FGF12
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Official Full Name
fibroblast growth factor 12
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Background
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Eac -
Synonyms
FGF12; fibroblast growth factor 12; FGF12B; FHF1; fibroblast growth factor 12B; fibroblast growth factor FGF 12b; fibroblast growth factor homologous factor 1; myocyte activating factor; FHF-1; FGF-12; myocyte-activating factor; fibroblast growth factor F;
- Involved Pathway
- Protein Function
- Interacting Protein
- FGF12 Related Research Area
- FGF12 Related Signal Pathway
FGF12 involved in several pathways and played different roles in them. We selected most pathways FGF12 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | IL1R2;FGF8A;FLNC;MAX;MAPK13;ATF4B1;RAP1A;RPS6KA4;TMEM37 |
| Ras signaling pathway | INS;PLA2G2E;TBK1;PIK3R5;GNB2;RASA4;KSR2;FGF19;IKBKG |
| Rap signaling pathway | FGFR1;FGF10;PRKD2;FLT1;PIK3R5;FGF18;MAP2K2;Itgam&Itgb2;PIK3R2 |
| PIK-Akt signaling pathway | PDGFC;FGF6;IFNA2;ITGA2;TNR;EIF4E2;GNB2;NR4A1;PPP2R5D |
| Regulation of actin cytoskeleton | PFN2L;RRAS;SLC9A1;APC;Itga10&Itgb1;DIAP1;MYLPFA;PIK3R1;ITGA2 |
| Pathways in cancer | LAMA1;STK36;FGF18;LAMB4;GNG11;ITGB1;FGF6;MMP1A;BDKRB2 |
| Melanoma | FGF8;PIK3CD;IGF1R;FGF19;Fgf15;CDH1;FGF13;PIK3CA;FGF16 |
FGF12 has several biochemical functions, for example, NOT fibroblast growth factor receptor binding, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF12 itself. We selected most functions FGF12 had, and list some proteins which have the same functions with FGF12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT fibroblast growth factor receptor binding | FGF12;FGF14 |
| growth factor activity | IL10;FGF6A;FGF6;NRG1;MANF;FGF20;NGF;GDNFA;IGF2A |
| heparin binding | SERPIND1;WISP1A;WISP1;CFH;F11;PGF;FN1;PTPRFB;CHRD |
| ion channel binding | PACS2;TCAP;BAK1;FXYD1;DIAP1;USP10;HOMER1;PDE4B;AKAP9 |
| protein binding | NSFL1C;MDFIC;UQCC1;CA1;CRIPAK;ZNF410;PCM1;LGR5;BLOC1S5 |
| sodium channel regulator activity | FXYD1;CAV3;GPLD1;FXYD2;TMPRSS3;SGK3;FXYD3;SCN3B;FGF13 |
FGF12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF12 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF12.
DCTD; COIL; IKZF1; ZNF460; LZTS2; DACH1; SRPK2; SRPK1
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