Metabolism Assays

Metabolism is the set of life-sustaining chemical transformations within the cells. Metabolism reactions allow living cells to grow and reproduce, maintain their structures, and respond to their sress. Metabolism is also refered to nutrition and the availability of nutrients. Bioenergetics describe the metabolic pathways by which the cell ultimately obtains energy. Metabolism reaction is very important to both humans and animals.

In Vitro Assays

• Cytochrome P450 inhibition
• Metabolic stability (microsomes, hepatocytes)
• Metabolite profiling and identification
• Multiple species cross-comparisons
• CYP450 reaction phenotyping
• Metabolic drug-drug interactions
• Protein binding (HTS fluorescence HSA, AGP binding), equilibrium
• HERG channel inhibition
• Aqueous solubility

Fatty Acids Related Assays

• Straightforward procedure
• Easy to perform, just add-mix-read
• Sensitive, accurate, and reliable
• WIDE assay range
• Easy to calculate results
• Fluorometric and/or colorimetric detection
• Suitable for high-throughput assays

Cholesterol/Cholesteryl Ester Quantification

• Straightforward procedure
• Easy to perform, just add-mix-read
• Sensitive, accurate, and reliable
• WIDE assay range
• Easy to calculate results
• Fluorometric and/or colorimetric detection
• Suitable for high-throughput assays