SARS-CoV-2 Proteins and Their Target Proteins

Featured Interaction Proteins

CAT.NO. Sequence PRODUCT NAME IDENTITY SPECIES SOURCE
AXL-535H Ala26-Pro440 Recombinant Human AXL protein, His-tagged (Active) AXL-His Human HEK293
AXL-536H Ala26-Pro440 Recombinant Human AXL protein, Fc-tagged AXL-Fc Human HEK293
AXL-770H Ala26-Pro449 Recombinant Human AXL protein, His-tagged AXL-His Human HEK293
AXL-585H Ala26-Pro449 Recombinant Human AXL protein, His-Avi-tagged AXL-His-Avi Human HEK293
AXL-584HB Ala26-Pro449 Recombinant Human AXL protein, His-Avi-tagged, Biotinylated AXL-His-Avi-Biotin Human HEK293
AXL-249H 473-end Recombinant Human AXL Receptor Tyrosine Kinase, His-tagged, Active AXL-His Human Sf 9 Insect cells
AXL-36H 464-885(end) Recombinant Human AXL protein, Flag-tagged, Biotinylated AXL-Flag Human Insect cells
Cat.No.  Product Name Identity Species Source
ACE2-736H Recombinant Human ACE2, His-tagged ACE2-His Human HEK293
ACE2-68H Recombinant Human ACE2, Fc-tagged ACE2-hFc Human HEK293
ACE2-185H Recombinant Human ACE2, mouse IgG1 Fc-tagged ACE2-mFc Human HEK293
TMPRSS2-1856H Recombinant Human TMPRSS2 Protein (106-492 aa), His-tagged TMPRSS2-His Human Yeast
TMPRSS2-4899H Recombinant Human TMPRSS2, his-tagged TMPRSS2-His Human HEK293
ACE2-229H Recombinant Human ACE2 protein, His/Avi-tagged ACE2-His/Avi Human Mammalian cells

Druggable Targets

Coronavirus Proteins

Cat.No.  Product name Identity Species Source
Spike-19V Recombinant COVID-19 (2019 novel coronavirus) Spike protein S1 subunit receptor binding domain (RBD), Mouse IgG1 Fc-tagged S1(RBD)-mFc SARS-CoV-2 HEK293
Spike-190V Recombinant COVID-19 Spike protein receptor binding domain (RBD), His-tagged S1(RBD)-His SARS-CoV-2 HEK293
Spike-191V Recombinant COVID-19 (2019 novel coronavirus) Spike protein S1 subunit, His-tagged S1-His SARS-CoV-2 HEK293
Spike-192V 2019-nCoV Recombinant COVID-19 Spike protein S1 subunit, Human IgG1 Fc-tagged S1-hFc SARS-CoV-2 HEK293
Spike-193V Recombinant COVID-19 (2019 novel coronavirus) Spike protein S1 subunit, Mouse IgG1 Fc-tagged S1-mFc SARS-CoV-2 HEK293
Spike-194V Recombinant COVID-19 (2019 novel coronavirus) Spike protein (S1+S2 ECD), His-tagged S1+S2(ECD)-His SARS-CoV-2 Baculovirus-Insect Cells
Spike-195V 2019-nCoV Recombinant COVID-19 Spike protein S1 subunit, His-tagged S1-His SARS-CoV-2 Baculovirus-Insect Cells
Spike-197V Recombinant COVID-19 Spike protein (S2 ECD), His-tagged S2(ECD)-His SARS-CoV-2 Baculovirus-Insect Cells
Spike-208V Recombinant COVID-19 Spike trimer protein (R683A, R685A), his-tagged, active S1+S2(ECD)-His SARS-CoV-2 HEK293
N-127V Recombinant COVID-19 (2019 novel coronavirus) N protein N-His SARS-CoV-2 E.coli
N-196V Recombinant COVID-19 Nucleocapsid protein, His-tagged N-His SARS-CoV-2 Baculovirus-Insect Cells
nCoVNP-126V Recombinant COVID-19 NP protein, His-tagged N-His SARS-CoV-2 HEK293
Plpro-198V Recombinant COVID-19 Plpro protein, His-tagged Plpro-His SARS-CoV-2 E.coli
3CL-Mpro-134V Recombinant COVID-19 3CL-Mpro protein, His-tagged 3CL-Mpro-His SARS-CoV-2 E.coli
Spike-193V Recombinant COVID-19 (2019 novel coronavirus) Spike protein S1 subunit, Mouse IgG1 Fc-tagged S1-mFc SARS-CoV-2 Human Cells
Spike-199V Recombinant 2019-nCoV (2019 novel coronavirus) Spike protein RBD, His/Avi-tagged S1(RBD)-His/Avi 2019-nCoV Mammalian cells
Spike-200V Recombinant 2019-nCoV (2019 novel coronavirus) Spike protein S1, His/Avi-tagged S1-His/Avi 2019-nCoV Mammalian cells
Spike-201V Recombinant SARS-CoV-2 Spike Glycoprotein (S1) protein, Fc-tagged S1-Fc SARS-CoV-2 HEK293
Spike-202V Recombinant SARS-CoV-2 Spike Glycoprotein (S2) protein, Fc-tagged S2-Fc SARS-CoV-2 HEK293
Spike-203V Recombinant SARS Coronavirus Spike Glycoprotein Mosaic (S1) protein S1 SARS-CoV E.coli
Spike-204V Recombinant SARS Coronavirus Spike Glycoprotein Mosaic (S2) protein S2 SARS-CoV E.coli
Spike-205V Recombinant SARS Coronavirus Spike Glycoprotein Mosaic (S2, S2') protein S2,S2' SARS-CoV E.coli
Spike-206V Recombinant MERS Coronavirus Spike 1 protein (S1), Fc-tagged S1-Fc MERS-CoV HEK293
Spike-207V Recombinant MERS Coronavirus Spike 1 protein (S1), His-tagged S1-His MERS-CoV E.coli
N-129V Recombinant SARS-CoV-2 Nucleocapsid phosphoprotein, His-tagged N-His SARS-CoV-2 E.coli
N-130V Recombinant SARS Coronavirus Nucleoprotein, His-tagged N-His SARS-CoV HEK293
N-131V Recombinant SARS Coronavirus Nucleoprotein, His-tagged N-His SARS-CoV E.coli
N-132V Recombinant SARS Coronavirus Nucleoprotein (C-Term) or the nucleocapsid core antigen N SARS-CoV E.coli
N-133V Recombinant SARS Coronavirus Nucleoprotein (N-Term) or the nucleocapsid core antigen N SARS-CoV E.coli
N-134V Recombinant SARS Coronavirus Nucleoprotein (N-Term, Mid) or the nucleocapsid core antigen N SARS-CoV E.coli
N-135V Recombinant Human-CoV(229E) Nucleoprotein, His-tagged N-His Human-CoV E.coli
N-136V Recombinant Human-CoV(NL63) Nucleoprotein, His-tagged N-His Human-CoV E.coli
N01-128V Recombinant COVID-19 N protein truncated N01, His-tagged N01-His SARS-CoV-2 E.coli
N02-129V Recombinant COVID-19 N protein truncated N02, His-tagged N02-His SARS-CoV-2 E.coli
N03-130V Recombinant COVID-19 N protein truncated N03, His-tagged N03-His SARS-CoV-2 E.coli
N04-131V Recombinant COVID-19 N protein truncated N04, His-tagged N04-His SARS-CoV-2 E.coli
N05-132V Recombinant COVID-19 N protein truncated N05, His-tagged N05-His SARS-CoV-2 E.coli
N06-133V Recombinant COVID-19 N protein truncated N06, His-tagged N06-His SARS-CoV-2 E.coli
Envelope-301V Recombinant SARS Coronavirus Envelope protein E SARS-CoV E.coli
Matrix-201V Recombinant SARS Coronavirus Matrix (Membrane) protein Matrix SARS-CoV E.coli
NSP1-001V Recombinant COVID-19 NSP1 protein, His-tagged NSP1-His SARS-CoV-2 HEK293
NSP2-191V Recombinant COVID-19 NSP2 protein, His-tagged NSP2-His SARS-CoV-2 HEK293
NSP3-81V Recombinant COVID-19 NSP3 protein, His-tagged NSP3-His SARS-CoV-2 HEK293
NSP4-82V Recombinant COVID-19 NSP4 protein, His-tagged NSP4-His SARS-CoV-2 HEK293
NSP5-11V Recombinant COVID-19 NSP5 protein, His-tagged NSP5-His SARS-CoV-2 HEK293
NSP6-193V Recombinant COVID-19 NSP6 protein, His-tagged NSP6-His SARS-CoV-2 HEK293
NSP7-194V Recombinant COVID-19 NSP7 protein, His-tagged NSP7-His SARS-CoV-2 HEK293
NSP8-196V Recombinant COVID-19 NSP8 protein, His-tagged NSP8-His SARS-CoV-2 HEK293
NSP9-027V Recombinant COVID-19 NSP9 protein, His-tagged NSP9-His SARS-CoV-2 HEK293
NSP10-151V Recombinant COVID-19 NSP10 protein, His-tagged NSP10-His SARS-CoV-2 HEK293
NSP12-662V Recombinant COVID-19 NSP12 protein, His-tagged NSP11-His SARS-CoV-2 HEK293
NSP13-22V Recombinant COVID-19 NSP13 protein, His-tagged NSP12-His SARS-CoV-2 HEK293
NSP14-286V Recombinant COVID-19 NSP14 protein, His-tagged NSP13-His SARS-CoV-2 HEK293
NSP15-592V Recombinant COVID-19 NSP15 protein, His-tagged NSP14-His SARS-CoV-2 HEK293
NSP16-922V Recombinant COVID-19 NSP16 protein, His-tagged NSP15-His SARS-CoV-2 HEK293
ORF3a-2833V Recombinant COVID-19 ORF3a protein, His-tagged ORF3a-His SARS-CoV-2 HEK293
ORF6-847V Recombinant COVID-19 ORF6 protein, His-tagged ORF6-His SARS-CoV-2 HEK293
ORF7a-92V Recombinant COVID-19 ORF7a protein, His-tagged ORF7a-His SARS-CoV-2 HEK293
ORF8-528V Recombinant COVID-19 ORF8 protein, His-tagged ORF8-His SARS-CoV-2 HEK293
ORF10-81V Recombinant COVID-19 ORF10 protein, His-tagged ORF10-His SARS-CoV-2 HEK293
SARSS-101V Recombinant SARS-CoV(Beijing 02) S(ΔTM) protein  S(ΔTM) SARS-CoV HEK293
SARSS-102V Recombinant SARS-CoV(Beijing 02) S(1-1190) protein S(1-1190) SARS-CoV HEK293
SARSS-103V Recombinant SARS-CoV(Beijing 02) S(RBD) protein S(RBD) SARS-CoV HEK293
SARSN-104V Recombinant SARS-CoV(Beijing 02) N protein N SARS-CoV E.coli
SARSM-105V Recombinant SARS-CoV(Beijing 02) M protein M SARS-CoV E.coli
MERSS-106V Recombinant MERS-CoV(EMC 2C/2012) S(ΔTM) protein  S(ΔTM) MERS-CoV HEK293
MERSS-107V Recombinant MERS-CoV(EMC 2C/2012) S(1-1190) protein S(1-1190) MERS-CoV HEK293
MERSS-108V Recombinant MERS-CoV(EMC 2C/2012) S(RBD) protein S(RBD) MERS-CoV HEK293
MERSN-109V Recombinant MERS-CoV(EMC 2C/2012) N protein N MERS-CoV E.coli
MERSM-110V Recombinant MERS-CoV(EMC 2C/2012) M protein M MERS-CoV E.coli
hCoVS-111V Recombinant Human-CoV(229E) S(ΔTM) protein  S(ΔTM) Human-CoV HEK293
hCoVS-112V Recombinant Human-CoV(229E) S(1-1190) protein S(1-1190) Human-CoV HEK293
hCoVS-113V Recombinant Human-CoV(229E) S(RBD) protein S(RBD) Human-CoV HEK293
bCoVS1-116V Recombinant Bat-CoV(HKU4-2) S1 protein S1 Bat-CoV HEK293
bSARSlS-118V Recombinant Bat SARS-like coronavirus/WIV1 S(1-1190) protein S(1-1190) Bat SARS-like-CoV HEK293
bSARSlS-119V Recombinant Bat SARS-like coronavirus/WIV1 S(RBD) protein S(RBD) Bat SARS-like-CoV HEK293
bSARSlS-120V Recombinant Bat SARS-like coronavirus/HKU3-1 S(1-1190) protein S(1-1190) Bat SARS-like-CoV HEK293
bSARSlS-121V Recombinant Bat SARS-like coronavirus/HKU3-1 S(RBD) protein S(RBD) Bat SARS-like-CoV HEK293
Cat.No. Product Name Source Tag
Spike-701V Recombinant COVID-19 Spike RBD protein(BA.2.74/Omicron), His-tagged HEK293 His
Spike-702V Recombinant COVID-19 Spike Trimer protein(BA.2.74/Omicron), His-tagged HEK293 His
Spike-703V Recombinant COVID-19 Spike RBD protein(BA.2.75/Omicron), His-tagged HEK293 His
Spike-704V Recombinant COVID-19 Spike Trimer protein(BA.2.75/Omicron), His-tagged HEK293 His
Spike-705V Recombinant COVID-19 Spike NTD protein(BA.2.75/Omicron), His-tagged HEK293 His
Spike-706V Recombinant COVID-19 Spike RBD protein(BA.2.76/Omicron), His-tagged HEK293 His
Spike-707V Recombinant COVID-19 Spike Trimer protein(BA.2.76/Omicron), His-tagged HEK293 His
N-708V Recombinant COVID-19 N protein(BA.4/Omicron), His-tagged HEK293 His
Spike-709V Recombinant COVID-19 Spike RBD protein(BA.4&BA.5/Omicron), His-Avi-tagged, Biotinylated HEK293 His-Avi
Spike-710V Recombinant COVID-19 Spike RBD protein(BA.4&BA.5/Omicron), His-tagged HEK293 His
Spike-711V Recombinant COVID-19 Spike S1 protein(BA.4&BA.5/Omicron), His-tagged HEK293 His
Spike-712V Recombinant COVID-19 Spike Trimer protein(BA.4/Omicron), His-tagged HEK293 His
Spike-713V Recombinant COVID-19 Spike Trimer protein(BA.4/Omicron), His-Avi-tagged, Biotinylated HEK293 His-Avi
N-714V Recombinant COVID-19 N protein(BA.5/Omicron), His-tagged HEK293 His
Spike-715V Recombinant COVID-19 Spike Trimer protein(BA.5/Omicron), His-Avi-tagged, Biotinylated HEK293 His-Avi
Spike-716V Recombinant COVID-19 Spike Trimer protein(BA.5/Omicron), His-tagged HEK293 His
Spike-717V Recombinant COVID-19 Spike RBD protein(BA.2.38/Omicron), His-tagged HEK293 His
Spike-718V Recombinant COVID-19 Spike Trimer protein(BA.2.38/Omicron), His-tagged HEK293 His
Cat.No. Product Name Source Tag
Spike-678V Recombinant COVID-19 Omicron RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H) protein, His-tagged HEK293 His
Spike-679V Recombinant COVID-19 Omicron RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H) protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Spike-680V Recombinant COVID-19 Omicron S-ECD protein, His-tagged HEK293 His
Spike-681V Recombinant COVID-19 Omicron S-ECD protein, His-tagged Insect cell His
Spike-682V Recombinant COVID-19 Omicron S-ECD protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Spike-685V Recombinant COVID-19 Omicron S1(A67V, Δ69-70, T95I, G142D/Δ143-145, Δ211/L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H) protein, His-tagged HEK293 His
N-686V Recombinant COVID-19 Omicron N(P13L, E31del, R32del, S33del, R203K, G204R) protein, His-tagged E.coli His
Spike-687V Recombinant COVID-19 Omicron RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H) protein, His-tagged HEK293 His
Spike-688V Recombinant COVID-19 Omicron RBD(G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493K, G496S, Q498R, N501Y, Y505H) protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
N-689V Recombinant COVID-19 Omicron N(P13L, E31del, R32del, S33del, R203K, G204R) protein, His-tagged HEK293 His
Cat.No. Product Name Source Tag
N-426S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(R203K, G204R) Protein, His-tagged E.coli His
N-427S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid (E378Q) Protein, His-tagged E.coli His
N-428S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(I292T) Protein, His-tagged E.coli His
N-429S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(D3L, R203K, G204R, S235F) Protein, His-tagged E.coli His
N-430S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(D3L, S235F) Protein, His-tagged E.coli His
N-441S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(S194L) Protein, His-tagged E.coli His
S-431S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) Protein, His-tagged Insect Cell His
S-432S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H) Protein, His-tagged HEK293 His
S-433S Recombinant SARS-CoV-2 Spike S1 ((HV69-70, Y145)deletion, N501Y, A570D, D614G, P681H) Protein, His/AVI-tagged, Biotinylated HEK293 His/AVI
S-434S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H) Protein, His-tagged, Biotinylated HEK293 His
S-435S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(HV69-70 deletion, N501Y, D614G) Protein, His-tagged HEK293 His
S-436S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(S494P) Protein, His-tagged HEK293 His
S-437S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N501Y) Protein, His-tagged HEK293 His
S-438S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N501Y) Protein, His-tagged, Biotinylated HEK293 His
S-439S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (N501Y) Protein, rFc-tagged HEK293 rFc
S-440S Recombinant SARS-CoV-2 Spike RBD (N501Y) Protein, His/AVI-tagged, Biotinylated HEK293 His/AVI
Cat.No. Product Name Source Tag
N-444S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid (T205I) Protein, His-tagged E.coli His
S-443S Recombinant SARS-CoV-2 Spike RBD (K417N, E484K, N501Y) Protein, Fc-tagged HEK293 Fc
S-445S Recombinant SARS-CoV-2 Spike S1+S2 ECD (D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged Insect Cell His
S-446S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged Insect Cell His
S-447S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1+S2 (L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged, Biotinylated Insect Cell His
S-448S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (D80A, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged Insect Cell His
S-449S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(K417N, E484K, N501Y, D614G) Protein, His-tagged HEK293 His
S-450S Recombinant SARS-CoV-2 Spike S1 (K417N, E484K, N501Y, D614G) Protein, His-tagged HEK293 His
S-451S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1 NTD (L18F, D80A, D215G, LAL242-244 deletion, R246I) Protein, His-tagged HEK293 His
S-452S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1 (L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G) Protein, His-tagged HEK293 His
S-453S Recombinant SARS-CoV-2 Spike S1 ((LAL242-244)deletion, L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G) Protein, His/AVI-tagged, Biotinylated HEK293 His/AVI
S-454S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K417N) Protein, His-tagged HEK293 His
S-455S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K417N) Protein, His-tagged, Biotinylated HEK293 His
S-456S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(E484K) Protein, His-tagged HEK293 His
S-457S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(E484K) Protein, His-tagged, Biotinylated HEK293 His
S-458S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K417N, E484K, N501Y) Protein, His-tagged HEK293 His
S-459S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K417N, E484K, N501Y) Protein, His-tagged, Biotinylated HEK293 His
S-460S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (E484K) Protein, rFc-tagged HEK293 rFc
S-461S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (K417N, E484K, N501Y) Protein, rFc-tagged HEK293 rFc
S-462S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (K417N) Protein, rFc-tagged HEK293 rFc
S-463S Recombinant SARS-CoV-2 Spike RBD (K417T, E484K, N501Y) Protein, Fc-tagged HEK293 Fc
Cat.No. Product Name Source Tag
N-588S Recombinant SARS-CoV-2 Nucleocapsid (S202N) Protein, His-tagged E.coli His
Cat.No. Product Name Source Tag
N-479S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(P13L) Protein, His-tagged E.coli His
Cat.No. Product Name Source Tag
S-425S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (N501Y) Protein, Fc-tagged HEK293 Fc
Cat.No. Product Name Source Tag
N-587S Recombinant SARS-CoV-2 Nucleocapsid (P67S, P199L) Protein, His-tagged E.coli His
Cat.No. Product Name Source Tag
N-408S Recombinant SARS-CoV-2 Nucleocapsid (P67S, R203M, D377Y) Protein, His-tagged E.coli His
Cat.No. Product Name Source Tag
N-584S Recombinant SARS-CoV-2 Nucleocapsid (P199L, M234I) Protein, His-tagged E.coli His
Cat.No. Product Name Source Tag
N-424S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid (T205I) Protein, His-tagged E.coli His
N-442S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(P13L) Protein, His-tagged E.coli His
N-477S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(R203K, G204R) Protein, His-tagged E.coli His
N-478S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid (P80R) Protein, His-tagged E.coli His
N-480S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(S194L) Protein, His-tagged E.coli His
N-481S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid(I292T) Protein, His-tagged E.coli His
N-482S Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid (T205I) Protein, His-tagged E.coli His
N-580S Recombinant SARS-CoV-2 Nucleocapsid (P199L) Protein, His-tagged E.coli His
N-581S Recombinant SARS-CoV-2 Nucleocapsid (A220V) Protein, His-tagged E.coli His
N-582S Recombinant SARS-CoV-2 Nucleocapsid (P67S) Protein, His-tagged E.coli His
N-583S Recombinant SARS-CoV-2 Nucleocapsid (M234L) Protein, His-tagged E.coli His
S-401S Recombinant SARS-CoV-2 Spike RBD (L452R, E484Q) Protein, Fc-tagged HEK293 Fc
S-402S Recombinant SARS-CoV-2 Spike RBD (L452R, E484Q) Protein, His/AVI-tagged, Biotinylated HEK293 His/AVI
S-409S Recombinant SARS-CoV-2 Spike S1+S2 ECD (E154K, L452R, E484Q, D614G, P681R, E1072K, K1073R) Protein, His-tagged Insect Cell His
S-410S Recombinant SARS-CoV-2 Spike S1 (E154K, L452R, E484Q, D614G, P681R) Protein, His-tagged HEK293 His
S-412S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(L452R) Protein, His-tagged HEK293 His
S-413S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(E484Q) Protein, His-tagged HEK293 His
S-414S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (L452R, E484Q) Protein, His-tagged HEK293 His
S-484S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (D614G) Protein, His-tagged Insect Cell His
S-485S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1+S2 ECD (HV69-70 deletion, D614G, D796H) Protein, His-tagged Insect Cell His
S-486S Recombinant SARS-CoV-2 (2019-nCoV) Spike S2 (E780Q) Protein, Fc-tagged HEK293 Fc
S-487S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(D614G), Fc-tagged HEK293 Fc
S-488S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(N234Q) Protein, His-tagged HEK293 His
S-491S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(D614G) Protein, His-tagged, HPLC-verified HEK293 His
S-492S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(A222V, D614G) Protein, His-tagged HEK293 His
S-493S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(L18F, D614G) Protein, His-tagged HEK293 His
S-494S Recombinant SARS-CoV-2 (2019-nCoV) Spike S1(HV69-70 deletion, N439K, D614G) Protein, His-tagged HEK293 His
S-495S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (V367F) Protein, mFcs-tagged HEK293 mFc
S-496S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (V367F) Protein, His-tagged HEK293 His
S-497S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(R408I) Protein, His-tagged HEK293 His
S-498S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(V341I) Protein, His-tagged HEK293 His
S-499S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(Y508H) Protein, His-tagged HEK293 His
S-500S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N439K) Protein, His-tagged HEK293 His
S-501S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(V503F) Protein, His-tagged HEK293 His
S-502S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A522V) Protein, His-tagged HEK293 His
S-503S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A372S) Protein, His-tagged HEK293 His
S-504S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (N354D) Protein, His-tagged HEK293 His
S-505S Recombinant SARS-CoV-2 Spike RBD (N354D) Protein, His-tagged, Biotinylated HEK293 His
S-506S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A520S) Protein, His-tagged HEK293 His
S-507S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A522S) Protein, His-tagged HEK293 His
S-508S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(D405V, Q414A) Protein, His-tagged HEK293 His
S-509S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(Q414E) Protein, His-tagged HEK293 His
S-510S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(P384L) Protein, His-tagged HEK293 His
S-511S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A348S) Protein, His-tagged HEK293 His
S-512S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F338L) Protein, His-tagged HEK293 His
S-513S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F377L) Protein, His-tagged HEK293 His
S-514S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(P521S) Protein, His-tagged HEK293 His
S-515S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(T478I) Protein, His-tagged HEK293 His
S-516S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(V483I) Protein, His-tagged HEK293 His
S-517S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(S359N) Protein, His-tagged HEK293 His
S-518S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K378R) Protein, His-tagged HEK293 His
S-519S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(Q409E) Protein, His-tagged HEK293 His
S-520S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(I472V) Protein, His-tagged HEK293 His
S-521S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A372T) Protein, His-tagged HEK293 His
S-522S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A344S) Protein, His-tagged HEK293 His
S-523S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A520V) Protein, His-tagged HEK293 His
S-524S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (A435S) Protein, His-tagged HEK293 His
S-525S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(E406Q) Protein, His-tagged HEK293 His
S-526S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F490S) Protein, His-tagged HEK293 His
S-527S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K378N) Protein, His-tagged HEK293 His
S-528S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N370S) Protein, His-tagged HEK293 His
S-529S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(Q414R) Protein, His-tagged HEK293 His
S-530S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(S477I) Protein, His-tagged HEK293 His
S-531S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(S477N) Protein, His-tagged HEK293 His
S-532S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(T385A) Protein, His-tagged HEK293 His
S-533S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(T393P) Protein, His-tagged HEK293 His
S-534S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(V395I) Protein, His-tagged HEK293 His
S-535S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (V483A) Protein, His-tagged HEK293 His
S-536S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A475V) Protein, His-tagged HEK293 His
S-537S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(G446V) Protein, His-tagged HEK293 His
S-538S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(G485S) Protein, His-tagged HEK293 His
S-539S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(G482S) Protein, His-tagged HEK293 His
S-540S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K444R) Protein, His-tagged HEK293 His
S-541S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N440K) Protein, His-tagged HEK293 His
S-542S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(E471Q) Protein, His-tagged HEK293 His
S-543S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(P479S) Protein, His-tagged HEK293 His
S-544S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(A352S) Protein, His-tagged HEK293 His
S-545S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (F342L) Protein, His-tagged HEK293 His
S-546S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(P337S) Protein, His-tagged HEK293 His
S-547S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(P521R) Protein, His-tagged HEK293 His
S-548S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(S477R) Protein, His-tagged HEK293 His
S-549S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(L455F) Protein, His-tagged HEK293 His
S-550S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(K458Q) Protein, His-tagged HEK293 His
S-551S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (K458R) Protein, His-tagged HEK293 His
S-552S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N481D) Protein, His-tagged HEK293 His
S-553S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F456L) Protein, His-tagged HEK293 His
S-554S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(Y505C) Protein, His-tagged HEK293 His
S-555S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F456E) Protein, His-tagged HEK293 His
S-556S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F486S) Protein, His-tagged HEK293 His
S-557S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(N487R) Protein, His-tagged HEK293 His
S-558S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(G446S) Protein, His-tagged HEK293 His
S-559S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(P499R) Protein, His-tagged HEK293 His
S-560S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(V445F) Protein, His-tagged HEK293 His
S-561S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(G476S) Protein, His-tagged HEK293 His
S-562S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD(F490L) Protein, His-tagged HEK293 His
S-563S Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD (W436R) Protein, His-tagged HEK293 His
S-564S Recombinant SARS-CoV-2 Spike RBD (N440D) Protein, His-tagged HEK293 His
S-565S Recombinant SARS-CoV-2 Spike RBD (F456Y) Protein, His-tagged HEK293 His
S-566S Recombinant SARS-CoV-2 Spike RBD (E471A) Protein, His-tagged HEK293 His
S-567S Recombinant SARS-CoV-2 Spike RBD (E471D) Protein, His-tagged HEK293 His
S-568S Recombinant SARS-CoV-2 Spike RBD (Y473F) Protein, His-tagged HEK293 His
S-569S Recombinant SARS-CoV-2 Spike RBD (A475T) Protein, His-tagged HEK293 His
S-570S Recombinant SARS-CoV-2 Spike RBD (G476A) Protein, His-tagged HEK293 His
S-571S Recombinant SARS-CoV-2 Spike RBD (S477G) Protein, His-tagged HEK293 His
S-572S Recombinant SARS-CoV-2 Spike RBD (P479L) Protein, His-tagged HEK293 His
S-573S Recombinant SARS-CoV-2 Spike RBD (P479H) Protein, His-tagged HEK293 His
S-574S Recombinant SARS-CoV-2 Spike RBD (N481K) Protein, His-tagged HEK293 His
S-575S Recombinant SARS-CoV-2 Spike RBD (E484A) Protein, His-tagged HEK293 His
S-576S Recombinant SARS-CoV-2 Spike RBD (E484D) Protein, His-tagged HEK293 His
S-577S Recombinant SARS-CoV-2 Spike RBD (N487D) Protein, His-tagged HEK293 His
S-578S Recombinant SARS-CoV-2 Spike RBD (Y449H) Protein, His-tagged HEK293 His
S-579S Recombinant SARS-CoV-2 Spike RBD (G502V) Protein, His-tagged HEK293 His
Cat# Product Name Identity Source
Spike-011V Recombinant 2019-nCoV Spike RBD(L452R, E484Q) Protein, His-tagged S1(RBD)(L452R, E484Q)-His HEK293
Spike-012V Recombinant 2019-nCoV Spike RBD(D377Y) Protein, His-tagged S1(RBD)(D377Y)-His E. coli
Spike-014V Recombinant 2019-nCoV S1(HV69-70del, Y144del, N501Y, A570D, D614G, P681H) Protein, His-tagged, Biotinylated S1(HV69-70del, Y144del, N501Y, A570D, D614G, P681H)-His HEK293
Spike-016V Recombinant 2019-nCoV Spike RBD(N501Y) Protein, His-tagged at the C-terminus, Biotinylated S1(RBD)(N501Y)-His HEK293
Spike-017V Recombinant 2019-nCoV Spike RBD(E484K) Protein, His-tagged, Biotinylated S1(RBD)(E484K)-His HEK293
Spike-018V Recombinant 2019-nCoV Spike S1 ( E154K, L452R, E484Q, D614G, P681R) Protein, His-tagged S1 ( E154K, L452R, E484Q, D614G, P681R)-His HEK293
Spike-019V Recombinant 2019-nCoV Spike S1(W152C, L452R, D614G) Protein, His-tagged S1(W152C, L452R, D614G)-His HEK293
N-021V Recombinant 2019-nCoV N(E378Q) Protein, His-tagged N(E378Q)-His E. coli
Spike-023V Recombinant 2019-nCoV Spike S1+S2 ECD(D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged S1+S2 ECD(D80A, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V)-His Insect Cells
Spike-024V Recombinant 2019-nCoV Spike S1+S2 ECD(L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701VV) Protein, His-tagged S1+S2 ECD(L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701VV)-His Insect Cells
Spike-025V Recombinant 2019-nCoV Spike S1+S2 ECD(L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged, Biotinylated S1+S2 ECD(L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G, A701V)-His Insect Cells
Spike-026V Recombinant 2019-nCoV Spike S1+S2 ECD(D80A, K417N, E484K, N501Y, D614G, A701V) Protein, His-tagged, Biotinylated S1+S2 ECD(D80A, K417N, E484K, N501Y, D614G, A701V)-His Insect Cells
Spike-027V Recombinant 2019-nCoV Spike S1 NTD(L18F, D80A, D215G, LAL242-244 deletion, R246I) Protein, His-tagged S1 NTD(L18F, D80A, D215G, LAL242-244 deletion, R246I)-His HEK293
Spike-028V Recombinant 2019-nCoV Spike S1(L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G) Protein, His-tagged, Biotinylated S1(L18F, D80A, D215G, LAL242-244 deletion, R246I, K417N, E484K, N501Y, D614G)-His HEK293
Spike-029V Recombinant 2019-nCoV Spike RBD(K417N) Protein, His-tagged, Biotinylated S1(RBD)(K417N)-His HEK293
Spike-030V Recombinant 2019-nCoV Spike RBD(K417N, E484K, N501Y) Protein, His-tagged, Biotinylated S1(RBD)(K417N, E484K, N501Y)-His HEK293
Spike-031V Recombinant 2019-nCoV Spike RBD(E484K) Protein, rFc-tagged S1(RBD)(E484K)-His HEK293
Spike-032V Recombinant 2019-nCoV Spike RBD(K417N, E484K, N501Y) Protein, rFc-tagged S1(RBD)(K417N, E484K, N501Y)-His HEK293
Spike-033V Recombinant 2019-nCoV Spike RBD(K417N) Protein, rFc-tagged S1(RBD)(K417N)-His HEK293
Spike-035V Recombinant 2019-nCoV Spike S1+S2 ECD(L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) Protein, His-tagged S1+S2 ECD(L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F)-His Insect Cells
Spike-036V Recombinant 2019-nCoV Spike S1+S2 ECD(L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I) Protein, His-tagged S1+S2 ECD(L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I)-His Insect Cells
Spike-037V Recombinant 2019-nCoV S1(L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y) Protein, His-tagged S1(L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y)-His HEK293
Spike-038V Recombinant 2019-nCoV Spike RBD(K417T, E484K, N501Y) Protein, rFc-tagged S1(RBD)(K417T, E484K, N501Y)-His HEK293
Spike-039V Recombinant 2019-nCoV Spike RBD(K417T) Protein, rFc-tagged S1(RBD)(K417T)-His HEK293
Spike-040V Recombinant 2019-nCoV Spike RBD(Y453F) Protein, rFc-tagged S1(RBD)(Y453F)-His HEK293
N-041V Recombinant 2019-nCoV N(P80R) Protein, His-tagged N(P80R)-His E. coli
N-042V Recombinant 2019-nCoV N(T205I) Protein, His-tagged N(T205I)-His E. coli
Spike-043V Recombinant 2019-nCoV Spike S1+S2 ECD(D614G) Protein, His-tagged S1+S2 ECD(D614G)-His Insect Cells
Spike-044V Recombinant 2019-nCoV Spike S1+S2 ECD(HV69-70 deletion, D614G, D796H) Protein, His-tagged S1+S2 ECD(HV69-70 deletion, D614G, D796H)-His Insect Cells
Spike-055V Recombinant 2019-nCoV Spike S2 ECD(E780Q) Protein, Fc-tagged S1S2 ECD(E780Q)-His HEK293
Spike-056V Recombinant 2019-nCoV Spike S1 ECD(D614G) Protein, Fc-tagged S1 ECD(D614G)-His HEK293
Spike-057V Recombinant 2019-nCoV Spike S1(Q677H) Protein, His-tagged S1(Q677H)-His HEK293
Spike-082V Recombinant 2019-nCoV Spike RBD (L452R, E484Q) Protein, His-Avi-tagged, Biotinylated S1(L452R, E484Q)-His HEK293
Spike-083V Recombinant 2019-nCoV Spike RBD (L452R, E484Q) Protein, His-tagged S1(L452R, E484Q)-His HEK293
Spike-084V Recombinant 2019-nCoV Spike S1(K417N, E484K, N501Y, D614G) Protein, His-tagged S1(K417N, E484K, N501Y, D614G)-His HEK293
Spike-085V Recombinant 2019-nCoV Spike S1(HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H) Protein, His-tagged S1(HV69-70 deletion, Y144 deletion, N501Y, A570D, D614G, P681H)-His HEK293
Spike-086V Recombinant 2019-nCoV Spike RBD (N501Y) Protein, Fc-tagged S1 RBD(N501Y)-Fc HEK293
Spike-048V Recombinant 2019-nCoV S1+S2 ECD(HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) Protein, His-tagged S1+S2 ECD(HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H)-His HEK293
Spike-02D Recombinant 2019-nCoV S1+S2 ECD(Y453F, 69-70del, I692V) Protein, His-tagged S1+S2 ECD(Y453F, 69-70del, I692V)-His Insect cells
Spike-045V Recombinant 2019-nCoV Spike S1(HV69-70del, N501Y, D614G) Protein, His-tagged S1(HV69-70del, N501Y, D614G)-His HEK293
Spike-046V Recombinant 2019-nCoV Spike S1(N501Y) Protein, His-tagged S1(N501Y)-His HEK293
Spike-047V Recombinant 2019-nCoV Spike RBD(K417N, E484K, N501Y) Protein, His-tagged S1 RBD(K417N, E484K, N501Y)-His HEK293
Spike-03S Recombinant 2019-nCoV S1+S2 ECD(L18F, D80A, D215G, 242-244 deletion, R246I, K417N, E484K, N501Y, A701V) Protein, His-tagged S1+S2 ECD(L18F, D80A, D215G, 242-244 deletion, R246I, K417N, E484K, N501Y, A701V)-His Insect cells
Spike-01U Recombinant 2019-nCoV S1+S2 ECD(HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H) Protein, His-tagged S1+S2 ECD(HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H)-His Insect cells
Spike-145V Recombinant 2019-nCoV Spike protein RBD(N501Y), His-tagged S1(RBD)(N501Y)-His HEK293
Spike-213V Recombinant COVID-19 S protein RBD(N354D), His-tagged S1(RBD)(N354D)-His HEK293
Spike-214V Recombinant COVID-19 S protein RBD (N354D, D364Y), His-tagged S1(RBD)(N354D, D364Y)-His HEK293
Spike-215V Recombinant COVID-19 S protein RBD (W436R), His-tagged S1(RBD)(W436R)-His HEK293
Spike-216V Recombinant COVID-19 S protein RBD (R408I), His-tagged S1(RBD)(R408I)-His HEK293
Spike-219V Recombinant COVID-19 Spike S1 (D614G) protein, His-tagged S1(D614G)-His HEK293
Spike-220V Recombinant COVID-19 Spike RBD (K458R) protein, His-tagged S1(RBD)(K458R)-His HEK293
Spike-221V Recombinant COVID-19 Spike RBD (F342L) protein, His-tagged S1(RBD)(F342L)-His HEK293
Spike-222V Recombinant COVID-19 Spike RBD (V483A) protein, His-tagged S1(RBD)(V483A)-His HEK293
Spike-223V Recombinant COVID-19 Spike RBD (A435S) protein, His-tagged S1(RBD)(A435S)-His HEK293
Spike-224V Recombinant COVID-19 Spike RBD (G476S) protein, His-tagged S1(RBD)(G476S)-His HEK293
Spike-300V Recombinant COVID-19 Spike RBD (V367F) protein, mFc-tagged S1(RBD)(V367F)-His HEK293
Spike-301V Recombinant COVID-19 Spike RBD (V341I) protein, His-tagged S1(RBD)(V341I)-His HEK293
Spike-302V Recombinant COVID-19 Spike RBD (Y508H) protein, His-tagged S1(RBD)(Y508H)-His HEK293
Spike-303V Recombinant COVID-19 Spike RBD (N439K) protein, His-tagged S1(RBD)(N439K)-His HEK293
Spike-304V Recombinant COVID-19 Spike RBD (V503F) protein, His-tagged S1(RBD)(V503F)-His HEK293
Spike-305V Recombinant COVID-19 Spike RBD (A522V) protein, His-tagged S1(RBD)(A522V)-His HEK293
Spike-306V Recombinant COVID-19 Spike RBD (S494P) protein, His-tagged S1(RBD)(S494P)-His HEK293
Spike-307V Recombinant COVID-19 Spike RBD (A372S) protein, His-tagged S1(RBD)(A372S)-His HEK293
Spike-308V Recombinant COVID-19 Spike RBD (A520S) protein, His-tagged S1(RBD)(A520S)-His HEK293
Spike-309V Recombinant COVID-19 Spike RBD (A522S) protein, His-tagged S1(RBD)(A522S)-His HEK293
Spike-310V Recombinant COVID-19 Spike RBD (D405V, Q414A) protein, His-tagged S1(RBD)(D405V, Q414A)-His HEK293
Spike-311V Recombinant COVID-19 Spike RBD (Q414E) protein, His-tagged S1(RBD)(Q414E)-His HEK293
Spike-312V Recombinant COVID-19 Spike RBD (P384L) protein, His-tagged S1(RBD)(P384L)-His HEK293
Spike-313V Recombinant COVID-19 Spike RBD (A348S) protein, His-tagged S1(RBD)(A348S)-His HEK293
Spike-314V Recombinant COVID-19 Spike RBD (F338L) protein, His-tagged S1(RBD)(F338L)-His HEK293
Spike-315V Recombinant COVID-19 Spike RBD (F377L) protein, His-tagged S1(RBD)(F377L)-His HEK293
Spike-316V Recombinant COVID-19 Spike RBD (L452R) protein, His-tagged S1(RBD)(L452R)-His HEK293
Spike-317V Recombinant COVID-19 Spike RBD (P521S) protein, His-tagged S1(RBD)(P521S)-His HEK293
Spike-318V Recombinant COVID-19 Spike RBD (T478I) protein, His-tagged S1(RBD)(T478I)-His HEK293
Spike-319V Recombinant COVID-19 Spike RBD (V483I) protein, His-tagged S1(RBD)(V483I)-His HEK293
Spike-320V Recombinant COVID-19 Spike RBD (S359N) protein, His-tagged S1(RBD)(S359N)-His HEK293
Spike-321V Recombinant COVID-19 Spike RBD (K378R) protein, His-tagged S1(RBD)(K378R)-His HEK293
Spike-322V Recombinant COVID-19 Spike RBD (Q409E) protein, His-tagged S1(RBD)(Q409E)-His HEK293
Spike-323V Recombinant COVID-19 Spike RBD (I472V) protein, His-tagged S1(RBD)(I472V)-His HEK293
Spike-324V Recombinant COVID-19 Spike RBD (A372T) protein, His-tagged S1(RBD)(A372T)-His HEK293
Spike-325V Recombinant COVID-19 Spike RBD (A344S) protein, His-tagged S1(RBD)(A344S)-His HEK293
Spike-326V Recombinant COVID-19 Spike RBD (A520V) protein, His-tagged S1(RBD)(A520V)-His HEK293
Spike-327V Recombinant COVID-19 Spike RBD (E406Q) protein, His-tagged S1(RBD)(E406Q)-His HEK293
Spike-328V Recombinant COVID-19 Spike RBD (F490S) protein, His-tagged S1(RBD)(F490S)-His HEK293
Spike-329V Recombinant COVID-19 Spike RBD (K378N) protein, His-tagged S1(RBD)(K378N)-His HEK293
Spike-330V Recombinant COVID-19 Spike RBD (N370S) protein, His-tagged S1(RBD)(N370S)-His HEK293
Spike-331V Recombinant COVID-19 Spike RBD (Q414R) protein, His-tagged S1(RBD)(Q414R)-His HEK293
Spike-332V Recombinant COVID-19 Spike RBD (S477I) protein, His-tagged S1(RBD)(S477I)-His HEK293
Spike-333V Recombinant COVID-19 Spike RBD (S477N) protein, His-tagged S1(RBD)(S477N)-His HEK293
Spike-334V Recombinant COVID-19 Spike RBD (T385A) protein, His-tagged S1(RBD)(T385A)-His HEK293
Spike-335V Recombinant COVID-19 Spike RBD (T393P) protein, His-tagged S1(RBD)(T393P)-His HEK293
Spike-336V Recombinant COVID-19 Spike RBD (V395I) protein, His-tagged S1(RBD)(V395I)-His HEK293
Spike-337V Recombinant COVID-19 Spike RBD (G485S) protein, His-tagged S1(RBD)(G485S)-His HEK293
Spike-338V Recombinant COVID-19 Spike RBD (G482S) protein, His-tagged S1(RBD)(G482S)-His HEK293
Spike-339V Recombinant COVID-19 Spike RBD (K444R) protein, His-tagged S1(RBD)(K444R)-His HEK293
Spike-340V Recombinant COVID-19 Spike RBD (N440K) protein, His-tagged S1(RBD)(N440K)-His HEK293
Spike-341V Recombinant COVID-19 Spike RBD (E471Q) protein, His-tagged S1(RBD)(E471Q)-His HEK293
Spike-342V Recombinant COVID-19 Spike RBD (P479S) protein, His-tagged S1(RBD)(P479S)-His HEK293
Spike-343V Recombinant COVID-19 Spike RBD (A352S) protein, His-tagged S1(RBD)(A352S)-His HEK293
Spike-344V Recombinant COVID-19 Spike RBD (K417N) protein, His-tagged S1(RBD)(K417N)-His HEK293
Spike-345V Recombinant COVID-19 Spike RBD (P337S) protein, His-tagged S1(RBD)(P337S)-His HEK293
Spike-346V Recombinant COVID-19 Spike RBD (P521R) protein, His-tagged S1(RBD)(P521R)-His HEK293
Spike-347V Recombinant COVID-19 Spike RBD (S477R) protein, His-tagged S1(RBD)(S477R)-His HEK293
N-348V Recombinant 2019-nCoV N(P13L) Protein, His-tagged N(P13L)-His E. coli
N-349V Recombinant 2019-nCoV N(S194L) Protein, His-tagged N(S194L)-His E. coli
N-350V Recombinant 2019-nCoV N(R203K, G204R) Protein, His-tagged N(R203K, G204R)-His E. coli
N-351V Recombinant 2019-nCoV N(I292T) Protein, His-tagged N(I292T)-His E. coli
N-352V Recombinant 2019-nCoV N(D3L, R203K, G204R, S235F) Protein, His-tagged N(D3L, R203K, G204R, S235F)-His E. coli
N-353V Recombinant 2019-nCoV N(D3L, S235F) Protein, His-tagged N(D3L, S235F)-His E. coli
Spike-354V Recombinant 2019-nCoV Spike RBD(V445F) Protein, His-tagged S1(RBD)(V445F)-His HEK293
Spike-355V Recombinant 2019-nCoV Spike RBD(G446S) Protein, His-tagged S1(RBD)(G446S)-His HEK293
Spike-356V Recombinant 2019-nCoV Spike RBD(G446V) Protein, His-tagged S1(RBD)(G446V)-His HEK293
Spike-357V Recombinant 2019-nCoV Spike RBD(Y453F) Protein, His-tagged S1(RBD)(Y453F)-His HEK293
Spike-358V Recombinant 2019-nCoV Spike RBD(L455F) Protein, His-tagged S1(RBD)(L455F)-His HEK293
Spike-359V Recombinant 2019-nCoV Spike RBD(F456E) Protein, His-tagged S1(RBD)(F456E)-His HEK293
Spike-360V Recombinant 2019-nCoV Spike RBD(F456L) Protein, His-tagged S1(RBD)(F456L)-His HEK293
Spike-361V Recombinant 2019-nCoV Spike RBD(K458Q) Protein, His-tagged S1(RBD)(K458Q)-His HEK293
Spike-362V Recombinant 2019-nCoV Spike RBD(N481D) Protein, His-tagged S1(RBD)(N481D)-His HEK293
Spike-363V Recombinant 2019-nCoV Spike RBD(E484K) Protein, His-tagged S1(RBD)(E484K)-His HEK293
Spike-364V Recombinant 2019-nCoV Spike RBD(E484Q) Protein, His-tagged S1(RBD)(E484Q)-His HEK293
Spike-365V Recombinant 2019-nCoV Spike RBD(F486S) Protein, His-tagged S1(RBD)(F486S)-His HEK293
Spike-366V Recombinant 2019-nCoV Spike RBD(N487R) Protein, His-tagged S1(RBD)(N487R)-His HEK293
Spike-367V Recombinant 2019-nCoV Spike RBD(F490L) Protein, His-tagged S1(RBD)(F490L)-His HEK293
Spike-368V Recombinant 2019-nCoV Spike RBD(P499R) Protein, His-tagged S1(RBD)(P499R)-His HEK293
Spike-369V Recombinant 2019-nCoV Spike RBD(Y505C) Protein, His-tagged S1(RBD)(Y505C)-His HEK293
Spike-370V Recombinant 2019-nCoV Spike S1(HV69-70 deletion, Y453F, D614G) Protein, His-tagged S1(HV69-70 deletion, Y453F, D614G)-His HEK293
Spike-371V Recombinant 2019-nCoV Spike S1(HV69-70 deletion, N439K, D614G) Protein, His-tagged S1(HV69-70 deletion, N439K, D614G)-His HEK293
Spike-372V Recombinant 2019-nCoV Spike S1(L18F, D614G) Protein, His-tagged S1(L18F, D614G)-His HEK293
Spike-373V Recombinant 2019-nCoV Spike S1(T20N, D614G) Protein, His-tagged S1(T20N, D614G)-His HEK293
Spike-374V Recombinant 2019-nCoV Spike S1(A222V, D614G) Protein, His-tagged S1(A222V, D614G)-His HEK293
Spike-375V Recombinant 2019-nCoV Spike S1(N234Q) Protein, His-tagged S1(N234Q)-His HEK293
Spike-376V Recombinant 2019-nCoV Spike S1 ECD (D614G) Protein, Fc-tagged S1 ECD (D614G)-His HEK293
Spike-377V Recombinant 2019-nCoV Spike S1+S2 ECD (R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P) Protein, His-tagged S1+S2 ECD (R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P)-His HEK293
Spike-378V Recombinant COVID-19 Spike RBD (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F) protein, His-tagged S1(RBD) (L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F)-His HEK293
Spike-379V Recombinant COVID-19 Spike RBD (D614G) protein, His-Avi-tagged S1(RBD) (D614G)-His HEK293
Spike-380V Recombinant COVID-19 Spike RBD (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, A701V) protein, His-tagged S1(RBD) (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G, A701V)-His HEK293
Spike-381V Recombinant COVID-19 S1 (HV69-70del) protein, His-tagged S1 (HV69-70del)-His HEK293
Spike-382V Recombinant COVID-19 S1 (Y144del) protein, His-tagged S1 (Y144del)-His HEK293
Spike-383V Recombinant COVID-19 S1 NTD(A222V) protein, His-tagged S1 NTD(A222V)-His HEK293
Spike-384V Recombinant COVID-19 S1 NTD(A262S) protein, His-tagged S1 NTD(A262S)-His HEK293
Spike-385V Recombinant COVID-19 S1 NTD(P272L) protein, His-tagged S1 NTD(P272L)-His HEK293
Spike-386V Recombinant COVID-19 S1 NTD(L18F, D80A, D215G, R246I) protein, His-tagged S1 NTD(L18F, D80A, D215G, R246I)-His HEK293
Spike-387V Recombinant COVID-19 Spike RBD (V367F) protein, His-tagged S1(RBD) (V367F)-His HEK293
Spike-388V Recombinant COVID-19 Spike RBD (A475V) protein, His-tagged S1(RBD) (A475V)-His HEK293
Spike-389V Recombinant COVID-19 Spike RBD (K417T, E484K, N501Y) protein, His-tagged S1(RBD) (K417T, E484K, N501Y)-His HEK293
Spike-390V Recombinant COVID-19 S1 (A570D) protein, His-tagged S1 (A570D)-His HEK293
Spike-391V Recombinant COVID-19 S1 (D614G) protein, His-Avi-tagged S1 (D614G)-His HEK293
Spike-392V Recombinant COVID-19 S1 (P681H) protein, His-tagged S1 (P681H)-His HEK293
Spike-393V Recombinant COVID-19 S1 (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G) protein, His-tagged S1 (L18F, D80A, D215G, R246I, K417N, E484K, N501Y, D614G)-His HEK293

Backgound

The COVID-19 outbreak has caused large numbers of death, as well as social and economic chaos worldwide. SARS-CoV-2 virus is the causative agent of this respiratory disease.

The scientific community has known that SARS-CoV-2 binds to host cell receptors through its surface spike (S) proteins and is endocytosed into cells through clathrin-mediated membrane fusion. The relationship and affinity between the host cell receptor and the virus surface protein determine the infectivity and cytophilic characteristics of the virus. The pathogenicity and invading of the virus are related to the type and function of the host cell. Crystal structure analysis confirmed that angiotensin-converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2 S protein, and the affinity of the two is 10-20 times that of SARS-CoV and ACE2, which is the reason of SARS-CoV-2 super infectivity.

SARS-CoV-2 Proteins and Their Target Proteins

So far, no clinically available antiviral drugs have been developed for SARS-CoV, SARS-CoV-2, or MERS-CoV. Some studies used affinity purification-mass spectrometry analysis that have identified hundreds of protein interactions between SARS-CoV-2 proteins and human proteins, including DNA replication (Nsp1), epigenetic and gene expression regulators (Nsp5, Nsp8, Nsp13, E), vesicle trafficking (Nsp6, Nsp7, Nsp10, Nsp13, Nsp15, Orf3a, E, Orf8), lipid modification (Spike), RNA processing and regulation (Nsp8, N), ubiquitin ligases (Orf10), signaling (Nsp8, Nsp13, N, Orf9b), nuclear transport machinery (Nsp9, Nsp15, Orf6), cytoskeleton (Nsp1, Nsp13), mitochondria (Nsp4, Nsp8, Orf9c), and extracellular matrix (Nsp9). Results from data analysis suggested that the viral proteins connect to a wide array of biological processes, including protein trafficking, translation, transcription, and ubiquitination regulation.

A total of 332 high confidence SARS-CoV-2-human protein-protein interactions (PPIs) have been identified. Among these, using a combination of a systematic chemoinformatic drug search with a pathway centric analysis, researchers have uncovered 66 druggable human proteins or host factors targeted by close to 70 different drugs and compounds, including FD A approved drugs, compounds in clinical trials as well as preclinical compounds. Additionally, this proteomic/chemoinformatic analysis gives these potential therapeutic perturbations a mechanistic context.

Creative BioMart has collected many SARS-CoV-2 related proteins and druggable target proteins, which can help you discover antiviral therapies against SARS-CoV-2 and other deadly coronavirus strains.

B.1.1.529 contains at least 50 mutations, 30 of which are on the spike protein (S protein). Not surprisingly, spike protein has become the research and development target of most vaccines. Some of the mutations are known to affect infectivity and immune escape, while others are newly identified. It is currently unknown what will happen when these mutations combine and their effects on the Sars-CoV-2 vaccine.

Backgound

Coronavirus uses its spike glycoprotein (S), a main target for neutralization antibody, to bind to its receptor, and mediate membrane fusion and virus entry. Its receptor binding domain (RBD) has a high affinity with the ACE2 receptor protein on the surface of human cells. The S protein is an ideal entry point for vaccine design. The neutralizing antibody binds to the viral S protein RBD to competitively block the virus binding to the ACE2 protein and infect cells, achieving the effect of immune prevention and even treatment.

Creative BioMart is still committed to overcoming the challenges posed by the COVID-19 pandemic. We have just added a new panel of mutant RBD/spike and nucleocapsid proteins. In addition to the Omicron variant, Creative BioMart also provides other COVID variants (Alpha, Beta, Gamma, Delta, Eta, Iota, Kappa, and Lambda). We will continue to update our catalog to include new mutant proteins.

We can now offer mutant spike RBD proteins, which are thermally stable and can produce antibodies with neutralizing activity. We will continue to work together with the worldwide scientists to find the path forward for today’s challenges, and to support tomorrow’s breakthroughs.
South Africa has detected a new mutant of the Sars-CoV-2-B.1.1.529. The World Health Organization (WHO) included B.1.1.529 on the Variant of Concern (VOC), named Omicron.

Advantages

Consistency and Safety: Recombinant proteins can be produced consistently and in high quantities, ensuring they exhibit the same characteristics time and again. They do not carry the risk of infection as they are not part of the live virus.

Easy Scalability: They can be easily scaled up for mass production, making them suitable for large-scale screening, vaccine development, etc.

Controlled study: They allow for the study of individual viral proteins in isolation, which is not possible with the complete virus.

Affordability: It's not overly expensive to produce recombinant proteins, which is an advantage, especially in a public health crisis where cost-effectiveness is paramount.

Manipulation Capability: Recombinant proteins can be manipulated and modified to study different aspects of the virus, such as how mutations could potentially affect its function and behavior.

Applications

SARS-CoV-2 strain mutant proteins and virus interaction proteins have several applications related to research, diagnostics, and therapeutics for COVID-19.

  • Study of Virus-Host Interactions: It is very crucial for understanding how the virus infects human cells. By examining the interaction between the SARS-CoV-2 proteins and human cells, researchers can gain valuable insights into the life cycle of the virus and how it exploits host cells.
  • Drug Development: The SARS-CoV-2 strain mutant proteins and virus interaction proteins have been extensively used in the development of potential anti-viral drugs. Understanding the structure and function of these proteins can be used to design drugs that can potentially inhibit these proteins, preventing the virus from replicating.
  • Vaccine Development: The spike protein of SARS-CoV-2, which is important for the virus's ability to infect human cells, is the target for most COVID-19 vaccines. Understanding how this protein and its variants interact with human cells helps in the development of more effective vaccines.
  • Diagnostics: SARS-CoV-2 strain mutant proteins can be used in the development of diagnostic tools. For instance, tests that detect the presence of viral proteins in the blood or other fluids can be used to confirm COVID-19 infection.
  • Therapeutics: Antibodies designed to target specific viral proteins can act as therapeutic drugs. For example, monoclonal antibody treatments for COVID-19 work by binding to the spike protein and blocking the virus's ability to attach to and infect cells.
  • Understanding Virus Evolution: Studying the changes and variations in SARS-CoV-2 strain mutant proteins over time can help understand how the virus evolves, giving critical insights for public health responses and future vaccine development.
  • Epidemiological Surveillance: The study of different strains can be used to trace the spread and mutation of the virus in the population, providing valuable information for predicting future outbreaks and monitoring the progress of the pandemic.

Case Study

Case 1: Stein SR, Ramelli SC, Grazioli A, et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature. 2022 Dec;612(7941):758-763. doi: 10.1038/s41586-022-05542-y. Epub 2022 Dec 14. PMID: 36517603; PMCID: PMC9749650.

The Researchers carried out complete autopsies on 44 patients who died with COVID-19, with extensive sampling of the central nervous system in 11 of these patients, to map and quantify the distribution, replication and cell-type specificity of SARS-CoV-2 across the human body, including the brain, from acute infection to more than seven months following symptom onset. We show that SARS-CoV-2 is widely distributed, predominantly among patients who died with severe COVID-19, and that virus replication is present in multiple respiratory and non-respiratory tissues, including the brain, early in infection.

Case 1

Fig1. SARS-CoV-2 protein and RNA expression in human CNS tissues. a, High-magnification visualization of hypothalamus from P38 labelled for SARS-CoV-2 N protein (green) and neuronal nuclear (NeuN) protein (magenta), demonstrating viral-specific protein expression in neurons (white arrowheads) by IF. The z-stack orthogonal views to the right and bottom of a demonstrate NeuN labelling in the nucleus and SARS-CoV-2 protein in the cytoplasm of the cell (red arrowhead).

Case 2: Ju X, Zhu Y, Wang Y, Li J, et al. A novel cell culture system modeling the SARS-CoV-2 life cycle. PLoS Pathog. 2021 Mar 12;17(3):e1009439. doi: 10.1371/journal.ppat.1009439. PMID: 33711082; PMCID: PMC7990224.
ARS-CoV-2 is classified as a biosafety level-3 (BSL-3) agent, impeding the basic research into its biology and the development of effective antivirals. The authors developed a biosafety level-2 (BSL-2) cell culture system for production of transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). This trVLP expresses a reporter gene (GFP) replacing viral nucleocapsid gene (N), which is required for viral genome packaging and virion assembly (SARS-CoV-2 GFP/ΔN trVLP).
They developed a convenient and efficient SARS-CoV-2 reverse genetics tool to dissect the virus life cycle under a BSL-2 condition. This powerful tool should accelerate our understanding of SARS-CoV-2 biology and its antiviral development.

Fig1. The recombinant SARS-CoV-2-GFP/ΔN trVLP can propagate with the help of viral N protein.

Fig1. The recombinant SARS-CoV-2-GFP/ΔN trVLP can propagate with the help of viral N protein. GFP expression was observed in Caco-2 or Caco-2-N cells using microscopy at indicated time point after inoculation; Representative images from one of three independent experiments.

Fig2. Reconstitution of functional N protein by intein-mediated protein splicing.

Fig2. Reconstitution of functional N protein by intein-mediated protein splicing. Western blot (WB) analysis of lysates from Caco-2 cells transduced with either full-length N or intein-N lentiviruses. The star indicates the full-length N protein. The WB is representative of three independent experiments.

Case 3: Fink K, Nitsche A, Neumann M, Grossegesse M, Eisele KH, Danysz W. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. doi: 10.3390/v13040539. PMID: 33804989; PMCID: PMC8063946.

Even if vaccines are approved, the need for antiviral agents against SARS-CoV-2 will persist. However, unequivocal evidence for efficacy against SARS-CoV-2 has not been demonstrated for any of the repurposed antiviral drugs so far. Amantadine was approved as an antiviral drug against influenza A, and antiviral activity against SARS-CoV-2 has been reasoned by analogy but without data. The authors tested the efficacy of amantadine in vitro in Vero E6 cells infected with SARS-CoV-2.

Fig1. In vitro binding interference of the SARS-CoV-2 spike protein to recombinant ACE2 and amantadine, remdesivir,
    or camostat mesylate. None of the drugs inhibit SARS-CoV-2 binding to its target protein

Fig1. In vitro binding interference of the SARS-CoV-2 spike protein to recombinant ACE2 and amantadine, remdesivir, or camostat mesylate. None of the drugs inhibit SARS-CoV-2 binding to its target protein

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