ACTBL2
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Official Full Name
actin, beta-like 2
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Synonyms
ACTBL2; actin, beta-like 2; beta-actin-like protein 2; DKFZp686D0972; ACT; ACTBL_HUMAN; actin like protein; actin, beta like 2; kappa actin; Kappa-actin; actin-like protein;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ACTBL2-1258H | Recombinant Human ACTBL2 | Mammalian Cell | His |
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| Human | ACTBL2-2418H | Recombinant Human ACTBL2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | ACTBL2-2418H-B | Recombinant Human ACTBL2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ACTBL2-1240M | Recombinant Mouse ACTBL2 Protein | Mammalian Cell | His |
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| Mouse | ACTBL2-282M | Recombinant Mouse ACTBL2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ACTBL2-282M-B | Recombinant Mouse ACTBL2 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ACTBL2 Related Articles
ACTBL2 involved in several pathways and played different roles in them. We selected most pathways ACTBL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTBL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ACTBL2 has several biochemical functions, for example, ATP binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTBL2 itself. We selected most functions ACTBL2 had, and list some proteins which have the same functions with ACTBL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | BMPR1B;HK1;KIF21A;DYRK3;PAK3;CSNK1G2;DDX4;DHX15;SYK |
| molecular_function | TMEM132C;TMEM132E;RASSF7B;TAS2R125;CRYBA2B;CCDC142;D19ERTD737E;CRAMP1L;GM10487 |
ACTBL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTBL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTBL2.
GABARAP; FN1; NS; ERBB3; polg_hcvh; ARRB2; HTR7; MYH9; ARRB1; Tpm1; GABARAPL2; Actb; PRKCD; STK4; CTR9; ml_thogv; Tubgcp5; Myh9
- Q&As
- Reviews
Q&As (21)
Ask a questionActbl2 is postulated to be essential for cell motility based on its functional impact on various cellular processes related to cell movement.
The discovery of ACTBL2 adds to our understanding of the molecular landscape of CRC and holds potential for the development of marker panels for improved early cancer detection.
CR-ACTBL2 cells, with knocked-out ACTBL2, and OE-ACTBL2 cells, overexpressing actbl2, differed from control cells in invasion, focal adhesion formation, actin polymerization ratio, and the formation of lamellipodia and stress fibers.
The findings highlight the negative prognostic impact of ACTBL2 in EOC, suggesting its importance as a potential marker for the disease.
ACTBL2 is identified as a significant pivotal regulator in a dysfunction module associated with thymoma, suggesting its involvement in the molecular dysregulation of the disease.
Knocking out or overexpressing actbl2 in melanoma cells results in differences in invasion, focal adhesion formation, actin polymerization ratio, and the formation of lamellipodia and stress fibers.
Actbl2 is believed to be an important factor for cell motility based on the observed effects on cell behavior, suggesting its involvement in regulating cellular movement.
Yes, siRNA knockdown of NFAT5 led to downregulation of ACTBL2, suggesting a molecular interplay between the two proteins.
Actbl2 is believed to be the seventh actin isoform and plays an essential role in cell motility.
Actbl2 exhibits the largest number of non-conserved amino acid substitutions among all actins.
Yes, ACTBL2 shows potential as a therapeutic target in thymoma, based on its identification as an important component of thymoma molecular dysregulation.
ACTBL2 plays a role in supporting vascular smooth muscle cell (VSMC) migration and is involved in the alignment with stress fibers and dispersion in lamellipodia.
EOC cell lines showed significantly increased mRNA and protein levels of ACTBL2 compared to the benign control.
The divergence of actin groups, including actbl2, started at the beginning of vertebrate evolution.
ACTBL2 is expressed at a low level in several melanoma cell lines, but a small subset of cells shows high ACTBL2 expression.
ACTBL2 has been identified as a novel protein that is upregulated in CRC, potentially serving as a marker for early cancer detection.
Biomechanical stretch acts as a determinant for NFAT5 expression and nuclear translocation, which controls the expression of cytoskeletal protein ACTBL2.
SiRNA knockdown of ACTBL2 resulted in significantly reduced cellular viability, proliferation, and migration in vitro.
ACTBL2 expression is inhibited in cells when NFAT5 is knocked down using siRNA.
The study suggests that ACTBL2 plays a crucial role in ovarian carcinogenesis by modulating cellular motility and proliferation.
Actbl2 has a separate evolutionary history from muscle actins and exhibits the largest number of non-conserved amino acid substitutions among all actins.
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