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Fgf21

  • Official Full Name

    fibroblast growth factor 21

  • Overview

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]
  • Synonyms

    FGF21; fibroblast growth factor 21;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Cell & Tissue Lysates
  • Bovine
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rat
  • Zebrafish
  • Bovine
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • HIS
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|S
  • mFc
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGF21-562H Recombinant Human FGF21 protein E.coli N/A 181
Human FGF21-3279H Active Recombinant Human FGF21 protein, His-tagged HEK293 His His29~Ser209
Human FGF21-564H Active Recombinant Human FGF21 protein, His-tagged E.coli His His29-Ser209
Human FGF21-28827TH Recombinant Human FGF21, His-tagged HEK293 His 209 amino acids
Human FGF21-28829TH Recombinant Human FGF21, Fc-tagged HEK293 Fc 209 amino acids
Human FGF21-104H Recombinant Human FGF21, His-tagged E.coli His
Human FGF21-28828TH Recombinant Human FGF21, FLAG-tagged HEK293 Flag 209 amino acids
Human FGF21-103H Recombinant Human Fibroblast Growth Factor 21 E.coli N/A
Human FGF21-192H Recombinant Human FGF21 protein, His/S-tagged E.coli His/S
Human FGF21-133H Recombinant Human FGF21 Protein, His-tagged E.coli His His29-Ser209
Human FGF21-4822HF Recombinant Full Length Human FGF21 Protein, GST-tagged In Vitro Cell Free System GST 30-209 amino acids
Human FGF21-879H Recombinant Human FGF21 Protein, mFc-Avi-tagged HEK293 mFc-Avi His29-Ser210
Human FGF21-653H Recombinant Human FGF21 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FGF21-4111H Recombinant Human FGF21 Protein, GST-tagged Wheat Germ GST
Human FGF21-947HFL Recombinant Full Length Human FGF21 Protein, C-Flag-tagged Mammalian cells Flag
Human FGF21-034H Active Recombinant Human FGF21 Protein E.coli
Human FGF21-907H Recombinant Human FGF21 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human FGF21-1966H Recombinant Human FGF21 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FGF21-415F Active Recombinant Human FGF21 Protein (182 aa) E.coli 182
Human FGF21-120F Active Recombinant Human FGF21 Protein (182 aa) E.coli 182
Human FGF21-907H-B Recombinant Human FGF21 Protein Pre-coupled Magnetic Beads HEK293
Human FGF21-2596H Recombinant Human FGF21 protein E.coli N/A His29-Ser209
Human FGF21-117H Active Recombinant Human FGF21 Protein (His29-Ser209), C-His tagged, Animal-free, Carrier-free E.coli C-His His29-Ser209
Human FGF21-287F Active Recombinant Human FGF21 Protein, His-tagged CHO His
Human FGF21-089H Recombinant Human FGF21 Protein, His29-Ser209, N-mFc-Avi tagged, Biotinylated HEK293 N-mFc-Avi His29-Ser209
Human FGF21-85H Active Recombinant Human FGF21 Protein E.coli
Human FGF21-301123H Recombinant Human FGF21 protein, GST-tagged E.coli GST His60-Ser209
Human FGF21-930H Recombinant Human FGF21 Protein, His-tagged HEK293F N-His His29-Ser209
Human FGF21-81H Recombinant Active Human FGF21 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Fgf21-563M Recombinant Mouse Fgf21 protein E.coli N/A 182
Mouse Fgf21-01M Active GMP Recombinant Mouse Fgf21 Protein, His-Tagged E.coli His
Mouse Fgf21-504M Recombinant Mouse Fgf21 E.coli His
Mouse Fgf21-258M Recombinant Mouse Fgf21, Fc-tagged HEK293 Fc
Mouse Fgf21-193M Recombinant Mouse Fgf21 protein, His/S-tagged E.coli His/S
Mouse Fgf21-109M Recombinant Mouse Fibroblast Growth Factor 21 E.coli N/A
Mouse Fgf21-256M Recombinant Mouse Fgf21, FLAG-tagged HEK293 Flag
Mouse Fgf21-574M Recombinant Mouse Fgf21 protein(Met1-Ser210), His-tagged HEK293 C-His Met1-Ser210
Mouse Fgf21-503M Recombinant Mouse Fgf21, His-tagged E.coli HIS
Mouse Fgf21-414M Recombinant Mouse Fibroblast Growth Factor 21, FLAG-tagged Human Cell Flag
Mouse Fgf21-110M Recombinant Mouse Fibroblast Growth Factor 21, His-tagged E.coli His
Mouse FGF21-36M Recombinant Mouse FGF21 Protein, His-tagged Insect Cell His
Mouse FGF21-1890MCL Recombinant Mouse FGF21 cell lysate Human Cell N/A
Mouse Fgf21-7399M Recombinant Mouse Fgf21 Protein, His-tagged Insect Cell His 29-210
Mouse Fgf21-414F Active Recombinant Mouse Fgf21 Protein (182 aa) E.coli 182
Mouse Fgf21-5453M Recombinant Mouse Fgf21 Protein (Ala29-Ser210), N-His tagged E.coli N-His Ala29-Ser210
Mouse Fgf21-257M Active Recombinant Mouse Fgf21 Protein (Ala29-Ser210), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala29-Ser210
Mouse Fgf21-2997M Recombinant Mouse Fgf21 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Fgf21-194R Recombinant Rat Pdgfa protein, His/S-tagged E.coli His/S
Rat Fgf21-589R Recombinant Rat Fgf21 protein E.coli N/A 180
Rat Fgf21-1490R Recombinant Rat Fgf21 Protein, His-tagged E.coli N-His Gly25-Ser208
Rat Fgf21-931R Recombinant Rat Fgf21 Protein, His-tagged HEK293F N-His Gly25-Ser208
Rat Fgf21-1491R Recombinant Rat Fgf21 Protein, His-tagged E.coli N-His Ala29-Ala207
Bovine FGF21-626B Recombinant Bovine Fibroblast Growth Factor 21 Bovine N/A
Cynomolgus Monkey FGF21-1236C Recombinant Cynomolgus FGF21 Protein, His-tagged HEK293 His
Zebrafish FGF21-4310Z Recombinant Zebrafish FGF21 Mammalian Cell His
Pig FGF21-932P Recombinant Pig FGF21 Protein, His&GST-tagged E.coli N-His&GST Arg28-Ser208
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • Fgf21 Related Signal Pathway

Fgf21 involved in several pathways and played different roles in them. We selected most pathways Fgf21 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fgf21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayARRB2A;CACNB3A;PTPN7;ECSIT;KRAS;RELA;TGFBR1;CACNA1BA;TGFBR1B
Ras signaling pathwayFGF12;ABL1;FGFR4;KSR2;PAK7;CALM4;PLA2G2D;SOS1;IKBKB
Rap signaling pathwayRAF1;PRKD1;Fgf15;PGF;ANGPT2;LCP2;ITGB1;ITGAM;FGF1
PIK-Akt signaling pathwayFASLG;GNG2;PPP2CA;MAP2K2;PIK3CD;PIK3R1;TLR2;LAMC2;FGF4
Regulation of actin cytoskeletonINSRR;RAC3B;VCL;CFL2L;ITGA11A;ARHGEF7B;PIP5K1AA;FGD1;INSB
Pathways in cancerPRKACB;TCEB2;FGFR2;CTBP2;MAP2K1;FGF2;GNG10;HIF1A;RAC3
MelanomaBAD;PIK3R1;PDGFRA;FGF6;TRP53;FGF11;AKT1;FGF18;MAP2K1

Fgf21 has several biochemical functions, for example, fibroblast growth factor receptor binding, growth factor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Fgf21 itself. We selected most functions Fgf21 had, and list some proteins which have the same functions with Fgf21. You can find most of the proteins on our site.

Function Related Protein
fibroblast growth factor receptor bindingFGF9;FRS3;FGF20B;KLB;FGF20A;FGF20;FGF10A;FGF5;FGF3
growth factor activityGDNFA;TIMP1;BMP5;TGFB1;PROK1;MDKA;IL3;VHL;Kitl
protein bindingPOR;UBE2D2;SMG9;PHF10;NPHP1;TRAM2;NDUFAF1;COA6;PPP4R1

Fgf21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fgf21 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fgf21.

KLB; CDC25A; MAPK7; TNS2; CDH7

Research Area

Related articles

Zhang, J; Li, Y; et al. Fibroblast growth factor 21, the endocrine FGF pathway and novel treatments for metabolic syndrome. DRUG DISCOVERY TODAY 19:579-589(2014).
Umberger, TS; Sloan, JH; et al. Novel sandwich immunoassays for the measurement of total and active FGF21. BIOANALYSIS 6:3283-3293(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How is FGF21 expression regulated in adipose tissue? 10/31/2022

FGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.

What are the effects of FGF21 on lipid metabolism? 08/27/2020

FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.

Can FGF21 be a biomarker for metabolic health? 08/07/2019

FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.

Is FGF21 involved in the regulation of insulin sensitivity? 03/03/2019

Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.

Does FGF21 have roles in energy expenditure? 11/11/2018

Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.

Are there gender-specific differences in FGF21 levels? 08/30/2017

Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.

What signaling pathways does FGF21 activate? 01/09/2016

FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.

Customer Reviews (3)

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Reviews
01/04/2022

    The manufacturer's history of producing high-quality products contributed to our trust in this protein.

    06/27/2021

      Collaboration with other research groups was made easier by the product's standardized use in the scientific community.

      03/03/2016

        The product's role in promoting collaboration and teamwork positively impacted the quality of our research.

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