochemical functions, for example, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF18 itself. We selected most functions FGF18 had, and list some proteins which have the same functions with FGF18. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity EFEMP1; PRL2C2; FGF18A; Il2; INHBB; MDKB; PROK1; REG1A; GSDF; GDF15
    type 1 fibroblast growth factor receptor binding FGF17; NPTN; FGF18; FGF8
    type 2 fibroblast growth factor receptor binding FGF10; FGF8; FGF17; FGF7; FGF18

    FGF18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF18 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF18.


    Correa, D; Somoza, RA; et al. Sequential exposure to fibroblast growth factors (FGF) 2, 9 and 18 enhances hMSC chondrogenic differentiation. OSTEOARTHRITIS AND CARTILAGE 23:443-453(2015).
    Portela, VM; Dirandeh, E; et al. The Role of Fibroblast Growth Factor-18 in Follicular Atresia in Cattle. BIOLOGY OF REPRODUCTION 92:-(2015).

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