Ion Channel Screening Assays

Ion channels regulate a wide range of physiological processes including rapid electrical signaling, fluid, hormone and transmitter secretion, and proliferation. They are, therefore, considered common targets for both toxins and therapeutics. Ion channels are not only important drug targets, but are also generally relevant for drug safety. Recent developed technologies and instrumentation have provided new opportunities for ion channel screening that enables higher throughput, extended information content, and access to novel ion channel targets. The assay results can then be used to predict compound effects in cells and tissues.

Creative BioMart provides a wide range of ion channel assays to quickly and accurately provide results for drug discovery and development. Our assays are established based on globally recognized standards.

• Ion Channel Binding Assay
• Ion Channel Profiling
• Cardiac Safety Assay
• Custom Cell Line Development

Creative BioMart offers a variety of solutions ranging from conventional manual electrophysiology to high throughput screening services. Screening conditions are highly customizable including:

• Perfusion Time
• Temperature
• Number of Concentrations

Our ion channel portfolio includes over a hundred channels, which have been organized into several panels based on current scientific findings. We provide functional, manual and automated ion channel screening for profiling and risk assessment.

Available Channel Panels	Target Experience	Assay Types & Technologies
Cancer Cardiac Cardiovascular Genitourinary Metabolic/Gastrointestinal Neurodegeneration/Stroke Pain/Inflammation Psychiatric Disorder Pulmonary/Respiratory Seizure/Convulsion	Sodium channels Potassium channels Calcium channels Chloride channels Voltage-gated channels Ligand-gated channels	Ion flux assay Fluorescence-based assay Automated electrophysiology Manual electrophysiology High throughput screening
Advantages	High throughput Fast turnaround time Highly customizable Over 10 years of experience

Creative BioMart has extensive experience in ion channel assays. Creative BioMart experts offer a range of electrophysiology solutions to meet your specific requirements including activation, inactivation and 2-pulse protocols. Please contact us for details.

Reference:

1. Dragicevic E, Schiemann J, Liss B. Dopamine midbrain neurons in health and Parkinson's disease: emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience. 284: 798-814. PMID 25450964 DOI: 10.1016/j.neuroscience.2014.10.037