• Official Full Name

    fibroblast growth factor 8 (androgen-induced)

  • Background

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
  • Synonyms

    FGF8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8; AIGF; androgen-induced growth factor; heparin-binding growth factor 8; KAL6; FGF-8; HBGF-8; MGC149376;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • GMP Proteins
    • Species :
    • Chicken
    • Horse
    • Human
    • Human/Mouse
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human cells
    • Mammalian Cell
    • Tag :
    • Fc
    • His
    • His(C
    • ter)
    • GST
    • SUMO
    • Met
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken FGF8-1997C Recombinant Chicken FGF8 Mammalian Cell His
    Horse FGF8-3321H Recombinant Horse FGF8 protein, His-tagged E.coli His
    Horse FGF8-934H Recombinant Horse FGF8 Protein, His-tagged E.coli N-His
    Human FGF8-1500H Recombinant Human FGF8 Protein, His-tagged E.coli N-His
    Human FGF8-6234HCL Recombinant Human FGF8 293 Cell Lysate HEK293 N/A
    Human FGF8-3362H Recombinant Human FGF8 protein, His-SUMO-tagged E.coli His-SUMO
    Human FGF8-3363H Recombinant Human FGF8 protein, His-tagged E.coli His
    Human FGF8-12H Recombinant Human FGF8 Protein, Animal Free Human cells
    Human FGF8-348H Active Recombinant Human FGF8, Met-tagged E.coli Met
    Human FGF8-28885TH Recombinant Human FGF8 E.coli N/A
    Human FGF8-789H Recombinant Human FGF8 Protein, His-tagged E.coli His
    Human FGF8-411F Recombinant Human FGF8 Protein (194 aa) E.coli
    Human FGF8-374H Active Recombinant Human Fibroblast Growth Factor 8 (Androgen-induced) HEK293 N/A
    Human FGF8-771H Active Recombinant Human FGF8 Protein E.coli N/A
    Human FGF8-647H Recombinant Human FGF8 Protein (Gln23-Arg215), Met E.coli N/A
    Human FGF8-041H Recombinant Human FGF8 Protein E. coli
    Human FGF8-1418H Recombinant Human FGF8 protein, His-GST-tagged E.coli His/GST
    Human FGF8-01H Active Recombinant Human FGF8 Protein, His-Tagged HEK293 His
    Human FGF8-047HG GMP Recombinant Human FGF8 protein, Fc-tagged HEK293 Fc
    Human FGF8-90H Recombinant Active Human FGF8 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human/Mouse FGF8-91H Recombinant Human/Mouse FGF8 Protein E.coli
    Human/Mouse FGF8-93H Recombinant Human/Mouse FGF8 Protein E.coli
    Human/Mouse FGF8-92H Recombinant Human/Mouse FGF8 Protein E.coli
    Mouse Fgf8-539M Recombinant Mouse Fgf8 protein E.coli N/A
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • FGF8 Related Articles
    • FGF8 Related Signal Pathway

    FGF8 involved in several pathways and played different roles in them. We selected most pathways FGF8 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathwayPLD2;SOS1;EFNA4;KSR2;MAPK9;PLA2G3;PGF;RASA4;PLA2G2A
    Rap signaling pathwayLPAR3;CDH1;PIK3R3;LPAR5;TEK;GNAI2;RAP1B;Itgam&Itgb2;P2RY1
    PIK-Akt signaling pathwayPPP2R5B;FGF4;KLK1B4;GNG2;HSP90AB1;LPAR2;IFNA10;ITGB8;CASP9
    Regulation of actin cytoskeletonITGB2;PDGFAA;MYL5;PPP1R12C;GNA13A;INS1;MSNB;DIAP3;ARHGEF7B
    Pathways in cancerAr;PLCB4;ARNT2;TPM3;PIK3CA;CDC42;WNT16;TCF7;PIK3CG

    FGF8 has several biochemical functions, for example, chemoattractant activity, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF8 itself. We selected most functions FGF8 had, and list some proteins which have the same functions with FGF8. You can find most of the proteins on our site.

    Function Related Protein
    chemoattractant activityBMP4;LGALS3;MIF;CCL16;SCG2;CCL15;CCL3;VEGFC;FIGF
    fibroblast growth factor receptor bindingFGF1;FGF4;FGF22;FGF8A;FGF6B;FGF2;FGF16;FGF20A;FGF8
    growth factor activityCDNF;IL4;FGF7;GMFB;MANF;THPO;GDNF;FGF13A;FGF13
    type 1 fibroblast growth factor receptor bindingFGF17;FGF18;FGF8;NPTN
    type 2 fibroblast growth factor receptor bindingFGF8;FGF17;FGF18;FGF7;FGF10

    FGF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF8.

    FGFR1; FGFR2

    Sautter, NB; Delaney, KL; et al. Tissue remodeling gene expression in a murine model of chronic rhinosinusitis. LARYNGOSCOPE 122:711-717(2012).
    Sato, A; Scholl, AM; et al. FGF8 signaling is chemotactic for cardiac neural crest cells. DEVELOPMENTAL BIOLOGY 354:18-30(2011).
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