FGF20

  • Official Full Name

    Fgf20 fibroblast growth factor 20

  • Overview

    Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic -cells. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance.
  • Synonyms

    FGF20; fibroblast growth factor 20; FGF-20;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGF20-15H Active Recombinant Human FGF20 protein, His-tagged E.coli His
Human FGF20-331H Active Recombinant Human FGF20 Protein E.coli N/A
Human FGF20-12869H Recombinant Human FGF20, GST-tagged E.coli GST 1-64a.a.
Human FGF20-178H Recombinant Human Fibroblast Growth Factor 20 E.coli N/A
Human FGF20-19H Recombinant Human FGF20 protein, His-tagged E.coli His Met1~Thr211
Human FGF20-6243HCL Recombinant Human FGF20 293 Cell Lysate HEK293 N/A
Human FGF20-80H Recombinant Active Human FGF20 Protein, His-tagged(C-ter) E.coli His(C-ter)
Human FGF20-116H Active Recombinant Human FGF20 Protein (Pro3-Thr211), C-His tagged, Animal-free, Carrier-free E.coli C-His Pro3-Thr211
Human FGF20-033H Active Recombinant Human FGF20 Protein E.coli
Mouse FGF20-5848M Recombinant Mouse FGF20 Protein Mammalian Cell His
Mouse Fgf20-2912M Recombinant Mouse Fgf20 protein, His-tagged E.coli His 1-211aa
Mouse FGF20-3233M Recombinant Mouse FGF20 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FGF20-3233M-B Recombinant Mouse FGF20 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fgf20-2911M Recombinant Mouse Fgf20 protein E.coli N/A 1-211aa
Rat FGF20-2332R Recombinant Rat FGF20 Protein Mammalian Cell His
Rat FGF20-1989R Recombinant Rat FGF20 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FGF20-1989R-B Recombinant Rat FGF20 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FGF20 Related Signal Pathway

FGF20 involved in several pathways and played different roles in them. We selected most pathways FGF20 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayNGF;FOS;NR4A1;FGF14;FGF20B;FGF19;HSPA1L;MYCB;CACNG6A
Ras signaling pathwayPDGFA;RALGDS;PRKACA;NGF;Kitl;PLA2G12A;CALM2;ABL2;FIGF
Rap signaling pathwayCALM3;CALM2;BCAR1;FGF1;FGF16;RAP1GAP;SRC;GNAQ;FGF20
PIK-Akt signaling pathwayPRKAA1;FGFR4;PPP2R2B;PRL;THBS4;MTCP1;PDGFD;RELA;RXRA
Regulation of actin cytoskeletonARPC5LA;FGF22;ITGB3B;FGFR3;GNA12;ABI2;WASLB;RRAS;ITGA10
Pathways in cancerFGFR3;HRAS;FGF14;PDGFRB;CTBP2;FZD6;BAX;WNT11;WNT5A
MelanomaFGF17;FGF22;FGF11;Fgf15;PDGFRB;PTEN;NRAS;FGF6;FGF1

FGF20 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF20 itself. We selected most functions FGF20 had, and list some proteins which have the same functions with FGF20. You can find most of the proteins on our site.

Function Related Protein
fibroblast growth factor receptor bindingFGF20;FGF18A;FGF20A;FGF10;FGF22;Fgf15;FGF2;FGF21;FGF3
growth factor activityNRG2;FGF11;PRL2C2;BMP2B;Pdgfa&Pdgfb;INHBAB;HBEGFA;NTF3;BMP16

FGF20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF20 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF20.

Research Area

Related articles

Munnamalai, V; Hayashi, T; et al. Notch Prosensory Effects in the Mammalian Cochlea Are Partially Mediated by Fgf20. JOURNAL OF NEUROSCIENCE 32:12876-12884(2012).
Hayashi, T; Ray, CA; et al. Fgf20 is required for sensory epithelial specification in the developing cochlea. JOURNAL OF NEUROSCIENCE 28:5991-5999(2008).
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