FGF8 involved in several pathways and played different roles in them. We selected most pathways FGF8 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| MAPK signaling pathway |
CACNA1H; FGF12; PRKACBB; MAP3K5; STK3; C11orf52; FGF11; MAX; PAK2; CACNA1C |
| Ras signaling pathway |
VEGFA; PAK7; CALM1; FGFR1; GNG7; ANGPT2; TBK1; GNGT2; FGFR2; RAB5B |
| Rap signaling pathway |
RAF1; PDGFD; INS2; CALM3; PLCB4; VEGFB; GNAS; RAPGEF5; PLCG1; FGF21 |
| PIK-Akt signaling pathway |
IL2RA; Il6ra; PPP2R1B; IFNA10; FGFR1; VTN; IGF1; FGF22; Gh; NRAS |
| Regulation of actin cytoskeleton |
CFL2L; TMSB4X; ACTN1; RDX; FGF1A; FGF6A; RAF1A; PIKFYVE; ITGA7; FGF18A |
| Pathways in cancer |
GNG11; SMAD3; RALBP1; DAPK2; NRAS; IKBKB; PTGER3; FGF7; BCL2; CXCR4 |
| Melanoma |
FGF11; FGF16; ARAF; MITF; PDGFB; TP53; MAPK1; FGF13; FGFR1; FGF3 |
FGF8 has several biochemical functions, for example, chemoattractant activity, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF8 itself. We selected most functions FGF8 had, and list some proteins which have the same functions with FGF8. You can find most of the proteins on our site.
| Function |
Related Protein |
| chemoattractant activity |
SAA3; BMP4; CCL16; MIF; SCG2; HMGB1; CCL5; HGF; CXCL12B; HMGB2 |
| fibroblast growth factor receptor binding |
FGF2; FGF8B; FGF9; FGF18A; FGF1A; FGF5; FGF1; Fgf15; FGF20A; FGF20 |
| growth factor activity |
IL3; THBS4B; FGF21; COL20A1; BMP6; NDR2; CXCL12; FGF14; INHBAA; FGF18A |
| type 1 fibroblast growth factor receptor binding |
FGF17; FGF8; FGF18; NPTN |
| type 2 fibroblast growth factor receptor binding |
FGF18; FGF8; FGF17; FGF7; FGF10 |
FGF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF8.
FGFR1; FGFR2
Sautter, NB; Delaney, KL; et al. Tissue remodeling gene expression in a murine model of chronic rhinosinusitis. LARYNGOSCOPE 122:711-717(2012).
Sato, A; Scholl, AM; et al. FGF8 signaling is chemotactic for cardiac neural crest cells. DEVELOPMENTAL BIOLOGY 354:18-30(2011).
