|Official Full Name||fibroblast growth factor 8 (androgen-induced)|
|Background||The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.|
|Synonyms||FGF8; fibroblast growth factor 8 (androgen-induced); fibroblast growth factor 8; AIGF; androgen-induced growth factor; heparin-binding growth factor 8; KAL6; FGF-8; HBGF-8; MGC149376|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
FGF8 involved in several pathways and played different roles in them. We selected most pathways FGF8 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|MAPK signaling pathway||FGF18; FGF16; RAC3; NF1; TRAF2; PAK1; CACNA2D3; Casp3; FGF5; GNG12A|
|Ras signaling pathway||RRAS2; GNG7; FGF9; RASAL3; PLA2G2D; CALM4; PLA1A; FGF11; FGFR1; ABL2|
|Rap signaling pathway||FGFR4; FGF7; VEGFA; CDC42; MAP2K1; PRKCG; RHOA; FPR1; FGFR3; ACTB|
|PIK-Akt signaling pathway||ITGB3; IFNAR2; IFNA1; F2R; FGFR1; LPAR4; TP53; TEK; THBS1; AKT1|
|Regulation of actin cytoskeleton||INS; ARPC5L; ACTB2; ITGA3B; FGD3; INS1; CHRM5A; ITGAM; VCLA; PPP1CAB|
|Pathways in cancer||BDKRB2; CCNA1; STK4; MAPK1; CASP9; NOS2; PLCB1; PRKACG; NFKBIA; FOXO1|
|Melanoma||CCND1; PIK3CA; FGF16; RAF1; FGF20; MDM2; FGF18; MITF; PDGFRB; PDGFC|
FGF8 has several biochemical functions, for example, chemoattractant activity, fibroblast growth factor receptor binding, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF8 itself. We selected most functions FGF8 had, and list some proteins which have the same functions with FGF8. You can find most of the proteins on our site.
|chemoattractant activity||MIF; SAA2; FGF8; FGF2; HMGB1; LGALS3; VEGFB; CCL16; FGF10; CCL15|
|fibroblast growth factor receptor binding||FGF8A; FGF20B; FGF10B; FGF20A; FGF6B; Fgf15; FGF18B; FRS3; FGF8B; FGF16|
|growth factor activity||FGF12; FGF9; IL4; GDNF; MDKA; HDGF; OGN; TYMP; IGF1; MSTNB|
|type 1 fibroblast growth factor receptor binding||FGF8; NPTN; FGF18; FGF17|
|type 2 fibroblast growth factor receptor binding||FGF10; FGF7; FGF17; FGF18; FGF8|
FGF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF8.