High-Throughput Screening

Creative BioMart offers a unique combination of target class and cell biology expertise to provide services tailored to your requirements. Our platforms offer high-throughput screening and high-content profiling using standard cell models, human primary cells or disease-related cell lines.

Based on experience in cell line generation, the development of the most physiological assay system, the application to high-throughput screening (HTS) technologies and the screening of our library of 850,000 synthetic compounds, we have delivered validated hit compounds from more than 20 HTS campaigns per year.

Our extensive experience in high-throughput screening, in-house image analysis algorithm design and disease biology allows us to make the right selection of cell type and assay parameters before initiating high content screening. Our expertise in assay development, image analysis and screening includes:

Advantages:

• Anchorage independence (in 3D)
• Apoptosis and cell death
• Autophagy and protein aggregation
• Cell motility and migration
• Cytoskeletal rearrangements
• Epigenetic modifications
• Live imaging (e.g., Ca flux)
• Marker expression
• Neurite outgrowth
• Receptor internalization and degradation
• Sub-cellular localization
• Translocation of transcription factors
• Viral replication

Creative BioMart is also able to provide compound screening services for client libraries with a capacity of up to 1 million compounds in single compound format or up to 3 million in compressed formats, with capacity to store a copy of your library for multiple screening campaigns. For details, please contact us.