FGF7

  • Official Full Name

    Fibroblast growth factor 7

  • Overview

    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
  • Synonyms

    FGF7; fibroblast growth factor 7; KGF; HBGF-7; keratinocyte growth factor; OTTHUMP00000162252; heparin-binding growth factor 7; HBGF 7; HBGF7; FGF 7; FGF-7; Heparin binding growth factor 7;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Hordeum Vulgare
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Rice Grain
  • Wheat Germ
  • C
  • His
  • Myc
  • DDK
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|S
  • B2M
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGF7-512H Active Recombinant Human FGF7 HEK293 N/A
Human FGF7-18H Active Recombinant Human FGF7 Protein, Pre-aliquoted E.coli Cys32-Thr194, with an N-terminal Met
Human FGF7-412HG Active GMP Recombinant Human FGF7 protein E.coli N/A
Human FGF7-410H Active Recombinant Human FGF7 Protein Rice Grain N/A
Human FGF7-28647TH Recombinant Human FGF7 protein E.coli N/A 163
Human FGF7-28410TH Recombinant Human FGF7, His-tagged His
Human FGF7-282H Recombinant Human FGF7 protein(Cys32-Thr194), His-tagged E.coli N-His Cys32-Thr194
Human FGF7-5416H Recombinant Human Fibroblast Growth Factor 7 HEK293 N/A
Human FGF7-682H Recombinant Human Fibroblast Growth Factor 7, His-tagged Hordeum Vulgare His
Human FGF7-189H Recombinant Human FGF7 protein, His/S-tagged E.coli His/S
Human FGF7-218H Recombinant Human FGF7, StrepII-tagged Human Cell Strep II 32-194, 163 a.a.
Human FGF7-188H Recombinant Human FGF7 protein E.coli N/A
Human FGF7-594H Active Recombinant Human FGF7 protein, His-tagged HEK293 His Cys 32 - Thr 194
Human FGF7-6236HCL Recombinant Human FGF7 293 Cell Lysate HEK293 N/A
Human FGF7-411HG Active GMP Recombinant Human FGF7 protein, Fc-tagged HEK293 Fc DNA sequence encoding Human KGF(NP_002000.1) was expressed with Fc tag at the C-terminal.
Human FGF7-2913H Recombinant Human FGF7 protein, His-B2M-tagged E.coli His-B2M 34-189aa
Human FGF7-36HG Recombinant Human FGF7 Protein, GMP Grade, Animal-Free E.coli
Human FGF7-14H Recombinant Human FGF-7 Reference standard E.coli N/A
Human FGF7-087H Active Recombinant Human FGF7 Protein E.coli
Human FGF7-15H Human FGF-7 Reference standard E.coli N/A
Human FGF7-142HG GMP Recombinant Human FGF7 protein E.coli N/A 163
Human FGF7-4116H Recombinant Human FGF7 Protein, GST-tagged Wheat Germ GST
Human FGF7-4837HF Recombinant Full Length Human FGF7 Protein, GST-tagged In Vitro Cell Free System GST 97 amino acids
Human FGF7-P013H Recombinant Human FGF7 therapeutic protein E.coli N/A 139aa
Human FGF7-087F Active Recombinant Human FGF7 Protein (164 aa) E.coli 164
Human FGF7-256H Recombinant Human FGF7 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human FGF7-638H Active Recombinant Human FGF7 Protein E.coli Tag Free
Human FGF7-04HG Active Recombinant Human FGF7 Protein (Cys32-Thr194), GMP Grade E.coli Cys32-Thr194
Human FGF7-1498H Recombinant Human FGF7 Protein, His&GST-tagged E.coli N-His&GST Cys32-Thr194
Human FGF7-1461H Active Recombinant Human FGF7 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Cys32-Thr194
Human FGF7-90H Active Recombinant Human FGF7 Protein E.coli
Human FGF7-3019H Recombinant Human FGF7 Protein (Cys32-Thr194), C-His tagged Mammalian cells C-His Cys32-Thr194
Human FGF7-10H Active Recombinant Human FGF7 Protein, Animal Free Human cells
Human FGF7-11H Active Recombinant Human FGF7 protein E.coli N/A 163 aa
Human FGF7-229F Active Recombinant Human FGF7 Protein CHO
Human FGF7-345F Active Recombinant Human FGF7 Protein (164 aa) E.coli 164
Human FGF7-346F Active Recombinant Human FGF7 Protein (181 aa), N-His-tagged E.coli N-His 181
Human FGF7-056H Recombinant Human FGF7 Protein E.coli 194
Human FGF7-057H Recombinant Human FGF7 Protein E.coli 194
Human FGF7-3020H Recombinant Human FGF7 Protein (Thr23-Thr216), C-His tagged Mammalian cells C-His Thr23-Thr216
Mouse Fgf7-597M Active Recombinant Mouse Fgf7 E.coli N/A Cys32-Thr194
Mouse Fgf7-649M Recombinant Mouse Fgf7 protein E.coli N/A 163
Mouse Fgf7-500M Recombinant Mouse Fgf7 protein(Cys32-Thr194), His-tagged E.coli N-His Cys32-Thr194
Mouse FGF7-5856M Recombinant Mouse FGF7 Protein Mammalian Cell His
Mouse Fgf7-190M Recombinant Mouse Fgf7 protein, His/S-tagged E.coli His/S
Mouse FGF7-3238M-B Recombinant Mouse FGF7 Protein Pre-coupled Magnetic Beads HEK293
Mouse FGF7-3238M Recombinant Mouse FGF7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fgf7-344F Active Recombinant Mouse Fgf7 Protein (163 aa) E.coli 163
Mouse Fgf7-2999M Recombinant Mouse Fgf7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Fgf7-372R Active Recombinant Rat Fibroblast Growth Factor 7 E.coli N/A
Rat Fgf7-191R Recombinant Rat Fgf7 protein, His/S-tagged E.coli His/S
Rat FGF7-2335R Recombinant Rat FGF7 Protein Mammalian Cell His
Rat FGF7-1992R-B Recombinant Rat FGF7 Protein Pre-coupled Magnetic Beads HEK293
Rat Fgf7-1499R Recombinant Rat Fgf7 Protein, His&GST-tagged E.coli N-His&GST Cys32-Thr194
Rat FGF7-1992R Recombinant Rat FGF7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FGF7-1701R Recombinant Rhesus monkey FGF7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FGF7-1523R Recombinant Rhesus Macaque FGF7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FGF7-1523R-B Recombinant Rhesus Macaque FGF7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish FGF7-1837Z Recombinant Zebrafish FGF7 Mammalian Cell His
Chicken FGF7-1900C Recombinant Chicken FGF7 Protein, His tagged E.coli N-His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FGF7 Related Signal Pathway

What is FGF7 protein?

FGF7 (fibroblast growth factor 7) gene is a protein coding gene which situated on the long arm of chromosome 15 at locus 15q21. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. The FGF7 protein is consisted of 194 amino acids and its molecular mass is approximately 22.5 kDa.

What is the function of FGF7 protein?

FGF7 protein is involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. It is a growth factor active on keratinocytes. FGF7 is required for normal branching morphogenesis and is a possible major paracrine effector of normal epithelial cell proliferation.

FGF7-7.jpg

Fig1. Schematic drawing of the proposed role of the cholesteatoma-associated fibroblasts (CHO-AFs) in the deregulation of epidermal proliferation and differentiation through a paracrine loop involving secretion of KGF. (Salvatore Raffa, 2012)

FGF7 Related Signaling Pathway

FGF7 is a fibroblast growth factor that is involved in a variety of biological processes, including cell proliferation, differentiation, and embryonic development. FGF7 mainly interacts with its receptor gene FGFR2IIIb to activate several signaling pathways, including the following major signaling pathways: MAPK/ERK signaling pathway, PI3K/AKT signaling pathway, JAK-STAT signaling pathway, etc.

FGF7 Related Diseases

Diseases associated with FGF7 include mucositis, short bowel syndrome, acanthoma and apert syndrome. FGF7 is also associated with the occurrence and development of pulmonary fibrosis and kidney disease. It is also involved in the proliferation and recovery of hepatocytes and gastrointestinal epithelial cells.

Bioapplications of FGF7

FGF7 can be used as a therapeutic protein to stimulate epithelial cell proliferation and repair. For some diseases, such as burns, spherical corneas, etc., exogenous applications of FGF7 have been shown to promote tissue repair and regeneration. At the same time, it can be used as a marker of some diseases to assist disease diagnosis; In the field of scientific research, FGF7 can be used as a signaling molecule to build animal disease models.

High Purity

.

FGF7-2.jpg

Fig2. Activity Data. (FGF7-18H)

Case Study 1: Shuyu Liu, 2023

FGF7-3.jpg

Fig1. Representative images of EdU-positive cells in day 10 organoids (top). SOX9 expression (middle, confocal images; bottom, Arivis Vision4D-reconstructed light sheet images).

Case Study 2: Salvador Pérez-Mora, 2023

FGF7-4.jpg

Fig2. Immunodetection of the EGF, FGF7, PCNA, and β-catenin proteins in histological sections.

FGF7-6.jpg

Fig2. Fibroblast growth factor receptor 2 (FGFR2) mutation-mediated activation of a disintegrin and metalloprotease 17 (ADAM17) promotes endometrial cancer (EC) progression via dual engagement of epidermal growth factor receptor (EGFR) and Notch signalling pathways. (Garima Dixit, 2023)

FGF7 involved in several pathways and played different roles in them. We selected most pathways FGF7 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMAPK3;MAP2K6;TGFBR2;PPM1AA;FGF11;MAP3K14;PRKACBB;TGFBR1B;MAPK1
Ras signaling pathwayGNG10;GAB1;RAB5B;ETS1;PRKACA;PDGFA;GNG13;PAK3;PLA1A
Rap signaling pathwayRASGRP3;SRC;CALM2;PLCE1;FGF3;MLLT4;FARP2;KLK1B4;FLT1
PIK-Akt signaling pathwayGNG13;PPP2R3C;FGF7;PTEN;TCL1A;RAC1;ANGPT2;IGF1R;GNB1
Regulation of actin cytoskeletonBRK1;MYLK4;PIP5K2;FGF17;PPP1R12C;ITGB7;FGD1;PIK3CD;PIKFYVE
Pathways in cancerLAMA4;ERBB2;TRAF3;MAPK9;MAPK8;FGF9;VEGFA;GLI1;BIRC7
MelanomaRB1;FGF3;FGF6;PIK3R2;PDGFA;FGF18;PIK3CG;PIK3R3;PTEN

FGF7 has several biochemical functions, for example, chemoattractant activity, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF7 itself. We selected most functions FGF7 had, and list some proteins which have the same functions with FGF7. You can find most of the proteins on our site.

Function Related Protein
chemoattractant activityNTF3;SAA1;SAA2;HMGB1;LGALS3;VEGFA;VEGFB;FGF10;FGF8
growth factor activityMDK;BMP15;REG1A;FGF18B;CSPG5;NRTN;FGF20;IL5;CD320
heparin bindingPTN;PCOLCE2;CECR1;Epy;CXCL11;SLIT3;AZU1;CCL15;FSTL1
protein bindingPPIL2;KCTD9;DDX55;PTPRR;AKT1;RPS6KA5;SILV;MRPL9;SEC31A
type 2 fibroblast growth factor receptor bindingFGF18;FGF8;FGF17;FGF7;FGF10

FGF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF7.

FGFR2; UBQLN1; FGF1; DESI1

Research Area

Related articles

Sheen, YS; Fan, SMY; et al. Visible Red Light Enhances Physiological Anagen Entry In Vivo and has Direct and Indirect Stimulative Effects In Vitro. LASERS IN SURGERY AND MEDICINE 47:50-59(2015).
Kook, SH; Jeon, YM; et al. Periodontal Fibroblasts Modulate Proliferation and Osteogenic Differentiation of Embryonic Stem Cells Through Production of Fibroblast Growth Factors. JOURNAL OF PERIODONTOLOGY 85:645-654(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
03/21/2022

    I highly recommend the FGF7 Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

    05/01/2021

      The FGF7 Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.

      10/01/2017

        What truly distinguishes the FGF7 Protein is the unparalleled technical support provided by the manufacturer.

        Q&As (5)

        Ask a question
        How does FGF7 aid in tissue repair? 11/12/2022

        FGF7 stimulates the proliferation and migration of epithelial cells, which are crucial for repairing damaged tissues.

        Are there any side effects associated with FGF7 treatment? 05/09/2019

        Side effects are generally mild, such as local irritation at the site of application, but comprehensive studies are ongoing.

        Can FGF7 be used in regenerative medicine? 06/16/2018

        Yes, FGF7 is being explored for its potential in regenerating tissues and promoting healing in various medical fields.

        How is FGF7 administered in clinical settings? 08/01/2017

        FGF7 can be administered topically or via injection, depending on the specific condition being treated.

        Is FGF7 used in dermatology? 02/13/2016

        Yes, FGF7 has been investigated for its potential in treating skin disorders, including conditions like psoriasis and atopic dermatitis.

        Ask a Question for All FGF7 Products

        Required fields are marked with *

        My Review for All FGF7 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends