FGF7
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Official Full Name
Fibroblast growth factor 7
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Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. -
Synonyms
FGF7; fibroblast growth factor 7; KGF; HBGF-7; keratinocyte growth factor; OTTHUMP00000162252; heparin-binding growth factor 7; HBGF 7; HBGF7; FGF 7; FGF-7; Heparin binding growth factor 7;
- Involved Pathway
- Protein Function
- Interacting Protein
- FGF7 Related Articles
- FGF7 Related Research Area
- FGF7 Related Signal Pathway
FGF7 involved in several pathways and played different roles in them. We selected most pathways FGF7 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | JUND;TAOK3;FGF8;PPP3CCB;CACNB1;Casp3;NGF;PDGFAB;MAPK7 |
| Ras signaling pathway | GNG2;FGF22;RELA;STK4;FGF8;GRIN1;GNB3;RALGDS;FASLG |
| Rap signaling pathway | PIK3CG;FGF12;INS;PRKD1;CALM1;KRAS;CALML5;CALM3;FGF20 |
| PIK-Akt signaling pathway | MET;MTOR;PPP2R5E;RPS6KB1;LPAR3;FGF20;PPP2R5C;ITGA8;IFNB1 |
| Regulation of actin cytoskeleton | FGFR4;PDGFB;NRAS;FGF10A;RAC3;ACTN3B;CDC42L2;ARHGEF7;ARHGEF7B |
| Pathways in cancer | MECOM;BRAF;FZD5;Ar;CCDC6;GNA11;TGFB3;PDGFA;HIF1A |
| Melanoma | FGF5;PIK3CG;PIK3CB;FGF9;FGF6;MAPK1;BRAF;NRAS;FGF3 |
FGF7 has several biochemical functions, for example, chemoattractant activity, growth factor activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGF7 itself. We selected most functions FGF7 had, and list some proteins which have the same functions with FGF7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemoattractant activity | BMP4;SAA2;FGF7;CCL16;HMGB1;LGALS3;HMGB2;SAA3;FGF2 |
| growth factor activity | NODAL;FGF17;RABEP2;CECR1A;FGF13;BMP7B;PDGFB;BMP1;EGF |
| heparin binding | PRELP;CTGFB;RSPO2;CFH;THBS3;PF4V1;Itgam&Itgb2;TGFBR3;RSPO4 |
| protein binding | TRAF3;KIAA0146;TAP1;ARHGAP9;MAP3K11;PYGB;HOXA9;NPHP3;N6AMT1 |
| type 2 fibroblast growth factor receptor binding | FGF18;FGF7;FGF8;FGF10;FGF17 |
FGF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGF7.
FGFR2; UBQLN1; FGF1; DESI1
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